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Current Topics in Medicinal Chemistry, ISSN 1568-0266, 02/2008, Volume 8, Issue 3, pp. 205 - 230
During the last decade there has been a growing interest towards the modulation of the cannabinoid CB1 receptor. The identification of CB1 cannabinoid receptor... 
CB1 | Antagonist | Endocannabinoid | Rimonabant | Cannabinoid | endocannabinoid | rimonabant | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | cannabinoid | RECEPTOR INVERSE AGONISTS | ENDOCANNABINOID SYSTEM | TRICYCLIC PYRAZOLES | CONSTRAINED ANALOGS | antagonist | MOLECULAR MODELING INVESTIGATIONS | IN-VIVO | BIOLOGICAL EVALUATION | NEUTRAL ANTAGONISM | PHARMACOLOGICAL EVALUATION
Journal Article
Psychopharmacology, ISSN 0033-3158, 3/2008, Volume 196, Issue 4, pp. 565 - 574
Cannabinoid CB1 antagonists/inverse agonists suppress food-motivated behaviors and are being evaluated as potential appetite suppressants. It has been... 
Biomedicine | Dopamine | Motivation | Operant | Reinforcement | Behavior | Reward | Pharmacology/Toxicology | Psychiatry | Instrumental | Behavioral economics | reward | NUCLEUS-ACCUMBENS DOPAMINE | HEDONIC IMPACT | BRAIN REWARD | PSYCHIATRY | motivation | behavioral economics | NEUROSCIENCES | operant | RECEPTOR ANTAGONIST | DORSOMEDIAL SHELL | instrumental | SELF-STIMULATION | REINFORCED BEHAVIOR | FEEDING-BEHAVIOR | PHARMACOLOGY & PHARMACY | WATER-INTAKE | reinforcement | behavior | dopamine | CONSUMMATORY RESPONSES | Food Preferences | Choice Behavior - drug effects | Piperidines - administration & dosage | Salicylamides - administration & dosage | Injections, Intraperitoneal | Rats | Male | Benzazepines - pharmacology | Dopamine Antagonists - administration & dosage | Rats, Sprague-Dawley | Feeding Behavior - drug effects | Reinforcement Schedule | Pyrazoles - administration & dosage | Animals | Receptor, Cannabinoid, CB1 - agonists | Conditioning, Operant - drug effects | Piperidines - pharmacology | Dopamine Antagonists - pharmacology | Benzazepines - administration & dosage | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Salicylamides - pharmacology | Pyrazoles - pharmacology | Proteins | Neurotransmitters | Brain research | Antagonist drugs | Animal behavior | Rodents | Neuropsychology | Addictions | Index Medicus
Journal Article
Journal Article
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 03/2019, Volume 10, pp. 207 - 207
Rimonabant was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was... 
rimonabant | fear conditioning | TM38837 | ENDOCANNABINOID SYSTEM | DISORDERS | CONDITIONED FEAR | STRATEGIES | cannabinoid CB1 receptor | PHARMACOLOGY & PHARMACY | peripheral CB1 receptor antagonist | RECEPTOR-TYPE 1 | AVOIDANCE-BEHAVIOR | EXTINCTION | EXPRESSION | MODULATION
Journal Article
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 11/2009, Volume 297, Issue 5, pp. 1162 - 1170
Journal Article
BEHAVIOURAL PHARMACOLOGY, ISSN 0955-8810, 12/2003, Volume 14, Issue 8, pp. 583 - 588
Cannabinoid CB1 receptor agonists, including delta-9-tetrahydrocannabinol (Delta(9)-THC) (the main psychoactive ingredient in marijuana) have been shown to... 
appetite suppressant | satiety | DELTA-THC | rat | motivation | HUMANS | marijuana | NEUROSCIENCES | THC | operant | RECEPTOR ANTAGONIST | CB1 antagonist | BODY-WEIGHT | DOPAMINE | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | APPETITE | anandamide | SR141716A | AGONIST
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2010, Volume 20, Issue 15, pp. 4573 - 4577
A rational design approach around a new pyrrole core with modulation of the topological polar surface area allowed the identification of the potent, selective... 
CB1 antagonist | Pyrrole | Peripherally-restricted cannabinoid antagonist | CELLS | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | RECEPTOR | FA/FA RATS | RIMONABANT | PREDICTION | INSULIN | STEATOSIS | DYSLIPIDEMIA | EXPRESSION
Journal Article
Journal Article