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International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2009, Volume 75, Issue 5, pp. 1528 - 1536
Purpose To find the mitigators of pneumonitis induced by moderate doses of thoracic radiation (10–15 Gy). Methods and Materials Unanesthetized WAG/RijCmcr... 
Radiology | Hematology, Oncology and Palliative Medicine | Radiation injury | mitigation | angiotensin-converting enzyme inhibitors | lung function | ACE | INDUCED PNEUMONOPATHY | BRADYKININ B-1 RECEPTOR | ENDOTHELIAL DYSFUNCTION | RAT | INDUCED LUNG INJURY | NEPHROPATHY | CONVERTING-ENZYME-INHIBITORS | ACE-INHIBITORS | IRRADIATION | ONCOLOGY | II TYPE-1 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiation Pneumonitis - pathology | Angiotensin Receptor Antagonists | Vasodilation - radiation effects | Radiation Pneumonitis - mortality | Respiratory Mechanics - drug effects | Captopril - therapeutic use | Vasoconstriction - physiology | Vasoconstriction - radiation effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Time Factors | Radiation Injuries, Experimental - drug therapy | Female | Lung - radiation effects | Pulmonary Artery - radiation effects | Vasodilation - physiology | Respiratory Mechanics - physiology | Radiation Injuries, Experimental - mortality | Drug Evaluation, Preclinical - methods | Lung - pathology | Rats | Renin-Angiotensin System - physiology | Respiratory Mechanics - radiation effects | Lung - physiopathology | Pulmonary Artery - drug effects | Radiation Dosage | Radiation Injuries, Experimental - pathology | Radiation Pneumonitis - physiopathology | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Vasoconstriction - drug effects | Pulmonary Artery - physiology | Captopril - administration & dosage | Animals | Losartan - therapeutic use | Renin-Angiotensin System - drug effects | Losartan - administration & dosage | Vasodilation - drug effects | Radiation Injuries, Experimental - physiopathology | Radiation Pneumonitis - drug therapy | Pneumonia | Bacterial pneumonia | Radiation | Index Medicus | HYDROLASES | RENIN | RADIATION EFFECTS | RATS | CARDIOVASCULAR AGENTS | ANGIOTENSIN | GLOBULINS | BIOLOGICAL EFFECTS | ENZYMES | DRUGS | VERTEBRATES | PNEUMONITIS | BIOLOGICAL RADIATION EFFECTS | MAMMALS | ANIMALS | INJURIES | RODENTS | NONSPECIFIC PEPTIDASES | ENZYME INHIBITORS | ORGANIC COMPOUNDS | RADIATION INJURIES | CHEST | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | DISEASES | VASOCONSTRICTORS | MITIGATION | PROTEINS | BODY | PEPTIDE HYDROLASES | angiotensin converting enzyme (ACE) inhibitors
Journal Article
Journal Article
Radiation Research, ISSN 0033-7587, 2013, Volume 179, Issue 5, pp. 549 - 556
Cognitive impairment precipitated by irradiation of normal brain tissue is commonly associated with radiation therapy for treatment of brain cancer, and... 
NERVOUS-SYSTEM | OBJECT RECOGNITION MEMORY | ADULT HIPPOCAMPAL NEUROGENESIS | THERAPEUTIC IRRADIATION | ENHANCED SYNAPTIC PLASTICITY | RAT DENTATE GYRUS | BIOPHYSICS | PROTEIN EXPRESSION | BIOLOGY | LONG-TERM POTENTIATION | GRANULE CELLS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | BRAIN | Inflammation - pathology | Microglia - metabolism | Rats, Inbred F344 | Cognition Disorders - metabolism | Male | Hippocampus - drug effects | Microglia - radiation effects | Pyridazines - pharmacology | Whole-Body Irradiation - adverse effects | Inflammation - metabolism | Long-Term Potentiation - drug effects | Inflammation - drug therapy | Radiation Injuries, Experimental - drug therapy | Recognition (Psychology) - radiation effects | Microglia - pathology | Neurogenesis - radiation effects | Neurogenesis - drug effects | Pyridazines - therapeutic use | Radiation Injuries, Experimental - metabolism | Cognition Disorders - physiopathology | Microglia - drug effects | Cognition Disorders - pathology | Rats | Hippocampus - pathology | Pyrimidines - pharmacology | Radiation Injuries, Experimental - pathology | Cognition Disorders - drug therapy | Long-Term Potentiation - radiation effects | Animals | Recognition (Psychology) - drug effects | Pyrimidines - therapeutic use | Hippocampus - radiation effects | Hippocampus - physiopathology | Radiation Injuries, Experimental - physiopathology | Cytokines - biosynthesis | Inflammation - physiopathology
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2017, Volume 313, Issue 2, pp. H392 - H407
Breast cancer radiotherapy increases the risk of heart failure with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radioresistant, but... 
Heart failure with preserved ejection fraction | Animal model | Diastolic dysfunction | Coronary microvasculature | Radiation | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MICROVASCULAR RAREFACTION | INDUCED MYOCARDIAL FIBROSIS | RISK | MODEL | FAILURE | INDUCED HEART-DISEASE | BREAST-CANCER | IRRADIATION | heart failure with preserved ejection fraction | coronary microvasculature | radiation | diastolic dysfunction | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | CARDIOVASCULAR-DISEASES | animal model | Dependovirus - genetics | Diastole | Male | Cyclic GMP-Dependent Protein Kinases - metabolism | Radiation Injuries, Experimental - etiology | Time Factors | Ventricular Dysfunction, Left - genetics | Myocardium - metabolism | Oxidative Stress - radiation effects | Signal Transduction - radiation effects | Radiation Injuries, Experimental - genetics | Radiation Injuries, Experimental - metabolism | Transduction, Genetic | Ventricular Function, Left - drug effects | Stroke Volume - drug effects | Ventricular Dysfunction, Left - etiology | Myocardium - pathology | Rats, Sprague-Dawley | Symporters - metabolism | Ventricular Dysfunction, Left - physiopathology | Ventricular Dysfunction, Left - metabolism | Animals | Cyclic GMP - metabolism | Symporters - genetics | Genetic Vectors | Dose-Response Relationship, Radiation | Radiation Injuries, Experimental - physiopathology
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 03/2019, Volume 60, Issue 4, pp. 1275 - 1285
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2013, Volume 700, Issue 1-3, pp. 42 - 50
Chronic inflammation in the brain is found in a range of neurodegenerative diseases such as Parkinson's or Alzheimer's disease. We have recently shown that... 
Infection | Incretins | Parkinson's disease | GLP-1 | Neurodegenerative diseases | Alzheimer's disease | Liraglutide | ALZHEIMERS-DISEASE | INJURY | CELL-PROLIFERATION | PROINFLAMMATORY CYTOKINES | INTERLEUKIN-6 | RODENT MODELS | GLUCAGON-LIKE PEPTIDE-1 | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Inflammation - pathology | Microglia - metabolism | Astrocytes - pathology | Body Weight - drug effects | Nitrites - metabolism | Male | Microglia - radiation effects | Eating - radiation effects | Astrocytes - radiation effects | Inflammation - metabolism | Inflammation - drug therapy | Radiation Injuries, Experimental - drug therapy | Anti-Inflammatory Agents - therapeutic use | Microglia - pathology | Radiation Injuries, Experimental - metabolism | Astrocytes - drug effects | Cytokines - metabolism | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Glucagon-Like Peptide 1 - analogs & derivatives | Mice, Inbred C57BL | Glucagon-Like Peptide 1 - pharmacology | Brain - radiation effects | Radiation Injuries, Experimental - pathology | Brain - drug effects | Eating - drug effects | Animals | Body Weight - radiation effects | Brain - pathology | Mice | Diabetes Mellitus, Type 2 - drug therapy | Radiation Injuries, Experimental - physiopathology | Astrocytes - metabolism | Glucagon-Like Peptide 1 - therapeutic use | Inflammation - physiopathology | Nitric Oxide Synthase Type II - metabolism
Journal Article
Clinical Science, ISSN 0143-5221, 04/2016, Volume 130, Issue 8, pp. 587 - 599
Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by CYP epoxygenases, and EETs are kidney protective in multiple pathologies. We determined... 
Fas | Novel small lipid molecule | Radiotherapy | Afferent arteriole | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | INDUCED APOPTOSIS | DNA-DAMAGE | CHRONIC OXIDATIVE STRESS | apoptosis | ANGIOTENSIN-II | ARACHIDONIC-ACID | novel small lipid molecule | IRRADIATION | ENDOTHELIUM | IN-VIVO | radiotherapy | afferent arteriole | INHIBITOR | RENAL INJURY | Fas Ligand Protein - metabolism | Kidney - blood supply | Captopril - pharmacology | Kidney - pathology | Apoptosis - drug effects | Blood Urea Nitrogen | Male | Steroid 16-alpha-Hydroxylase - metabolism | fas Receptor - metabolism | Cytochrome P450 Family 2 | Kidney - metabolism | Radiation Injuries, Experimental - prevention & control | Hypertension - prevention & control | Radiation-Protective Agents - pharmacology | Renal Circulation - drug effects | Albuminuria - metabolism | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Cytoprotection | Radiation Injuries, Experimental - metabolism | Kidney - drug effects | Eicosanoids - pharmacology | Acute Kidney Injury - pathology | Rats | Radiation Injuries, Experimental - pathology | Albuminuria - prevention & control | Acute Kidney Injury - physiopathology | Acute Kidney Injury - prevention & control | Hypertension - physiopathology | Aryl Hydrocarbon Hydroxylases - metabolism | Hypertension - metabolism | Kidney - radiation effects | Animals | Signal Transduction - drug effects | Fibrosis | Acute Kidney Injury - metabolism | Radiation Injuries, Experimental - physiopathology | Index Medicus
Journal Article