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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 45, pp. E4869 - E4877
... rhabdomyosarcoma and neuroendocrine breast carcinomas. Here we report on the use of a structure-based drug design to develop two selective, next-generation covalent FGFR inhibitors, the FGFR irreversible inhibitors 2 (FIIN-2) and 3 (FIIN-3... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | ErbB Receptors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | ErbB Receptors - chemistry | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
Wiley interdisciplinary reviews. Developmental biology, ISSN 1759-7684, 2015, Volume 4, Issue 3, pp. 215 - 266
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs... 
FAMILIAL TUMORAL CALCINOSIS | LIGAND-BINDING SPECIFICITY | NEGATIVE-FEEDBACK-REGULATION | FACTOR HOMOLOGOUS FACTORS | APICAL ECTODERMAL RIDGE | GONADOTROPIN-RELEASING-HORMONE | FACTOR RECEPTOR 4 | POTENTIAL THERAPEUTIC TARGET | DEVELOPMENTAL BIOLOGY | HEPARAN-SULFATE PROTEOGLYCANS | EPITHELIAL-MESENCHYMAL INTERACTIONS | Humans | Cell Proliferation - physiology | Embryonic Development - physiology | Cell Movement - physiology | Fibroblast Growth Factors - metabolism | Animals | Models, Biological | Homeostasis - physiology | Receptors, Fibroblast Growth Factor - metabolism | Signal Transduction - physiology | Organogenesis - physiology | Energy Metabolism - physiology | Cell Differentiation - physiology | Voltage-Gated Sodium Channels - metabolism | Pattern formation | Fibroblast growth factor | Congenital defects | Intracellular signalling | AKT protein | Nervous system | Kinases | Cofactors | Proteins | Signal transduction | Embryogenesis | Developmental stages | Fibroblasts | Sodium channels (voltage-gated) | Growth factors | Protein-tyrosine kinase | Adaptor proteins | Tyrosine | Sodium channels | Cell survival | MAP kinase | Metabolism | Progenitor cells | 1-Phosphatidylinositol 3-kinase | Organogenesis | Stem cells | Intracellular | Metabolic disorders | Cancer | Advanced Reviews
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 545, Issue 7653, pp. 224 - 228
...(1). Although much is known about vascular endothelial growth factor (VEGF)-dependent regulation of vascular development and metabolism(2,3... 
GENE-EXPRESSION DATA | MAINTENANCE | MULTIDISCIPLINARY SCIENCES | MOUSE | LYMPHANGIOGENESIS | ENDOTHELIAL-CELL METABOLISM | MECHANISMS | GROWTH-FACTOR | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Cell Proliferation | Lymphatic Vessels - cytology | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Proto-Oncogene Proteins c-myc - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - deficiency | Lymphatic Vessels - metabolism | Animals | Receptor, Fibroblast Growth Factor, Type 3 - deficiency | Endothelial Cells - cytology | Glycolysis | Female | Mice | Hexokinase - metabolism | Lymphangiogenesis | Neovascularization, Physiologic | Cell Movement | Fibroblast growth factors | Metabolism | Observations | Health aspects | Cell proliferation | Fibroblast growth factor | Leukocyte migration | c-Myc protein | Homeostasis | Biology | Myc protein | Kinases | Blood | Defects | Angiogenesis | Control | Cell growth | Metabolites | Rodents | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Growth factors | Medical research | Enzymes | Grants | Hexokinase | Endothelial cells | Endothelium | Signaling | Oxygenation | Cell migration | Fibroblast growth factor receptors
Journal Article