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Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 06/2008, Volume 118, Issue 7, pp. 2609 - 2619
.... Gene expression analyses revealed that GR cells exhibited markedly reduced IGF-binding protein 3 (IGFBP-3) and IGFBP-4 RNA... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Insulin-Like Growth Factor Binding Protein 3 - genetics | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Gene Expression - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Insulin Receptor Substrate Proteins | Insulin-Like Growth Factor Binding Protein 4 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor II - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Quinazolines - pharmacology | Insulin-Like Growth Factor I - metabolism | Tyrosine | Phenols | Binding proteins | Analysis | Cancer cells | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 52, Issue 4, pp. 550 - 559
Background & Aims IGF signaling has a relevant role in a variety of human malignancies... 
Gastroenterology and Hepatology | IGF signaling | Hepatocellular carcinoma | A12 | Molecular therapy | miR-100 | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Hepatocytes - pathology | MicroRNAs - metabolism | Liver Neoplasms - therapy | Insulin Receptor Substrate Proteins - metabolism | Receptor, IGF Type 2 - metabolism | Receptor, IGF Type 2 - genetics | Insulin-Like Growth Factor II - genetics | Carcinoma, Hepatocellular - genetics | Insulin Receptor Substrate Proteins - genetics | Hepatocytes - physiology | Insulin-Like Growth Factor Binding Proteins - genetics | Liver Neoplasms - genetics | Antibodies, Monoclonal - pharmacology | Receptor, IGF Type 1 - genetics | Insulin-Like Growth Factor II - metabolism | Hep G2 Cells | Cell Division - physiology | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Liver Neoplasms - metabolism | Receptor, IGF Type 1 - immunology | Insulin-Like Growth Factor Binding Protein 3 | Signal Transduction - physiology | Carcinoma, Hepatocellular - therapy | Mice | Mice, Inbred BALB C | Apoptosis - physiology | Carcinoma, Hepatocellular - metabolism | Liver cancer | Analysis | Transplantation of organs, tissues, etc | Hepatoma | Hepatitis C | Vascular endothelial growth factor | Endothelium | Protein binding | Index Medicus | molecular therapy | hepatocellular carcinoma
Journal Article
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 03/2007, Volume 13, Issue 7, pp. 663 - 669
The insulin-like growth factor (IGF)-I is implicated in the regulation of protein turnover and exerts potent mitogenic and differentiating effects on most cell types... 
PI 3-kinase | IGF-I receptor | Akt | Insulin receptor | ERK | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Brain - metabolism | Receptor, IGF Type 1 - metabolism | Insulin-Secreting Cells - metabolism | Animals | Signal Transduction | Humans | Myocardium - metabolism | Muscle, Skeletal - metabolism | Insulin-Like Growth Factor I - metabolism
Journal Article
Clinical cancer research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2314 - 2327
Purpose: We previously reported an insulin-like growth factor (IGF) gene expression signature, based on genes induced or repressed by IGF-I, which correlated with poor prognosis in breast cancer... 
Life Sciences & Biomedicine | Oncology | Science & Technology | NIH 3T3 Cells | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, IGF Type 1 - antagonists & inhibitors | Receptors, Estrogen - metabolism | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Receptor, ErbB-2 - metabolism | Immunoblotting | Gene Expression Profiling | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Receptor, Insulin - genetics | Gene Expression Regulation, Neoplastic - drug effects | Pyrazoles - pharmacology | Triazines - pharmacology | Mice, SCID | Receptor, Insulin - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Receptor, IGF Type 1 - genetics | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Pyrazoles - administration & dosage | Animals | Breast Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Triazines - administration & dosage | Cell Line, Tumor | Mice, Inbred NOD | Receptor, Insulin - metabolism | Cell Proliferation - drug effects | Mice | Insulin-Like Growth Factor I - metabolism | Cluster Analysis | Index Medicus | IGF | triple-negative breast cancer | BMS-754807 | IGF-IR | small molecule inhibitor
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 35, pp. 29713 - 29721
Journal Article
PLoS biology, ISSN 1545-7885, 10/2008, Volume 6, Issue 10, pp. e254 - 2153
Journal Article