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Clinical Cancer Research, ISSN 1078-0432, 05/2014, Volume 20, Issue 10, pp. 2651 - 2662
Purpose: To investigate the autocrine/endocrine role of Id1-induced insulin-like growth factor-II (IGF-II) in esophageal cancer, and evaluate the potential of... 
ACTIVATION | METASTASIS | CDNA MICROARRAY | ONCOLOGY | SIGNALING PATHWAY | PROSTATE-CANCER | SQUAMOUS-CELL CARCINOMA | GENE-EXPRESSION | GROWTH-FACTOR-II | ID-1 | TUMORS | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Insulin-Like Growth Factor II - immunology | Esophageal Neoplasms - pathology | Antibodies, Neutralizing - immunology | Insulin-Like Growth Factor II - genetics | Lung Neoplasms - secondary | RNA Interference | Esophageal Neoplasms - metabolism | Endocrine System - metabolism | Antimetabolites, Antineoplastic - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Autocrine Communication | Antibodies, Monoclonal - pharmacology | Antibodies, Neutralizing - pharmacology | Inhibitor of Differentiation Protein 1 - metabolism | Receptor, IGF Type 1 - genetics | Blotting, Western | Insulin-Like Growth Factor II - metabolism | Xenograft Model Antitumor Assays | Animals | Lung Neoplasms - prevention & control | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Inhibitor of Differentiation Protein 1 - genetics | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Mice | Esophageal Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2609 - 2619
Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs), resistance invariably develops. We investigated mechanisms of acquired... 
BREAST-CANCER | GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | GROWTH-FACTOR-RECEPTOR | T790M MUTATIONS | IN-VIVO | TUMOR-CELLS | ANTITUMOR-ACTIVITY | GEFITINIB SENSITIVITY | ERLOTINIB | Insulin-Like Growth Factor Binding Protein 3 - genetics | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Gene Expression - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Insulin Receptor Substrate Proteins | Insulin-Like Growth Factor Binding Protein 4 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor II - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Quinazolines - pharmacology | Insulin-Like Growth Factor I - metabolism | Tyrosine | Phenols | Binding proteins | Analysis | Cancer cells | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2007, Volume 448, Issue 7157, pp. 1015 - 1021
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 52, Issue 4, pp. 550 - 559
Background & Aims IGF signaling has a relevant role in a variety of human malignancies. We analyzed the underlying molecular mechanisms of IGF signaling... 
Gastroenterology and Hepatology | IGF signaling | Hepatocellular carcinoma | A12 | Molecular therapy | miR-100 | SIGNALING PATHWAYS | RECEPTOR | MONOCLONAL-ANTIBODY | PROLIFERATION | FACTOR-II GENE | INSULIN | INHIBITION | GROWTH | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | MICRORNA | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Hepatocytes - pathology | MicroRNAs - metabolism | Liver Neoplasms - therapy | Insulin Receptor Substrate Proteins - metabolism | Receptor, IGF Type 2 - metabolism | Receptor, IGF Type 2 - genetics | Insulin-Like Growth Factor II - genetics | Carcinoma, Hepatocellular - genetics | Insulin Receptor Substrate Proteins - genetics | Hepatocytes - physiology | Insulin-Like Growth Factor Binding Proteins - genetics | Liver Neoplasms - genetics | Antibodies, Monoclonal - pharmacology | Receptor, IGF Type 1 - genetics | Insulin-Like Growth Factor II - metabolism | Hep G2 Cells | Cell Division - physiology | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Liver Neoplasms - metabolism | Receptor, IGF Type 1 - immunology | Insulin-Like Growth Factor Binding Protein 3 | Signal Transduction - physiology | Carcinoma, Hepatocellular - therapy | Mice | Mice, Inbred BALB C | Apoptosis - physiology | Carcinoma, Hepatocellular - metabolism | Liver cancer | Analysis | Transplantation of organs, tissues, etc | Hepatoma | Hepatitis C | Vascular endothelial growth factor | Endothelium | Protein binding | Index Medicus | molecular therapy | hepatocellular carcinoma
Journal Article
Cancer Cell, ISSN 1535-6108, 2004, Volume 5, Issue 3, pp. 231 - 239
Journal Article
Journal of Molecular Cell Biology, ISSN 1674-2788, 2013, Volume 5, Issue 1, pp. 3 - 13
Dysregulation of microRNAs is a common feature in human cancers, including breast cancer (BC). Here we describe the epigenetic regulation of miR-148a and... 
DNMT1 | IGF-IR | IRS1 | tumor angiogenesis | breast cancer | miR-152 | miR-148a | PROMOTER HYPERMETHYLATION | METHYLATION | RECEPTOR | HUMAN BREAST-CANCER | CELL BIOLOGY | DNA METHYLTRANSFERASE 1 | EARLY EVENT | EXPRESSION | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | MICRORNA | Receptor, IGF Type 1 - metabolism | Cell Proliferation | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Insulin Receptor Substrate Proteins - metabolism | Vascular Endothelial Growth Factor A - genetics | Breast Neoplasms - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA Methylation | Neoplasm Grading | Cell Transformation, Neoplastic - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Adult | Female | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Promoter Regions, Genetic | Signal Transduction | DNA (Cytosine-5-)-Methyltransferase 1 | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Receptor, IGF Type 1 - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Aged | MicroRNAs - genetics | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 3, pp. 1029 - 1040
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2314 - 2327
Purpose: We previously reported an insulin-like growth factor (IGF) gene expression signature, based on genes induced or repressed by IGF-I, which correlated... 
INSULIN | RECEPTOR MONOCLONAL-ANTIBODY | IN-VITRO | INHIBITION | ONCOLOGY | SUBTYPES | GROWTH | EXPRESSION | MAMMARY EPITHELIAL-CELLS | GENE-TRANSCRIPTION | BASAL | NIH 3T3 Cells | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, IGF Type 1 - antagonists & inhibitors | Receptors, Estrogen - metabolism | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Receptor, ErbB-2 - metabolism | Immunoblotting | Gene Expression Profiling | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Receptor, Insulin - genetics | Gene Expression Regulation, Neoplastic - drug effects | Pyrazoles - pharmacology | Triazines - pharmacology | Mice, SCID | Receptor, Insulin - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Receptor, IGF Type 1 - genetics | Xenograft Model Antitumor Assays | Taxoids - administration & dosage | Pyrazoles - administration & dosage | Animals | Breast Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Triazines - administration & dosage | Cell Line, Tumor | Mice, Inbred NOD | Receptor, Insulin - metabolism | Cell Proliferation - drug effects | Mice | Insulin-Like Growth Factor I - metabolism | Cluster Analysis | Index Medicus | IGF | triple-negative breast cancer | BMS-754807 | IGF-IR | small molecule inhibitor
Journal Article