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Genes and Development, ISSN 0890-9369, 10/2008, Volume 22, Issue 20, pp. 2767 - 2772
A key cellular response to DNA double-strand breaks ( DSBs) is 5 '-to-3 ' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle... 
DNA damage checkpoint | Exonuclease 1 | DNA resection | DNA repair | RecQ helicases | ATR | RECOMBINATION | RPA | PROTEIN | DEVELOPMENTAL BIOLOGY | DAMAGE CHECKPOINT ACTIVATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | EXONUCLEASE-1 | REPAIR | REPLICATION FORKS | GENETICS & HEREDITY | END RESECTION | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | Bloom Syndrome - metabolism | RecQ Helicases - genetics | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Transfection | Recombination, Genetic | Bone Neoplasms - genetics | Tumor Cells, Cultured | DNA Helicases - genetics | Osteosarcoma - metabolism | DNA Repair - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | DNA Helicases - metabolism | Plasmids | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Helicases - antagonists & inhibitors | Osteosarcoma - genetics | Microscopy, Fluorescence | Osteosarcoma - pathology | Saccharomyces cerevisiae - growth & development | Nucleases | DNA damage | Analysis | Chemical properties | Research | Helicases | Mutation (Biology) | Research Communication
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1525 - 1530
Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was used to identify molecules that... 
Molecules | Cell growth | DNA | DNA damage | Cell nucleus | Cell lines | HeLa cells | Werner syndrome | DNA repair | Apoptosis | Human disease | Genomic instability | POLY(ADP-RIBOSE) POLYMERASE | CELLS | FORK | RECQ HELICASES | human disease | TELOMESTATIN | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | SUBSTRATE-SPECIFICITY | IN-VITRO | REPAIR | DISSOCIATION | genomic instability | Apoptosis - drug effects | DNA Replication - drug effects | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Maleimides - pharmacology | Exodeoxyribonucleases - antagonists & inhibitors | Immunoblotting | RecQ Helicases - genetics | Dose-Response Relationship, Drug | Topoisomerase I Inhibitors - pharmacology | Time Factors | Enzyme Inhibitors - chemistry | Molecular Structure | Stress, Physiological - drug effects | Exodeoxyribonucleases - genetics | DNA Damage - drug effects | Cell Line | Cell Survival - drug effects | Topotecan - pharmacology | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Drug Synergism | Adenosine Triphosphatases - antagonists & inhibitors | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Oxazoles - pharmacology | S Phase - drug effects | HeLa Cells | Histones - metabolism | Maleimides - chemistry | Proliferating Cell Nuclear Antigen - metabolism | DNA replication | Research | Helicases | Biological Sciences
Journal Article
Leukemia, ISSN 0887-6924, 10/2017, Volume 31, Issue 10, pp. 2104 - 2113
Multiple myeloma (MM) is a plasma cell cancer with poor survival, characterized by the expansion of multiple myeloma cells (MMCs) in the bone marrow. Using a... 
MOLECULAR CLASSIFICATION | PROGNOSTIC-FACTOR | THERAPY | ONCOLOGY | DNA-DAMAGE | SQUAMOUS-CELL CARCINOMA | GENE-EXPRESSION | BORTEZOMIB | PARP INHIBITORS | HEMATOLOGY | CANCER | PLASMA-CELLS | RNA, Small Interfering - genetics | DNA Replication - drug effects | DNA, Neoplasm - metabolism | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | RecQ Helicases - genetics | Bortezomib - pharmacology | Molecular Targeted Therapy | DNA Breaks, Double-Stranded | Plasma Cells - drug effects | Plasma Cells - enzymology | Multiple Myeloma - drug therapy | RNA Interference | Melphalan - pharmacology | Tumor Cells, Cultured | Multiple Myeloma - enzymology | Neoplasm Proteins - genetics | RecQ Helicases - physiology | DNA-Cytosine Methylases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Enzyme Induction | Poly (ADP-Ribose) Polymerase-1 - metabolism | Enzyme Inhibitors - therapeutic use | Multiple Myeloma - pathology | RecQ Helicases - antagonists & inhibitors | MicroRNAs - genetics | DNA Damage | DNA, Neoplasm - genetics | Cell Cycle - drug effects | DNA Methylation - drug effects | Drug Resistance, Neoplasm - physiology | Neoplastic Stem Cells - enzymology | Multiple Myeloma - genetics | Care and treatment | Multiple myeloma | Development and progression | Genetic aspects | Drug resistance | Helicases | Health aspects | Deregulation | Phosphorylation | Prognosis | Toxicity | Genes | DNA damage | Poly(ADP-ribose) | Cytotoxicity | Genomes | ADP | DNA helicase | Ribose | Melphalan | Bone marrow | Ataxia | Damage | Deoxyribonucleic acid--DNA | Bortezomib | Cell survival | Poly(ADP-ribose) polymerase | Unwinding | Patients | Survival | RecQ protein | Polymerase | Poly(ADP-ribose) Polymerase 1 | Depletion | DNA microarrays | Inhibitors | Medical prognosis | Plasma cells | Ataxia telangiectasia | Ataxia telangiectasia mutated protein | Metal matrix composites | Apoptosis | Cancer | Life Sciences | Genetics | Original
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 01/2018, Volume 413, pp. 1 - 10
Human RecQ helicases that share homology with RecQ helicase play critical roles in diverse biological activities such as DNA replication, transcription,... 
Premature aging syndromes | Aneuploidy | DNA replication | RecQ helicases | Mitotic checkpoint | Cancer | OXIDATIVE STRESS | MCM PROTEINS | SYNDROME GENE-PRODUCT | DNA-DAMAGE | RAPADILINO SYNDROME | P53 | REPAIR | ONCOLOGY | ROTHMUND-THOMSON-SYNDROME | EXPRESSION | BALLER-GEROLD-SYNDROME | Limb Deformities, Congenital - enzymology | Genomic Instability | Limb Deformities, Congenital - genetics | Cell Proliferation | RecQ Helicases - metabolism | Humans | Rothmund-Thomson Syndrome - enzymology | Craniosynostoses - enzymology | RecQ Helicases - genetics | Antineoplastic Agents - therapeutic use | DNA, Mitochondrial - genetics | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Patella - abnormalities | Biomarkers, Tumor - metabolism | Heart Septal Defects, Atrial - genetics | Anal Canal - enzymology | Patella - enzymology | Biomarkers, Tumor - antagonists & inhibitors | Heart Septal Defects, Atrial - enzymology | Genetic Predisposition to Disease | DNA, Mitochondrial - metabolism | Craniosynostoses - genetics | Neoplasms - enzymology | DNA Replication | Radius - abnormalities | Cell Transformation, Neoplastic - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Anal Canal - abnormalities | Rothmund-Thomson Syndrome - genetics | Dwarfism - genetics | Phenotype | Radius - enzymology | RecQ Helicases - antagonists & inhibitors | DNA Repair | Dwarfism - enzymology | Biomarkers, Tumor - genetics | Mutation | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Medical research | Genomics | Cancer cells | Medicine, Experimental | Genetic aspects | Disease susceptibility | Genetic transcription | Recombination | Transcription | DNA damage | Homology | Rothmund-Thomson syndrome | Inactivation | Carcinogenesis | DNA helicase | Proteins | Carcinogens | Aging | Deoxyribonucleic acid--DNA | Stability | Deactivation | Gene expression | Patients | RecQ protein | Cells | DNA biosynthesis | Bone cancer | Bloom's syndrome | Werner's syndrome | Lymphomas | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/2010, Volume 29, Issue 18, pp. 3140 - 3155
Journal Article
Cancer Research, ISSN 0008-5472, 09/2013, Volume 73, Issue 17, pp. 5497 - 5507
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2007, Volume 104, Issue 47, pp. 18836 - 18841
RecQ helicases are involved in the processing of DNA structures arising during replication, recombination, and repair throughout all kingdoms of life.... 
Yeasts | Phenotypes | Mutagens | DNA | Homologous recombination | Plants | Eukaryotic cells | Genetic mutation | Crossovers | Seedlings | Holliday junction | Blooms syndrome | Topoisomerase | Crossover suppression | Mus81 | TOPOISOMERASE-III-ALPHA | STRAND BREAK REPAIR | BLOOMS-SYNDROME HELICASE | MULTIDISCIPLINARY SCIENCES | WERNERS-SYNDROME GENES | GENOME STABILITY | crossover suppression | SACCHAROMYCES-CEREVISIAE | SGS1 | topoisomerase | DROSOPHILA BLM | Holliday Junction | SCHIZOSACCHAROMYCES-POMBE | TOXIC RECOMBINATION | Endonucleases - genetics | Arabidopsis - growth & development | RecQ Helicases - metabolism | RecQ Helicases - genetics | DNA Repair - genetics | Endonucleases - metabolism | Arabidopsis Proteins - metabolism | Cisplatin - toxicity | Base Sequence | Sensitivity and Specificity | Gene Expression Regulation, Plant | Recombination, Genetic - genetics | DNA, Plant - genetics | Bleomycin - toxicity | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | DNA Topoisomerases, Type I - metabolism | DNA Topoisomerases, Type I - genetics | Mutation - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Gene Expression Regulation, Enzymologic | Phenotype | DNA, Bacterial - genetics | RecQ Helicases - antagonists & inhibitors | Complications and side effects | Gene mutations | Genetic aspects | Research | Werner syndrome | Helicases | Risk factors | Biological Sciences
Journal Article