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Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
Science, ISSN 0036-8075, 3/2002, Volume 295, Issue 5564, pp. 2465 - 2468
Selective estrogen receptor modulators (SERMs) mimic estrogen action in certain tissues while opposing it in others. The therapeutic effectiveness of SERMs... 
Neuroscience | Transfection | RNA | Genes | Cell lines | Small interfering RNA | Phenols | Reports | Breast cancer | Selective estrogen receptor modulators | Endometrial neoplasms | HUMAN ESTROGEN-RECEPTOR | ACTIVATION | COACTIVATOR | ANTIESTROGEN | GENE | PROMOTER-CONTEXT | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | C-MYC | 4-HYDROXYTAMOXIFEN | CANCER | Raloxifene Hydrochloride - pharmacology | Receptors, Estrogen - metabolism | Histone Acetyltransferases | Humans | Endometrial Neoplasms - metabolism | Endometrium - drug effects | Insulin-Like Growth Factor I - genetics | Genes, myc | Breast - metabolism | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Endometrial Neoplasms - genetics | Female | Transcription, Genetic | Tumor Cells, Cultured | Estradiol - pharmacology | Repressor Proteins - metabolism | Endometrium - metabolism | Tamoxifen - metabolism | Promoter Regions, Genetic | Response Elements | Gene Silencing | Histone Deacetylases - metabolism | Transcription Factors - genetics | Organ Specificity | Selective Estrogen Receptor Modulators - metabolism | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Raloxifene Hydrochloride - metabolism | Breast Neoplasms - genetics | Receptors, Estrogen - chemistry | Cell Cycle | Breast - drug effects | Tamoxifen - pharmacology | Nuclear Receptor Coactivator 1 | Selective Estrogen Receptor Modulators - pharmacology | Raloxifene | Tamoxifen | Drug therapy | Health aspects | Tissue | Molecules | Estrogen
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2011, Volume 39, Issue 12, pp. 2347 - 2354
Raloxifene, a selective estrogen receptor modulator, exhibits quite large interindividual variability in pharmacokinetics and pharmacodynamics. In women,... 
Glucuronosyltransferase - genetics | Raloxifene Hydrochloride - metabolism | Glucuronides - metabolism | Humans | Kidney - enzymology | Genotype | Microsomes, Liver - enzymology | Intestines - enzymology | Polymorphism, Genetic
Journal Article
Cell Death and Disease, ISSN 2041-4889, 01/2014, Volume 5, Issue 1, pp. e1038 - e1038
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2006, Volume 46, Issue 12, pp. 1426 - 1438
Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of drugs such as bupropion, efavirenz, propofol, and selegiline, among others. More than 200... 
HPLC/MS/MS | P450 2B6 | rhCYP2B6 | Drug‐drug interactions | in vitro | Drug-drug interactions | In vitro | Raloxifene Hydrochloride - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Humans | Microsomes, Liver - metabolism | Sertraline - chemistry | Bupropion - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Antifungal Agents - chemistry | Xenobiotics - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Xenobiotics - classification | Clotrimazole - metabolism | Platelet Aggregation Inhibitors - pharmacology | Oxazines - pharmacology | Antifungal Agents - pharmacology | Itraconazole - metabolism | Serotonin Uptake Inhibitors - metabolism | Clotrimazole - pharmacology | Serotonin Uptake Inhibitors - chemistry | Antidepressive Agents, Second-Generation - pharmacology | Clotrimazole - chemistry | Itraconazole - chemistry | Selective Estrogen Receptor Modulators - metabolism | Ticlopidine - analogs & derivatives | Raloxifene Hydrochloride - metabolism | Platelet Aggregation Inhibitors - chemistry | Oxazines - chemistry | Kinetics | Serotonin Uptake Inhibitors - pharmacology | Selective Estrogen Receptor Modulators - pharmacology | Bupropion - metabolism | Ticlopidine - pharmacology | Area Under Curve | Reverse Transcriptase Inhibitors - pharmacology | Ticlopidine - chemistry | Benzoxazines | Xenobiotics - pharmacokinetics | Itraconazole - pharmacology | Oxazines - metabolism | Microsomes, Liver - drug effects | Antifungal Agents - metabolism | Ticlopidine - metabolism | Molecular Structure | Platelet Aggregation Inhibitors - metabolism | Sertraline - metabolism | Sertraline - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Algorithms | Bupropion - pharmacology | Reverse Transcriptase Inhibitors - metabolism | Antidepressive Agents, Second-Generation - metabolism | Raloxifene Hydrochloride - chemistry | Cytochrome P-450 CYP2B6 | Cytochromes | Research | Health aspects | Drug interactions
Journal Article
American Journal of Health-System Pharmacy, ISSN 1079-2082, 09/2000, Volume 57, Issue 18, pp. 1669 - 1675
Journal Article