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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Cancer Research, ISSN 0008-5472, 01/2013, Volume 73, Issue 4, pp. 1298 - 1307
Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on... 
DEDIFFERENTIATED LIPOSARCOMA | GENE | ONCOLOGY | COPY-NUMBER | GROWTH | MDM2 | CLASSIFICATION | PLEOMORPHIC SARCOMA | EXPRESSION | CANCER | CELL-LINE | Immunohistochemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Cyclin-Dependent Kinase 4 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Arginine - analogs & derivatives | Liposarcoma - metabolism | Neoplasm Grading | RNA Interference | Receptors, Fibroblast Growth Factor - genetics | Female | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Liposarcoma - pathology | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Liposarcoma - genetics | Pyrimidines - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Amplification | Receptors, Fibroblast Growth Factor - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2017, Volume 135, pp. 531 - 543
A series of 2-oxo-3, 4-dihydropyrimido[4,5- ]-pyrimidinyl derivatives were designed and synthesized as new irreversible inhibitors of the FGFR family. One of... 
FGFR | Irreversible inhibitor | 2-Oxo-3,4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives | CHEMISTRY, MEDICINAL | DISCOVERY | FAMILY | AZD4547 | 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives | SELECTIVE INHIBITOR | POTENT | PATHWAY | REACTIVATION | RESISTANCE | TYROSINE KINASE INHIBITOR | TARGETING FGFR | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Structure-Activity Relationship | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Drug Screening Assays, Antitumor | Fibroblast growth factors | Enzyme inhibitors | Drug discovery | Lung cancer, Non-small cell | Derivatives (Financial instruments) | Resveratrol | Index Medicus
Journal Article
Cancer Science, ISSN 1347-9032, 10/2015, Volume 106, Issue 10, pp. 1278 - 1287
Cancer‐associated fibroblasts ( CAF s), as the activated fibroblasts in the tumor stroma, are important modifiers of tumour progression. In the present study,... 
Cancer‐associated fibroblasts | extracellular signal‐regulated kinase | fibroblast growth factor | colon cancer | metalloproteinase‐7 | Extracellular signal-regulated kinase | Cancer-associated fibroblasts | Fibroblast growth factor | Metalloproteinase-7 | Colon cancer | CELLS | extracellular signal-regulated kinase | ACTIVATION | PROLIFERATION | MESENCHYMAL TRANSITION | MICROENVIRONMENT | ONCOLOGY | COLORECTAL-CANCER | GROWTH | STROMAL FIBROBLASTS | RECURRENCE | EXPRESSION | metalloproteinase-7 | Human Umbilical Vein Endothelial Cells | Dextran Sulfate | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Colonic Neoplasms - genetics | Fibroblasts - secretion | Phosphorylation | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Azoxymethane | MAP Kinase Signaling System - genetics | Fibroblast Growth Factor 3 - pharmacology | Matrix Metalloproteinase 7 - metabolism | RNA Interference | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Fibroblast Growth Factor 3 - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Disease Models, Animal | Fibroblasts - metabolism | Colitis, Ulcerative - metabolism | HCT116 Cells | Fibroblast Growth Factor 1 - metabolism | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Colitis, Ulcerative - pathology | Pyrimidines - pharmacology | Disease Progression | HT29 Cells | Animals | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice | RNA, Small Interfering | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Dextran | Prevention | Analysis | Development and progression | Fibroblast growth factors | Neovascularization | Sulfates | Mitogens | Protein kinases | Tumors | Cancer | Index Medicus | Original
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2017, Volume 60, Issue 15, pp. 6516 - 6527
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2014, Volume 446, Issue 1, pp. 54 - 60
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1993 - 12
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2015, Volume 5, Issue 4, pp. 424 - 437
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76551 - e76551
Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. Despite advances in modern therapy, patients with relapsed or metastatic disease have... 
POTENT | GENE | EMBRYONAL RHABDOMYOSARCOMA | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TYROSINE KINASE INHIBITOR | ALVEOLAR RHABDOMYOSARCOMA | MYELOID-LEUKEMIA | NEUROBLASTOMA | IDENTIFICATION | CANCER MODELS | Cell Cycle - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Apoptosis - drug effects | Humans | Rhabdomyosarcoma - metabolism | Rhabdomyosarcoma - pathology | Apoptosis - genetics | Pyridazines - pharmacology | Female | Rhabdomyosarcoma - drug therapy | Tumor Burden - genetics | Phosphorylation - drug effects | Receptor, Fibroblast Growth Factor, Type 4 - genetics | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Cell Line | Gene Expression | Imidazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Tumor Burden - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Rhabdomyosarcoma - genetics | Mutation | Cell Cycle - drug effects | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Tyrosine | Fibroblast growth factors | Prognosis | Sarcoma | Pediatrics | Fibroblast growth factor | Phosphorylation | Leukemia | Rhabdomyosarcoma | Colorectal cancer | Oncology | Kinases | Cancer therapies | Cell surface | Metastases | Signal transduction | Penicillin | Fibroblast growth factor receptor 4 | Fibroblasts | Protein-tyrosine kinase receptors | Inhibition | Children | Growth factors | Protein-tyrosine kinase | Chromosomes | Medical research | Therapeutic applications | Stat3 protein | Muscles | Soft tissue sarcoma | Pharmacology | FDA approval | Gene expression | Patients | Chemical compounds | Myogenesis | Regeneration | Musculoskeletal system | Inhibitors | Medical prognosis | Tumors | Apoptosis | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2012, Volume 18, Issue 14, pp. 3880 - 3888
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2008, Volume 50, Issue 1, pp. 118 - 127
Background/Aims FGFR4, a member of the fibroblast growth factor receptor family, has been recently associated with progression of melanoma, breast and head and... 
Gastroenterology and Hepatology | Tyrosine kinase | HCC | Proliferation | FGFR4 | Alpha-fetoprotein | Apoptosis | TYROSINE KINASE DOMAIN | SPECIFICITY | MESENCHYMAL TRANSITION | CANCER | FGFR4 ARG ALLELE | OVEREXPRESSION | INHIBITION | LIVER | SQUAMOUS-CELL CARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Liver - pathology | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Case-Control Studies | Carcinoma, Hepatocellular - drug therapy | Liver - drug effects | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | alpha-Fetoproteins - metabolism | Liver - metabolism | Liver Neoplasms - drug therapy | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Fibroblast Growth Factors - pharmacology | Pyrimidines - pharmacology | Disease Progression | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Polymorphism, Single Nucleotide - genetics | Apoptosis - physiology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Carcinoma, Hepatocellular - metabolism | Tyrosine | RNA | Melanoma | Development and progression | Hepatoma | Monosaccharides | Proteins | Liver cancer | Analysis | Fibroblast growth factors | Hepatitis C | Health aspects | Sugars | Enzyme-linked immunosorbent assay | Index Medicus
Journal Article
Journal Article