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Nucleic Acids Research, ISSN 0305-1048, 02/2016, Volume 44, Issue 5, pp. 1989 - 2006
Journal Article
Genes and Development, ISSN 0890-9369, 10/2008, Volume 22, Issue 20, pp. 2767 - 2772
A key cellular response to DNA double-strand breaks ( DSBs) is 5 '-to-3 ' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle... 
DNA damage checkpoint | Exonuclease 1 | DNA resection | DNA repair | RecQ helicases | ATR | DAMAGE CHECKPOINT | RPA | ACTIVATION | COMPLEX | PROTEIN | MRE11 | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | EXONUCLEASE-1 | REPAIR | REPLICATION FORKS | GENETICS & HEREDITY | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | Humans | Bloom Syndrome - metabolism | RecQ Helicases - genetics | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Transfection | Recombination, Genetic | Bone Neoplasms - genetics | Tumor Cells, Cultured | DNA Helicases - genetics | Osteosarcoma - metabolism | DNA Repair - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | DNA Helicases - metabolism | Plasmids | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Helicases - antagonists & inhibitors | Osteosarcoma - genetics | Microscopy, Fluorescence | Osteosarcoma - pathology | Saccharomyces cerevisiae - growth & development | Nucleases | DNA damage | Analysis | Chemical properties | Research | Helicases | Mutation (Biology) | Research Communication
Journal Article
Genes and Development, ISSN 0890-9369, 02/2011, Volume 25, Issue 4, pp. 350 - 362
Repair of dsDNA breaks requires processing to produce 3'-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins:... 
BLM helicase | DNA2 nuclease | DNA break repair | EXO1 nuclease | DNA end resection | Homologous recombination | NUCLEASE ACTIVITY | PROTEIN | HUMAN EXONUCLEASE 1 | MISMATCH REPAIR | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | XENOPUS DNA2 | homologous recombination | SGS1 | GENETICS & HEREDITY | BLOOM-SYNDROME | 5' STRAND RESECTION | MRE11 NUCLEASE | RecQ Helicases - metabolism | Humans | DNA Repair Enzymes - genetics | Replication Protein A - physiology | Multiprotein Complexes - genetics | RecQ Helicases - genetics | DNA Repair - genetics | DNA Breaks, Double-Stranded | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | Replication Protein A - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | DNA Helicases - genetics | RecQ Helicases - physiology | DNA Repair Enzymes - physiology | DNA-Binding Proteins - physiology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | DNA-Binding Proteins - genetics | Multiprotein Complexes - physiology | DNA Helicases - metabolism | Models, Biological | Exodeoxyribonucleases - metabolism | Exodeoxyribonucleases - physiology | Nuclear Proteins - physiology | In Vitro Techniques | Cell Cycle Proteins - physiology | DNA Helicases - physiology | Protein Binding - physiology | Research Paper
Journal Article
Journal Article
Frontiers in Bioscience, ISSN 1093-9946, 06/2012, Volume 17, Issue 6, pp. 2070 - 2088
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1525 - 1530
Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was used to identify molecules that... 
Molecules | Cell growth | DNA | DNA damage | Cell nucleus | Cell lines | HeLa cells | Werner syndrome | DNA repair | Apoptosis | Human disease | Genomic instability | POLY(ADP-RIBOSE) POLYMERASE | CELLS | FORK | RECQ HELICASES | human disease | TELOMESTATIN | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | SUBSTRATE-SPECIFICITY | IN-VITRO | REPAIR | DISSOCIATION | genomic instability | Apoptosis - drug effects | DNA Replication - drug effects | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Maleimides - pharmacology | Exodeoxyribonucleases - antagonists & inhibitors | Immunoblotting | RecQ Helicases - genetics | Dose-Response Relationship, Drug | Topoisomerase I Inhibitors - pharmacology | Time Factors | Enzyme Inhibitors - chemistry | Molecular Structure | Stress, Physiological - drug effects | Exodeoxyribonucleases - genetics | DNA Damage - drug effects | Cell Line | Cell Survival - drug effects | Topotecan - pharmacology | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Drug Synergism | Adenosine Triphosphatases - antagonists & inhibitors | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Oxazoles - pharmacology | S Phase - drug effects | HeLa Cells | Histones - metabolism | Maleimides - chemistry | Proliferating Cell Nuclear Antigen - metabolism | DNA replication | Research | Helicases | Biological Sciences
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2001, Volume 29, Issue 21, pp. 4378 - 4386
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2012, Volume 46, Issue 1, pp. 43 - 53
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 04/2010, Volume 38, Issue 16, pp. 5518 - 5526
Journal Article