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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1609 - 1614
Radiation therapy can result in bone injury with the development of fractures and often can lead to delayed and nonunion of bone. There is no prevention or... 
Femur | Free radicals | Stem cells | Irradiation | Bone marrow | Bones | Physical trauma | Bone marrow cells | Radiation damage | Mesenchymal stem cells | CFU-fibroblast | Self-renewal | Angiography | Repopulation | Differentiation | MIGRATION | CAPACITY | differentiation | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | OSTEOGENESIS | self-renewal | angiography | CHEMOTHERAPY | TRANSPLANTATION | ORIGIN | ENGRAFTMENT | THERAPY | repopulation | Femur - pathology | Leukocyte Common Antigens - metabolism | Mesenchymal Stromal Cells - radiation effects | Blood Vessels - pathology | Bone Marrow - radiation effects | Blood Vessels - radiation effects | Radiation Injuries, Experimental - etiology | Free Radicals - metabolism | Antigens, Ly - metabolism | Colony-Forming Units Assay | Membrane Proteins - metabolism | Radiation Injuries, Experimental - metabolism | Osteoblasts - radiation effects | Femur - metabolism | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Mesenchymal Stromal Cells - metabolism | Thiobarbituric Acid Reactive Substances - metabolism | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Fibroblasts - pathology | Femur - radiation effects | Integrin beta1 - metabolism | Osteoblasts - pathology | Animals | Fibroblasts - radiation effects | Bone Marrow - pathology | Mice | Mesenchymal Stromal Cells - pathology | Bone Marrow Cells - metabolism | Physiological aspects | Complications and side effects | Stem cell research | Care and treatment | Radiotherapy | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12822 - 12827
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2010, Volume 48, Issue 2, pp. 348 - 356
Ionizing radiation (IR) and/or chemotherapy causes not only acute tissue damage but also late effects including long-term (or residual) bone marrow (BM)... 
Oxidative stress | Ionizing radiation | Senescence | Free radicals | Hematopoietic stem cells | NADPH OXIDASE | DNA-DAMAGE REPAIR | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-RENEWAL | INDUCED GENOMIC INSTABILITY | ROS | ENDOCRINOLOGY & METABOLISM | ATM | IONIZING-RADIATION | CYTOTOXIC AGENTS | Whole-Body Irradiation | Reactive Oxygen Species - metabolism | Oxidative Stress | Hematopoietic Stem Cells - pathology | Male | NADPH Oxidases - genetics | Female | NADPH Oxidases - biosynthesis | Acetylcysteine - administration & dosage | Hematopoietic Stem Cells - radiation effects | Radiation Injuries, Experimental - genetics | Radiation Injuries, Experimental - metabolism | DNA Damage - drug effects | Hematopoietic Stem Cells - drug effects | Mice, Inbred C57BL | Cells, Cultured | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | NADPH Oxidase 4 | Onium Compounds - pharmacology | Radiation Injuries, Experimental - pathology | Transplantation Tolerance - drug effects | Gene Expression Regulation - drug effects | Animals | Bone Marrow - pathology | Gene Expression Regulation - radiation effects | Cell Proliferation - drug effects | Mice | DNA Damage - radiation effects | Cell Proliferation - radiation effects | senescence | hematopoietic stem cells | ionizing radiation | oxidative stress
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0174474
Radiotherapy-induced gut toxicity is among the most prevalent dose-limiting toxicities following radiotherapy. Prevention of radiation enteropathy requires... 
LIPID-PEROXIDATION | GLUTATHIONE | INFLAMMASOME ACTIVATION | MULTIDISCIPLINARY SCIENCES | PATHOBIOLOGY | MUCOSITIS | MODEL | SUPEROXIDE-DISMUTASE | RADIATION-INJURY | EXPRESSION | CANCER | Intestinal Mucosa - radiation effects | Intestinal Mucosa - metabolism | Gels | Intestine, Small - pathology | Oxidative Stress | Rats, Wistar | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Oxidative Phosphorylation | Radiation-Protective Agents - administration & dosage | Male | NF-kappa B - metabolism | Radiation Injuries, Experimental - pathology | Intestinal Mucosa - drug effects | Melatonin - administration & dosage | Radiation Injuries, Experimental - prevention & control | Animals | Tongue - radiation effects | Intestine, Small - drug effects | Intestine, Small - radiation effects | Intestine, Small - metabolism | Drug Evaluation, Preclinical | Apoptosis | Intestinal Mucosa - pathology | Radiation Injuries, Experimental - metabolism | Usage | Melatonin | Care and treatment | Mucositis | Microbiota (Symbiotic organisms) | Radiotherapy | Health aspects | Oxidative stress | Neurosciences | Tongue | Post-irradiation | Toxicity | Mucosa | Cytotoxicity | Inflammatory response | Activation | Cancer therapies | Small intestine | Cell adhesion & migration | Mitochondria | Rodents | Digestive tract | Drug dosages | NF-κB protein | Medical research | Digestive system | Rats | Inflammation | Radiation therapy | Studies | Pathology | Irradiation | Cancer
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2013, Volume 32, Issue 2, pp. 231 - 244
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2013, Volume 700, Issue 1-3, pp. 42 - 50
Chronic inflammation in the brain is found in a range of neurodegenerative diseases such as Parkinson's or Alzheimer's disease. We have recently shown that... 
Infection | Incretins | Parkinson's disease | GLP-1 | Neurodegenerative diseases | Alzheimer's disease | Liraglutide | ALZHEIMERS-DISEASE | INJURY | CELL-PROLIFERATION | PROINFLAMMATORY CYTOKINES | INTERLEUKIN-6 | RODENT MODELS | GLUCAGON-LIKE PEPTIDE-1 | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Inflammation - pathology | Microglia - metabolism | Astrocytes - pathology | Body Weight - drug effects | Nitrites - metabolism | Male | Microglia - radiation effects | Eating - radiation effects | Astrocytes - radiation effects | Inflammation - metabolism | Inflammation - drug therapy | Radiation Injuries, Experimental - drug therapy | Anti-Inflammatory Agents - therapeutic use | Microglia - pathology | Radiation Injuries, Experimental - metabolism | Astrocytes - drug effects | Cytokines - metabolism | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Glucagon-Like Peptide 1 - analogs & derivatives | Mice, Inbred C57BL | Glucagon-Like Peptide 1 - pharmacology | Brain - radiation effects | Radiation Injuries, Experimental - pathology | Brain - drug effects | Eating - drug effects | Animals | Body Weight - radiation effects | Brain - pathology | Mice | Diabetes Mellitus, Type 2 - drug therapy | Radiation Injuries, Experimental - physiopathology | Astrocytes - metabolism | Glucagon-Like Peptide 1 - therapeutic use | Inflammation - physiopathology | Nitric Oxide Synthase Type II - metabolism
Journal Article