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Cancer science, ISSN 1347-9032, 2016, Volume 107, Issue 8, pp. 1134 - 1140
Journal Article
Cancer science, ISSN 1347-9032, 2016, Volume 107, Issue 7, pp. 1039 - 1046
...‐8201a is a human epidermal growth factor receptor 2 (HER2)‐targeting antibody–drug conjugate prepared using a novel linker... 
topoisomerase I inhibitor | T‐DM | HER2 | bystander killing | Antibody‐drug conjugate | T-DM | Antibody-drug conjugate | HODGKINS LYMPHOMA | GEMTUZUMAB OZOGAMICIN | ADVANCED BREAST-CANCER | BRENTUXIMAB VEDOTIN | ACUTE MYELOID-LEUKEMIA | TRASTUZUMAB EMTANSINE | CHALLENGES | THERAPY | ONCOLOGY | EXPRESSION | CATHEPSIN-B | Receptor, ErbB-2 - genetics | Breast Neoplasms - immunology | Humans | Ado-Trastuzumab Emtansine | Stomach Neoplasms - pathology | Maytansine - pharmacology | Immunoconjugates - immunology | Breast Neoplasms - enzymology | Immunoconjugates - pharmacology | Topoisomerase I Inhibitors - pharmacology | Neoplasms - genetics | Antibodies, Monoclonal, Humanized - pharmacology | Female | Camptothecin - immunology | Receptor, ErbB-2 - immunology | Camptothecin - analogs & derivatives | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Maytansine - analogs & derivatives | Neoplasms - enzymology | Stomach Neoplasms - immunology | Animals | Breast Neoplasms - genetics | Bystander Effect - drug effects | Breast Neoplasms - pathology | Mice, Nude | Neoplasms - immunology | Cell Membrane Permeability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal, Humanized - immunology | Neoplasms - pathology | Camptothecin - pharmacology | Maytansine - immunology | Trastuzumab | Viral antibodies | Epidermal growth factor | Imaging systems | Antibodies | Permeability | Drug therapy | Biopharmaceutics | Tumors | Antigens | Hematology | Laboratories | Toxicity | DNA topoisomerase | Polymerization | Clinical trials | Cytotoxicity | Breast cancer | ErbB-2 protein | Stomach cancer | Hypotheses | Antitumor agents | Xenografts | Antitumor activity | Lymphomas | Drug dosages | Payloads | Index Medicus | Original
Journal Article
Gene, ISSN 0378-1119, 2006, Volume 366, Issue 1, pp. 2 - 16
The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK... 
Signal transduction | ErbB | EGF | Growth factors | ERBB-FAMILY RECEPTORS | growth factors | signal transduction | EXTRACELLULAR DOMAIN | HUMAN BREAST-CANCER | FACTOR-ALPHA CDNA | CELL LUNG-CANCER | MAMMARY-GLAND DEVELOPMENT | GENETICS & HEREDITY | TYROSINE KINASE INHIBITOR | TGF-ALPHA | GENE COPY NUMBER | TRANSGENIC MICE | Carcinoma - drug therapy | Receptor, Epidermal Growth Factor - genetics | Epidermal Growth Factor - genetics | Humans | Epidermal Growth Factor - metabolism | Protein Structure, Tertiary - genetics | Signal Transduction - genetics | Cell Transformation, Neoplastic - metabolism | Enzyme Inhibitors - therapeutic use | Gene Amplification - drug effects | Receptor, Epidermal Growth Factor - metabolism | Animals | Signal Transduction - drug effects | Cell Transformation, Neoplastic - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma - genetics | Gene Amplification - genetics | Carcinoma - metabolism | Cell Transformation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Dimerization | Gene Expression Regulation, Neoplastic - genetics | Tyrosine | Cell research | Glycosaminoglycans | Development and progression | Anticoagulants (Medicine) | Hormones | Transforming growth factors | Lung cancer, Non-small cell | Phosphatidylinositol | Somatotropin | Keratin | Prolactin | Gliomas | Analysis | Phospholipases | Iron oxides | Health aspects | Protein kinases | Metallothionein | Cancer | Protein binding
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 526, Issue 7572, pp. 263 - 267
.... In late-stage colorectal cancer, the most commonly used targeted therapies are the monoclonal antibodies cetuximab and panitumumab, which prevent epidermal growth factor receptor (EGFR) activation(1... 
PANITUMUMAB | THERAPY | MULTIDISCIPLINARY SCIENCES | SEQUENCE | ACQUIRED-RESISTANCE | SOMATIC MUTATION | IDENTIFICATION | GENE COPY NUMBER | ACTIVATING MUTATIONS | BREAST | INSIGHTS | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-2 - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Genomics | Humans | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Cetuximab - therapeutic use | Molecular Targeted Therapy | Receptor, Fibroblast Growth Factor, Type 1 - genetics | MAP Kinase Kinase 1 - genetics | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Insulin Receptor Substrate Proteins - genetics | Colorectal Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Cetuximab - pharmacology | DNA Copy Number Variations - genetics | Mutation - genetics | Genome, Human - genetics | Receptor, Epidermal Growth Factor - chemistry | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Exome - genetics | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gene mutations | Colorectal cancer | Drug metabolism | Genetic aspects | Identification and classification | Health aspects | Proteins | Epidermal growth factor | Genes | Clinical trials | Mutation | Kinases | Cancer therapies | Tumors
Journal Article
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2009, Volume 101, Issue 19, pp. 1308 - 1324
The monoclonal antibodies panitumumab and cetuximab that target the epidermal growth factor receptor (EGFR... 
CELL LUNG-CANCER | PHASE-III TRIAL | TYROSINE KINASE INHIBITORS | COLON-CANCER | KRAS MUTATIONS | K-RAS MUTATIONS | PROGRESSION-FREE-SURVIVAL | ONCOLOGY | CETUXIMAB PLUS IRINOTECAN | IN-SITU HYBRIDIZATION | GENE COPY NUMBER | PTEN Phosphohydrolase - drug effects | Predictive Value of Tests | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Antibodies, Monoclonal - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | Colorectal Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - drug effects | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Cetuximab | Odds Ratio | PTEN Phosphohydrolase - genetics | Proto-Oncogene Proteins - drug effects | Antibodies, Monoclonal - pharmacology | Proto-Oncogene Proteins - genetics | Randomized Controlled Trials as Topic | Phosphatidylinositol 3-Kinases - genetics | Disease-Free Survival | Proto-Oncogene Proteins p21(ras) - drug effects | Animals | Class I Phosphatidylinositol 3-Kinases | Mutation - drug effects | Proto-Oncogene Proteins B-raf - drug effects | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Colorectal Neoplasms - pathology | Neoplasm Staging | Research Design | Usage | Care and treatment | Prognosis | Gene mutations | Colorectal cancer | Monoclonal antibodies | Development and progression | Genetic aspects | Research | Biological markers | Health aspects | Review
Journal Article
Journal Article