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2012, Methods in molecular biology, ISBN 1617794309, Volume 821
Web Resource
Frontiers in Immunology, ISSN 1664-3224, 06/2019
Journal Article
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 06/2007, Volume 42, Issue 6, p. S231
Journal Article
Angiogenesis, ISSN 0969-6970, 7/2016, Volume 19, Issue 3, pp. 359 - 371
Journal Article
Nature, ISSN 0028-0836, 12/2017, Volume 552, Issue 7685, pp. 368 - 373
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 04/2018, Volume 41, Issue 4, pp. 2099 - 2107
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 44, pp. 18052 - 18061
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of protein synthesis and potential target for modifying cellular metabolism in... 
autophagy | mechanistic target of rapamycin (mTOR) | RAG GTPASES | amino acid | BIOCHEMISTRY & MOLECULAR BIOLOGY | mammalian target of rapamycin (mTOR) | RAGULATOR | CANCER | dynamin | GROWTH | DYNASORE | endocytosis | REQUIRES | PROTEINS | INHIBITOR | mTORC1 | SUFFICIENCY | Humans | Cytoplasm - metabolism | Ras Homolog Enriched in Brain Protein - genetics | Protein Transport - drug effects | Ras Homolog Enriched in Brain Protein - metabolism | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Amino Acids - metabolism | Mechanistic Target of Rapamycin Complex 1 - genetics | Lysosomes - metabolism | Membrane Transport Modulators - pharmacology | HEK293 Cells | Dynamin II - metabolism | Biomarkers - metabolism | Lysosomes - drug effects | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Dynamin II - genetics | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Enzyme Activation - drug effects | Clathrin - metabolism | Mechanistic Target of Rapamycin Complex 1 - metabolism | Dynamin II - antagonists & inhibitors | Clathrin - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 1 - agonists | Monomeric GTP-Binding Proteins - metabolism | Mutation | Cytoplasm - drug effects | Microscopy, Fluorescence | Amino Acid Substitution | Index Medicus | Cell Biology
Journal Article
Oncogene, ISSN 0950-9232, 05/2013, Volume 32, Issue 20, pp. 2521 - 2526
Rictor and its binding partner Sin1 are indispensable components of mTORC2 (mammalian target of rapamycin complex 2). The mTORC2 signaling complex functions as... 
Rictor (rapamycin-insensitive companion of mTOR) | RhoGDI2 | Rho proteins | Cell migration | SITE | ACTIVATION | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | rictor (rapamycin-insensitive companion of mTOR) | CELL BIOLOGY | DICTYOSTELIUM | GDP-DISSOCIATION INHIBITOR | AKT PHOSPHORYLATION | ONCOLOGY | GROWTH | GENETICS & HEREDITY | cell migration | ENDOPLASMIC-RETICULUM | MTOR COMPLEX | Up-Regulation | TOR Serine-Threonine Kinases - metabolism | Minor Histocompatibility Antigens | Humans | rac GTP-Binding Proteins - metabolism | Multiprotein Complexes - genetics | cdc42 GTP-Binding Protein - metabolism | Mechanistic Target of Rapamycin Complex 2 | Cell Movement - physiology | Gene Knockdown Techniques | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | rho Guanine Nucleotide Dissociation Inhibitor beta - genetics | rac GTP-Binding Proteins - genetics | Neuropeptides - genetics | Proteomics - methods | rho Guanine Nucleotide Dissociation Inhibitor beta - metabolism | Fibroblasts - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Cells, Cultured | Neuropeptides - metabolism | Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Proteins - metabolism | cdc42 GTP-Binding Protein - genetics | Fibroblasts - cytology | Mice | rac1 GTP-Binding Protein | Proteins | Usage | Physiological aspects | Cellular signal transduction | Rapamycin | Research | Health aspects | Signal transduction | Oncology | Kinases | Cell adhesion & migration | Index Medicus | rictor (rapamycin-insensitive companion of mTOR | RhoGDI2 (Rho-GDP dissociation inhibitor 2)
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2007, Volume 405, Issue 3, pp. 513 - 522
The mTOR (mammalian target of rapamycin) protein kinase is an important regulator of cell growth. Two complexes of mTOR have been identified: complex 1,... 
Mammalian target of rapamycin (mTOR) | Protein kinase | Protein observed with Rictor-1 (Protor) | mTOR complex-2 (mTORC2) | Proline-rich repeat protein-5 (PRR-5) | Rapamycin-insensitive companion of mTOR (Rictor) | Cancer | proline-rich repeat protein-5 (PRR-5) | protein observed with Rictor-1 (Protor) | ACTIVATION | AKT/PKB | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | mammalian target of rapamycin (mTOR) | rapamycin-insensitive companion of mTOR (Rictor) | protein kinase | RAPTOR | REGULATOR | PATHWAY | TOR | GROWTH | cancer | PDK1 | Protein Kinases - metabolism | Cell Line | Carrier Proteins - metabolism | Humans | Protein Isoforms | Gene Silencing | Protein Binding | TOR Serine-Threonine Kinases | Rapamycin-Insensitive Companion of mTOR Protein | Index Medicus | HEK-293 cells, human embryonic kidney cells | SPAK, Ste20 | PI3K, phosphoinositide 3-kinase | mTORC, mTOR complex | EST, expressed sequence tag | Protor, protein observed with Rictor | DTT, dithiothreitol | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | NCBI, National Center for Biotechnology Information | IGF-1, insulin-like growth factor-1 | S6K, S6 kinase | mTOR, mammalian target of rapamycin | TAP, tandem affinity purification | Rictor, rapamycin-insensitive companion of mTOR | Raptor, regulatory associated protein of mTOR | siRNA, small interfering RNA | I.M.A.G.E., Integrated Molecular Analysis of Genomes and their Expression | SPS1-related proline | alanine-rich kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted... 
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | 3T3-L1 ADIPOCYTES | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | p110 alpha E545K mutation | phosphoinositide 4-kinase (PI4K) | pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 | BREAST-CANCER | INSULIN | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | PIK3CA GENE | IN-VIVO | MUTATIONS | INHIBITORS | IA PI3K ISOFORMS | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | PI3K, phosphoinositide 3-kinase | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 3, pp. e0213489 - e0213489
[This corrects the article DOI: 10.1371/journal.pone.0099719.]. 
Glaucoma | Hypertension | Neuroprotection | Rapamycin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 12, pp. 3186 - 3191
Journal Article
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, pp. 1 - 19
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, pp. e0188417 - e0188417
Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many... 
MAMMALIAN TARGET | RAPAMYCIN | TUBEROUS SCLEROSIS COMPLEX | WHITE-MATTER | INTEGRITY | MULTIDISCIPLINARY SCIENCES | REMYELINATION | AKT | RICTOR | DIFFERENTIATION | CNS MYELINATION | Cell Proliferation - genetics | Central Nervous System - metabolism | Signal Transduction | White Matter - metabolism | White Matter - growth & development | Mechanistic Target of Rapamycin Complex 1 - metabolism | Mice, Knockout | Myelin Sheath - metabolism | Central Nervous System - growth & development | Cell Differentiation - genetics | Mechanistic Target of Rapamycin Complex 2 - metabolism | Mechanistic Target of Rapamycin Complex 1 - genetics | Animals | Rapamycin-Insensitive Companion of mTOR Protein - genetics | Gene Expression Regulation, Developmental | Myelin Sheath - genetics | Mice | Mechanistic Target of Rapamycin Complex 2 - genetics | Oligodendrocyte Precursor Cells - metabolism | Myelination | Demyelinating diseases | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Risk factors | TOR protein | Brain | Conduction | Pediatrics | Neurosciences | Phosphorylation | Spinal cord | Nuclear magnetic resonance--NMR | Laboratories | Change detection | Nervous system | Gene deletion | Kinases | Glial stem cells | Proteins | Nerve conduction | Signal transduction | Pathways | Clonal deletion | Precursors | Rodents | Oligodendrocytes | Deletion | Biomedical engineering | Myelin | Abnormalities | Rapamycin | Substantia alba | 1-Phosphatidylinositol 3-kinase | Neurology | Signaling | Cell number | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article