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Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 4908 - 4927
synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrations in the postsynaptic density (PSD) fraction from the... 
NMDA RECEPTOR | DOMAIN | STIMULATION | INHIBITION | CALPAIN | CLONING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATIONS | HIPPOCAMPAL-NEURONS | PLASTICITY | Oncogene Proteins - genetics | ras Proteins - genetics | Phosphorylation | ras GTPase-Activating Proteins - chemistry | rap1 GTP-Binding Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | ras Proteins - metabolism | Neurons - cytology | GTPase-Activating Proteins - metabolism | Receptors, N-Methyl-D-Aspartate - genetics | Cyclin-Dependent Kinase 5 - chemistry | Cyclin-Dependent Kinase 5 - genetics | ras GTPase-Activating Proteins - genetics | Receptors, N-Methyl-D-Aspartate - chemistry | ras Proteins - chemistry | Proto-Oncogene Proteins p21(ras) - chemistry | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | rap1 GTP-Binding Proteins - metabolism | ras GTPase-Activating Proteins - metabolism | Oncogene Proteins - chemistry | Cells, Cultured | Oncogene Proteins - metabolism | Rats | Synapses - enzymology | GTPase-Activating Proteins - chemistry | Cyclin-Dependent Kinase 5 - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Animals | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry | Neurons - enzymology | GTPase-Activating Proteins - genetics | rap1 GTP-Binding Proteins - genetics | rap GTP-Binding Proteins | Index Medicus | Ras Protein | Ras-related Protein 1 (Rap1) | Postsynaptic Density | Ca2 | Synaptic Plasticity | Small GTPase | Neurobiology | Mass Spectrometry (MS) | Cyclin-dependent Kinase 5 (CDK5) | Protein Kinase | Calmodulin-dependent Protein Kinase II (CaMKII) | Synaptic GTPase-activating Protein (synGAP)
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 03/2015, Volume 27, Issue 3, pp. 532 - 544
In addition to providing skeletal support, the bone is an endocrine organ that produces osteocalcin, whose uncarboxylated form (GluOC) increases insulin... 
Osteoblast | Osteocalcin | Adipose tissue | PPARγ | Cell signaling | Adiponectin | MAP KINASE | DEPENDENT PROTEIN-KINASE | GAMMA PPAR-GAMMA | GLUCOSE-UTILIZATION | PPAR gamma | PEPTIDE-1 SECRETION | CELL BIOLOGY | GPRC6A RECEPTOR | CYCLIC-AMP | INSULIN-RESISTANCE | GENE-EXPRESSION | ENERGY-METABOLISM | Nitriles - pharmacology | Receptors, G-Protein-Coupled - metabolism | rap1 GTP-Binding Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Adipocytes - cytology | Osteocalcin - pharmacology | Adipocytes - drug effects | PPAR gamma - metabolism | Adipose Tissue - metabolism | RNA Interference | Adiponectin - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | rap1 GTP-Binding Proteins - metabolism | Butadienes - pharmacology | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | 3T3-L1 Cells | Gene Expression Regulation - drug effects | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Adipocytes - metabolism | Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice | Receptors, G-Protein-Coupled - genetics | Adipose Tissue - drug effects | rap1 GTP-Binding Proteins - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Protein binding | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 07/2011, Volume 22, Issue 14, pp. 2509 - 2519
Activation of Rap1 small GTPases stabilizes cell-cell junctions, and this activity requires Krev Interaction Trapped gene 1 (KRIT1). Loss of KRIT1 disrupts... 
ENCODING KRIT1 | PATHOGENESIS | CEREBRAL CAVERNOUS MALFORMATIONS | AUTOMATED PROTEIN-STRUCTURE | RAP1 | BARRIER FUNCTION | BINDING-PROTEIN | CCM1 | I-TASSER | STRUCTURE PREDICTION | CELL BIOLOGY | Microtubule-Associated Proteins - chemistry | KRIT1 Protein | Microtubule-Associated Proteins - genetics | rap1 GTP-Binding Proteins - chemistry | Microtubule-Associated Proteins - metabolism | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Microtubules - metabolism | HEK293 Cells | Muscle Proteins - metabolism | Muscle Proteins - physiology | Umbilical Veins - cytology | Endothelial Cells - physiology | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | rap1 GTP-Binding Proteins - metabolism | Gene Expression | Signal Transduction | Zebrafish Proteins - chemistry | Cardiovascular System - growth & development | Endothelial Cells - metabolism | Zebrafish Proteins - metabolism | Intercellular Junctions - metabolism | Proto-Oncogene Proteins - genetics | Monomeric GTP-Binding Proteins - genetics | Intercellular Junctions - genetics | Zebrafish - growth & development | Zebrafish - genetics | Zebrafish Proteins - physiology | Muscle Proteins - genetics | Animals | Cardiovascular System - metabolism | Monomeric GTP-Binding Proteins - metabolism | Microtubules - genetics | Monomeric GTP-Binding Proteins - chemistry | Zebrafish - metabolism | Protein Conformation | RNA, Small Interfering | Zebrafish Proteins - genetics | Genetic Vectors | rap1 GTP-Binding Proteins - genetics | Index Medicus
Journal Article
BMC Genomics, ISSN 1471-2164, 06/2012, Volume 13, Issue 1, pp. 255 - 255
Background: Telomeres are nucleoprotein complexes at the end of linear eukaryotic chromosomes which maintain the genome integrity by regulating telomere... 
LIFE-SPAN | REPLICATION | PHOSPHATASE 1 | INTERFACE | DROSOPHILA-MELANOGASTER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | LENGTH | GENETICS & HEREDITY | SIR PROTEINS | MULTIPLE SEQUENCE ALIGNMENT | SACCHAROMYCES-CEREVISIAE | Protein Phosphatase 1 - chemistry | Repressor Proteins - classification | Humans | Telomere-Binding Proteins - classification | Phylogeny | Drosophila Proteins - metabolism | Drosophila melanogaster - metabolism | Saccharomyces cerevisiae - metabolism | Telomere-Binding Proteins - genetics | RNA Interference | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Drosophila Proteins - antagonists & inhibitors | Repressor Proteins - metabolism | Saccharomyces cerevisiae Proteins - classification | Retroelements | Carrier Proteins - antagonists & inhibitors | Computational Biology | Repressor Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Carrier Proteins - genetics | Protein Phosphatase 1 - metabolism | Animals | Carrier Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | DNA Damage | Drosophila Proteins - genetics | HeLa Cells | Evolution, Molecular | RNA, Small Interfering - metabolism | Physiological aspects | Research | Nucleoproteins | Telomerase | DNA damage | Proteins | Telomeres | Transposons | Genomics | Genomes | Genetics | Yeast | DNA repair | Deoxyribonucleic acid--DNA | Index Medicus | Retrotransposons | Recombination | Rap1 protein | Conserved sequence | Heat | Heterochromatin | Evolutionary conservation | Evolution | Bioinformatics | Chromosomes
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2014, Volume 383, Issue 1-2, pp. 193 - 202
In the pituitary the activation of cyclic adenosine 3′-5′-monophosphate (cAMP) dependent pathways generates proliferative signals in somatotrophs, whereas in... 
cAMP | Exchange proteins directly activated by cAMP (Epac) | cAMP-dependent protein kinase A (PKA) | CAMP-dependent protein kinase A (PKA) | CAMP | CYCLASE | SUBUNIT 1A PROTEIN | REGULATORY SUBUNIT | EXOCYTOSIS | ANALOGS | cAMP-dependent protein kinase A (MA) | CAMP (Epac) | CELL BIOLOGY | PATHWAY | RAP1 | Exchange proteins directly activated by | ENDOCRINOLOGY & METABOLISM | MUTATIONS | EXPRESSION | ADENOMAS | Somatotrophs - metabolism | Cyclin D1 - metabolism | Somatotrophs - pathology | Cell Proliferation | Pituitary Gland - metabolism | Adenoma - genetics | Humans | Gene Expression Regulation, Neoplastic | Lactotrophs - metabolism | Gonadotrophs - metabolism | Protein Subunits - metabolism | Adenoma - metabolism | Prolactinoma - genetics | Prolactinoma - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Guanine Nucleotide Exchange Factors - metabolism | Cyclic AMP - metabolism | Prolactinoma - pathology | Protein Subunits - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | rap1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Gonadotrophs - pathology | Signal Transduction | Pituitary Gland - pathology | Pituitary Neoplasms - genetics | Rats | Pituitary Neoplasms - pathology | Pituitary Neoplasms - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Cyclin D1 - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Adenoma - pathology | Lactotrophs - pathology | rap1 GTP-Binding Proteins - genetics | Protein kinases | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e110296 - e110296
Journal Article
Oncogene, ISSN 0950-9232, 07/2007, Volume 26, Issue 32, pp. 4635 - 4647
Telomerase-negative cancer cells can maintain their telomeres by a recombination-mediated alternative lengthening of telomeres (ALT) process. We reported... 
Telomeres | siRNA | Alternative lengthening of telomeres | Methionine restriction | PML | ALT-associated PML bodies | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | telomeres | DNA-DAMAGE | MAMMALIAN-CELLS | PROTEIN COMPLEX | CELL BIOLOGY | HUMAN RAP1 | METABOLIC DEFECT | LARGE-BODY FORMATION | NUCLEAR-BODIES | ONCOLOGY | alternative lengthening of telomeres | methionine restriction | GENETICS & HEREDITY | PROMYELOCYTIC LEUKEMIA BODIES | TUMOR-CELL-LINES | Humans | Neoplasm Proteins - antagonists & inhibitors | Resting Phase, Cell Cycle | Autoantigens - genetics | RNA Interference | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Telomeric Repeat Binding Protein 2 - antagonists & inhibitors | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | DNA-Binding Proteins - antagonists & inhibitors | Telomeric Repeat Binding Protein 2 - physiology | Genetic Techniques | Autoantigens - physiology | Tumor Suppressor Proteins - physiology | G1 Phase | Cell Line, Tumor | Intracellular Signaling Peptides and Proteins - physiology | Cell Cycle Proteins - physiology | Telomeric Repeat Binding Protein 1 - physiology | Tumor Suppressor Proteins - antagonists & inhibitors | Neoplasm Proteins - physiology | DNA Repair Enzymes - genetics | Telomeric Repeat Binding Protein 1 - genetics | Cell Cycle Proteins - antagonists & inhibitors | MRE11 Homologue Protein | Telomere-Binding Proteins - genetics | Tumor Suppressor Proteins - genetics | Telomere-Binding Proteins - physiology | Cell Cycle Proteins - genetics | Telomere - metabolism | DNA Repair Enzymes - antagonists & inhibitors | Nuclear Proteins - genetics | Methionine - deficiency | Telomere - genetics | Transcription Factors - physiology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Antigens, Nuclear - physiology | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Telomere-Binding Proteins - antagonists & inhibitors | Antigens, Nuclear - genetics | Nuclear Proteins - antagonists & inhibitors | Telomeric Repeat Binding Protein 1 - antagonists & inhibitors | Cell Proliferation - drug effects | Nuclear Proteins - physiology | Telomeric Repeat Binding Protein 2 - genetics | Tumor Suppressor p53-Binding Protein 1 | Promyelocytic Leukemia Protein | Physiological aspects | Genetic aspects | Research | Cancer cells | Proteins | Ribonucleic acid | Cell cycle | Genetics | Oncology | Ribonucleic acid--RNA | DNA repair | Cancer | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2005, Volume 7, Issue 7, pp. 712 - 718
Journal Article