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Molecular and Cellular Biology, ISSN 0270-7306, 10/2001, Volume 21, Issue 19, pp. 6706 - 6717
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
SIGNAL-TRANSDUCTION | ACTIVATED PROTEIN-KINASE | ONCOGENIC RAS | INDUCED APOPTOSIS | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | B-RAF | GROWTH-FACTOR | CELL-CYCLE PROGRESSION | INDEPENDENT PATHWAYS | SERINE/THREONINE KINASE | CELL BIOLOGY | MAP Kinase Kinase 1 | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Nucleus - metabolism | Extracellular Matrix - physiology | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | rho GTP-Binding Proteins - genetics | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins - genetics | cdc42 GTP-Binding Protein - physiology | rho GTP-Binding Proteins - physiology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins c-akt | Animals | rac1 GTP-Binding Protein - physiology | cdc42 GTP-Binding Protein - genetics | Proto-Oncogene Proteins - physiology | Anoikis | Fibroblasts - cytology | Mice | Mutation | Mitogen-Activated Protein Kinase 3 | Apoptosis | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | rac1 GTP-Binding Protein - genetics | Protein-Serine-Threonine Kinases | Biodiversity | Cellular Biology | Embryology and Organogenesis | Life Sciences | Mitogen-Activated Protein Kinase Kinases | Fibroblasts | Proto-Oncogene Proteins | Subcellular Processes | Mitogen-Activated Protein Kinases | Proto-Oncogene Proteins c-raf | Extracellular Matrix | Biochemistry, Molecular Biology | Systematics, Phylogenetics and taxonomy | Tumor Suppressor Protein p53 | cdc42 GTP-Binding Protein | Development Biology | rac1 GTP-Binding Protein | Mitogen-Activated Protein Kinase 1 | Molecular biology | rho GTP-Binding Proteins | Cell Nucleus | Cancer | Cell Growth and Development
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
ACTIVATION | MEK INHIBITION | DETERMINANTS | RAF | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | DEFICIENCY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer
Journal Article
Oncogene, ISSN 1476-5594, 2003, Volume 22, Issue 43, pp. 6785 - 6793
.... Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same transcript. We report here that Bim-EL when phosphorylated by Erk1/2 is rapidly degraded via the proteasome pathway... 
Erk1/2 | Bim | Apoptosis | Proteasome | proteasome | ACTIVATION | BAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY MEMBER | apoptosis | DEATH | INDUCTION | CELL-SURVIVAL | CELL BIOLOGY | ONCOLOGY | SIGNALING PATHWAY | GENETICS & HEREDITY | EXPRESSION | DEPENDENT DEGRADATION | Phosphorylation | Tetradecanoylphorbol Acetate | Humans | Molecular Sequence Data | Multienzyme Complexes - metabolism | Proteasome Endopeptidase Complex | Lymphoma - metabolism | Caspases - metabolism | Cysteine Endopeptidases - metabolism | Transfection | Bcl-2-Like Protein 11 | Time Factors | Carrier Proteins - chemistry | Proto-Oncogene Proteins | Tumor Cells, Cultured | Binding Sites | Amino Acid Sequence | Cell Line | Antineoplastic Agents, Hormonal - pharmacology | Cell Survival | Gene Expression Regulation | Glutathione Transferase - metabolism | Serine - chemistry | Proto-Oncogene Proteins c-raf - metabolism | Membrane Proteins | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Models, Biological | Protein Isoforms | K562 Cells | Tamoxifen - pharmacology | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Bim-L protein | Bim-EL protein | Bim-S protein | Bim protein | Multienzyme Complexes | Serine | Life Sciences | Glutathione Transferase | Carrier Proteins | Mitogen-Activated Protein Kinases | Cysteine Endopeptidases | Antineoplastic Agents, Hormonal | Proto-Oncogene Proteins c-raf | Biochemistry, Molecular Biology | Tamoxifen | Lymphoma | Caspases | Mitogen-Activated Protein Kinase 1 | Molecular biology | Cancer
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 1, p. e0147758
A critical and understudied property of endothelial cells is their ability to form lumens and tube networks. Although considerable information has been... 
COLLAGEN MATRIX | 3-DIMENSIONAL EXTRACELLULAR MATRICES | VASCULAR LUMEN FORMATION | IN-VITRO | CELL MORPHOGENESIS | ANGIOGENESIS | ACTIVATING PROTEIN | MULTIDISCIPLINARY SCIENCES | CAPILLARY LUMEN | BLOOD-VESSEL FORMATION | MOLECULAR-MECHANISMS | rap GTP-Binding Proteins - antagonists & inhibitors | ras Proteins - genetics | p120 GTPase Activating Protein - metabolism | Humans | rac GTP-Binding Proteins - metabolism | ras Proteins - metabolism | Male | cdc42 GTP-Binding Protein - metabolism | Phosphoproteins - antagonists & inhibitors | GTPase-Activating Proteins - metabolism | p120 GTPase Activating Protein - genetics | Phosphoproteins - metabolism | rac GTP-Binding Proteins - antagonists & inhibitors | Tubulin - metabolism | RNA Interference | rac GTP-Binding Proteins - genetics | cdc42 GTP-Binding Protein - antagonists & inhibitors | rap GTP-Binding Proteins - genetics | Phorbol Esters - pharmacology | Female | Cell Line | Endothelial Cells - metabolism | GTPase-Activating Proteins - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Phosphoproteins - genetics | p120 GTPase Activating Protein - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Endothelial Cells - cytology | cdc42 GTP-Binding Protein - genetics | Cytoskeleton - metabolism | Vacuoles - metabolism | Mice | GTPase-Activating Proteins - genetics | rap GTP-Binding Proteins - metabolism | Microscopy, Fluorescence | Endothelial Cells - drug effects | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Guanosine triphosphatase | Endothelium | Cdc42 protein | Polarization | Membranes | Raf protein | K-Ras protein | Morphogenesis | Proteins | Lumens | Tubulin | Actin | IQGAP1 protein | Tubes | Physiology | Growth factors | Skewed distributions | RhoA protein | Rac1 protein | Guanosine triphosphatases | Pharmacology | siRNA | Rac2 protein | Endothelial cells | Effectors | Cytoskeleton | Membrane trafficking | Regulation | Molecular biology | Vacuoles | Integrins | Guanosinetriphosphatase
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 01/1999, Volume 19, Issue 1, pp. 136 - 146
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
TRANSCRIPTION FACTOR CREB | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TERNARY COMPLEX FACTORS | LONG-TERM POTENTIATION | GROWTH-FACTOR | B-RAF | SERUM RESPONSE ELEMENT | IMMEDIATE-EARLY GENES | DIFFERENTIAL REGULATION | CELL BIOLOGY | Phosphorylation | Protein-Tyrosine Kinases - metabolism | Transcriptional Activation | Male | Extracellular Space | MAP Kinase Kinase 1 | Brain - metabolism | Mitogen-Activated Protein Kinase Kinases | Corpus Striatum - pathology | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins | Mitogen-Activated Protein Kinases | Proto-Oncogene Proteins - metabolism | ets-Domain Protein Elk-1 | Glutamic Acid - pharmacology | Signal Transduction | Gene Expression Regulation | Rats | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-raf - metabolism | Animals | Cyclic AMP Response Element-Binding Protein - metabolism | Brain - pathology | Proto-Oncogene Proteins c-fos - genetics | Glutamic Acid - metabolism | Transcription Factors | Kinetics | Mitogen-Activated Protein Kinase 1 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 | Brain | Protein-Serine-Threonine Kinases | Neurons and Cognition | Life Sciences | Proto-Oncogene Proteins | Cyclic AMP Response Element-Binding Protein | Proto-Oncogene Proteins c-raf | Trans-Activation (Genetics) | Proto-Oncogene Proteins c-fos | Glutamic Acid | Corpus Striatum | Protein-Tyrosine Kinases | Ca(2+)-Calmodulin Dependent Protein Kinase | Cell Growth and Development
Journal Article
Trends in immunology, ISSN 1471-4906, 2004, Volume 25, Issue 10, pp. 513 - 517
Journal Article
FEBS letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3760 - 3772
... DA system, and their crosstalk with proteins and signaling pathways associated with PD. 
Rearranged during transfection | Parkinson disease | Drug addiction | Mouse model | Dopaminergic system | Glia cell line-derived neurotrophic factor | MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | subunits of the Ca2+-sensitive, voltage gated A-type K+ channel | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | proprotein convertase subtilisin/kexin type 6 | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | MPTP | GTPase | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | catechol-O-methyltransferase | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | Raf | CoREST | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | ENTERIC NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | CELL BIOLOGY | MICE LACKING GDNF | C-RET | BIOPHYSICS | NEUROTROPHIC FACTOR PROMOTES | MULTIPLE ENDOCRINE NEOPLASIA | SURVIVAL IN-VIVO | RECEPTOR TYROSINE KINASE | CELL-LINE | EARLY-ONSET PARKINSONISM | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease
Journal Article