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Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7691, pp. 189 - 194
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 6/2002, Volume 157, Issue 6, pp. 929 - 939
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2011, Volume 20, Issue 4, pp. 472 - 486
Extensive crosstalk among ErbB/HER receptors suggests that blocking signaling from more than one family member may be essential to effectively treat cancer and... 
CELL LUNG-CANCER | TYROSINE KINASE INHIBITORS | GROWTH-FACTOR RECEPTOR | ACTIVATION | GEFITINIB | THERAPY | ERBB3 | ONCOLOGY | ACQUIRED-RESISTANCE | MONOCLONAL-ANTIBODY | METASTATIC COLORECTAL-CANCER | CELL BIOLOGY | Antibody Specificity | Phosphorylation | Humans | Antibodies, Monoclonal - adverse effects | Macaca fascicularis | Antibodies, Monoclonal - therapeutic use | Crystallography, X-Ray | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Receptor, ErbB-3 - chemistry | Antineoplastic Agents - toxicity | MAP Kinase Signaling System | Antibodies, Monoclonal, Humanized | Receptor, ErbB-3 - immunology | Female | Cetuximab | Drug Evaluation, Preclinical | Proto-Oncogene Proteins c-akt - metabolism | Binding, Competitive | Receptor, Epidermal Growth Factor - immunology | Signal Transduction | Immunoglobulin G - chemistry | Immunoglobulin G - therapeutic use | Receptor, ErbB-3 - antagonists & inhibitors | Antineoplastic Agents - chemistry | Receptor, Epidermal Growth Factor - chemistry | Immunoglobulin G - adverse effects | Antibodies, Bispecific - therapeutic use | Animals | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Antibodies, Bispecific - chemistry | Mice | Antibodies, Bispecific - toxicity | Binding Sites, Antibody | Care and treatment | Immunoglobulin G | Comparative analysis | Drug resistance | Saturated fatty acids | Antigenic determinants | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 10/2013, Volume 73, Issue 19, pp. 6024 - 6035
HER2/HER3 dimerization resulting from overexpression of HER2 or neuregulin (NRG1) in cancer leads to HER3-mediated oncogenic activation of phosphoinositide... 
BREAST-CANCER | EXTRACELLULAR REGION | COMPLEX | DOMAIN | ACTIVATION | ERBB3 | ONCOLOGY | AFFINITY | CRYSTAL-STRUCTURE | FACTOR RECEPTOR | TRASTUZUMAB RESISTANCE | Receptor, ErbB-3 - metabolism | Immunoprecipitation | Humans | Protein Conformation - drug effects | Receptor, ErbB-2 - metabolism | Immunoblotting | Receptor, ErbB-3 - chemistry | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Receptor, ErbB-3 - immunology | Antibodies, Monoclonal, Humanized - pharmacology | Female | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Phosphorylation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Receptor, ErbB-3 - antagonists & inhibitors | Survival Rate | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Mice, Nude | Neuregulin-1 - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Breast Neoplasms - mortality | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Multimerization - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | PI-3 kinase | NRG | ligand-independent | Antibody | neuregulin | SCCHN | EGFR | resistance | feedback | HER | PIK3CA | cancer | HER2 | HER3 | ligand-dependent
Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1006 - 1012
Her3 (also known as ErbB3) belongs to the epidermal growth factor receptor tyrosine kinases and is well credentialed as an anti-cancer target but is thought to... 
ADJUVANT CHEMOTHERAPY | LUNG-CANCER | DOMAIN | PROTEIN | MET AMPLIFICATION | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELECTIVE INHIBITORS | EXTENDED 5-SUBSTITUENT | OVARIAN-CANCER | HER2-POSITIVE BREAST-CANCER | Proto-Oncogene Proteins c-met - metabolism | Adenine - chemical synthesis | Receptor, ErbB-2 - genetics | Antineoplastic Agents - chemical synthesis | Humans | Protein Multimerization | Receptor, ErbB-2 - chemistry | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Molecular Targeted Therapy | Receptor, ErbB-3 - chemistry | Proteolysis | Adenosine Triphosphate - metabolism | Antineoplastic Agents - pharmacology | Acrylamides - pharmacology | Protein Kinase Inhibitors - chemical synthesis | Catalytic Domain | Adenine - analogs & derivatives | Signal Transduction | Receptor, ErbB-3 - antagonists & inhibitors | Adenine - pharmacology | Cysteine - chemistry | Receptor, ErbB-3 - genetics | Proto-Oncogene Proteins c-met - genetics | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Cell Proliferation - drug effects | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Adamantane - chemistry | Proto-Oncogene Proteins c-met - chemistry | Adenosine Triphosphate - chemistry | Acrylamides - chemical synthesis | Signal transduction | Cell growth | Phosphorylation | Pharmacology | Epidermal growth factor | Kinases
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 31, pp. 12772 - 12782
The iron-regulated metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1) has been shown to inhibit numerous oncogenic signaling pathways in cancer... 
ANTIPROLIFERATIVE ACTIVITY | TGF-BETA | epidermal growth factor receptor (EGFR) | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | TYROSINE KINASES | NDRG1 | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | cancer therapy | TUMOR-CELL MIGRATION | metastasis | cell signaling | PROSTATE-CANCER | GENE-1 NDRG1 | iron | SELECTIVE ANTITUMOR-ACTIVITY | Receptor, ErbB-3 - metabolism | Humans | Protein Multimerization | Receptor, ErbB-2 - chemistry | Receptor, ErbB-2 - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Receptor, ErbB-3 - chemistry | Receptors, Transferrin - agonists | Carcinogenesis | Antigens, CD - metabolism | Cell Cycle Proteins - chemistry | Endocytosis | Receptor, Epidermal Growth Factor - metabolism | Clathrin-Coated Vesicles | Proteolysis | Receptor, ErbB-2 - antagonists & inhibitors | Signal Transduction | Cell Cycle Proteins - metabolism | Receptor, ErbB-3 - antagonists & inhibitors | Receptor, ErbB-3 - agonists | Iron - metabolism | Receptors, Transferrin - metabolism | Receptor, Epidermal Growth Factor - chemistry | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Models, Biological | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Ligands | Endosomes - enzymology | Receptor, ErbB-2 - agonists | Transferrin - metabolism | Index Medicus | Minireviews
Journal Article