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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 10/2007, Volume 293, Issue 4, pp. 1561 - 1572
Increasing efferent renal sympathetic nerve activity (ERSNA) increases afferent renal nerve activity (ARNA). To test whether the ERSNA-induced increases in... 
Prazosin | EP4 receptor | Rauwolscine | Pelvis | Substance P
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2008, Volume 155, Issue 4, pp. 494 - 504
Journal Article
Neurochemistry International, ISSN 0197-0186, 01/2000, Volume 36, Issue 1, pp. 7 - 18
[ super(125)I]17 alpha -hydroxy-20 alpha -yohimban-16 beta -(N-4-hydroxyphenethyl)carboxami de or [ super(125)I]rauwolscine-OHPC, a new radioiodinated probe... 
rauwolscine
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 05/2012, Volume 166, Issue 2, pp. 721 - 736
BACKGROUND AND PURPOSE beta-Adrenoceptors are expressed in human and experimental animal breast cancer cells. However, the effect of the agonists and... 
rauwolscine | SIGNALING PATHWAYS | BETA-ADRENERGIC-RECEPTORS | PHOSPHORYLATION | salbutamol | BETA-ADRENOCEPTOR | RAT MAMMARY-GLAND | LINES | BLOCKERS | propranolol | PHARMACOLOGY & PHARMACY | adrenoceptors | PROGESTERONE-RECEPTOR | mammary tumour | isoprenaline | AGONIST
Journal Article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 05/2017, Volume 65, Issue 19, pp. 3965 - 3974
4-[2-(t-Butylamino)-1-hydroxyethyl]phenol (buctopamine, 4), a new beta(2) receptor agonist (beta(2)-agonist), was found to be an adulterant in feed additives... 
H-3 RAUWOLSCINE | FOOD SCIENCE & TECHNOLOGY | feed additive | TANDEM MASS-SPECTROMETRY | ADRENERGIC-RECEPTORS | CHROMATOGRAPHY | BETA-AGONISTS | hair | metabolite | identification | URINE | LIVER | AGRICULTURE, MULTIDISCIPLINARY | PHYSIOLOGICAL DISPOSITION | RAT-BRAIN | BEEF | CHEMISTRY, APPLIED | beta-agonist
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, ISSN 0363-6119, 10/2007, Volume 293, Issue 4, pp. R1561 - R1572
Increasing efferent renal sympathetic nerve activity (ERSNA) increases afferent renal nerve activity (ARNA). To test whether the ERSNA-induced increases in... 
rauwolscine | PHYSIOLOGY | RAT-KIDNEY | pelvis | RELEASE | DORSAL-ROOT GANGLION | EP4 receptor | MECHANOSENSITIVE NEURONS | INHIBITION | ENHANCEMENT | RECEPTOR ACTIVATION | substance P | SUBSTANCE-P | PROSTAGLANDIN E | BRADYKININ | prazosin
Journal Article
Life Sciences, ISSN 0024-3205, 08/2015, Volume 138, pp. 86 - 93
Aims: This study was performed to examine whether acute pressure overload induced by transverse aortic constriction (TAC) inhibits the neurogenic vasopressor... 
CP55940 (PubChem CID: 104895) | Chemical compounds studied in this article AM251 (PubChem CID: 2125) | Glibenclamide (CID:3488) | Rauwolscine hydrochloride (PubChem CID: 197067)
Journal Article
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, ISSN 0271-678X, 03/2015, Volume 35, Issue 3, pp. 501 - 511
We quantified the binding potentials (BPND) of [C-11]yohimbine binding in rat brain to alpha-2 adrenoceptors to evaluate [C-11]yohimbine as an in vivo marker... 
ALPHA-2-ADRENOCEPTORS | NORADRENALINE RELEASE | H-3 RAUWOLSCINE | BLOOD-FLOW | NEUROSCIENCES | ISOFLURANE ANESTHESIA | alpha-2 adrenoceptors | GRAPHICAL ANALYSIS | CYCLOSPORINE-A | amphetamine challenge | ENDOCRINOLOGY & METABOLISM | [C-11]yohimbine | ALPHA-ADRENERGIC RECEPTORS | YOHIMBINE BINDING | HEMATOLOGY | AMPHETAMINE | reference region | Inhibition plot
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 10/2008, Volume 155, Issue 4, pp. 494 - 504
Background and purpose: Breast cancer, the most common cancer in women in most countries, is a highly stressful disease. Catecholamines released during stress... 
SUBTYPE | rauwolscine | DUCTAL CARCINOMAS | ACTIVATION | BETA-ADRENERGIC-RECEPTORS | MEDROXYPROGESTERONE ACETATE | clonidine | yohimbine | ARACHIDONIC-ACID METABOLISM | mouse | BREAST-CANCER CELLS | IN-VITRO | ESTROGEN | PHARMACOLOGY & PHARMACY | PROGESTERONE-RECEPTOR | mammary tumour
Journal Article
MOVEMENT DISORDERS, ISSN 0885-3185, 08/2003, Volume 18, Issue 8, pp. 872 - 883
Previous studies in the MPTP-lesioned primate model of Parkinson's disease have demonstrated that alpha(2) adrenergic receptor antagonists such as idazoxan,... 
H-3 RAUWOLSCINE | SUBTYPES | JP-1730 | FOLLOW-UP | DOPA-INDUCED DYSKINESIAS | alpha-adrenergic | dyskinesia | CLINICAL NEUROLOGY | UNILATERAL PALLIDOTOMY | AMANTADINE | marmoset | NEURAL MECHANISMS | RAT-BRAIN | AGONIST-INDUCED DYSKINESIA | BINDING
Journal Article
CURRENT CANCER DRUG TARGETS, ISSN 1568-0096, 07/2011, Volume 11, Issue 6, pp. 763 - 774
We have previously described enhanced human breast cancer cell proliferation and mouse mammary tumor growth induced by alpha(2)-adrenergic agonists, associated... 
rauwolscine | carcinoma-associated fibroblasts | ANGIOGENESIS | breast cancer | MODEL | HUMAN BREAST CARCINOMAS | CANCER | ONCOLOGY | ALPHA-ADRENERGIC-RECEPTOR | Clonidine | mammary tumor | adrenoceptors | ANTAGONISTS | EXPRESSION | GLAND
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2008, Volume 155, Issue 4, pp. 494 - 504
Background and purpose: Breast cancer, the most common cancer in women in most countries, is a highly stressful disease. Catecholamines released during stress... 
clonidine | mouse | yohimbine | rauwolscine | mammary tumour | Research Papers
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 7/2006, Volume 58, Issue 1, pp. 50 - 61
Adrenergic compounds (epinephrine and norepinephrine) are the most important hormones released during stress. Several different receptors are associated with... 
Cell proliferation | Normal breast | Biomedicine | Oncology | Cancer Research | Breast cancer | Clonidine | Rauwolscine | Pharmacology/Toxicology | α 2 -Adrenoceptors | Adrenoceptors
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2007, Volume 151, Issue 8, pp. 1293 - 1304
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2009, Volume 157, Issue 8, pp. 1474 - 1482
Background and purpose:  We examined whether cannabinoid CB1 and histamine H3 receptors resemble α2-adrenoceptors in that their presynaptically mediated... 
urethane anaesthesia | H3 receptor | α2-adrenoceptor | CB1 receptor | 3H-Nα-methylhistamine binding | 3H-noradrenaline release | 3H-rauwolscine binding | pentobarbitone anaesthesia | 3H-rimonabant binding | pithed rat | 3H‐Nα‐methylhistamine binding | 3H‐rauwolscine binding | α2‐adrenoceptor | 3H‐rimonabant binding | 3H‐noradrenaline release | Pithed rat | Urethane anaesthesia | 3H-Na-methylhistamine binding | Pentobarbitone anaesthesia | A2-adrenoceptor | H-3-rauwolscine binding | ALPHA-ADRENOCEPTORS | NORADRENALINE RELEASE | SYMPATHETIC-NERVES | H-3-rimonabant binding | ACETYLCHOLINE | H-3 receptor | H-3-noradrenaline release | PHYSIOPHARMACOLOGICAL INVESTIGATIONS | MOUSE-BRAIN CORTEX | PITHED RATS | alpha-adrenoceptor | H-3 RECEPTORS | PHARMACOLOGY & PHARMACY | H-3-N-alpha-methylhistamine binding | MEDIATED INHIBITION | CB1 RECEPTORS | Electric Stimulation | Rats, Wistar | Receptors, Presynaptic - physiology | Pentobarbital - pharmacology | Anesthetics - pharmacology | Male | Thiourea - pharmacology | Cerebral Cortex - metabolism | Receptor, Cannabinoid, CB1 - physiology | Adrenergic alpha-2 Receptor Agonists | Cardiovascular System - physiopathology | Receptor, Cannabinoid, CB1 - agonists | Cyclohexanols - pharmacology | Radioligand Assay | Vasoconstrictor Agents - pharmacology | Mice, Inbred C57BL | Rats | Cardiovascular System - drug effects | Imidazoles - pharmacology | Animals | Decerebrate State | Mice | Urethane - pharmacology | Histamine Agonists - pharmacology | In Vitro Techniques | Thiourea - analogs & derivatives | Index Medicus | Research Papers
Journal Article
Brain Research, ISSN 0006-8993, 08/2006, Volume 1106, Issue 1, pp. 82 - 90
Hypoxia preconditioning has been shown to produce tolerance against brain injuries. The hypothesis of this study is that chronic hypobaric hypoxia may also... 
Tolerance | Locus coeruleus (LC) | [3H]Rauwolscine binding | Alpha-2 adrenoceptor | Intracellular recording | Chronic hypobaric hypoxia | H]Rauwolscine binding | intracellular recording | NORADRENALINE RELEASE | locus coeruleus (LC) | chronic hypobaric hypoxia | RECEPTOR | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | alpha-2 adrenoceptor | PROTECTS | SLICES | [H-3]rauwolscine binding | INHIBITION | GLUTAMATE | STRESS | EXPRESSION | tolerance | BRAIN | Receptors, Glutamate - metabolism | Rats, Wistar | Locus Coeruleus - drug effects | Receptors, Adrenergic, alpha-2 - metabolism | Male | Adrenergic alpha-Antagonists - pharmacology | Receptors, Glutamate - drug effects | Oxygen Consumption - physiology | Hypoxia, Brain - metabolism | Receptors, Adrenergic, alpha-2 - drug effects | Ischemic Preconditioning - methods | Up-Regulation - physiology | Binding Sites - physiology | Action Potentials - drug effects | Binding Sites - drug effects | Cell Survival - physiology | Organ Culture Techniques | Cell Survival - drug effects | Acute Disease | Binding, Competitive - physiology | Rats | Excitatory Amino Acid Antagonists - pharmacology | Action Potentials - physiology | Binding, Competitive - drug effects | Hypoxia, Brain - physiopathology | Up-Regulation - drug effects | Animals | Norepinephrine - metabolism | Adrenergic alpha-Agonists - pharmacology | Chronic Disease | Locus Coeruleus - metabolism | Brain | Neurons | Membrane potentials | Amino acids | Clonidine | Universities and colleges | Glutamate | Injuries | Organic acids
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 9982 - 9987
Arginine contains the guanidinium group and thus has structural similarity to ligands of imidazoline and α-2 adrenoceptors (α-2 AR). Therefore, we investigated... 
Cell culture techniques | Signal transduction | Receptors | Imidazolines | Fluorescence | Agonists | Ligands | Toxins | Endothelial cells | Whooping cough | Calcium | Agmatine | Rauwolscine | rauwolscine | calcium | DEPENDENT VASODILATION | VASCULAR RELAXATION | MULTIDISCIPLINARY SCIENCES | agmatine | RELAXING FACTOR | PORCINE CORONARY-ARTERIES | RELEASE | SYNTHASE | SMOOTH-MUSCLE | CHOLESTEROL-FED RABBITS | S-NITROSOTHIOLS | Endothelium, Vascular - cytology | Aniline Compounds | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Culture Media, Serum-Free | Adrenergic alpha-Antagonists - pharmacology | Calcium - analysis | Agmatine - pharmacology | Virulence Factors, Bordetella - pharmacology | Type C Phospholipases - antagonists & inhibitors | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Idazoxan - pharmacology | Arginine - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Agmatine - chemistry | Dexmedetomidine - pharmacology | Molecular Structure | Cell Culture Techniques | Nitric Oxide Synthase Type III - metabolism | Umbilical Veins - cytology | Nitrates - analysis | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Nifedipine - pharmacology | Idazoxan - chemistry | Endothelial Cells - metabolism | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Imidazolines - pharmacology | Calcium Channel Blockers - pharmacology | Enzyme Activation - drug effects | Arginine - chemistry | Xanthenes | Endothelial Cells - cytology | Arginine - pharmacology | Lipopolysaccharides - pharmacology | Second Messenger Systems - physiology | Nitrites - analysis | Endothelial Cells - enzymology | Fluorescent Dyes | Biological Sciences
Journal Article
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