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Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | ErbB Receptors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | ErbB Receptors - chemistry | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | kinase inhibitor | structure-based drug design | cancer drug resistance | PNAS Plus | drug discovery
Journal Article
PloS one, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e33870 - e33870
.... However, the identity of the predominant metabolic tissue in which a major FGFR-KLB resides that critically mediates the differential actions and metabolism effects of FGF19 and FGF21 remain unclear... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Diabetes Mellitus - genetics | Membrane Proteins - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Diabetes Mellitus - metabolism | Fibroblast Growth Factors - genetics | Multiprotein Complexes - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Mice, Knockout | Obesity - metabolism | Fibroblast Growth Factors - metabolism | Multiprotein Complexes - metabolism | Animals | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Adipose Tissue | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Type 2 diabetes | Physiological aspects | Obesity | Cellular signal transduction | Fibroblast growth factors | Liver | Adipose tissue | Body fat | Laboratories | Dietary minerals | Science | Homeostasis | Biology | Adipocytes | Metabolic syndrome | Angiogenesis | Signal transduction | Rodents | Animal tissues | Fibroblast growth factor receptor 4 | Fibroblasts | Physiology | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Binding | Heparan sulfate | Fibroblast growth factor 1 | Fasting | Diabetes mellitus | Melanoma | Gene expression | Metabolism | Ablation | Musculoskeletal system | Signaling | Proteomics | Stem cells | Affinity | Insulin resistance | Diabetes | Kinetics | Nanotechnology | Cancer | Fibroblast growth factor receptors | Index Medicus
Journal Article
American journal of physiology. Lung cellular and molecular physiology, ISSN 1040-0605, 09/2015, Volume 309, Issue 5, pp. L463 - L474
...), which store neutral lipids. PDGF-A is required but acts in conjunction with other differentiation factors arising from adjacent epithelia or within fibroblasts... 
Adipocyte | PDGF receptor-α | Cell differentiation | Endosome | Fibroblast | Respiratory System | Physiology | Life Sciences & Biomedicine | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Cell Proliferation | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Extracellular Matrix - metabolism | Fibroblast Growth Factors - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Myofibroblasts - metabolism | Fibroblast Growth Factors - metabolism | Pulmonary Alveoli - metabolism | Pulmonary Alveoli - cytology | Cell Differentiation | Membrane Proteins - metabolism | Cyclin-Dependent Kinases | Fibroblast Growth Factor 10 - genetics | Fibroblast Growth Factor 10 - metabolism | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | RNA, Messenger - genetics | Mice, Transgenic | Myofibroblasts - cytology | Platelet-Derived Growth Factor - metabolism | Animals | Elastin - biosynthesis | Chaperonin 10 - genetics | Multivesicular Bodies - metabolism | Mice | Receptor, Fibroblast Growth Factor, Type 1 - biosynthesis | Physiological aspects | Fibroblasts | Fibroblast growth factors | Signal transduction | RNA-protein interactions | Rodents | Heat shock proteins | Protein expression | Index Medicus | cell differentiation | endosome | fibroblast | adipocyte
Journal Article
The FEBS journal, ISSN 1742-4658, 04/2016, Volume 283, Issue 9, pp. 1653 - 1668
...). To elucidate the role of the fibroblast growth factor (FGF) signaling in these two cell populations, we previously analyzed freshly isolated cells for their FGF receptor (FGFR) signature... 
fibro/adipocytes | adipogenesis | fibroblast growth factor receptor | adipogenic differentiation | βKlotho | αKlotho | PiggyBac transposon | FAPs | FGF21 | satellite cells | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Adipocytes - cytology | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Adipogenesis - genetics | Fibroblasts - metabolism | Cell Line | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Satellite Cells, Skeletal Muscle - cytology | Gene Expression Regulation | Mice, Transgenic | Satellite Cells, Skeletal Muscle - metabolism | Lipid Droplets | Animals | Adipocytes - metabolism | Fibroblasts - cytology | Mice | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Index Medicus | Piggybac transposon | Fibro | Adipogenic differentiation | Satellite cells | adipocytes | Fibroblast growth factor receptors | Adipogenesis
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14379 - 14384
...Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice Xinle Wu a,1 , Hongfei Ge a , Bryan Lemon a , Jennifer... 
Adipose tissues | Molecules | Receptors | Phosphorylation | Bile acids | Liver | Homeostasis | Fibroblast growth factors | Heparin | Adipocytes | Diabetes | FGF21 | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Transcriptional Activation | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Tissue Distribution | Adipose Tissue - metabolism | Fibroblast Growth Factors - metabolism | Membrane Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Cell Line | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Glucose Tolerance Test | Membrane Proteins - genetics | Liver - metabolism | Mice, Inbred C57BL | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Obesity - metabolism | Animals | Fibroblast Growth Factors - pharmacokinetics | Glucose - pharmacokinetics | Glucose - metabolism | Protein Binding | Mice, Obese | Mice | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Glucose metabolism | Hormone receptors | Research | Chemical properties | Signal transduction | Rodents | Glucose | Gene expression | Metabolism | Index Medicus | Biological Sciences | liver | diabetes
Journal Article