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1. The purple digit: An algorithmic approach to diagnosis
by Brown, Patrick J and Zirwas, Matthew J and English, Joseph C
American Journal of Clinical Dermatology, ISSN 1175-0561, 2010, Volume 11, Issue 2, pp. 103 - 116
The acute onset of purple digits is a concerning manifestation and may represent underlying, potentially life-threatening disease. Correctly identifying the... 
BLUE TOE SYNDROME | CHILBLAIN LUPUS-ERYTHEMATOSUS | DERMATOLOGICAL MANIFESTATIONS | CHOLESTEROL EMBOLIZATION SYNDROME | INFECTIOUS PURPURA FULMINANS | CLINICAL-MANIFESTATIONS | INTRAVENOUS STREPTOKINASE | PERIPHERAL GANGRENE | RAYNAUDS-PHENOMENON | CUTANEOUS MANIFESTATIONS | DERMATOLOGY | Toes - blood supply | Frostbite - diagnosis | Cold Temperature | Diagnosis, Differential | Vascular Diseases - etiology | Humans | Pulse | Fingers - pathology | Vascular Diseases - diagnosis | Algorithms | Fingers - blood supply | Adult | Toes - pathology
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2. Full Text Preliminary analysis of the Very Early Diagnosis of Systemic Sclerosis (VEDOSS) EUSTAR multicentre study: evidence for puffy fingers as a pivotal sign for suspicion of systemic sclerosis
by Minier, Tünde and Guiducci, Serena and Bellando-Randone, Silvia and Bruni, Cosimo and Lepri, Gemma and Czirják, László and Distler, Oliver and Walker, Ulrich A and Fransen, Jaap and Allanore, Yannick and Denton, Christopher and Cutolo, Maurizio and Tyndall, Alan and Müller-Ladner, Ulf and Matucci-Cerinic, Marco and EUSTAR Co-Workers and EUSTAR co-workers and and the EUSTAR co-workers
Annals of the Rheumatic Diseases, ISSN 0003-4967, 12/2014, Volume 73, Issue 12, pp. 2087 - 2093
Objectives The EULAR (European League Against Rheumatism) Scleroderma Trials and Research Group (EUSTAR) has identified preliminary criteria for very early... 
Systemic Sclerosis | Disease Activity | Pulmonary Fibrosis | Autoantibodies | Outcomes research | ORGAN INVOLVEMENT | MORTALITY | METAANALYSIS | EVOLUTION | DISEASE | VALIDATION | RAYNAUDS-PHENOMENON | MICROVASCULAR DAMAGE | RHEUMATOLOGY | CLASSIFICATION CRITERIA | MANIFESTATIONS | Telangiectasis - diagnosis | Microscopic Angioscopy | Skin Ulcer - diagnosis | Antibodies, Antinuclear - immunology | Humans | Middle Aged | Male | Skin Ulcer - immunology | Fingers - pathology | Scleroderma, Systemic - immunology | Raynaud Disease - diagnosis | Scleroderma, Systemic - diagnosis | Telangiectasis - complications | Scleroderma, Systemic - complications | Fingers - blood supply | Skin Ulcer - complications | Adult | Female | Raynaud Disease - immunology | Telangiectasis - immunology | Early Diagnosis | Cohort Studies | Raynaud Disease - complications | Symptomatology | Complications and side effects | Usage | Systemic scleroderma | Analysis | Scleroderma (Disease) | Clinical trials | Diagnosis | Raynaud's disease | Risk factors | Studies | Immunoglobulins | Signs | Laboratories | Mortality | Classification | RNA polymerase | Scleroderma | Data bases
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3. Full Text Heparin-induced thrombocytopenia: diagnosis and management
by Warkentin, Theodore E
Circulation, ISSN 0009-7322, 2004, Volume 110, Issue 18, pp. e454 - 458
PERIPHERAL VASCULAR DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | DIRECT THROMBIN INHIBITOR | VENOUS LIMB GANGRENE | WARFARIN | LEPIRUDIN | Recombinant Proteins - therapeutic use | Toes - blood supply | Pipecolic Acids - immunology | Heart Valve Prosthesis Implantation | Humans | Middle Aged | Platelet Activation - immunology | Platelet Factor 4 - immunology | Postoperative Complications - prevention & control | Warfarin - adverse effects | Heparin - therapeutic use | Heparin - adverse effects | Necrosis | Warfarin - therapeutic use | Pipecolic Acids - therapeutic use | Female | Thrombocytopenia - therapy | Thrombosis - prevention & control | Hirudins - immunology | Ischemia - pathology | Raynaud Disease - complications | Thrombocytopenia - immunology | Autoimmune Diseases - immunology | Anticoagulants - therapeutic use | Thrombocytopenia - chemically induced | Autoimmune Diseases - diagnosis | Anticoagulants - adverse effects | Autoantibodies - immunology | Heparin - immunology | Anticoagulants - immunology | Recombinant Proteins - immunology | Fingers - blood supply | Aortic Valve Insufficiency - surgery | Autoimmune Diseases - therapy | Thrombocytopenia - diagnosis | Autoimmune Diseases - chemically induced | Ischemia - etiology
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4. Full Text International consensus criteria for the diagnosis of Raynaud's phenomenon
by Maverakis, Emanual and Patel, Forum and Kronenberg, Daniel G and Chung, Lorinda and Fiorentino, David and Allanore, Yannick and Guiducci, Serena and Hesselstrand, Roger and Hummers, Laura K and Duong, Chris and Kahaleh, Bashar and Macgregor, Alexander and Matucci-Cerinic, Marco and Wollheim, Frank A and Mayes, Maureen D and Gershwin, M. Eric and Department of Rheumatology and Lund University and Reumatologi och molekylär skelettbiologi and Lunds universitet
Journal of Autoimmunity, ISSN 0896-8411, 2014, Volume 48, Issue Jan 31, pp. 60 - 65
Abstract Vasoconstriction accompanied by changes in skin color is a normal physiologic response to cold. The distinction between this normal physiology and... 
Allergy and Immunology | Raynaud's phenomenon | Primary Raynaud's | Secondary Raynaud's | Diagnostic criteria | SCLERODERMA | CAPILLAROSCOPY | VIBRATION | IMMUNOLOGY | DIGITAL BLOOD-PRESSURE | FLOW | DISTAL-DORSAL DIFFERENCE | Mixed Connective Tissue Disease - diagnosis | Scleroderma, Systemic - diagnosis | Diagnosis, Differential | Sjogren's Syndrome - diagnosis | Dermatomyositis - diagnosis | Data Collection | International Cooperation | Autoimmune Diseases - diagnosis | Arthritis, Rheumatoid - diagnosis | Raynaud Disease - diagnosis | Consensus | Lupus Erythematosus, Systemic - diagnosis | Autoimmunity | Physiological aspects | Analysis | Rheumatology and Autoimmunity | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Reumatologi och inflammation
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5. Full Text The differential diagnosis of raynaud's phenomenon and practical approach to assessment with a focus on imaging
by Herrick, AL
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2017, Volume 76, Issue 6
Usage | Raynaud's disease | Diagnosis | Thermography (Copying process) | Imaging systems | Thermography
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6. Full Text The pathogenesis, diagnosis and treatment of Raynaud phenomenon
by Herrick, Ariane L
Nature Reviews Rheumatology, ISSN 1759-4790, 08/2012, Volume 8, Issue 8, pp. 469 - 479
The past 10 years have seen the publication of results from several multicentre clinical trials in primary and systemic sclerosis (SSc)-related Raynaud... 
SYSTEMIC-SCLEROSIS PATIENTS | COOLING-INDUCED CONTRACTION | DOUBLE-BLIND | COLD-INDUCED CONSTRICTION | CONNECTIVE-TISSUE DISEASE | PLACEBO-CONTROLLED TRIAL | RHEUMATOLOGY | CALCIUM-CHANNEL BLOCKERS | EULAR SCLERODERMA TRIALS | ENDOTHELIAL GROWTH-FACTOR | RESEARCH GROUP EUSTAR | Capillaries - pathology | Nails - blood supply | Blood Vessels - pathology | Humans | Connective Tissue Diseases - diagnosis | Male | Connective Tissue Diseases - therapy | Raynaud Disease - etiology | Raynaud Disease - diagnosis | Raynaud Disease - therapy | Sex Factors | Female | Connective Tissue Diseases - complications | Care and treatment | Autoantibodies | Nitric oxide | Physiological aspects | Research | Raynaud's disease | Diagnosis | Risk factors
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7. Full Text Diagnosis and management of Raynaud's phenomenon
by Beth Goundry and Laura Bell and Matthew Langtree and Arumugam Moorthy
BMJ: British Medical Journal, ISSN 0959-8138, 2/2012, Volume 344, Issue 7843, pp. 37 - 42
SUMMARY POINTS Raynaud's phenomenon is caused by episodic vasospasm and ischaemia of the extremities, particularly the digits, in response to cold or emotional... 
CLINICAL REVIEW | Systemic scleroderma | Raynaud disease | Connective tissue diseases | Ulcers | Vasodilators | Rheumatology | Placebos | Experimentation | Arthritis | Symptoms | PATHOGENESIS | MEDICINE, GENERAL & INTERNAL | SCLERODERMA | EFFICACY | ILOPROST THERAPY | GINKGO-BILOBA | NITROGLYCERIN | DOUBLE-BLIND | PHENOMENON SECONDARY | PLACEBO-CONTROLLED TRIAL | SYSTEMIC-SCLEROSIS | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Raynaud Disease - therapy | Vasodilator Agents - therapeutic use | Humans | Serotonin Uptake Inhibitors - therapeutic use | Raynaud Disease - etiology | Referral and Consultation | Angiotensin Receptor Antagonists - therapeutic use | Raynaud Disease - diagnosis | Endothelin Receptor Antagonists
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8. The diagnosis and treatment of Raynaud's phenomenon: A practical approach
by Pope, Janet E
Drugs, ISSN 0012-6667, 2007, Volume 67, Issue 4, pp. 517 - 525
Raynaud's phenomenon is a common disorder with vasospasm of the digital arteries causing pallor with cyanosis and/or rubor. It can be primary (idiopathic),... 
CONTROLLED-TRIAL | THERAPY | DIGITAL ULCERS | DISEASE | DOUBLE-BLIND | SECONDARY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SYSTEMIC-SCLEROSIS | GLYCERYL TRINITRATE | BOSENTAN | Raynaud Disease - therapy | Raynaud Disease - diagnosis | Humans | Raynaud Disease - physiopathology | Calcium Channel Blockers - therapeutic use | Smoking Cessation
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9. Full Text Assessing microvascular changes in systemic sclerosis diagnosis and management
by Sulli, Alberto and Cutolo, Maurizio and Smith, Vanessa
Nature Reviews Rheumatology, ISSN 1759-4790, 10/2010, Volume 6, Issue 10, pp. 578 - 587
Microvascular damage and dysfunction represent the earliest morphological and functional markers of systemic sclerosis (SSc), a progressive connective tissue... 
CONTROLLED-TRIAL | CYCLOSPORINE-A | PULMONARY ARTERIAL-HYPERTENSION | SCLERODERMA-SPECTRUM DISORDERS | SECONDARY RAYNAUDS-PHENOMENON | RHEUMATOLOGY | CLASSIFICATION CRITERIA | VASCULAR-DISEASE | PREDICTIVE FACTORS | NAILFOLD VIDEOCAPILLAROSCOPY ASSESSMENT | INVIVO CAPILLARY MICROSCOPY | Microscopic Angioscopy | Raynaud Disease - drug therapy | Prognosis | Nails - blood supply | Vasodilator Agents - therapeutic use | Humans | Immunosuppressive Agents - therapeutic use | Microvessels - pathology | Laser-Doppler Flowmetry | Raynaud Disease - diagnosis | Randomized Controlled Trials as Topic | Skin - blood supply | Scleroderma, Systemic - diagnosis | Raynaud Disease - physiopathology | Scleroderma, Systemic - physiopathology | Thermography - methods | Scleroderma, Systemic - drug therapy | Skin - pathology | Complications and side effects | Blood circulation disorders | Care and treatment | Systemic scleroderma | Scleroderma (Disease) | Diagnosis | Research | Risk factors
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10. Full Text Cardiac magnetic resonance imaging in systemic sclerosis: a cross-sectional observational study of 52 patients
by Hachulla, A-L and Launay, D and Gaxotte, V and de Groote, P and Lamblin, N and Devos, P and Hatron, P-Y and Beregi, J-P and Hachulla, E
Annals of the Rheumatic Diseases, ISSN 0003-4967, 12/2009, Volume 68, Issue 12, pp. 1878 - 1884
Objectives:To assess the prevalence and patterns of cardiac abnormalities as detected by cardiac magnetic resonance imaging (MRI) in systemic sclerosis... 
SCLERODERMA | MYOCARDIAL FIBROSIS | MRI | DIASTOLIC FUNCTION | PERFUSION | DYSFUNCTION | RHEUMATOLOGY | DOPPLER-ECHOCARDIOGRAPHY | ACCURACY | Cross-Sectional Studies | Scleroderma, Limited - pathology | Humans | Middle Aged | Scleroderma, Systemic - pathology | Magnetic Resonance Imaging - methods | Male | Scleroderma, Diffuse - diagnosis | Ventricular Dysfunction, Left - diagnosis | Ventricular Dysfunction, Right - diagnosis | Heart Diseases - diagnosis | Scleroderma, Systemic - diagnosis | Contrast Media | Scleroderma, Diffuse - pathology | Scleroderma, Limited - diagnosis | Scleroderma, Systemic - complications | Adult | Female | Aged | Hypertension, Pulmonary - etiology | Heart Diseases - pathology | Heart Ventricles - pathology | Usage | Research | Diagnosis | Magnetic resonance imaging | Systemic scleroderma | Scleroderma (Disease) | Hypertension | Studies | Nuclear magnetic resonance--NMR | Heart attacks | Raynaud disease | Medical prognosis | 1506 | Clinical and Epidemiological Research
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11. Full Text AB1218 Diagnosis of primary raynaud's phenomenon and capillaroscopy
by S. Lambova
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2018, Volume 77, p. 1707
Background Raynaud's phenomenon (RP) is a clinical expression of recurrent reversible vasospasm of small peripheral arteries and arterioles. It is a common... 
Statistical analysis | Arterioles | Raynaud disease | Vasoconstriction | Fibromyalgia | Data processing | Quantitation | Medical diagnosis | Patients | Arteries | Systemic sclerosis | Microvasculature | Differential diagnosis
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12. Full Text AB0679 The clinical value of nailfold capillaroscopy in the early diagnosis of systemic sclerosis
by Gao, W and Zhang, G and Zhang, L and Xu, K and Li, B and Yang, Y and Yan, M
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2017, Volume 76, Issue Suppl 2, p. 1290
BackgroundVascular changes was early pathological changes of SSc, gradually appearing with irreversible fibrosis of the skin and internal organs. Early... 
Raynaud disease | Connective tissue diseases | Systemic sclerosis | Classification | Fibrosis | Arthritis | Skin | Diagnosis | Scleroderma | Health risk assessment | Medical diagnosis
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13. Full Text Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group
by Avouac, J and Fransen, J and Walker, UA and Riccieri, V and Smith, V and Muller, C and Miniati, I and Tarner, IH and Randone, S Bellando and Cutolo, M and Allanore, Y and Distler, O and Valentini, G and Czirjak, L and Müller-Ladner, U and Furst, DE and Tyndall, A and Matucci-Cerinic, M and EUSTAR Grp and EUSTAR Group
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2011, Volume 70, Issue 3, pp. 476 - 481
Objective To identify a core set of preliminary items considered as important for the very early diagnosis of systemic sclerosis (SSc). Methods A list of items... 
SENSITIVITY | CLASSIFICATION CRITERIA | RHEUMATOLOGY | Microscopic Angioscopy | Diagnosis, Differential | Humans | Raynaud Disease - etiology | Scleroderma, Systemic - immunology | Skin Diseases - etiology | Edema - etiology | Scleroderma, Systemic - diagnosis | Delphi Technique | Fingers | Antibodies, Antinuclear - blood | Scleroderma, Systemic - complications | Early Diagnosis | Usage | Diagnosis | Research | Systemic scleroderma | Delphi technique | Scleroderma (Disease) | Studies | Medical research | Experts | Raynaud disease | Mortality | Classification | Response rates | Scleroderma
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14. Full Text Skin signs of systemic diseases
by Rigopoulos, Dimitris, MD and Larios, George, MD and Katsambas, Andreas, MD
Clinics in Dermatology, ISSN 0738-081X, 2011, Volume 29, Issue 5, pp. 531 - 540
Abstract The skin should not be considered as an isolated organ but rather as a definite functioning system that communicates with the internal environment.... 
Dermatology | DIABETES-MELLITUS | RHEUMATOID-ARTHRITIS | LEOPARD-SYNDROME | DERMATOMYOSITIS | PRIMARY SJOGRENS-SYNDROME | PSEUDOXANTHOMA ELASTICUM | REITERS-SYNDROME | THYROID-DISEASE | GASTROINTESTINAL DISORDERS | CUTANEOUS MANIFESTATIONS | DERMATOLOGY | Lung Diseases - diagnosis | Humans | Arthritis - diagnosis | Connective Tissue Diseases - diagnosis | Male | Endocrine System Diseases - diagnosis | Raynaud Disease - diagnosis | Gastrointestinal Diseases - diagnosis | Cutis Laxa - diagnosis | Skin Diseases - diagnosis | LEOPARD Syndrome | Female | Ehlers-Danlos Syndrome - diagnosis | Mucocutaneous Lymph Node Syndrome - diagnosis | Cardiovascular Diseases - diagnosis
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15. Full Text Evidence for oesophageal and anorectal involvement in very early systemic sclerosis (VEDOSS): Report from a single VEDOSS/EUSTAR centre
by Gemma, Lepri and Serena, Guiducci and Silvia, Bellando-Randone and Iacopo, Giani and Cosimo, Bruni and Jelena, Blagojevic and Giulia, Carnesecchi and Alessandra, Radicati and Filippo, Pucciani and Marco, Matucci-Cerinic
Annals of the Rheumatic Diseases, ISSN 0003-4967, 10/2013, Volume 74, Issue 1, pp. 124 - 128
Background The oesophagus is the first gastrointestinal (GI) tract involved in systemic sclerosis (SSc), followed by the anorectum. Objective Evaluation of... 
TRANSIT | MANOMETRY | RHEUMATOLOGY | Rectal Diseases - etiology | Microscopic Angioscopy | Humans | Middle Aged | Rectal Diseases - physiopathology | Male | Lung - diagnostic imaging | Raynaud Disease - etiology | Lung Diseases - etiology | Scleroderma, Systemic - diagnosis | Anus Diseases - diagnosis | Anus Diseases - physiopathology | Scleroderma, Systemic - complications | Scleroderma, Systemic - physiopathology | Anal Canal - physiopathology | Adult | Female | Esophageal Diseases - diagnosis | Manometry | Lung Diseases - diagnosis | Lung - physiopathology | Esophageal Diseases - etiology | Radiography | Esophageal Sphincter, Lower - physiopathology | Esophageal Diseases - physiopathology | Lung Diseases - physiopathology | Respiratory Function Tests | Anus Diseases - etiology | Early Diagnosis | Rectal Diseases - diagnosis | Esophageal diseases | Systemic scleroderma | Anus | Abnormalities | Scleroderma (Disease) | Anorectal disorders | Diagnosis | Risk factors
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