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International Journal of Molecular Sciences, ISSN 1661-6596, 2018, Volume 19, Issue 12, p. 4130
Human liver slice function was stressed by daily dosing of acetaminophen (APAP) or diclofenac (DCF) to investigate injury and repair. Initially, untreated... 
Repair and injury | Human liver slices | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | OXIDATIVE STRESS | OXIDANT STRESS | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | DICLOFENAC | MECHANISMS | TOXICITY | CHEMISTRY, MULTIDISCIPLINARY | METABOLISM | human liver slices | KIDNEY | repair and injury
Journal Article
Archives of Toxicology, ISSN 0340-5761, 2017, Volume 91, Issue 10, pp. 3403 - 3413
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 328 - 338
Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to... 
Early onset of fibrosis | Precision-cut liver slices | Antifibrotic drugs | Liver fibrosis | Ex vivo model | ROSMARINIC ACID | ANGIOTENSIN-II | ANTI-FIBROTIC DRUGS | IN-VITRO | INHIBITS ACTIVATION | HEPATIC STELLATE CELLS | ENDOPLASMIC-RETICULUM | DERMAL FIBROBLASTS | GROWTH-FACTOR | IMATINIB MESYLATE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Niacinamide - analogs & derivatives | Rats, Wistar | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Male | Valproic Acid - pharmacology | Depsides - pharmacology | Perindopril - pharmacology | Collagen Type I - genetics | Liver - drug effects | Benzamides - pharmacology | Benzylisoquinolines - pharmacology | Organ Culture Techniques | Liver Cirrhosis - drug therapy | Gene Expression | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Down-Regulation | Liver - metabolism | Rats | Transforming Growth Factor beta1 - genetics | Pyrimidines - pharmacology | Cinnamates - pharmacology | HSP47 Heat-Shock Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Animals | Models, Biological | HSP47 Heat-Shock Proteins - metabolism | Connective Tissue Growth Factor - genetics | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Connective Tissue Growth Factor - metabolism | Pyridones - pharmacology | Proto-Oncogene Proteins c-sis - antagonists & inhibitors | Drugs | Liver diseases | Analysis | Liver | Fibrosis | Gene expression | Growth factors | Index Medicus | FIBROSIS | DRUGS | GENES | LIVER | RATS | 60 APPLIED LIFE SCIENCES | ATP
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e95462
Journal Article
Archives of toxicology, ISSN 0340-5761, 03/2017, Volume 91, Issue 3, pp. 1401 - 1412
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 1, p. e86795
Although drug induced steatosis represents a mild type of hepatotoxicity it can progress into more severe non-alcoholic steatohepatitis. Current models used... 
rat-liver | induced cholestasis | fatty-acids | gene-expression | mitochondrial dysfunction | therapeutic targets | heparg cells | oxidative stress | hepatic steatosis | drug | RAT-LIVER | HEPARG CELLS | DRUG | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MITOCHONDRIAL DYSFUNCTION | THERAPEUTIC TARGETS | INDUCED CHOLESTASIS | FATTY-ACIDS | HEPATIC STEATOSIS | Liver - pathology | Gene Expression - drug effects | Oligonucleotide Array Sequence Analysis | Fatty Liver - pathology | Humans | Transcriptome | Extracellular Matrix - metabolism | Hepatocytes - pathology | Male | Gene Expression Profiling | Hepatocytes - metabolism | Fatty Liver - chemically induced | PPAR gamma - metabolism | Valproic Acid - pharmacology | Liver - drug effects | PPAR-beta - agonists | Hepatocytes - drug effects | Amiodarone - pharmacology | PPAR gamma - genetics | Fatty Liver - genetics | Fatty Liver - metabolism | PPAR-beta - metabolism | Tissue Culture Techniques | Extracellular Matrix - drug effects | Liver - metabolism | Mice, Inbred C57BL | Tetracycline - pharmacology | Enzyme Inhibitors - pharmacology | PPAR alpha - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | PPAR-beta - genetics | Animals | Models, Biological | Lipid Metabolism - drug effects | PPAR gamma - agonists | PPAR alpha - agonists | Mice | PPAR alpha - metabolism | Extracellular Matrix - pathology | Animal experimentation | Divalproex | DNA microarrays | Liver diseases | Genes | Amiodarone | Valproic acid | Drugs | Oxidative stress | Animal models | Liver | Lipids | Drug development | Toxicology | Mitochondria | Risk assessment | Rodents | Extracellular matrix | Mathematical models | Lipid metabolism | Hepatotoxicity | Deoxyribonucleic acid--DNA | Research & development--R&D | Data processing | Metabolism | Biological assays | Gene expression | Fatty acids | Steatosis | Signaling | Acids | Hepatocytes | Fibrosis | Biomarkers | Food safety | Peroxisome proliferator-activated receptors | Research & development | Deoxyribonucleic acid | R&D | DNA
Journal Article