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Journal of lipid research, ISSN 1539-7262, 2010, Volume 51, Issue 4, pp. 771 - 784
The farnesoid X receptor (FXR) is a bile acid activated nuclear receptor. Zucker (fa/fa) rats, harboring a loss of function mutation of the leptin receptor, develop diabetes, insulin resistance, obesity, and liver steatosis... 
RESPONSE ELEMENT | TYROSINE PHOSPHORYLATION | METABOLISM | LINKING OBESITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | ANIMAL-MODELS | FARNESOID-X-RECEPTOR | NONALCOHOLIC STEATOHEPATITIS | MECHANISMS | AGONISTS | Liver - pathology | Fatty Liver - pathology | Male | Muscle, Skeletal - metabolism | Insulin Receptor Substrate Proteins - metabolism | RNA, Messenger - metabolism | Thiazolidinediones - administration & dosage | Obesity - blood | Thiazolidinediones - therapeutic use | Hypoglycemic Agents - administration & dosage | Liver - drug effects | Time Factors | Lipids - blood | Muscle, Skeletal - drug effects | Chenodeoxycholic Acid - therapeutic use | Lipid Metabolism - genetics | Phosphorylation - drug effects | Drug Therapy, Combination | Disease Models, Animal | Hypoglycemic Agents - therapeutic use | Fatty Liver - blood | Obesity - complications | Liver - metabolism | Fatty Liver - prevention & control | Insulin Resistance | Rats | Chenodeoxycholic Acid - administration & dosage | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Random Allocation | Chenodeoxycholic Acid - analogs & derivatives | Gene Expression Regulation - drug effects | Rats, Zucker | Animals | Hypolipidemic Agents - administration & dosage | Lipid Metabolism - drug effects | Hypolipidemic Agents - therapeutic use | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article
The Journal of nutrition, ISSN 1541-6100, 2009, Volume 139, Issue 8, pp. 1495 - 1501
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 3, p. e59443
... (BCKDC) activities. Male obese Zucker rats (11weeks old) had increased body weight (BW, 53%), liver (107%) and fat (, 300%), but lower plantaris and gastrocnemius masses... 
INSULIN | OXIDATION | ACID DEHYDROGENASE KINASE | SKELETAL-MUSCLE | HYDROXYPROLINE EXCRETION | PLASMA | TURNOVER | GLUCOSE | MULTIDISCIPLINARY SCIENCES | FAT | BRANCHED-CHAIN AMINO | Biomarkers - metabolism | Leucine - metabolism | Adipose Tissue - physiology | Body Weight | Organ Size | Rats | Male | Muscle, Skeletal - physiology | Creatinine - urine | Metabolomics - methods | Obesity - metabolism | Rats, Zucker | Tandem Mass Spectrometry | Animals | Proteins - metabolism | Carnitine - urine | Chromatography, Liquid | Liver - physiology | Carbon Radioisotopes - metabolism | Carnitine - analogs & derivatives | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - blood | Amino Acids, Branched-Chain - blood | Type 2 diabetes | Obesity | Branched chain amino acids | Proteolysis | Body weight | Physiological aspects | Protein biosynthesis | Heart | Plasma | Metabolomics | Liver | Hydroxyproline | Chain branching | Amino acids | Chains | Lipids | Leucine | Glucose | Kinases | Protein turnover | Proteins | Metabolites | Rodents | Animal tissues | Physiology | Oxidation | Carbon 14 | Deposition | Enzymes | Protein metabolism | Accretion | Kidneys | Diabetes mellitus | Muscles | Dietary intake | Metabolism | Gene expression | Substrates | Medicine | Nutrition research | Musculoskeletal system | Diet | Protein synthesis | Insulin resistance | Catabolism | Diabetes | Endocrinology
Journal Article
Journal Article
The Journal of physiology, ISSN 0022-3751, 07/2017, Volume 595, Issue 13, pp. 4351 - 4364
.... We investigated both the independent and combined effects of exercise training and ALA consumption in obese Zucker rats, aiming to determine the potential for additive improvements in cardiovascular function... 
METABOLIC SYNDROME | SERUM-CHOLESTEROL | PUFA | MITOCHONDRIAL BIOGENESIS | angiogenesis | exercise physiology | N-3 FATTY-ACIDS | PHYSICAL-EXERCISE | diabetic cardiomyopathy | heart | LIPID PROFILE | INSULIN-RESISTANCE | FISH-OIL | CORONARY-HEART-DISEASE | PHYSIOLOGY | NEUROSCIENCES | Blood Pressure | Exercise Therapy - methods | Cardiovascular Diseases - etiology | Heart Rate | Cardiovascular Diseases - physiopathology | Diastole | Obesity - complications | Cardiovascular Diseases - drug therapy | Cholesterol - blood | Cardiovascular Diseases - therapy | alpha-Linolenic Acid - therapeutic use | Rats | Male | Obesity - physiopathology | Rats, Zucker | Animals | alpha-Linolenic Acid - administration & dosage | Physical Conditioning, Animal | Intervention | Oxidative stress | Phosphorylation | Physical training | Oxidizing agents | Cardiovascular disease | Vasodilation | Training | Antioxidants | Proteins | Angiogenesis | Rodents | Attenuation | Blood pressure | Endurance | Fitness training programs | Heart diseases | Carbonyls | Stroke | Effectiveness | Hyperlipidemia | Markers | Durability | Esterification | Cholesterol | Skeletal muscle | Stroke volume | Linolenic acid | Oxidative phosphorylation | Fibrosis | Cardiac output | Cardiovascular diseases | Integrative | Research Paper
Journal Article
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 1, p. e0211281
.... In order to get some further insight into the relationship of pulmonary hypertension with obesity, insulin resistance and hyperglycemia, herein we have used the Zucker diabetic fatty rats (ZDF/clr-lepr fa... 
INSULIN | LEPTIN | OXYGEN-CONSUMPTION | OBESITY | ACTIVATION | MULTIDISCIPLINARY SCIENCES | GUIDELINES | KV7 CHANNELS | HYPERTENSION | ASSOCIATION | EXPRESSION | Lung - pathology | Blood Glucose - analysis | Bone Morphogenetic Protein Receptors, Type II - genetics | Gene Expression Regulation | Rats | Arterial Pressure - physiology | Vasoconstriction - drug effects | Bone Morphogenetic Protein Receptors, Type II - metabolism | Obesity - pathology | Potassium Channels - genetics | Pulmonary Artery - physiology | Potassium Channels - metabolism | Rats, Zucker | Animals | Amidines - pharmacology | Lung - metabolism | Hemodynamics | Benzylamines - pharmacology | Cytokines - blood | Obesity - veterinary | Complications and side effects | Rats as laboratory animals | Messenger RNA | Genetic aspects | Research | Diabetes | Gene expression | Health aspects | Pulmonary hypertension | Risk factors | Animal models | Arteries | Proteins | Hyperglycemia | Vascular diseases | Rodents | Blood pressure | Potassium channels (voltage-gated) | Diabetes mellitus (non-insulin dependent) | Thickening | Hypertension | Obesity | Bone morphogenetic protein receptor type II | Nutrition | Diabetes mellitus | Health risks | Septum | Risk analysis | KCNQ5 protein | Insulin | Nitric-oxide synthase | Weight | Pulmonary artery | Endothelium | Heart rate | KCNQ4 protein | Lungs | Leptin | KCNQ1 protein | Insulin resistance | Acetylcholine | Ventricle | Mutation | Potassium | Metabolic disorders | Hypertrophy
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2006, Volume 291, Issue 4, pp. 1780 - 1787
Journal Article
Journal Article