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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
Annals of Oncology, ISSN 0923-7534, 03/2014, Volume 25, Issue 3, pp. 552 - 563
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2015, Volume 22, Issue 6, pp. 1020 - 1032
Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of death due to cardiovascular complications, including left ventricular... 
KIDNEY-DISEASE | MORTALITY | KLOTHO | POINT MUTATION | SPECIFICITY | ENDOCRINOLOGY & METABOLISM | INHIBITOR | BLOCKADE | BINDING | EXPRESSION | FGF RECEPTOR | CELL BIOLOGY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Humans | Glucuronidase - metabolism | Fibroblast Growth Factors - genetics | Male | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Hypertrophy, Left Ventricular - pathology | HEK293 Cells | Receptor, Fibroblast Growth Factor, Type 4 - deficiency | Female | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Disease Models, Animal | Phospholipase C gamma - metabolism | Mutagenesis, Site-Directed | Myocytes, Cardiac - cytology | Signal Transduction | Hypertrophy, Left Ventricular - metabolism | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Cells, Cultured | Rats | Rats, Sprague-Dawley | Gene Knock-In Techniques | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Animals | Glucuronidase - genetics | Myocytes, Cardiac - metabolism | Mice | Calcineurin - metabolism | Hypertension | Medical colleges | Chronic kidney failure | Heart enlargement | Stem cells | Physiological aspects | Fibroblast growth factors | Phospholipases | Drug discovery | T cells | Health aspects | Heart | Resveratrol | Development and progression | Kidney diseases | Cells
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33870
Background: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and... 
BETA-KLOTHO | PPAR-ALPHA | TRANSCRIPTS ENCODING MEMBRANE | METABOLIC REGULATOR | MULTIDISCIPLINARY SCIENCES | INCREASES ENERGY-EXPENDITURE | ACTIVATED-RECEPTOR-GAMMA | FIBROBLAST-GROWTH-FACTOR | BILE-ACID SYNTHESIS | MOUSE KLOTHO GENE | INSULIN SENSITIVITY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Diabetes Mellitus - genetics | Membrane Proteins - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Diabetes Mellitus - metabolism | Fibroblast Growth Factors - genetics | Multiprotein Complexes - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Mice, Knockout | Obesity - metabolism | Fibroblast Growth Factors - metabolism | Multiprotein Complexes - metabolism | Animals | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Adipose Tissue | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Type 2 diabetes | Physiological aspects | Obesity | Cellular signal transduction | Fibroblast growth factors | Liver | Adipose tissue | Body fat | Laboratories | Dietary minerals | Science | Homeostasis | Biology | Adipocytes | Metabolic syndrome | Angiogenesis | Signal transduction | Rodents | Animal tissues | Fibroblast growth factor receptor 4 | Fibroblasts | Physiology | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Binding | Heparan sulfate | Fibroblast growth factor 1 | Fasting | Diabetes mellitus | Melanoma | Gene expression | Metabolism | Ablation | Musculoskeletal system | Signaling | Proteomics | Stem cells | Affinity | Insulin resistance | Transduction | Diabetes | Kinetics | Nanotechnology | Cancer | Fibroblast growth factor receptors
Journal Article
The Journal of Pathology, ISSN 0022-3417, 09/2007, Volume 213, Issue 1, pp. 82 - 90
Fibroblast growth factor receptors (FGFRs) mediate the tumourigenic effects of FGFs in prostate cancer. These receptors are therefore potential therapeutic... 
prostate cancer | tissue microarray | laser capture microdissection | fibroblast growth factor receptors | Laser capture microdissection | Tissue microarray | Prostate cancer | Fibroblast growth factor receptors | FACTOR FAMILY | ISOFORMS | FGF | SPECIFICITY | RESTORATION | PATHOLOGY | TUMORIGENICITY | ARG ALLELE | EPITHELIAL-CELLS | GENES | PROGRESSION | Immunohistochemistry | Prostatic Neoplasms - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Cell Proliferation | Microdissection | Oligonucleotide Array Sequence Analysis | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Male | Gene Expression Profiling | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Case-Control Studies | Receptors, Fibroblast Growth Factor - analysis | Prostatic Neoplasms - genetics | RNA Interference | Receptor, Fibroblast Growth Factor, Type 2 - analysis | Receptors, Fibroblast Growth Factor - genetics | Transcription, Genetic | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Receptor, Fibroblast Growth Factor, Type 1 - analysis | Receptor, Fibroblast Growth Factor, Type 3 - genetics | RNA, Small Interfering - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - analysis | Microscopy, Confocal | Receptors, Fibroblast Growth Factor - metabolism | Cell Line, Tumor | Polymorphism, Single Nucleotide | Receptor, Fibroblast Growth Factor, Type 3 - analysis | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Protein Isoforms - genetics
Journal Article
Cancer Research, ISSN 0008-5472, 01/2013, Volume 73, Issue 4, pp. 1298 - 1307
Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on... 
DEDIFFERENTIATED LIPOSARCOMA | GENE | ONCOLOGY | COPY-NUMBER | GROWTH | MDM2 | CLASSIFICATION | PLEOMORPHIC SARCOMA | EXPRESSION | CANCER | CELL-LINE | Immunohistochemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Cyclin-Dependent Kinase 4 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Arginine - analogs & derivatives | Liposarcoma - metabolism | Neoplasm Grading | RNA Interference | Receptors, Fibroblast Growth Factor - genetics | Female | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Liposarcoma - pathology | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Liposarcoma - genetics | Pyrimidines - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Amplification | Receptors, Fibroblast Growth Factor - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 08/2009, Volume 297, Issue 2, pp. 282 - 291
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 03/2011, Volume 300, Issue 3, pp. E508 - E517
Li H, Martin A, David V, Quarles LD. Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype. Am J Physiol Endocrinol Metab 300:... 
Fibroblast growth factor receptor 4 | Hypophosphatemia | Fibroblast growth factor 23 | Vitamin D | Klotho | Fibroblast growth factor receptor 3 | fibroblast growth factor receptor 4 | PHYSIOLOGY | VITAMIN-D METABOLISM | fibroblast growth factor 23 | vitamin D | fibroblast growth factor receptor 3 | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | REGULATING PHOSPHATE | PHOSPHATE HOMEOSTASIS | IN-VIVO | ENDOCRINOLOGY & METABOLISM | MICE | FIBROBLAST GROWTH FACTOR-23 | hypophosphatemia | FGF23 | EXPRESSION | Immunohistochemistry | Kidney - physiology | Tomography, X-Ray Computed | Hypophosphatemia - metabolism | Mice, 129 Strain | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 1 - physiology | Bone and Bones - metabolism | Gene Deletion | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Mice, Inbred C57BL | Fibroblast Growth Factors - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Absorptiometry, Photon | Mice, Knockout | Receptor, Fibroblast Growth Factor, Type 3 - physiology | Homozygote | Hypophosphatemia - genetics | Phenotype | Phosphates - metabolism | Animals | Receptor, Fibroblast Growth Factor, Type 4 - physiology | Mice, Obese | Vitamin D - metabolism | Mice | Gene mutations | Physiological aspects | Calcifediol | Genetic aspects | Research | Alfacalcidol | Fibroblast growth factor receptors
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2017, Volume 135, pp. 531 - 543
A series of 2-oxo-3, 4-dihydropyrimido[4,5- ]-pyrimidinyl derivatives were designed and synthesized as new irreversible inhibitors of the FGFR family. One of... 
FGFR | Irreversible inhibitor | 2-Oxo-3,4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives | CHEMISTRY, MEDICINAL | DISCOVERY | FAMILY | AZD4547 | 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives | SELECTIVE INHIBITOR | POTENT | PATHWAY | REACTIVATION | RESISTANCE | TYROSINE KINASE INHIBITOR | TARGETING FGFR | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Structure-Activity Relationship | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Drug Screening Assays, Antitumor | Fibroblast growth factors | Enzyme inhibitors | Drug discovery | Lung cancer, Non-small cell | Derivatives (Financial instruments) | Resveratrol
Journal Article
Journal Article