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11/2009
In order to maintain genome stability, DNA damage needs to be detected and repaired in a timely fashion. To cope with damaged DNA, cells have evolved... 
Checkpoint | Rad53 | DNA damage | 0307 | saccharomyces cerevisiae
Dissertation
Molecular Cell, ISSN 1097-2765, 05/2018, Volume 70, Issue 4, pp. 628 - 638.e5
Cell survival to replication stress depends on the activation of the Mec1 -Rad53 checkpoint response that protects the integrity of stalled forks and controls... 
Rad53 | cyclin | Mad2 | 4E-BP | translation | Caf20 | Clb5 | Clb6 | intra-S checkpoint | replication origins | MITOTIC CHECKPOINT PROTEINS | SPINDLE CHECKPOINT | MAD2 | ACTIVATION | CLB5 | BUDDING YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERACTION MAP | SACCHAROMYCES-CEREVISIAE | RAD53 KINASE | DNA-REPLICATION | CELL BIOLOGY | Proteins | Protein biosynthesis | DNA synthesis | Genetic translation | Sediments (Geology)
Journal Article
DNA Repair, ISSN 1568-7864, 02/2019, Volume 74, pp. 1 - 16
Cells respond to DNA damage by activating cell cycle checkpoints, arresting cell division or DNA replication while damage is repaired. In activation of the... 
DNA damage checkpoint | Rad9 | Rad53 | Rtt107 | DNA damage response | Saccharomyces cerevisiae | COMPLEX | HISTONE H2A | FORK RESTART | PHOSPHORYLATION | SACCHAROMYCES-CEREVISIAE | REPAIR | SLX4 | GENETICS & HEREDITY | S-PHASE | TOXICOLOGY | HOMOLOGOUS RECOMBINATION | RAD53 KINASE
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2009, Volume 11, Issue 8, pp. 925 - 933
Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation... 
YEAST | MITOTIC CHROMOSOME TRANSMISSION | UBIQUITIN-CONJUGATING ENZYMES | IN-VIVO | H3 VARIANT | S-PHASE | CELL-CYCLE | DNA-SYNTHESIS | SACCHAROMYCES-CEREVISIAE | RAD53 KINASE | CELL BIOLOGY | Phosphorylation | Immunoprecipitation | Molecular Chaperones - metabolism | Saccharomyces cerevisiae - genetics | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Ubiquitination | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Chromatin Assembly Factor-1 | Cell Cycle Proteins - metabolism | Molecular Chaperones - genetics | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | Blotting, Western | Chromosomal Proteins, Non-Histone - genetics | Hydrolysis | Tyrosine - metabolism | Histones - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Checkpoint Kinase 2 | Protein Binding | Histones - metabolism | Mutation | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Proteolysis | Ligases | DNA | Histones | Physiological aspects | Genetic aspects | Research | Rad53 | Ubiquitylation | Ubc4 | Ubc5 | Tom1 | Proteasome
Journal Article
Journal Article
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 10/2019, Volume 30, Issue 22, pp. 2771 - 2789
Budding yeast treated with hydroxyurea (HU) activate the S phase checkpoint kinase Rad53, which prevents DNA replication forks from undergoing aberrant... 
TRANSCRIPTION FACTORS | CELL-CYCLE REGULATION | PERICENTRIC CHROMATIN | BUDDING YEAST | DAMAGE-INDUCED PHOSPHORYLATION | RAD53 PROTEIN-KINASE | SINGLE-STRANDED-DNA | CHROMOSOME SEGREGATION | STRESS | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY
Journal Article
CELL REPORTS, ISSN 2211-1247, 07/2019, Volume 28, Issue 4, pp. 1090 - 1090
In budding yeast, a single DNA double-strand break (DSB) triggers the activation of Mec1(ATR)-dependent DNA damage checkpoint. After about 12 h, cells turn off... 
G2/M ARREST | YEAST | MEC1/ATR | RAD53 | RPA | PROTEIN-KINASE | DEGRON SYSTEM | ADAPTATION | DOUBLE-STRAND BREAK | MEC1-DEPENDENT PHOSPHORYLATION | CELL BIOLOGY
Journal Article
Cell Reports, ISSN 2211-1247, 07/2019, Volume 28, Issue 4, pp. 1090 - 1102.e3
In budding yeast, a single DNA double-strand break (DSB) triggers the activation of Mec1 -dependent DNA damage checkpoint. After about 12 h, cells turn off the... 
checkpoint | Rad53 | Rad9 | DNA damage response | cell cycle | S. cerevisiae | PIKK | Mec1/ATR | Ddc2/ATRIP
Journal Article
MOLECULAR CELL, ISSN 1097-2765, 06/2004, Volume 14, Issue 5, pp. 657 - 666
Nucleosome loss from a promoter region has recently been described as a potential mechanism for transcriptional regulation. We investigated whether H3/H4... 
TRANSITION | RAD53 | HIR PROTEINS | POSITIONED NUCLEOSOMES | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHO5 PROMOTER | ASSEMBLY FACTOR-I | SACCHAROMYCES-CEREVISIAE | BINDING | DNA-REPLICATION | CELL BIOLOGY
Journal Article
DNA Repair, ISSN 1568-7864, 11/2019, Volume 83, p. 102674
Ribonucleotide reductase (RNR) catalyzes the rate limiting step in dNTP biosynthesis and is tightly regulated at the transcription and activity levels. One of... 
Ribonucleotide reductase | Fusarium oxysporum | GENOTOXIC STRESS | INHIBITOR SML1 | SPD1 | YEAST | RAD53 | DAMAGE RESPONSE | REPAIR | GENETICS & HEREDITY | CHECKPOINT | TOXICOLOGY | POOLS | CELL
Journal Article
by McCormick, Mark A and Delaney, Joe R and Tsuchiya, Mitsuhiro and Tsuchiyama, Scott and Shemorry, Anna and Sim, Sylvia and Chou, Annie Chia-Zong and Ahmed, Umema and Carr, Daniel and Murakami, Christopher J and Schleit, Jennifer and Sutphin, George L and Wasko, Brian M and Bennett, Christopher F and Wang, Adrienne M and Wang, Dennis and Olsen, Brady and Beyer, Richard P and Bammler, Theodor K and Prunkard, Donna and Johnson, Simon C and Pennypacker, Juniper K and An, Elroy and Anies, Arieanna and Castanza, Anthony S and Choi, Eunice and Dang, Nick and Enerio, Shiena and Fletcher, Marissa and Fox, Lindsay and Goswami, Sarani and Higgins, Sean A and Holmberg, Molly A and Hu, Di and Hui, Jessica and Jelic, Monika and Jeong, Ki-Soo and Johnston, Elijah and Kerr, Emily O and Kim, Diana and Kim, Jin and Kirkland, Katie and Klum, Shannon and Kotireddy, Soumya and Liao, Eric and Lim, Michael and Lin, Michael S and Lo, Winston C and Lockshon, Dan and Miller, Hillary A and Moller, Richard M and Muller, Brian and Oakes, Jonathan and Pak, Diana N and Peng, Zhao Jun and Pham, Kim M and Pollard, Tom G and Pradeep, Prarthana and Pruett, Dillon and Rai, Dilreet and Robison, Brett and Rodriguez, Ariana A and Ros, Bopharoth and Sage, Michael and Singh, Manpreet K and Smith, Erica D and Snead, Katie and Solanky, Amrita and Spector, Benjamin L and Steffen, Kristan K and Tchao, Bie Nga and Ting, Marc K and Vander Wende, Helen and Welton, K. Linnea and Westman, Eric A and Brem, Rachel B and Liu, Xin-guang and Suh, Yousin and Zhou, Zhongjun and Kaeberlein, Matt and Kennedy, Brian K
Cell Metabolism, ISSN 1550-4131, 11/2015, Volume 22, Issue 5, pp. 895 - 906
Journal Article