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1. Full Text G-quadruplexes and helicases
by Mendoza, Oscar and Bourdoncle, Anne and Boulé, Jean-Baptiste and Brosh, Robert M and Mergny, Jean-Louis
Nucleic Acids Research, ISSN 0305-1048, 02/2016, Volume 44, Issue 5, pp. 1989 - 2006
Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological... 
RECQ FAMILY HELICASES | HYBRID G-QUADRUPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE PIF1 | SINGLE-STRANDED-DNA | BLOOM-SYNDROME PROTEIN | MITOCHONDRIAL-DNA | WARSAW BREAKAGE SYNDROME | SUBSTRATE-SPECIFIC INHIBITION | RNA G-QUADRUPLEX | IRON-SULFUR CLUSTERS | DNA Helicases - chemistry | Gene Expression | Basic-Leucine Zipper Transcription Factors - metabolism | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Fanconi Anemia Complementation Group Proteins - genetics | DNA Replication | RecQ Helicases - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Fanconi Anemia Complementation Group Proteins - chemistry | DNA, Single-Stranded - chemistry | DNA, Single-Stranded - genetics | DNA Helicases - metabolism | Guanine - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Basic-Leucine Zipper Transcription Factors - chemistry | Exodeoxyribonucleases - metabolism | G-Quadruplexes | Guanine - chemistry | RecQ Helicases - chemistry | Exodeoxyribonucleases - chemistry | Exodeoxyribonucleases - genetics | DNA Helicases - genetics | Life Sciences | Biochemistry, Molecular Biology | Survey and Summary
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2. Full Text DNA helicases Sgs1 and BLM promote DNA double-strand break resection
by Gravel, Serge and Chapman, J. Ross and Magill, Christine and Jackson, Stephen P
Genes and Development, ISSN 0890-9369, 10/2008, Volume 22, Issue 20, pp. 2767 - 2772
A key cellular response to DNA double-strand breaks ( DSBs) is 5 '-to-3 ' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle... 
DNA damage checkpoint | Exonuclease 1 | DNA resection | DNA repair | RecQ helicases | ATR | DAMAGE CHECKPOINT | RPA | ACTIVATION | COMPLEX | PROTEIN | MRE11 | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | EXONUCLEASE-1 | REPAIR | REPLICATION FORKS | GENETICS & HEREDITY | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | Bloom Syndrome - metabolism | RecQ Helicases - genetics | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Transfection | Recombination, Genetic | Bone Neoplasms - genetics | Tumor Cells, Cultured | DNA Helicases - genetics | Osteosarcoma - metabolism | DNA Repair - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | DNA Helicases - metabolism | Plasmids | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Helicases - antagonists & inhibitors | Osteosarcoma - genetics | Microscopy, Fluorescence | Osteosarcoma - pathology | Saccharomyces cerevisiae - growth & development | Nucleases | DNA damage | Analysis | Chemical properties | Research | Helicases | Mutation (Biology) | Research Communication
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3. Full Text Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends
by Zhu, Zhu and Chung, Woo-Hyun and Shim, Eun Yong and Lee, Sang Eun and Ira, Grzegorz
Cell, ISSN 0092-8674, 2008, Volume 134, Issue 6, pp. 981 - 994
Formation of single-strand DNA (ssDNA) tails at a double-strand break (DSB) is a key step in homologous recombination and DNA-damage signaling. The enzyme(s)... 
DNA | GENOME INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | ESSENTIAL IN-VIVO | STALLED REPLICATION FORKS | HOMOLOGOUS RECOMBINATION | CHECKPOINT ACTIVATION | SACCHAROMYCES-CEREVISIAE | TOPOISOMERASE-III | MITOTIC RECOMBINATION | ENDONUCLEASE ACTIVITY | CELL BIOLOGY | Protein Structure, Tertiary | RecQ Helicases - metabolism | Adenosine Triphosphatases - metabolism | RecQ Helicases - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA Breaks, Double-Stranded | Gene Conversion | Saccharomyces cerevisiae - metabolism | DNA Helicases - metabolism | Animals | DNA Repair | Endodeoxyribonucleases - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Helicases - genetics | Nucleases | DNA binding proteins
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4. Full Text BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
by Nimonkar, Amitabh V and Genschel, Jochen and Kinoshita, Eri and Polaczek, Piotr and Campbell, Judith L and Wyman, Claire and Modrich, Paul and Kowalczykowski, Stephen C
Genes and Development, ISSN 0890-9369, 02/2011, Volume 25, Issue 4, pp. 350 - 362
Repair of dsDNA breaks requires processing to produce 3'-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins:... 
BLM helicase | DNA2 nuclease | DNA break repair | EXO1 nuclease | DNA end resection | Homologous recombination | NUCLEASE ACTIVITY | PROTEIN | HUMAN EXONUCLEASE 1 | MISMATCH REPAIR | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | XENOPUS DNA2 | homologous recombination | SGS1 | GENETICS & HEREDITY | BLOOM-SYNDROME | 5' STRAND RESECTION | MRE11 NUCLEASE | RecQ Helicases - metabolism | Humans | DNA Repair Enzymes - genetics | Replication Protein A - physiology | Multiprotein Complexes - genetics | RecQ Helicases - genetics | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RecQ Helicases - physiology | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Multiprotein Complexes - physiology | DNA Helicases - metabolism | Models, Biological | Exodeoxyribonucleases - metabolism | Exodeoxyribonucleases - physiology | Nuclear Proteins - physiology | In Vitro Techniques | Cell Cycle Proteins - physiology | DNA Helicases - physiology | Protein Binding - physiology | Research Paper
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5. Full Text DNA2 drives processing and restart of reversed replication forks in human cells
by Thangavel, Saravanabhavan and Berti, Matteo and Levikova, Maryna and Pinto, Cosimo and Gomathinayagam, Shivasankari and Vujanovic, Marko and Zellweger, Ralph and Moore, Hayley and Lee, Eu Han and Hendrickson, Eric A and Cejka, Petr and Stewart, Sheila and Lopes, Massimo and Vindigni, Alessandro
Journal of Cell Biology, ISSN 0021-9525, 2015, Volume 208, Issue 5, pp. 545 - 562
Accurate processing of stalled or damaged DNA replication forks is paramount to genomic integrity and recent work points to replication fork reversal and... 
NUCLEASE ACTIVITY | END-RESECTION | STRAND BREAK REPAIR | XENOPUS DNA2 | HELICASE ACTIVITY | HUMAN RECQ1 | INDEPENDENT ROLE | HOMOLOGOUS RECOMBINATION | GENOME STABILITY | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Rad51 Recombinase - metabolism | Cell Line | Rad51 Recombinase - genetics | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | DNA Repair Enzymes - genetics | Nuclear Proteins - metabolism | RecQ Helicases - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Carrier Proteins - genetics | DNA Helicases - metabolism | MRE11 Homologue Protein | Carrier Proteins - metabolism | DNA Replication - physiology | DNA Repair Enzymes - metabolism | Exodeoxyribonucleases - metabolism | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | Cell interaction | Identification and classification | DNA replication
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6. Full Text The RecQ DNA helicases in DNA repair
by Bernstein, Kara A and Gangloff, Serge and Rothstein, Rodney
Annual Review of Genetics, ISSN 0066-4197, 12/2010, Volume 44, Issue 1, pp. 393 - 417
The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with... 
Bloom syndrome | Rothmund-Thomson syndrome | RecQ,Werner syndrome | homologous recombination | DNA repair | TOPOISOMERASE-III-ALPHA | SYNDROME GENE-PRODUCT | BLOOMS-SYNDROME HELICASE | REPLICATION PROTEIN-A | HOLLIDAY JUNCTION DISSOLVASOME | RecQ | WERNERS-SYNDROME PROTEIN | FAITHFUL CHROMOSOME SEGREGATION | MEIOTIC CROSSING-OVER | ESCHERICHIA-COLI RECQ | GENETICS & HEREDITY | ROTHMUND-THOMSON-SYNDROME | Werner syndrome | Genomic Instability | Disease - genetics | RecQ Helicases - metabolism | DNA Repair | Humans | Bacteria - enzymology | RecQ Helicases - genetics | RecQ Helicases - chemistry | DNA replication | Analysis | Chemical properties | Research | Structure | Helicases | Aging | Rothmund-Thomson Syndrome | Werner Syndrome | Bloom Syndrome | Homologous Recombination
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7. Superfamily 2 helicases
by Byrd, Alicia K and Raney, Kevin D
Frontiers in Bioscience, ISSN 1093-9946, 06/2012, Volume 17, Issue 6, pp. 2070 - 2088
Superfamily 2 helicases are involved in all aspects of RNA metabolism, and many steps in DNA metabolism. This review focuses on the basic mechanistic,... 
Helicase | Superfamily 2 | DExH | DEAH | DEAD-box | Review H4R molecular pharmacology | CHROMATIN REMODELING COMPLEXES | VIRUS NS3 HELICASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPAIR COUPLING FACTOR | ESCHERICHIA-COLI | Review | SINGLE-STRANDED-DNA | I RESTRICTION ENDONUCLEASES | CELL BIOLOGY | DEXH/D RNA HELICASES | STALLED REPLICATION FORKS | DEAD-BOX PROTEINS
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8. Full Text DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2
by Cejka, Petr and Cannavo, Elda and Polaczek, Piotr and Masuda-Sasa, Taro and Pokharel, Subhash and Campbell, Judith L and Kowalczykowski, Stephen C
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7311, pp. 112 - 116
The repair of DNA double-strand breaks (DSBs) by homologous recombination requires processing of broken ends. For repair to start, the DSB must first be... 
YEAST | SGS1 | MULTIDISCIPLINARY SCIENCES | IN-VIVO | REPLICATION-PROTEIN-A | DOUBLE-STRAND BREAKS | RECBCD ENZYME | BLM HELICASE | MRE11 NUCLEASE | RECOMBINATIONAL REPAIR | RECQ HELICASE | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | DNA Helicases - metabolism | RecQ Helicases - metabolism | DNA Repair | Endodeoxyribonucleases - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Replication Protein A - metabolism | Deoxyribonucleases - metabolism | Genetic aspects | Saccharomyces | Research | DNA repair | Proteins | E coli | Deoxyribonucleic acid--DNA | DNA helicase | recombination | Sgs1 | Rmi1 | Top3 | topoisomerase | Dna2 | replication protein-A | double-strand break resection
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9. Full Text DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells
by Sturzenegger, Andreas and Burdova, Kamila and Kanagaraj, Radhakrishnan and Levikova, Maryna and Pinto, Cosimo and Cejka, Petr and Janscak, Pavel
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 39, pp. 27314 - 27326
The 5'-3' resection of DNA ends is a prerequisite for the repair of DNA double strand breaks by homologous recombination, microhomology-mediated end joining,... 
REPAIR | COMPLEX | MECHANISM | SGS1 | EXO1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MRE11-RAD50-XRS2 | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | PROMOTES | WERNER-SYNDROME PROTEIN | Ubiquitin-Activating Enzymes - genetics | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | DNA Repair Enzymes - genetics | Multienzyme Complexes - metabolism | RecQ Helicases - genetics | Multienzyme Complexes - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | Ubiquitin-Activating Enzymes - metabolism | DNA Breaks, Double-Stranded | DNA - genetics | DNA-Binding Proteins - metabolism | DNA Helicases - metabolism | MRE11 Homologue Protein | Epistasis, Genetic - physiology | DNA Repair Enzymes - metabolism | Exodeoxyribonucleases - metabolism | HEK293 Cells | Exodeoxyribonucleases - genetics | DNA Helicases - genetics | Genomic Instability | DNA and Chromosomes | DNA Repair | RecQ | DNA Damage | DNA Recombination | DNA Helicase
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10. Full Text Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
by Monika Aggarwal and Joshua A. Sommers and Robert H. Shoemaker and Robert M. Brosh and Richard D. Kolodner
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1525 - 1530
Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was used to identify molecules that... 
Molecules | Cell growth | DNA | DNA damage | Cell nucleus | Cell lines | HeLa cells | Werner syndrome | DNA repair | Apoptosis | Human disease | Genomic instability | POLY(ADP-RIBOSE) POLYMERASE | CELLS | FORK | RECQ HELICASES | human disease | TELOMESTATIN | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | SUBSTRATE-SPECIFICITY | IN-VITRO | REPAIR | DISSOCIATION | genomic instability | Apoptosis - drug effects | DNA Replication - drug effects | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Maleimides - pharmacology | Exodeoxyribonucleases - antagonists & inhibitors | Immunoblotting | RecQ Helicases - genetics | Dose-Response Relationship, Drug | Topoisomerase I Inhibitors - pharmacology | Time Factors | Enzyme Inhibitors - chemistry | Molecular Structure | Stress, Physiological - drug effects | Exodeoxyribonucleases - genetics | DNA Damage - drug effects | Cell Line | Cell Survival - drug effects | Topotecan - pharmacology | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Drug Synergism | Adenosine Triphosphatases - antagonists & inhibitors | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Oxazoles - pharmacology | S Phase - drug effects | HeLa Cells | Histones - metabolism | Maleimides - chemistry | Proliferating Cell Nuclear Antigen - metabolism | DNA replication | Research | Helicases | Biological Sciences
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11. Full Text Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1
by Pedrazzi, Graziella and Perrera, Claudia and Blaser, Heiko and Kuster, Patrick and Marra, Giancarlo and Davies, Sally L and Ryu, Gi-Hyuck and Freire, Raimundo and Hickson, Ian D and Jiricny, Josef and Stagljar, Igor
Nucleic Acids Research, ISSN 0305-1048, 11/2001, Volume 29, Issue 21, pp. 4378 - 4386
Bloom's syndrome (BS) is a rare genetic disorder characterised by genomic instability and cancer susceptibility. BLM, the gene mutated in BS, encodes a member... 
YEAST | REPLICATION | SGS1 | CLONING | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECQ | DNA HELICASE | WERNERS-SYNDROME GENES | SACCHAROMYCES-CEREVISIAE | HOLLIDAY JUNCTIONS | MutL Protein Homolog 1 | Blotting, Far-Western | Saccharomyces cerevisiae - genetics | Humans | Base Pair Mismatch | Neoplasm Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | RecQ Helicases | Recombination, Genetic | Conserved Sequence | Bloom Syndrome | Neoplasm Proteins - genetics | DNA Helicases - genetics | Carrier Proteins | Protein Structure, Tertiary | Cell Line | DNA Helicases - chemistry | Adenosine Triphosphatases - metabolism | Neoplasm Proteins - chemistry | Nuclear Proteins - metabolism | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | Precipitin Tests | Protein Interaction Mapping | Protein Transport | DNA Helicases - metabolism | Two-Hybrid System Techniques | Adaptor Proteins, Signal Transducing | DNA Repair | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Fungal Proteins - metabolism
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12. Full Text RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability
by Chang, EYC and Novoa, CA and Aristizabal, MJ and Coulombe, Y and Segovia, R and Chaturvedi, R and Shen, YQ and Keong, C and Tam, AS and Jones, SJM and Masson, JY and Kobor, MS and Stirling, PC
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 12/2017, Volume 216, Issue 12, pp. 3991 - 4005
Sgs1, the orthologue of human Bloom's syndrome helicase BLM, is a yeast DNA helicase functioning in DNA replication and repair. We show that SGS1 loss... 
YEAST SGS1 | RNASE-H | BLOOM-SYNDROME CELLS | REPAIR | TRANSCRIPTION-REPLICATION CONFLICTS | DNA-DAMAGE | PAUSE SITES | SACCHAROMYCES-CEREVISIAE | FANCONI-ANEMIA | RNA/DNA HYBRIDS | CELL BIOLOGY | Genomic Instability | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | Bloom Syndrome - metabolism | RecQ Helicases - genetics | Saccharomyces cerevisiae - ultrastructure | RNA - genetics | Saccharomyces cerevisiae - metabolism | Nucleic Acid Conformation | Fibroblasts - metabolism | RNA - metabolism | Bloom Syndrome - pathology | Gene Expression Regulation | DNA Replication | Gene Dosage | Bloom Syndrome - genetics | DNA - metabolism | Saccharomyces cerevisiae Proteins - genetics | Fibroblasts - pathology | DNA - genetics | DNA - chemistry | Histones - genetics | DNA Repair | Saccharomyces cerevisiae Proteins - metabolism | Cell Line, Tumor | Protein Binding | Histones - metabolism | Cell Line, Transformed
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13. Full Text BLM Helicase Ortholog Sgs1 Is a Central Regulator of Meiotic Recombination Intermediate Metabolism
by De Muyt, Arnaud and Jessop, Lea and Kolar, Elizabeth and Sourirajan, Anuradha and Chen, Jianhong and Dayani, Yaron and Lichten, Michael
Molecular Cell, ISSN 1097-2765, 04/2012, Volume 46, Issue 1, pp. 43 - 53
The BLM helicase has been shown to maintain genome stability by preventing accumulation of aberrant recombination intermediates. We show here that the BLM... 
JOINT MOLECULES | DOUBLE HOLLIDAY JUNCTIONS | BLOOMS-SYNDROME HELICASE | BUDDING YEAST | MUS81/MMS4 ENDONUCLEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSSING-OVER | HOMOLOGOUS RECOMBINATION | SACCHAROMYCES-CEREVISIAE | DOUBLE-STRAND-BREAK | RECQ HELICASE | CELL BIOLOGY | Crossing Over, Genetic - physiology | Endonucleases - genetics | DNA, Fungal - genetics | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | DNA, Cruciform - metabolism | RecQ Helicases - genetics | Endonucleases - metabolism | Meiotic Prophase I - physiology | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | Flap Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Endodeoxyribonucleases - genetics | Holliday Junction Resolvases - genetics | DNA, Fungal - metabolism | Endodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Mutation | DNA, Cruciform - genetics | Flap Endonucleases - genetics | Holliday Junction Resolvases - metabolism | Nucleases | Oncology, Experimental | Physiological aspects | DNA binding proteins | Research | Cells | Cancer | DNA helicase | Recombination | Cell cycle | Prophase | Genomes | Meiosis | Recombinants | Nuclease | Metabolism | Holliday junctions
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14. Full Text Active and passive mechanisms of helicases
by Manosas, Maria and Xi, Xu Guang and Bensimon, David and Croquette, Vincent
Nucleic Acids Research, ISSN 0305-1048, 04/2010, Volume 38, Issue 16, pp. 5518 - 5526
In this work, we discuss the active or passive character of helicases. In the past years, several studies have used the theoretical framework proposed by... 
E. COLI UVRD | BACTERIOPHAGE T7 | NS3 HELICASE | HEPATITIS-C VIRUS | MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | UNWINDING MECHANISM | REPLICATION FORK | POLYMERASE | MONOMER | SINGLE-STRANDED-DNA | DNA Helicases - metabolism | DNA - chemistry | Biocatalysis | Models, Biological | RecQ Helicases - metabolism | DNA - metabolism | Viral Proteins - metabolism | Nucleic Acid Enzymes
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