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Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | ErbB Receptors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | ErbB Receptors - chemistry | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | kinase inhibitor | structure-based drug design | cancer drug resistance | PNAS Plus | drug discovery
Journal Article
Oncogene, ISSN 1476-5594, 08/2012, Volume 32, Issue 25, pp. 3059 - 3070
Fibroblast growth factor receptors (FGFRs) can act as driving oncoproteins in certain cancers, making them attractive drug targets... 
tyrosine kinase inhibitors | ERK1/2 | FGFR | PKB | acquired resistance | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Multiple Myeloma - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Pyrazoles - pharmacology | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Pyrimidines - pharmacology | Stomach Neoplasms - drug therapy | Urinary Bladder Neoplasms - drug therapy | Receptor Protein-Tyrosine Kinases - drug effects | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Receptors, Fibroblast Growth Factor - metabolism | Cell Line, Tumor | Mutation | Multiple Myeloma - genetics | Gene mutations | Analysis | Physiological aspects | Genetic aspects | Fibroblast growth factors | Research | Health aspects | Fibroblast growth factor receptors | Proteins | Signal transduction | Inhibitor drugs | Gene expression | Cancer | Index Medicus
Journal Article
Clinical cancer research, ISSN 1557-3265, 05/2013, Volume 19, Issue 13, pp. 3693 - 3702
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 10, pp. 3758 - 3769
.... We previously reported that IL-1 beta stimulation leads to fibroblast growth factor (FGF2) expression, enhancing migration and proliferation of mammalian CECs... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Proliferation | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Zinc Finger E-box-Binding Homeobox 1 - antagonists & inhibitors | Endothelium, Corneal - pathology | Eye Proteins - agonists | Wound Healing | Zinc Finger E-box-Binding Homeobox 1 - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Endothelium, Corneal - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - agonists | Collagen Type I - genetics | Snail Family Transcription Factors - genetics | RNA Interference | Zinc Finger E-box Binding Homeobox 2 - metabolism | Cell Shape | Snail Family Transcription Factors - antagonists & inhibitors | Cell Transdifferentiation | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Eye Proteins - antagonists & inhibitors | Eye Proteins - genetics | Biomarkers - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Endothelium, Corneal - cytology | Collagen Type I - metabolism | Snail Family Transcription Factors - metabolism | Cells, Cultured | Gene Expression Regulation | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 2 - chemistry | Zinc Finger E-box Binding Homeobox 2 - agonists | Collagen Type I - agonists | Eye Proteins - metabolism | Zinc Finger E-box-Binding Homeobox 1 - agonists | Zinc Finger E-box Binding Homeobox 2 - genetics | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Enzyme Activation | Cell Movement | Index Medicus | endothelial-mesenchymal transition | endothelium | ZEB1 | cornea | SNAI1 | fibroblast growth factor (FGF) | mesenchymal transition | fibrosis | corneal endothelium | zinc finger | FGF2 | Cell Biology
Journal Article
PloS one, ISSN 1932-6203, 11/2010, Volume 5, Issue 11, pp. e14117 - e14117
... EGFR is dominant for growth signaling, but not in cell lines where EGFR signaling is absent. A luciferase reporter containing... 
Fibroblast Growth Factor 7 - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Coculture Techniques | Humans | Lung Neoplasms - metabolism | Fibroblast Growth Factor 2 - pharmacology | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Fibroblasts - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Fibroblasts - drug effects | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Fibroblasts - cytology | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Tyrosine | Phenols | Fibroblast growth factors | RNA | Analysis | Luciferase | Fibroblast growth factor | Biotechnology | Transcription | Gene regulation | Lung cancer | Biology | Kinases | Cell adhesion & migration | Morphogenesis | Epidermal growth factor | Fibroblast growth factor receptor 7 | Gefitinib | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Fibroblast growth factor 2 | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Non-small cell lung carcinoma | Gene expression | Src protein | Self sufficiency | Pulmonary hypertension | Studies | Signaling | Inhibitors | Monoclonal antibodies | Ligands | Mutation | Tumors | Fibroblast growth factor receptors | Index Medicus
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 07/2012, Volume 337, Issue 6099, pp. 1231 - 1235
.... Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors examined) harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor (FGFR) genes (FGFR1 or FGFR3... 
Exons | Neurons | Genes | REPORTS | Stem cells | Aneuploidy | Chromosomes | Cells | Tumors | Daughter cells | Cancer | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Microtubule-Associated Proteins - chemistry | Neoplasm Transplantation | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Mitosis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Fetal Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Brain Neoplasms - metabolism | Oncogene Proteins, Fusion - chemistry | Spindle Apparatus - metabolism | Glioblastoma - genetics | Oncogene Fusion | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Nuclear Proteins - genetics | Chromosomal Instability | Pyrazoles - pharmacology | Protein Structure, Tertiary | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Enzyme Inhibitors - pharmacology | Brain Neoplasms - genetics | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Nuclear Proteins - chemistry | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Fetal Proteins - genetics | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Fetal Proteins - chemistry | Physiological aspects | Development and progression | Fibroblast growth factors | Genetic aspects | Research | Health aspects | Glioblastoma multiforme | Proteins | Kinases | Brain cancer | Genomics | Pharmaceutical sciences | Index Medicus
Journal Article
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