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The New England journal of medicine, ISSN 1533-4406, 08/2017, Volume 377, Issue 9, pp. 829 - 838
Alectinib, a potent ALK tyrosine kinase inhibitor, was more effective and somewhat less toxic than crizotinib when used as primary therapy in patients with ALK -positive non... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Central Nervous System Neoplasms - secondary | Young Adult | Pyridines - adverse effects | Anaplastic Lymphoma Kinase | Antineoplastic Agents - adverse effects | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Receptor Protein-Tyrosine Kinases - analysis | Pyrazoles - adverse effects | Pyridines - therapeutic use | Crizotinib | Carbazoles - adverse effects | Kaplan-Meier Estimate | Carcinoma, Non-Small-Cell Lung - mortality | Disease-Free Survival | Animals | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Piperidines - adverse effects | Intention to Treat Analysis | Carbazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Central Nervous System Neoplasms - drug therapy | Drugs | Care and treatment | Analysis | Comparative analysis | Lung cancer, Non-small cell | Health aspects | Systemic diseases | Toxicity | Lung cancer | Central nervous system | Non-small cell lung carcinoma | Oncology | Nervous system | Metastasis | Radiation therapy | Patients | Lymphoma | Cancer therapies | Survival | Mutation | Protein-tyrosine kinase | Drug dosages | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e90344 - e90344
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin signalling pathway... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA, Small Interfering - genetics | Cell Proliferation | Diabetes Mellitus, Experimental - enzymology | Streptozocin | Cell Count | Diabetes Mellitus, Experimental - genetics | Male | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Endoplasmic Reticulum - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Diabetes Mellitus, Experimental - chemically induced | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Insulin Secretion | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Endoplasmic Reticulum - enzymology | Cell Line | Signal Transduction | Gene Expression Regulation | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Glucose - pharmacology | Mice, Knockout | Insulin - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Insulin-Secreting Cells - drug effects | Diabetes Mellitus, Experimental - pathology | Glucose - metabolism | Mice | Insulin-Secreting Cells - pathology | Apoptosis | Insulin-Secreting Cells - enzymology | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Cell proliferation | Pathogenesis | p53 Protein | AKT protein | Kinases | Proteins | Signal transduction | Cell growth | Clonal deletion | Rodents | Animal tissues | Pancreas | Tyrosine | Secretion | Diabetes mellitus | Stat3 protein | Extracellular signal-regulated kinase | Insulin | Ablation | Signaling | Insulin resistance | Endoplasmic reticulum | Protein-tyrosine-phosphatase | Index Medicus | Apoptosi | Rats as laboratory animals | Insulina | Diabetis | Pàncrees | Glucose | Diabetes | Rates (Animals de laboratori) | Glucosa
Journal Article
Journal Article