X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (16740) 16740
Publication (2593) 2593
Book Chapter (164) 164
Book / eBook (127) 127
Book Review (89) 89
Dissertation (64) 64
Conference Proceeding (63) 63
Web Resource (26) 26
Government Document (19) 19
Magazine Article (9) 9
Data Set (3) 3
Streaming Video (3) 3
Newspaper Article (2) 2
Paper (1) 1
Presentation (1) 1
Reference (1) 1
Video Recording (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (11552) 11552
index medicus (8751) 8751
proto-oncogene proteins b-raf - genetics (6139) 6139
animals (5217) 5217
mutation (5069) 5069
oncology (4855) 4855
female (4627) 4627
male (4303) 4303
cancer (3696) 3696
middle aged (3112) 3112
biochemistry & molecular biology (2820) 2820
signal transduction (2743) 2743
mice (2733) 2733
cell biology (2647) 2647
melanoma (2563) 2563
aged (2537) 2537
adult (2459) 2459
phosphorylation (2397) 2397
braf (2261) 2261
cell line, tumor (2226) 2226
activation (1948) 1948
proto-oncogene proteins c-raf - metabolism (1944) 1944
expression (1769) 1769
melanoma - genetics (1752) 1752
tumors (1707) 1707
proto-oncogene proteins b-raf - metabolism (1642) 1642
raf (1604) 1604
b-raf (1573) 1573
genetic aspects (1570) 1570
apoptosis (1538) 1538
proto-oncogene proteins b-raf - antagonists & inhibitors (1518) 1518
research (1469) 1469
article (1456) 1456
kinases (1452) 1452
proteins (1416) 1416
melanoma - drug therapy (1405) 1405
analysis (1290) 1290
melanoma - pathology (1289) 1289
mutations (1257) 1257
map kinase (1256) 1256
ras proteins - genetics (1240) 1240
prognosis (1236) 1236
pathology (1226) 1226
aged, 80 and over (1216) 1216
metastasis (1169) 1169
gene mutations (1157) 1157
pathway (1144) 1144
colorectal neoplasms - genetics (1136) 1136
proto-oncogene proteins - genetics (1118) 1118
antineoplastic agents - therapeutic use (1098) 1098
ras proteins - metabolism (1085) 1085
thyroid neoplasms - genetics (1066) 1066
dna mutational analysis (1047) 1047
immunohistochemistry (1039) 1039
protein-serine-threonine kinases - metabolism (1027) 1027
antineoplastic agents - pharmacology (1015) 1015
cells (1012) 1012
colorectal cancer (1011) 1011
rats (1010) 1010
proto-oncogene proteins c-raf (1006) 1006
neoplasms (1003) 1003
enzyme activation (998) 998
cell line (979) 979
proto-oncogene proteins - metabolism (976) 976
ras (976) 976
signal transduction - drug effects (971) 971
gene expression (949) 949
protein kinase inhibitors - pharmacology (937) 937
care and treatment (931) 931
survival (916) 916
vemurafenib (912) 912
growth (902) 902
mitogen-activated protein kinases - metabolism (901) 901
gene (898) 898
carcinoma (877) 877
raf protein (850) 850
skin neoplasms - genetics (850) 850
proto-oncogene proteins c-raf - genetics (846) 846
mutation - genetics (844) 844
cell proliferation (833) 833
metastatic melanoma (830) 830
extracellular signal-regulated map kinases - metabolism (826) 826
inhibition (823) 823
molecular sequence data (820) 820
cells, cultured (818) 818
braf mutation (817) 817
research article (809) 809
multidisciplinary sciences (787) 787
cell proliferation - drug effects (766) 766
health aspects (761) 761
gene expression regulation, neoplastic (759) 759
colorectal neoplasms - pathology (758) 758
treatment outcome (751) 751
transfection (749) 749
thyroid neoplasms - pathology (748) 748
proto-oncogene proteins p21 (744) 744
young adult (737) 737
dermatology (734) 734
microsatellite instability (723) 723
genetics & heredity (717) 717
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Robarts - Stacks (87) 87
Online Resources - Online (26) 26
Collection Dvlpm't (Acquisitions) - Vendor file (17) 17
UTL at Downsview - May be requested (15) 15
Trinity College (John W Graham) - Stacks (7) 7
UofT at Mississauga - Stacks (6) 6
St. Michael's College (John M. Kelly) - 2nd Floor (4) 4
Engineering & Comp. Sci. - Stacks (3) 3
Victoria University E.J. Pratt - Stacks (3) 3
Media Commons - Audio Visual (1) 1
Robarts - In process for Downsview (1) 1
UofT at Scarborough - Not Returned (1) 1
UofT at Scarborough - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (16523) 16523
Chinese (143) 143
French (105) 105
German (87) 87
Japanese (66) 66
Swedish (31) 31
Russian (30) 30
Spanish (26) 26
Korean (25) 25
Czech (10) 10
Hungarian (10) 10
Polish (9) 9
Portuguese (9) 9
Turkish (4) 4
Arabic (3) 3
Italian (3) 3
Afrikaans (2) 2
Catalan (2) 2
Dutch (2) 2
Bosnian (1) 1
Bulgarian (1) 1
Croatian (1) 1
Danish (1) 1
Finnish (1) 1
Fulah (1) 1
Hebrew (1) 1
Norwegian (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 431 - 435
Activating mutations in KRAS and BRAF are found in more than 30% of all human tumours and 40% of melanoma, respectively, thus targeting this pathway could have... 
SELECTIVE INHIBITOR | POTENT | EFFICACY | MECHANISM | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | C-RAF | B-RAF | MUTATIONS | PROTEINS | Neoplasms - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Diphenylamine - pharmacology | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | ras Proteins - metabolism | Protein Transport - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase Kinases - metabolism | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Benzamides - pharmacology | Cell Membrane - metabolism | raf Kinases - genetics | Cell Membrane - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Pyrazoles - pharmacology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Indenes - pharmacology | raf Kinases - chemistry | Proto-Oncogene Proteins c-raf - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Neoplasms - enzymology | Proto-Oncogene Proteins - genetics | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins c-raf - deficiency | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Ras genes | Growth | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Mitogen-activated protein kinases | Competition | Clinical trials | Enzymes | Kinases | Proteins | Cellular | Inhibitors | Pathways | Tumours | Signalling | Dimerization
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 427 - 430
Tumours with mutant BRAF are dependent on the RAF–MEK–ERK signalling pathway for their growth. We found that ATP-competitive RAF inhibitors inhibit ERK... 
SELECTIVE INHIBITOR | ACTIVATION | MELANOMA | MECHANISM | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HETERODIMERIZATION | KINASE INHIBITOR | B-RAF | CRAF | ONCOGENIC BRAF | Neoplasms - metabolism | ras Proteins - genetics | Phosphorylation | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | Transcriptional Activation - drug effects | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Adenosine Triphosphate - metabolism | Indoles - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Cell Line | raf Kinases - chemistry | Catalytic Domain | Neoplasms - enzymology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Care and treatment | Enzyme inhibitors | Gene mutations | Cellular signal transduction | Genetic aspects | Research | Health aspects | Cancer | Proteins | Competition | Drugs | Mutation | Kinases | Tumors | Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 6, pp. 9251 - 9266
Activating mutations in the KRAS and BRAF genes, leading to hyperactivation of the RAS/RAF/MAPK oncogenic signaling cascade, are common in patients with... 
Signaling pathways | Xenograft models | RAS | RAF | Colorectal cancer | WILD-TYPE | colorectal cancer | ACTIVATED PROTEIN-KINASE | TUMOR PROGRESSION | xenograft models | ACQUIRED-RESISTANCE | ANTI-EGFR THERAPY | LY2228820 DIMESYLATE | CELL BIOLOGY | SELECTIVE INHIBITOR | signaling pathways | RAF INHIBITORS | NEGATIVE FEEDBACK | MAPK PATHWAY | Apoptosis - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Rats, Nude | Dose-Response Relationship, Drug | Transfection | RNA Interference | Time Factors | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins A-raf - antagonists & inhibitors | Colorectal Neoplasms - enzymology | Genetic Predisposition to Disease | Proto-Oncogene Proteins c-raf - genetics | HCT116 Cells | Proto-Oncogene Proteins A-raf - genetics | Pyrimidines - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins A-raf - metabolism | HT29 Cells | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Phenotype | Animals | Tumor Burden - drug effects | Proto-Oncogene Proteins B-raf - genetics | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-raf - antagonists & inhibitors | Mutation | Colorectal Neoplasms - pathology | G1 Phase Cell Cycle Checkpoints - drug effects
Journal Article
Cancer Research, ISSN 0008-5472, 06/2008, Volume 68, Issue 12, pp. 4853 - 4861
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 968 - 972
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas(1). Pre-clinical studies have... 
TRANSFORMATION | CELLS | ACTIVATION | TUMOR PROGRESSION | GENE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | BRAF | MUTATIONS | CANCER | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer
Journal Article