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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Cancer Discovery, ISSN 2159-8274, 12/2012, Volume 2, Issue 12, pp. 1118 - 1133
Journal Article
Oncogene, ISSN 0950-9232, 06/2013, Volume 32, Issue 25, pp. 3059 - 3070
Fibroblast growth factor receptors (FGFRs) can act as driving oncoproteins in certain cancers, making them attractive drug targets. Here we have characterized... 
tyrosine kinase inhibitors | ERK1/2 | FGFR | PKB | acquired resistance | MULTIPLE-MYELOMA | BLADDER-CANCER | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | STOMACH-CANCER | LINES | CELL BIOLOGY | C/EBP-ALPHA | AMPLIFICATION | GENE | ONCOLOGY | GASTRIC-CANCER | GENETICS & HEREDITY | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Multiple Myeloma - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Pyrazoles - pharmacology | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Pyrimidines - pharmacology | Stomach Neoplasms - drug therapy | Urinary Bladder Neoplasms - drug therapy | Receptor Protein-Tyrosine Kinases - drug effects | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Receptors, Fibroblast Growth Factor - metabolism | Cell Line, Tumor | Mutation | Multiple Myeloma - genetics | Gene mutations | Analysis | Physiological aspects | Genetic aspects | Fibroblast growth factors | Research | Health aspects | Fibroblast growth factor receptors | Proteins | Signal transduction | Inhibitor drugs | Gene expression | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 01/2013, Volume 73, Issue 4, pp. 1298 - 1307
Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on... 
DEDIFFERENTIATED LIPOSARCOMA | GENE | ONCOLOGY | COPY-NUMBER | GROWTH | MDM2 | CLASSIFICATION | PLEOMORPHIC SARCOMA | EXPRESSION | CANCER | CELL-LINE | Immunohistochemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Cyclin-Dependent Kinase 4 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Arginine - analogs & derivatives | Liposarcoma - metabolism | Neoplasm Grading | RNA Interference | Receptors, Fibroblast Growth Factor - genetics | Female | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Liposarcoma - pathology | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Liposarcoma - genetics | Pyrimidines - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Amplification | Receptors, Fibroblast Growth Factor - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2017, Volume 135, pp. 531 - 543
A series of 2-oxo-3, 4-dihydropyrimido[4,5- ]-pyrimidinyl derivatives were designed and synthesized as new irreversible inhibitors of the FGFR family. One of... 
FGFR | Irreversible inhibitor | 2-Oxo-3,4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives | CHEMISTRY, MEDICINAL | DISCOVERY | FAMILY | AZD4547 | 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives | SELECTIVE INHIBITOR | POTENT | PATHWAY | REACTIVATION | RESISTANCE | TYROSINE KINASE INHIBITOR | TARGETING FGFR | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Structure-Activity Relationship | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Drug Screening Assays, Antitumor | Fibroblast growth factors | Enzyme inhibitors | Drug discovery | Lung cancer, Non-small cell | Derivatives (Financial instruments) | Resveratrol | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 15, pp. 6516 - 6527
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2014, Volume 10, Issue 2, pp. e1004135 - e1004135
Author Summary Cholangiocarcinoma is a cancer that affects the bile ducts. Unfortunately, many patients diagnosed with cholangiocarcinoma have disease that... 
C-VIRUS-INFECTION | GROWTH-FACTOR RECEPTOR | BILIARY-TRACT CANCER | K-RAS MUTATIONS | RISK-FACTORS | GENETICS & HEREDITY | TUMOR-SUPPRESSOR GENE | HEPATITIS-C | PRIMARY SCLEROSING CHOLANGITIS | FLUKE-ASSOCIATED CHOLANGIOCARCINOMA | NEGATIVE BREAST-CANCER | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - genetics | Prognosis | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Transcriptome | Imidazoles - administration & dosage | Molecular Targeted Therapy | Receptor, Epidermal Growth Factor - metabolism | Pyridazines - administration & dosage | Quinazolines - administration & dosage | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Bile Duct Neoplasms - genetics | Bile Duct Neoplasms - drug therapy | Bile Ducts, Intrahepatic - pathology | Pyrimidines - administration & dosage | Signal Transduction - genetics | Cholangiocarcinoma - pathology | Protein Kinase Inhibitors | Cholangiocarcinoma - drug therapy | Cell Line, Tumor | Cholangiocarcinoma - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Bile Duct Neoplasms - pathology | Mutation | Genome, Human | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Sulfonamides - administration & dosage | Antimitotic agents | Analysis | Genomics | Research | Antineoplastic agents | Health aspects | Tumors | Index Medicus | Studies | Hepatitis | Substance abuse treatment | Genetic engineering | Genomes | Kinases | Gene expression | Patients | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 10, pp. 3758 - 3769
Investigating stimulation of endogenous wound healing in corneal endothelial cells (CECs) may help address the global shortage of donor corneas by decreasing... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRANSFORMATION | FGF-2 | FGF-2-MEDIATED CELL-PROLIFERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR SNAIL | TUMOR-CELLS | I COLLAGEN | E-CADHERIN | IDIOPATHIC PULMONARY-FIBROSIS | EXPRESSION | Cell Proliferation | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Zinc Finger E-box-Binding Homeobox 1 - antagonists & inhibitors | Endothelium, Corneal - pathology | Eye Proteins - agonists | Wound Healing | Zinc Finger E-box-Binding Homeobox 1 - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Endothelium, Corneal - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - agonists | Collagen Type I - genetics | Snail Family Transcription Factors - genetics | RNA Interference | Zinc Finger E-box Binding Homeobox 2 - metabolism | Cell Shape | Snail Family Transcription Factors - antagonists & inhibitors | Cell Transdifferentiation | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Eye Proteins - antagonists & inhibitors | Eye Proteins - genetics | Biomarkers - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Endothelium, Corneal - cytology | Collagen Type I - metabolism | Snail Family Transcription Factors - metabolism | Cells, Cultured | Gene Expression Regulation | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 2 - chemistry | Zinc Finger E-box Binding Homeobox 2 - agonists | Collagen Type I - agonists | Eye Proteins - metabolism | Zinc Finger E-box-Binding Homeobox 1 - agonists | Zinc Finger E-box Binding Homeobox 2 - genetics | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Enzyme Activation | Cell Movement | Index Medicus | endothelial-mesenchymal transition | endothelium | ZEB1 | cornea | SNAI1 | fibroblast growth factor (FGF) | mesenchymal transition | fibrosis | corneal endothelium | zinc finger | FGF2 | Cell Biology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 25, pp. 8713 - 8717
Journal Article
Annals of Oncology, ISSN 0923-7534, 11/2014, Volume 25, Issue 11, pp. 2244 - 2251
Journal Article