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Journal of Hepatology, ISSN 0168-8278, 2010, Volume 52, Issue 4, pp. 550 - 559
Background & Aims IGF signaling has a relevant role in a variety of human malignancies. We analyzed the underlying molecular mechanisms of IGF signaling... 
Gastroenterology and Hepatology | IGF signaling | Hepatocellular carcinoma | A12 | Molecular therapy | miR-100 | SIGNALING PATHWAYS | RECEPTOR | MONOCLONAL-ANTIBODY | PROLIFERATION | FACTOR-II GENE | INSULIN | INHIBITION | GROWTH | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | MICRORNA | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Hepatocytes - pathology | MicroRNAs - metabolism | Liver Neoplasms - therapy | Insulin Receptor Substrate Proteins - metabolism | Receptor, IGF Type 2 - metabolism | Receptor, IGF Type 2 - genetics | Insulin-Like Growth Factor II - genetics | Carcinoma, Hepatocellular - genetics | Insulin Receptor Substrate Proteins - genetics | Hepatocytes - physiology | Insulin-Like Growth Factor Binding Proteins - genetics | Liver Neoplasms - genetics | Antibodies, Monoclonal - pharmacology | Receptor, IGF Type 1 - genetics | Insulin-Like Growth Factor II - metabolism | Hep G2 Cells | Cell Division - physiology | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Liver Neoplasms - metabolism | Receptor, IGF Type 1 - immunology | Insulin-Like Growth Factor Binding Protein 3 | Signal Transduction - physiology | Carcinoma, Hepatocellular - therapy | Mice | Mice, Inbred BALB C | Apoptosis - physiology | Carcinoma, Hepatocellular - metabolism | Liver cancer | Analysis | Transplantation of organs, tissues, etc | Hepatoma | Hepatitis C | Vascular endothelial growth factor | Endothelium | Protein binding | molecular therapy | hepatocellular carcinoma
Journal Article
Development, ISSN 0950-1991, 05/2011, Volume 138, Issue 9, pp. 1795 - 1805
Journal Article
Journal Article
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 02/2018, Volume 233, Issue 2, pp. 979 - 989
These results suggest that HSF1 phosphorylation stabilizes IGF‐IIR protein stability by downregulating RNF126 during cardiac hypertrophy. 
RNF126 | cardiac hypertrophy | hypertension | HSF1 | IGF‐IIR | IGF-IIR | HEAT-SHOCK FACTOR-1 | APOPTOSIS | G-ALPHA-Q | TRANSCRIPTIONAL ACTIVATION | PHYSIOLOGY | RECEPTOR | GROWTH-FACTOR-II | FAILURE | CELL BIOLOGY | REPRESSION | MICE | CARDIOPROTECTION | Antihypertensive Agents - pharmacology | Heat Shock Transcription Factors - metabolism | Phosphorylation | Tetrazoles - pharmacology | Cardiomegaly - etiology | Rats, Inbred WKY | Cardiomegaly - pathology | Hypertension - drug therapy | Extracellular Signal-Regulated MAP Kinases - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Receptor, IGF Type 2 - metabolism | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Biphenyl Compounds - pharmacology | Time Factors | Lithium Chloride - pharmacology | Female | Hypertension - enzymology | Protein Stability | Disease Models, Animal | Rats, Inbred SHR | Cell Line | Angiotensin II - pharmacology | Signal Transduction | Heat-Shock Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Cardiomegaly - enzymology | Glycogen Synthase Kinase 3 beta - metabolism | Hypertension - pathology | Protein Transport | Myocytes, Cardiac - pathology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Receptor, Angiotensin, Type 1 - metabolism | Hypertension - complications | Apoptosis | Hypertension | Ubiquitin | Heart | Synthesis | Glycogen | Angiotensin | Hypertrophy | Stability | Extracellular signal-regulated kinase | Glycogen synthase kinase 3 | Cardiomyocytes | Insulin-like growth factors | Kinases | Insulin | Coronary artery disease | Proteins | Signaling | Inhibition | Insulin-like growth factor II | HSF1 protein | Angiotensin II | Heart diseases | Ubiquitin-protein ligase | Index Medicus
Journal Article
The Journal of Physiology, ISSN 0022-3751, 10/2011, Volume 589, Issue 19, pp. 4709 - 4722
Non‐Technical Summary  Cardiovascular disease is responsible for 30% of deaths worldwide and epidemiological data demonstrate that poor growth before birth is... 
PLACENTAL GROWTH | ADULT DISEASE | HYPERTROPHY | IGF-I | PHYSIOLOGY | FACTOR-II | MESSENGER-RNA | SHEEP FETUS | LATE-GESTATION | GENE-EXPRESSION | NEUROSCIENCES | BLOOD-PRESSURE | Receptor, IGF Type 1 - metabolism | Gene Expression - genetics | Heart - embryology | Fetus - metabolism | Heart Ventricles - embryology | Fetal Growth Retardation - genetics | Insulin-Like Growth Factor I - genetics | RNA, Messenger - metabolism | Receptor, IGF Type 2 - metabolism | Receptor, IGF Type 2 - genetics | DNA Methylation | Insulin-Like Growth Factor II - genetics | Myocardium - metabolism | Insulin-Like Growth Factor II - biosynthesis | Signal Transduction | Heart - growth & development | RNA, Messenger - genetics | Fetal Growth Retardation - metabolism | Receptor, IGF Type 1 - genetics | Insulin-Like Growth Factor II - metabolism | Animals | Heart Ventricles - growth & development | Fetus - embryology | Myocytes, Cardiac - metabolism | Sheep | Heart Ventricles - metabolism | Cardiomegaly - genetics | Insulin-Like Growth Factor I - metabolism | Cardiomegaly - metabolism | Messenger RNA | Genetic research | Physiological aspects | Glucose | Gene expression | Methylation | Coronary heart disease | Dextrose | Heart | Rodents | Fetuses | DNA methylation | Cardiovascular disease | Insulin-like growth factors | Birth weight | Insulin | Cardiovascular
Journal Article
Journal Article