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Frontiers in Pharmacology, ISSN 1663-9812, 10/2019, Volume 10
The mycotoxin zearalenone (ZEN) is produced by many plant pathogenic Fusarium species. It is well known for its estrogenic activity in humans and animals, but... 
Fusarium | HSP90 | glycosylation | wheat | Arabidopsis | radicicol
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 08/2008, Volume 130, Issue 31, pp. 10293 - 10298
Diketo-1,3-dioxin-2-ones underwent retro-Diels-Alder reaction on heating in toluene at 110 degrees C to generate alpha,gamma,epsilon-triketo-ketenes. These... 
ACETYLKETENE | 2,2,6-TRIMETHYL-4H-1,3-DIOXIN-4-ONE | ROUTES | RADICICOL | THERMAL-DECOMPOSITION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Organic Letters, ISSN 1523-7060, 06/2019, Volume 21, Issue 12, pp. 4788 - 4792
Heterologous expression of a unique biosynthetic gene cluster (BGC) comprising a highly reducing polyketide synthase and stand-alone thioesterase genes in... 
SYNTHASE | ENCODES | SYSTEM | SPACE | BIOSYNTHETIC GENE-CLUSTER | RADICICOL | PATHWAY | CHEMISTRY, ORGANIC | HETEROLOGOUS EXPRESSION | INHIBITOR
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2010, Volume 132, Issue 13, pp. 4530 - 4531
Hypothemycin is a macrolide protein kinase inhibitor from the fungus Hypomyces subiculosus. During biosynthesis, its carbon framework is assembled by two... 
GIBBERELLA-ZEAE | GENE-CLUSTER | RADICICOL | CHEMISTRY, MULTIDISCIPLINARY | ZEARALENONE | Polyketide Synthases - metabolism | Hypocreales - enzymology | Zearalenone - chemistry | Zearalenone - analogs & derivatives | Molecular Structure | Lactones - metabolism | Lactones - chemistry | Zearalenone - biosynthesis
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 06/2019, Volume 17, Issue 22, pp. 5601 - 5614
The first asymmetric total synthesis and stereochemical assignments of 10-membered macrolactones relgro and 10 '-oxorelgro are disclosed. To this end,... 
TRANSFORMATION | HSP90 | HYDROLYTIC KINETIC RESOLUTION | RADICICOL | ACID LACTONES | KINASE | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | BETA-RESORCYLIC MACROLIDE
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10
The molecular chaperone Hsp90 is an important regulator of proteostasis. It has remained unclear why S. cerevisiae possesses two Hsp90 isoforms, the... 
YEAST | MOLECULAR CHAPERONE HSP90 | PROTEIN | COCHAPERONE | RADICICOL | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | N-TERMINAL DOMAIN | IDENTIFICATION | BINDING | CYCLE
Journal Article
Medicinal research reviews, ISSN 0198-6325, 1/2016, Volume 36, Issue 1, pp. 92 - 118
The 90 kDa heat shock proteins (Hsp90) are responsible for the conformational maturation of nascent polypeptides and the rematuration of denatured proteins.... 
Hsp90 | chaperone | natural product-based drug design | radicicol | geldanamycin
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 06/2019, Volume 9
AIP56 (apoptosis inducing protein of 56 kDa) is a key virulence factor secreted by virulent strains of Photobacterium damselae subsp. piscicida (Phdp), a... 
CELL CHAPERONE HSP90 | PROTEIN | ENTRY | MEMBRANE TRANSLOCATION | RADICICOL | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | BOTULINUM C2 TOXIN | TRAFFICKING | MOLECULAR-CLONING | DIPHTHERIA-TOXIN
Journal Article
Journal of Ginseng Research, ISSN 1226-8453, 2018
Background: The ascomycete fungi Cylindrocarpon destructans (Cd) and Fusarium solani (Fs) cause ginseng root rot and significantly reduce the quality and yield... 
Transcriptomes | Cylindrocarpon destructans | Fusarium solani | Radicicol | Ginseng root rot
Journal Article
Organic Letters, ISSN 1523-7060, 11/2017, Volume 19, Issue 21, pp. 6004 - 6007
Asymmetric total syntheses of (+)-pochonin D (1) and (+)-monocillin II (2), Hsp90 inhibitors with potent anticancer activity, have been accomplished where the... 
HSP90 INHIBITORS | CONCISE SYNTHESES | STEM-CELLS | RADICICOL | ANALOGS | BIOLOGICAL EVALUATION | CHEMISTRY | CHEMISTRY, ORGANIC | LEUKEMIA | ASYMMETRIC TOTAL-SYNTHESIS | CANCER
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 05/2015, Volume 54, Issue 19, pp. 3024 - 3036
Hsp90 is an ATP-dependent chaperone of widespread interest as a drug target. Here, using an, LC-MS/ MS chemoproteomics platform based on a lysine-reactive ATP... 
IN-VITRO | POTENT | DESIGN | PROTEIN | RADICICOL | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | MOLECULAR CHAPERONE | HYDROLYSIS | INSIGHTS
Journal Article
Topics in Current Chemistry, ISSN 0340-1022, 2013, Volume 328, pp. 155 - 240
Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential role in many cellular processes including cell cycle control, cell... 
Hsp90 | HtpG | Phosphorylation | ATPase | Conformational dynamics | TRAP-1 | Cochaperone | Geldanamycin | Acetylation | Radicicol | Grp94 | HSP90 Heat-Shock Proteins - chemistry | Models, Molecular | Crystallography, X-Ray | Protein Processing, Post-Translational | Structure-Activity Relationship | HSP90 Heat-Shock Proteins - physiology
Conference Proceeding
Tetrahedron, ISSN 0040-4020, 2009, Volume 65, Issue 17, pp. 3446 - 3453
WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hair-growth stimulant, we have been searching for an... 
Hair-growth | Radicicol | WNT-5A | Pochonin | METABOLITES | CHEMISTRY, ORGANIC | MONORDEN
Journal Article
TETRAHEDRON LETTERS, ISSN 0040-4039, 01/2012, Volume 53, Issue 1, pp. 56 - 58
First total synthesis of recently isolated resorcylic acid lactone paecilomycin E has been accomplished. The key reactions include olefin metathesis, Mitsunobu... 
ALCOHOLS | Stille coupling | RESORCYLIC ACID LACTONES | METABOLITES | RADICICOL | Metathesis | COMPOUND | CHEMISTRY, ORGANIC | Resorcylic acid lactone | Mitsunobu | Macrolactone
Journal Article
Journal of Fishery Sciences of China, ISSN 1005-8737, 2017, Volume 24, Issue 5, pp. 988 - 994
Journal Article
2013, Topics in Current Chemistry-Series, Volume 328, 86
Book Chapter
Tetrahedron Letters, ISSN 0040-4039, 08/2017, Volume 58, Issue 35, pp. 3453 - 3456
The first total synthesis of greensporone C, a cytotoxic 14-membered resorcylic acid lactone, has been accomplished a longest linear sequence of 16 steps in... 
Resorcylic acid lactone | Ring-closing metathesis | Greensporone C | Total synthesis | CELLS | RESORCYLIC ACID LACTONES | RADICICOL | CHEMISTRY, ORGANIC | EXPRESSION | Synthesis | Organic compounds
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 2010, Volume 14, Issue 3, pp. 412 - 420
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 06/2015, Volume 2015, Issue 18, pp. 3983 - 3993
The first total synthesis of the chlorinated resorcylic acid lactone cochliomycin C is achieved starting from the readily available sugar D‐lyxose. The... 
Alkynylation | Ring closing metathesis | Natural products | Macrolides | Total synthesis | Lactones | METABOLITES | PANEL | ANALOGS | RADICICOL | COMPOUND | CHEMISTRY, ORGANIC | KINASE INHIBITORS | POCHONINS | DEOXY | RESORCYLIC ACID LACTONES
Journal Article
by Qin, FF and Li, Y and Lin, RM and Zhang, X and Mao, ZC and Ling, J and Yang, YH and Zhuang, X and Du, SS and Cheng, XY and Xie, BY
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 07/2019, Volume 67, Issue 26, pp. 7266 - 7273
Chemical investigation of fungus Pochonia chlamydosporia strain 170, derived from rice fermentation sediment samples, afforded seven radicicol analogues,... 
antibacterial activity | METABOLITES | FUNGI | Pochonia chlamydosporia | FOOD SCIENCE & TECHNOLOGY | IDENTIFICATION | GENOME | Xanthomonas campestris pv. campestris | AGRICULTURE, MULTIDISCIPLINARY | RESORCYLIC ACID LACTONE | biosynthetic gene cluster | CHEMISTRY, APPLIED | MONOCILLIN-I | radicicol analogues
Journal Article
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