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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6099, pp. 1231 - 1235
The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors... 
Exons | Neurons | Genes | REPORTS | Stem cells | Aneuploidy | Chromosomes | Cells | Tumors | Daughter cells | Cancer | ANEUPLOIDY | SELECTIVE INHIBITOR | POTENT | MULTIDISCIPLINARY SCIENCES | CANCER | RECEPTOR TYROSINE KINASE | DISCOVERY | CHROMOSOMAL INSTABILITY | FAMILY | Microtubule-Associated Proteins - chemistry | Neoplasm Transplantation | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Mitosis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Fetal Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Brain Neoplasms - metabolism | Oncogene Proteins, Fusion - chemistry | Spindle Apparatus - metabolism | Glioblastoma - genetics | Oncogene Fusion | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Nuclear Proteins - genetics | Chromosomal Instability | Pyrazoles - pharmacology | Protein Structure, Tertiary | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Enzyme Inhibitors - pharmacology | Brain Neoplasms - genetics | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Nuclear Proteins - chemistry | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Fetal Proteins - genetics | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Fetal Proteins - chemistry | Physiological aspects | Development and progression | Fibroblast growth factors | Genetic aspects | Research | Health aspects | Glioblastoma multiforme | Proteins | Kinases | Brain cancer | Genomics | Pharmaceutical sciences | Index Medicus
Journal Article
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 4, p. 767
Fibroblast growth factor receptor 1 (FGFR1) has become a potential target for the treatment of cancer. Designing FGFR1-selective inhibitors remains fundamental... 
MD-simulation | Binding free energy | Selectivity | Inhibitors | FGFR4 | FGFR1 | selectivity | inhibitors | FACTOR RECEPTOR FAMILY | binding free energy | TYROSINE KINASE | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOFORM SELECTIVITY | CHEMISTRY, MULTIDISCIPLINARY | BCR-ABL INHIBITOR | AZD4547 | LUNG-CANCER | RESISTANCE | FORCE-FIELD | MOLECULAR-DYNAMICS SIMULATIONS | Catalytic Domain - drug effects | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Molecular Dynamics Simulation | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Molecular Docking Simulation | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Mutation | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Pyrazoles - pharmacology | Fibroblast growth factor | Molecular structure | Homology | Drug development | Energy | Mathematical analysis | Fibroblast growth factor receptor 4 | Docking | Fibroblast growth factor receptor 1 | Computer simulation | Exploration | Pharmacology | Free energy | Molecular chains | Electronic structure | Simulation | Computation | Binding energy | Computer applications | Predictions | Binding sites | Cancer | Fibroblast growth factor receptors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9747 - 9752
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury. Their... 
Carbohydrates | Receptors | Polysaccharides | Glycosaminoglycans | Tetrasaccharides | Heparin | Sulfates | Binding sites | Crystal structure | Sulfation | CHONDROITIN SULFATE | SIGNALING PATHWAYS | NEURITE OUTGROWTH | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DIMERIZATION | FIBROBLAST-GROWTH-FACTOR | NEUROTROPHIN RECEPTORS | HEPARIN | HIPPOCAMPAL-NEURONS | BINDING | Tumor Necrosis Factor-alpha - metabolism | Chondroitin Sulfates - metabolism | Fibroblast Growth Factor 2 - chemistry | Tumor Necrosis Factor-alpha - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Molecular Sequence Data | Glycosaminoglycans - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - genetics | PC12 Cells | Antigens, Protozoan - metabolism | Computer Simulation | Oligosaccharides - chemistry | Fibroblast Growth Factor 2 - metabolism | Antigens, Protozoan - genetics | Carbohydrate Sequence | Microarray Analysis - methods | Protein Structure, Tertiary | Amino Acid Sequence | Antigens, Protozoan - chemistry | Glycosaminoglycans - metabolism | Models, Molecular | Rats | Binding Sites - genetics | Chondroitin Sulfates - chemistry | Oligosaccharides - metabolism | Proteins - genetics | Sequence Homology, Amino Acid | Animals | Proteins - metabolism | Tumor Necrosis Factor-alpha - chemistry | Fibroblast Growth Factor 2 - genetics | Protein Binding | Carbohydrates - analysis | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Proteins - chemistry | Cellular signal transduction | Research | Properties | Protein-protein interactions | Studies | Spinal cord injuries | T cell receptors | Kinases | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2007, Volume 117, Issue 2, pp. 457 - 463
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2006, Volume 103, Issue 16, pp. 6281 - 6286
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 23, pp. 20677 - 20687
Journal Article
Cancer Letters, ISSN 0304-3835, 06/2018, Volume 423, pp. 36 - 46
The Hippo pathway plays a critical role in organ size control, tissue homeostasis and tumor genesis through its key transcription regulator Yes-associated... 
YAP1 | TEAD | Lung cancer | Cancer stem cell properties | FGFR1 | GROWTH-CONTROL | COACTIVATOR | ORGAN SIZE CONTROL | TUMOR | YAP | CELL-PROLIFERATION | BREAST-CANCER | ONCOLOGY | ESOPHAGEAL CANCER | EXPRESSION | PROMOTES APOPTOSIS | Adaptor Proteins, Signal Transducing - chemistry | Neoplasm Transplantation | Up-Regulation | Cell Proliferation | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Lung Neoplasms - pathology | Phosphoproteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Phosphoproteins - chemistry | Cell Self Renewal | Neoplastic Stem Cells - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Lung Neoplasms - genetics | Promoter Regions, Genetic | Signal Transduction | Phosphoproteins - genetics | Animals | Gene Amplification | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Immunohistochemistry | Metastasis | Analysis | Stem cells | Transcription | Lung | Homeostasis | Biology | Kinases | Metastases | Proteins | Signal transduction | Fibroblast growth factor receptor 1 | Fibroblast growth factor 2 | Therapeutic applications | Lung carcinoma | Mammals | Gene expression | Suppressors | Yes-associated protein | Studies | Signaling | Binding sites | Cancer | Tumors | Index Medicus
Journal Article