X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (50451) 50451
Book Review (9058) 9058
Publication (5590) 5590
Book Chapter (358) 358
Book / eBook (139) 139
Conference Proceeding (130) 130
Dissertation (27) 27
Reference (16) 16
Data Set (6) 6
Newspaper Article (6) 6
Newsletter (4) 4
Magazine Article (3) 3
Presentation (2) 2
Paper (1) 1
Streaming Video (1) 1
Trade Publication Article (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (48221) 48221
humans (31284) 31284
animals (31076) 31076
phosphorylation (14853) 14853
mice (14492) 14492
signal transduction (13904) 13904
biochemistry & molecular biology (12100) 12100
cell biology (9988) 9988
protein-tyrosine kinases - metabolism (9934) 9934
male (8383) 8383
female (8048) 8048
receptor protein-tyrosine kinases - metabolism (7275) 7275
rats (7193) 7193
activation (6876) 6876
expression (6771) 6771
oncology (6364) 6364
cell line (6138) 6138
cells, cultured (6121) 6121
proteins (5835) 5835
immunology (5419) 5419
receptor (5008) 5008
molecular sequence data (4995) 4995
tyrosine (4909) 4909
research (4858) 4858
cancer (4438) 4438
kinases (4357) 4357
receptor protein-tyrosine kinases - genetics (4355) 4355
amino acid sequence (4225) 4225
gene expression (4107) 4107
cell line, tumor (4060) 4060
mutation (3953) 3953
cells (3888) 3888
signal transduction - physiology (3832) 3832
tyrosine - metabolism (3724) 3724
tyrosine kinase (3677) 3677
abridged index medicus (3666) 3666
neurosciences (3638) 3638
signal transduction - drug effects (3599) 3599
apoptosis (3589) 3589
article (3547) 3547
signal-transduction (3490) 3490
physiological aspects (3467) 3467
receptors (3464) 3464
multidisciplinary sciences (3435) 3435
proto-oncogene proteins - metabolism (3430) 3430
transfection (3295) 3295
enzyme activation (3261) 3261
protein-tyrosine kinase (3211) 3211
analysis (3193) 3193
protein binding (3169) 3169
tumor cells, cultured (3098) 3098
endocrinology & metabolism (2986) 2986
enzyme inhibitors - pharmacology (2945) 2945
protein (2938) 2938
protein-tyrosine kinases - antagonists & inhibitors (2927) 2927
research article (2730) 2730
ligands (2705) 2705
growth-factor receptor (2668) 2668
blotting, western (2661) 2661
tyrosine phosphorylation (2620) 2620
immunohistochemistry (2594) 2594
adult (2592) 2592
mice, inbred c57bl (2570) 2570
genetic aspects (2537) 2537
middle aged (2487) 2487
receptor, epidermal growth factor - metabolism (2481) 2481
base sequence (2479) 2479
gene-expression (2463) 2463
in-vivo (2437) 2437
protein-tyrosine kinases - genetics (2422) 2422
pharmacology & pharmacy (2381) 2381
protein tyrosine phosphatases - metabolism (2330) 2330
hematology (2281) 2281
mice, knockout (2273) 2273
rna, messenger - metabolism (2222) 2222
medicine (2189) 2189
kinetics (2186) 2186
proto-oncogene proteins - genetics (2166) 2166
biology (2148) 2148
physiology (2143) 2143
gene (2139) 2139
phosphorylation - drug effects (2122) 2122
cell proliferation (2103) 2103
models, biological (2073) 2073
rodents (2071) 2071
binding sites (2043) 2043
phosphoproteins - metabolism (2012) 2012
kinase (1967) 1967
binding (1957) 1957
identification (1943) 1943
genetics & heredity (1939) 1939
time factors (1934) 1934
rats, sprague-dawley (1933) 1933
dose-response relationship, drug (1867) 1867
aged (1864) 1864
biophysics (1844) 1844
in-vitro (1838) 1838
tumors (1838) 1838
health aspects (1826) 1826
phosphatidylinositol 3-kinases - metabolism (1816) 1816
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (95) 95
Collection Dvlpm't (Acquisitions) - Closed Orders (11) 11
Online Resources - Online (7) 7
UofT at Mississauga - Stacks (7) 7
UTL at Downsview - May be requested (6) 6
UofT at Scarborough - Stacks (4) 4
Collection Dvlpm't (Acquisitions) - Vendor file (3) 3
Chemistry (A D Allen) - Stacks (1) 1
Dentistry (Harry R Abbott) - Stacks (1) 1
Engineering & Comp. Sci. - Stacks (1) 1
Providence Healthcare - Reference (1) 1
Providence Healthcare - Stacks (1) 1
St. Michael's Hospital - Stacks (1) 1
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (1) 1
Toronto East General Hospital - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (50226) 50226
Chinese (197) 197
Japanese (143) 143
French (50) 50
Russian (31) 31
German (22) 22
Spanish (20) 20
Polish (13) 13
Hungarian (8) 8
Italian (3) 3
Portuguese (3) 3
Dutch (2) 2
Arabic (1) 1
Bulgarian (1) 1
Czech (1) 1
Danish (1) 1
Hebrew (1) 1
Korean (1) 1
Norwegian (1) 1
Swedish (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7480, pp. 394 - 400
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7471, pp. 333 - 339
Journal Article
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 505 - 509
Mutationally activated kinases define a clinically validated class of targets for cancer drug therapy(1). However, the efficacy of kinase inhibitors in... 
CELL LUNG-CANCER | SURVIVAL | HETEROGENEITY | ACTIVATION | RECEPTOR TYROSINE KINASES | THERAPY | MET AMPLIFICATION | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | SENSITIVITY | TUMOR-CELLS | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Melanoma - enzymology | Phosphatidylinositol 3-Kinases - metabolism | Hepatocyte Growth Factor - pharmacology | Breast Neoplasms - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Ligands | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Antimitotic agents | Physiological aspects | Antineoplastic agents | Growth factors | Health aspects | Phosphotransferases | Substance abuse treatment | Epidermal growth factor | Rodents | Biomarkers | Breast cancer | Insulin-like growth factors | Kinases | Drug resistance | Tumors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 03/2016, Volume 6, Issue 3, pp. 270 - 285
Journal Article