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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2009, Volume 329, Issue 3, pp. 928 - 937
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3526 - 3533
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 350, Issue 1, pp. 5 - 13
This study aims to investigate the effects of ramipril (RPL) on endothelial dysfunction associated with diabetes mellitus using cultured human aortic... 
DIABETES-MELLITUS | HIGH-FAT | OXIDATIVE STRESS | REACTIVE OXYGEN | NITRIC-OXIDE SYNTHASE | INSULIN-RESISTANCE | HEART-FAILURE | PHARMACOLOGY & PHARMACY | HIGH-SUCROSE DIET | VASCULAR DYSFUNCTIONS | GLYCATION END-PRODUCTS | AMP-Activated Protein Kinases - metabolism | Diabetes Mellitus, Experimental - drug therapy | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Protoporphyrins - pharmacology | Male | Diabetes Mellitus, Experimental - blood | Insulin Resistance - physiology | Ramipril - analogs & derivatives | Diabetes Mellitus, Experimental - chemically induced | Ramipril - pharmacology | Phosphorylation - drug effects | Ramipril - therapeutic use | Vasodilation - physiology | Diabetes Mellitus, Experimental - metabolism | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Heme Oxygenase (Decyclizing) - metabolism | Diabetes Mellitus, Experimental - physiopathology | Pyrazoles - pharmacology | Endothelial Cells - metabolism | Aorta - drug effects | Cells, Cultured | Rats | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Animals | Naphthalimides - pharmacology | Signal Transduction - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Kinase - antagonists & inhibitors | NF-E2-Related Factor 2 - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Glucose - metabolism | Benzimidazoles - pharmacology | Glycation End Products, Advanced - blood | Protein Kinase Inhibitors - pharmacology | Ramipril - antagonists & inhibitors | Oxidative Stress - drug effects | Vasodilation - drug effects | Endothelial Cells - pathology | Aorta - physiology | Endothelial Cells - drug effects
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 10/2015, Volume 80, Issue 4, pp. 662 - 669
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 02/2016, Volume 130, Issue 2, pp. 110 - 116
Journal Article
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2013, Volume 35, Issue 3, pp. 226 - 235
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169258
textabstractAim: The combination of weight excess and hypertension significantly contributes to cardiovascular risk and progressive kidney damage. An... 
GLOMERULAR-FILTRATION-RATE | DOUBLE-BLIND TRIAL | COLLECTING DUCT RENIN | MULTIDISCIPLINARY SCIENCES | BODY-MASS INDEX | SMOOTH-MUSCLE-CELLS | ANGIOTENSIN-II | (PRO)RENIN RECEPTOR | BLOOD-PRESSURE | INHIBITOR ALISKIREN | URINARY RENIN | Antihypertensive Agents - pharmacology | Overweight - complications | Humans | Middle Aged | Hypertension - drug therapy | Male | Glomerular Filtration Rate - drug effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Renal Circulation - drug effects | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Ramipril - pharmacology | Ramipril - therapeutic use | Amides - pharmacology | Albuminuria - etiology | Double-Blind Method | Fumarates - therapeutic use | Kidney Diseases - prevention & control | Renin-Angiotensin System - physiology | Amides - therapeutic use | Overweight - physiopathology | Albuminuria - prevention & control | Antihypertensive Agents - therapeutic use | Hypertension - physiopathology | Cross-Over Studies | Renin - antagonists & inhibitors | Fumarates - pharmacology | Hypertension - complications | Renin-Angiotensin System - drug effects | Hemodynamics - drug effects | Kidney Diseases - etiology | Blood Pressure Monitoring, Ambulatory | Hypertension | Renin inhibitors | Care and treatment | Analysis | Dosage and administration | Hemodynamics | Research | Renin-angiotensin system | Nephrology | Clinical trials | Randomization | Renin | Peptidyl-dipeptidase A | Rodents | Blood pressure | Inhibition | Drug dosages | Obesity | Filtration | Kidneys | Health risks | Pharmacology | Metabolism | Angina pectoris | Glomerular filtration rate | Medicine | Direct reduced iron | Weight reduction | Angiotensin | Diabetes | Circulatory system | Cardiovascular diseases
Journal Article
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 05/2004, Volume 109, Issue 18, pp. 2213 - 2220
Background-The renin-angiotensin-aldosterone system is involved in the pathogenesis of atherosclerosis, partially because of its pro-oxidative properties. We... 
Angiotensin-converting enzyme | Aldosterone | Macrophages | Angiotensin | Atherosclerosis | atherosclerosis | OXIDATIVE STRESS | SUPEROXIDE | CARDIAC & CARDIOVASCULAR SYSTEMS | aldosterone | HEART-FAILURE | macrophages | SPIRONOLACTONE | INFLAMMATION | DISEASE | angiotensin | PERIPHERAL VASCULAR DISEASE | EPLERENONE | HYPERTENSION | HEMATOLOGY | E-DEFICIENT MICE | EXPRESSION | angiotensin-converting enzyme | Aldosterone - toxicity | Receptor, Angiotensin, Type 1 - physiology | Apolipoproteins E - deficiency | Humans | NADPH Oxidases - metabolism | Peptidyl-Dipeptidase A - physiology | Protein Transport - drug effects | Aortic Diseases - metabolism | Angiotensin II Type 1 Receptor Blockers | RNA, Messenger - biosynthesis | Cell Line - drug effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Arteriosclerosis - chemically induced | Lipid Peroxidation - drug effects | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Lipoproteins, LDL - metabolism | Ramipril - pharmacology | Macrophages, Peritoneal - drug effects | Mineralocorticoid Receptor Antagonists | Losartan - pharmacology | Macrophages, Peritoneal - enzymology | Mice, Knockout | Peptidyl-Dipeptidase A - biosynthesis | Arteriosclerosis - prevention & control | Arteriosclerosis - metabolism | Mice | Oxidative Stress - drug effects | Arteriosclerosis - pathology | Phosphoproteins - metabolism | Aortic Diseases - chemically induced | Receptors, Mineralocorticoid - physiology | Peptidyl-Dipeptidase A - genetics | Spironolactone - pharmacology | Superoxides - metabolism | Enzyme Induction - drug effects | Membrane Proteins - metabolism | Ramipril - therapeutic use | Spironolactone - analogs & derivatives | Spironolactone - therapeutic use | Aortic Diseases - pathology | Cell Line - metabolism | Aldosterone - physiology | Aldosterone - pharmacology | Hormone Antagonists - pharmacology | Animals | Apolipoproteins E - genetics | Losartan - therapeutic use | Hormone Antagonists - therapeutic use | Angiotensin II - physiology
Journal Article
Journal Article