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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 13, pp. 4312 - 4323
A new approach to generating information on ligand receptor interactions within the binding pocket of G protein-coupled receptors has been developed, called... 
Triazoles - chemistry | Models, Molecular | Binding Sites - genetics | Pyrimidines - chemistry | Xanthines - chemistry | Small Molecule Libraries | Drug Design | Receptor, Adenosine A2A - chemistry | Ligands | Receptor, Adenosine A2A - genetics | Triazines - chemistry | Mutation | Adenosine A2 Receptor Antagonists - chemistry | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2013, Volume 110, Issue 36, pp. 14711 - 14716
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2011, Volume 31, Issue 27, pp. 10067 - 10075
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2008, Volume 105, Issue 31, pp. 10744 - 10749
Journal Article
Nature Communications, 06/2016, Volume 7, pp. 11915 - 11915
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2009, Volume 29, Issue 47, pp. 14741 - 14751
Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by accumulation of beta-amyloid peptide (namely Abeta(1-42)) and... 
Memory Disorders - physiopathology | Presynaptic Terminals - pathology | Rats, Wistar | Peptide Fragments - toxicity | Nerve Degeneration - physiopathology | Male | Adenosine A2 Receptor Antagonists | Neuroprotective Agents - pharmacology | Nerve Degeneration - prevention & control | Caffeine - pharmacology | Receptor, Adenosine A2A - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Cell Survival - physiology | Cell Survival - drug effects | Alzheimer Disease - physiopathology | Maze Learning - physiology | Presynaptic Terminals - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Alzheimer Disease - drug therapy | Phosphodiesterase Inhibitors - pharmacology | Rats | Pyrimidines - pharmacology | Receptor, Adenosine A2A - metabolism | Maze Learning - drug effects | Down-Regulation - genetics | Mice, Knockout | Triazoles - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Synaptic Membranes - drug effects | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Memory Disorders - drug therapy | Peptide Fragments - antagonists & inhibitors | Alzheimer Disease - metabolism | Presynaptic Terminals - metabolism | Mice | Synaptic Membranes - metabolism | Nerve Degeneration - drug therapy | Memory Disorders - chemically induced | Index Medicus
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2015, Volume 78, Issue 11, pp. 763 - 774
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2009, Volume 29, Issue 48, pp. 15100 - 15103
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 02/2016, Volume 13, Issue 1, pp. 48 - 48
Background: Conditions of inflammatory tissue distress are associated with high extracellular levels of adenosine, due to increased adenosine triphosphate... 
Experimental autoimmune encephalomyelitis | Adenosine | Multiple sclerosis | IMMUNOLOGY | NEUROSCIENCES | NEURONAL DAMAGE | GENETIC INACTIVATION | IMMUNE-SYSTEM | TRAUMATIC BRAIN-INJURY | MULTIPLE-SCLEROSIS | MARROW-DERIVED CELLS | CENTRAL-NERVOUS-SYSTEM | MYELIN DEBRIS | A(2A) RECEPTOR | T-CELLS | Microglia - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Peptide Fragments - toxicity | Phagocytosis - genetics | Cell Movement - genetics | Cell Movement - immunology | Myelin-Oligodendrocyte Glycoprotein - toxicity | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Time Factors | Adenosine - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Receptor, Adenosine A2A - genetics | Disease Models, Animal | Cell Proliferation - genetics | Phagocytosis - drug effects | Encephalomyelitis, Autoimmune, Experimental - pathology | Cytokines - metabolism | Microglia - drug effects | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Mice, Transgenic | Up-Regulation - genetics | Receptor, Adenosine A2A - metabolism | Up-Regulation - drug effects | Cell Movement - drug effects | Macrophages - metabolism | Animals | Adenosine - analogs & derivatives | Phenethylamines - therapeutic use | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Myelin Proteolipid Protein - toxicity | CD4-Positive T-Lymphocytes - drug effects | Complications and side effects | Patient outcomes | Interferon | Dosage and administration | Inflammation | Research | Muscle proteins | Drug therapy | Adenosine triphosphate | Index Medicus
Journal Article