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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2015, Volume 22, Issue 6, pp. 1020 - 1032
Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of death due to cardiovascular complications, including left ventricular... 
SIGNAL-TRANSDUCTION | MORTALITY | FACTOR FAMILY | KLOTHO | POINT MUTATION | TYROSINE KINASE | ENDOCRINOLOGY & METABOLISM | CHRONIC KIDNEY-DISEASE | CANCER PROGRESSION | EXPRESSION | FGF RECEPTOR | CELL BIOLOGY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Humans | Glucuronidase - metabolism | Fibroblast Growth Factors - genetics | Male | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Hypertrophy, Left Ventricular - pathology | HEK293 Cells | Receptor, Fibroblast Growth Factor, Type 4 - deficiency | Female | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Disease Models, Animal | Phospholipase C gamma - metabolism | Mutagenesis, Site-Directed | Myocytes, Cardiac - cytology | Signal Transduction | Hypertrophy, Left Ventricular - metabolism | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Cells, Cultured | Rats | Rats, Sprague-Dawley | Gene Knock-In Techniques | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Animals | Glucuronidase - genetics | Myocytes, Cardiac - metabolism | Mice | Calcineurin - metabolism | Hypertension | Medical colleges | Chronic kidney failure | Heart enlargement | Stem cells | Physiological aspects | Fibroblast growth factors | Phospholipases | Drug discovery | T cells | Health aspects | Heart | Resveratrol | Development and progression | Kidney diseases | Cells | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e33870 - e33870
Background: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and... 
BETA-KLOTHO | PPAR-ALPHA | TRANSCRIPTS ENCODING MEMBRANE | METABOLIC REGULATOR | MULTIDISCIPLINARY SCIENCES | INCREASES ENERGY-EXPENDITURE | ACTIVATED-RECEPTOR-GAMMA | FIBROBLAST-GROWTH-FACTOR | BILE-ACID SYNTHESIS | MOUSE KLOTHO GENE | INSULIN SENSITIVITY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Diabetes Mellitus - genetics | Membrane Proteins - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Diabetes Mellitus - metabolism | Fibroblast Growth Factors - genetics | Multiprotein Complexes - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Mice, Knockout | Obesity - metabolism | Fibroblast Growth Factors - metabolism | Multiprotein Complexes - metabolism | Animals | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Adipose Tissue | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Type 2 diabetes | Physiological aspects | Obesity | Cellular signal transduction | Fibroblast growth factors | Liver | Adipose tissue | Body fat | Laboratories | Dietary minerals | Science | Homeostasis | Biology | Adipocytes | Metabolic syndrome | Angiogenesis | Signal transduction | Rodents | Animal tissues | Fibroblast growth factor receptor 4 | Fibroblasts | Physiology | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Binding | Heparan sulfate | Fibroblast growth factor 1 | Fasting | Diabetes mellitus | Melanoma | Gene expression | Metabolism | Ablation | Musculoskeletal system | Signaling | Proteomics | Stem cells | Affinity | Insulin resistance | Transduction | Diabetes | Kinetics | Nanotechnology | Cancer | Fibroblast growth factor receptors | Index Medicus
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 08/2009, Volume 297, Issue 2, pp. 282 - 291
Journal Article
Cancer Research, ISSN 0008-5472, 01/2013, Volume 73, Issue 4, pp. 1298 - 1307
Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on... 
DEDIFFERENTIATED LIPOSARCOMA | GENE | ONCOLOGY | COPY-NUMBER | GROWTH | MDM2 | CLASSIFICATION | PLEOMORPHIC SARCOMA | EXPRESSION | CANCER | CELL-LINE | Immunohistochemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Cyclin-Dependent Kinase 4 - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Arginine - analogs & derivatives | Liposarcoma - metabolism | Neoplasm Grading | RNA Interference | Receptors, Fibroblast Growth Factor - genetics | Female | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Liposarcoma - pathology | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Liposarcoma - genetics | Pyrimidines - pharmacology | Cyclin-Dependent Kinase 4 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Amplification | Receptors, Fibroblast Growth Factor - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Phenylurea Compounds - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Index Medicus
Journal Article
The Journal of Pathology, ISSN 0022-3417, 09/2007, Volume 213, Issue 1, pp. 82 - 90
Fibroblast growth factor receptors (FGFRs) mediate the tumourigenic effects of FGFs in prostate cancer. These receptors are therefore potential therapeutic... 
prostate cancer | tissue microarray | laser capture microdissection | fibroblast growth factor receptors | Laser capture microdissection | Tissue microarray | Prostate cancer | Fibroblast growth factor receptors | FACTOR FAMILY | ISOFORMS | FGF | SPECIFICITY | RESTORATION | PATHOLOGY | TUMORIGENICITY | ARG ALLELE | EPITHELIAL-CELLS | GENES | PROGRESSION | Immunohistochemistry | Prostatic Neoplasms - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Cell Proliferation | Microdissection | Oligonucleotide Array Sequence Analysis | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Male | Gene Expression Profiling | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Case-Control Studies | Receptors, Fibroblast Growth Factor - analysis | Prostatic Neoplasms - genetics | RNA Interference | Receptor, Fibroblast Growth Factor, Type 2 - analysis | Receptors, Fibroblast Growth Factor - genetics | Transcription, Genetic | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Receptor, Fibroblast Growth Factor, Type 1 - analysis | Receptor, Fibroblast Growth Factor, Type 3 - genetics | RNA, Small Interfering - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - analysis | Microscopy, Confocal | Receptors, Fibroblast Growth Factor - metabolism | Cell Line, Tumor | Polymorphism, Single Nucleotide | Receptor, Fibroblast Growth Factor, Type 3 - analysis | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Protein Isoforms - genetics | Index Medicus
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 09/2015, Volume 309, Issue 5, pp. L463 - L474
Pulmonary alveolar fibroblasts produce extracellular matrix in a temporally and spatially regulated pattern to yield a durable yet pliable gas-exchange... 
Adipocyte | PDGF receptor-α | Cell differentiation | Endosome | Fibroblast | cell differentiation | PHYSIOLOGY | LUNG DEVELOPMENT | PROLIFERATION | FACTOR RECEPTOR-ALPHA | UBIQUITINATION | MORPHOGENESIS | endosome | fibroblast | PDGF receptor-alpha | RESPIRATORY SYSTEM | adipocyte | FGF18 | DIFFERENTIATION | STROMAL CELLS | FGFR3 | ADIPOSE-TISSUE | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Cell Proliferation | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Extracellular Matrix - metabolism | Fibroblast Growth Factors - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Myofibroblasts - metabolism | Fibroblast Growth Factors - metabolism | Pulmonary Alveoli - metabolism | Pulmonary Alveoli - cytology | Cell Differentiation | Membrane Proteins - metabolism | Cyclin-Dependent Kinases | Fibroblast Growth Factor 10 - genetics | Fibroblast Growth Factor 10 - metabolism | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | RNA, Messenger - genetics | Mice, Transgenic | Myofibroblasts - cytology | Platelet-Derived Growth Factor - metabolism | Animals | Elastin - biosynthesis | Chaperonin 10 - genetics | Multivesicular Bodies - metabolism | Mice | Receptor, Fibroblast Growth Factor, Type 1 - biosynthesis | Physiological aspects | Fibroblasts | Fibroblast growth factors | Signal transduction | RNA-protein interactions | Rodents | Heat shock proteins | Protein expression | Physiology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14379 - 14384
FGF19 is a hormone that regulates bile acid and glucose homeostasis. Progress has been made in identifying cofactors for receptor activation. However, several... 
Adipose tissues | Molecules | Receptors | Phosphorylation | Bile acids | Liver | Homeostasis | Fibroblast growth factors | Heparin | Adipocytes | Diabetes | FGF21 | BETA-KLOTHO | SIGNAL | HOMEOSTASIS | SPECIFICITY | liver | MULTIDISCIPLINARY SCIENCES | RECEPTOR | FIBROBLAST-GROWTH-FACTOR | SUPPRESSION | DETERMINES | diabetes | FGF23 | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Transcriptional Activation | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Tissue Distribution | Adipose Tissue - metabolism | Fibroblast Growth Factors - metabolism | Membrane Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Cell Line | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Glucose Tolerance Test | Membrane Proteins - genetics | Liver - metabolism | Mice, Inbred C57BL | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Obesity - metabolism | Animals | Fibroblast Growth Factors - pharmacokinetics | Glucose - pharmacokinetics | Glucose - metabolism | Protein Binding | Mice, Obese | Mice | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Glucose metabolism | Hormone receptors | Research | Chemical properties | Signal transduction | Rodents | Glucose | Gene expression | Metabolism | Index Medicus | Biological Sciences
Journal Article
Cell Metabolism, ISSN 1550-4131, 2005, Volume 2, Issue 4, pp. 217 - 225
Journal Article
FEBS Journal, ISSN 1742-464X, 05/2016, Volume 283, Issue 9, pp. 1653 - 1668
Regeneration of skeletal muscles is required throughout life to ensure optimal performance. Therefore, a better understanding of the resident cells involved in... 
fibro/adipocytes | adipogenesis | FAP | FGF | fibroblast growth factor receptor | adipogenic differentiation | βKlotho | αKlotho | PiggyBac transposon | satellite cells | FAPs | FGF21 | PROGENITORS | CONNECTIVE-TISSUE FIBROBLASTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIBROBLAST-GROWTH-FACTOR | MYOGENIC CELLS | GENE | METABOLIC-ACTIVITY | alpha Klotho | DIFFERENTIATION | beta Klotho | ADIPOSE-TISSUE | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Adipocytes - cytology | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Adipogenesis - genetics | Fibroblasts - metabolism | Cell Line | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Satellite Cells, Skeletal Muscle - cytology | Gene Expression Regulation | Mice, Transgenic | Satellite Cells, Skeletal Muscle - metabolism | Lipid Droplets | Animals | Adipocytes - metabolism | Fibroblasts - cytology | Mice | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Index Medicus | Piggybac transposon | Fibro | Adipogenic differentiation | Satellite cells | adipocytes | Fibroblast growth factor receptors | Adipogenesis
Journal Article