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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 13, pp. 3479 - 3484
Nonsense mutations underlie about 10% of rare genetic disease cases. They introduce a premature termination codon (PTC) and prevent the formation of... 
Premature stop codon readthrough | Rare genetic diseases | Nonsense mutation | Cancer | Gentamicin B1 | gentamicin B1 | nonsense mutation | premature stop codon readthrough | READTHROUGH | CODONS | MULTIDISCIPLINARY SCIENCES | FORCE-FIELD | cancer | rare genetic diseases | TRANSFER-RNA | SELECTION | Gene mutations | Health aspects | Codon | Biological Sciences
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2019, Volume 14, Issue 4
Nonsense suppression therapy (NST) utilizes compounds such as PTC124 (Ataluren) to induce translational read-through of stop variants by promoting the... 
READTHROUGH | CODONS | REP1 | MULTIDISCIPLINARY SCIENCES | MUTATIONS | ATALUREN
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1595, pp. 81 - 92
Translational readthrough, the decoding of stop codons as sense codons, leads to C-terminal extension of proteins which may lead to the formation of protein... 
Stop codon context | Stop codon readthrough | Readthrough induction | Dual reporter system | Translational readthrough | Flow Cytometry - methods | Gene Expression | Cells, Cultured | Protein Biosynthesis - genetics | Codon, Terminator | Luminescent Measurements - methods | Genes, Reporter
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2018, Volume 502, Issue 3, pp. 422 - 428
The gene encodes α-actinin-3 protein, which stabilizes the contractile apparatus at the Z-line in skeletal muscle cell fast fibers. A nonsense mutation of the... 
α-Actinin-3 | Premature termination codon | Readthrough | ACTN3 | Nonsense-mediated mRNA decay | Aminoglycoside | alpha-Actinin-3 | CODON READTHROUGH | PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE METABOLISM | DEFICIENCY | SPEED | BIOPHYSICS | GENE | MECHANISTIC INSIGHTS | STOP CODON | MESSENGER-RNA DECAY | TERMINATION
Journal Article
ACTA NEUROPATHOLOGICA COMMUNICATIONS, ISSN 2051-5960, 04/2019, Volume 7, Issue 1, pp. 51 - 15
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2018, Volume 9, Issue 12, pp. 1285 - 1291
Nonsense suppressors (NonSups) induce "readthrough", i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the... 
eukaryotic translation | ribosome | in vitro assay | nonsense suppressors | readthrough | Premature termination codon (PTC) | ANTIBIOTICS | CHEMISTRY, MEDICINAL | READ-THROUGH | STOP CODON READTHROUGH | COGNATE TRANSFER-RNAS | GENE | AMINOGLYCOSIDE | ELONGATION | TERMINATION | ATALUREN
Journal Article
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, ISSN 1941-3149, 11/2016, Volume 9, Issue 11
Background-Several compounds have been reported to induce translational readthrough of premature stop codons resulting in the production of full-length protein... 
nonsense mutation | FIBROSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | ASSAY | MECHANISMS | LONG-QT SYNDROME | MAMMALIAN-CELLS | STOP CODON READTHROUGH | mutation | sodium channels | readthrough | DISEASE | induced pluripotent stem cells | THERAPIES | SCN5A | MESSENGER-RNA DECAY | ATALUREN
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2016, Volume 113, Issue 44, pp. 12508 - 12513
Journal Article
RSC Advances, ISSN 2046-2069, 2016, Volume 6, Issue 52, pp. 46037 - 46047
An easy method to achieve a fluorinated graphene oxide-silica nanohybrid (GOSF) is presented. Graphene oxide (GO) was synthesized by Hummer's modified method,... 
NANOPARTICLES | ROUTE | NANOCOMPOSITES | READTHROUGH | PERFORMANCE | STRUCTURAL MODEL | DERIVATIVES | SHEETS | CHEMISTRY, MULTIDISCIPLINARY | COMPOSITE | DEBRIS
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 11/2012, Volume 136, Issue 2, pp. 227 - 266
Nonsense codons, generated from nonsense mutations or frameshifts, contribute significantly to the spectrum of inherited human diseases such as cystic... 
Inducible expression system | Premature termination codon | Nonsense suppression therapy | Aminoglycoside | Non-aminoglycoside | Readthrough | Nonsense codon | EXON JUNCTION COMPLEX | AMINOGLYCOSIDE ANTIBIOTICS | STOP CODON READTHROUGH | MOTOR-NEURON GENE | TRANSLATIONAL TERMINATION EFFICIENCY | EUKARYOTIC PROTEIN-SYNTHESIS | SPINAL MUSCULAR-ATROPHY | INDUCED READ-THROUGH | CYSTIC-FIBROSIS PATIENTS | PHARMACOLOGY & PHARMACY | MESSENGER-RNA DECAY | Muscular Dystrophy, Duchenne - drug therapy | Humans | Gene Expression Regulation | Genetic Diseases, Inborn - genetics | Codon, Nonsense - drug effects | RNA, Messenger - analysis | Rett Syndrome - drug therapy | Animals | Cystic Fibrosis - genetics | Hemophilia A - genetics | Muscular Dystrophy, Duchenne - genetics | Hemophilia A - drug therapy | Rett Syndrome - genetics | Cystic Fibrosis - drug therapy | Genetic Diseases, Inborn - drug therapy | Aminoglycosides - therapeutic use | Inositol | Luciferase | Cystic fibrosis | Biosynthesis | Gene expression | Prothrombin complex concentrate | Carnitine | Blood coagulation factor VIII | Codon | Hemophilia | Physiological aspects | Genetic aspects | Pharmaceutical industry | Enzyme-linked immunosorbent assay | Protein binding | Nonsense mutation | Duchenne's muscular dystrophy | Amino acids | spinal muscular atrophy | Gene therapy | Epidemiology | Cancer | Hereditary diseases | Pharmaceuticals
Journal Article