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Nature genetics, ISSN 1546-1718, 2003, Volume 33, Issue 3, pp. 388 - 391
Journal Article
Circulation research, ISSN 1524-4571, 2014, Volume 114, Issue 4, pp. 677 - 688
RATIONALE:Evidence is increasing of a link between interferon (IFN) and pulmonary arterial hypertension (PAH... 
SURVIVAL | systemic | LUNG | CARDIAC & CARDIOVASCULAR SYSTEMS | chemokine CXCL10 | VIRUS | scleroderma | CHRONIC HEPATITIS-C | ALPHA | RECEPTOR | IFNAR1 subunit | SYSTEMIC-SCLEROSIS | interferon alpha-beta receptor | inflammation | interferon type I | ENDOTHELIAL-CELLS | DISEASE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | endothelin-1 | HEMATOLOGY | pulmonary arterial hypertension | Interferon-alpha - pharmacology | Interferon-beta - immunology | Humans | Male | Lung - cytology | Signal Transduction - immunology | Chemokine CXCL10 - immunology | Receptor, Interferon alpha-beta - genetics | Organ Culture Techniques | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Interferon-alpha - metabolism | Endothelin-1 - metabolism | Mice, Inbred C57BL | Scleroderma, Systemic - metabolism | Cells, Cultured | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary - immunology | Hypertension, Pulmonary - metabolism | Scleroderma, Systemic - immunology | Interferon-alpha - immunology | Mice, Knockout | Endothelial Cells - immunology | Endothelin-1 - immunology | Animals | Interferon-beta - metabolism | Interferon-beta - pharmacology | Receptor, Interferon alpha-beta - immunology | Endothelial Cells - cytology | Interferon-gamma - immunology | Mice | Chemokine CXCL10 - metabolism | Interferon-gamma - pharmacology | scleroderma, systemic | IFNAR1 subunit, interferon alpha-beta receptor
Journal Article
Journal of virology, ISSN 1098-5514, 2012, Volume 86, Issue 18, pp. 9888 - 9898
.... Mortality was associated with undetectable levels of alpha/beta interferon (IFN-α/β) in serum, ∼50- and ∼10-fold increases in levels of IFN... 
ANTIBODY-DEPENDENT ENHANCEMENT | VIROLOGY | IFN-ALPHA-BETA | DENDRITIC CELLS | INNATE IMMUNE-RESPONSES | NONHEMATOPOIETIC CELLS | SIGNALING PATHWAY | POSITIVE FEEDBACK | DENGUE VIRUS | HUMAN KERATINOCYTES | VIRAL-INFECTION | Interferon-alpha - pharmacology | Shock, Hemorrhagic - prevention & control | Humans | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Receptor, Interferon alpha-beta - physiology | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Host-Pathogen Interactions - immunology | Alphavirus Infections - prevention & control | Interferon Regulatory Factor-7 - physiology | Chikungunya virus - physiology | Receptor, Interferon alpha-beta - genetics | Chikungunya virus - pathogenicity | Chikungunya Fever | Virus Replication - drug effects | Adaptor Proteins, Vesicular Transport - physiology | Interferon-alpha - biosynthesis | Receptor, Interferon alpha-beta - deficiency | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Interferon-beta - biosynthesis | Alphavirus Infections - immunology | Chikungunya virus - immunology | Alphavirus Infections - pathology | Interferon Regulatory Factor-3 - physiology | Mice, Knockout | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Host-Pathogen Interactions - genetics | Interferon Regulatory Factor-7 - deficiency | Myeloid Differentiation Factor 88 - physiology | Mice | Shock, Hemorrhagic - immunology | Life Sciences | Santé publique et épidémiologie | Pathogenesis and Immunity
Journal Article
The Journal of infectious diseases, ISSN 1537-6613, 2013, Volume 207, Issue 12, pp. 1909 - 1921
.... Here, we closely followed infection and disease progression in CCHFV-infected interferon α/β receptor knockout (IFNAR... 
Pathology | Disease models | Interleukins | Tissue samples | Crimean Congo hemorrhagic fever virus | Viral diseases | Viruses | Infections | Platelets | Dosage | pathology | coagulopathy | proinflammatory response | thrombocytopenia | CCHFV | interferon α/β receptor knockout mice | CELLS | INFECTIOUS DISEASES | PREDICTOR | MICROBIOLOGY | MODEL | IMMUNOLOGY | PATHOGENESIS | TRANSMISSION | REPLICATION | DISSEMINATED INTRAVASCULAR COAGULATION | beta receptor knockout mice | CCHF VIRUS | AFRICAN | interferon alpha | Liver - virology | Spleen - virology | Liver - pathology | Viremia | Hemorrhagic Fever, Crimean - complications | Humans | Liver Failure, Acute - virology | Viral Load | Blood Coagulation Disorders - virology | Hemorrhagic Fever, Crimean - immunology | Receptor, Interferon alpha-beta - genetics | Spleen - pathology | Disease Models, Animal | Hemorrhagic Fever Virus, Crimean-Congo - physiology | Cytokines - metabolism | Lymphoid Tissue - virology | Mice, Inbred C57BL | Thrombocytopenia - immunology | Hemorrhagic Fever Virus, Crimean-Congo - immunology | Thrombocytopenia - pathology | Thrombocytopenia - virology | Disease Progression | Mice, Knockout | Lymphoid Tissue - pathology | Animals | Hemorrhagic Fever, Crimean - pathology | Blood Coagulation Disorders - pathology | Receptor, Interferon alpha-beta - immunology | Blood Coagulation Disorders - immunology | Liver Failure, Acute - immunology | Liver Failure, Acute - pathology | Chemokines - metabolism | Mice | Major and Brief Reports | β receptor knockout mice | interferon α
Journal Article
PLoS pathogens, ISSN 1553-7374, 2014, Volume 10, Issue 4, p. e1003989
...) and IRF7, and the positive feedback loop mediated by IFNAR1 (IFN alpha/beta receptor 1), are required for the induction... 
DOUBLE-STRANDED-RNA | CYCLIC GMP-AMP | KAPPA-B KINASE | COMPLEX CLASS-II | DEPENDENT PROTEIN-KINASE | MICROBIOLOGY | ANTIGEN PRESENTATION | INTERFERON INDUCTION | INTRACELLULAR DNA | VIROLOGY | TOLL-LIKE RECEPTORS | INNATE IMMUNE SENSOR | PARASITOLOGY | Dendritic Cells - immunology | Lysosomes - genetics | Immunity, Innate - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Endosomes - metabolism | Bone Marrow Cells - virology | Phosphorylation - genetics | Bone Marrow Cells - immunology | Interferon-beta - genetics | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Nucleotidyltransferases - metabolism | Vaccinia - metabolism | Protein-Serine-Threonine Kinases - metabolism | Receptor, Interferon alpha-beta - metabolism | Endosomes - genetics | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | Viral Proteins - genetics | Mice, Knockout | Interferon-beta - metabolism | Receptor, Interferon alpha-beta - immunology | Vaccinia - immunology | Virulence Factors - metabolism | Mice | Lysosomes - immunology | RNA-Binding Proteins - metabolism | Endosomes - immunology | RNA-Binding Proteins - genetics | Interferon-beta - immunology | Virulence Factors - genetics | Viral Proteins - immunology | Virulence Factors - immunology | Interferon Regulatory Factor-3 - genetics | Vaccinia virus - immunology | Lysosomes - metabolism | Female | Membrane Proteins - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Interferon Regulatory Factor-3 - immunology | Vaccinia virus - metabolism | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | Vaccinia - genetics | Animals | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein-Serine-Threonine Kinases - immunology | Nucleotidyltransferases - immunology | Bone Marrow Cells - metabolism | Microbiological research | Dendritic cells | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Vaccinia | Health aspects | DNA sequencing | Proteins | Studies | Smallpox | Transcription factors | Genes | Deoxyribonucleic acid | DNA | Infections | Genomes | Vaccines | Viral infections | Immune system
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2013, Volume 340, Issue 6129, pp. 202 - 207
Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease progression in persistent infections... 
T lymphocytes | Isotypes | Lymphocytic choriomeningitis virus | Genes | REPORTS | Blocking antibodies | Antivirals | Antibodies | Viruses | Infections | Immunity | GAMMA | MULTIDISCIPLINARY SCIENCES | CHRONIC HEPATITIS-C | INTERLEUKIN-10 RECEPTOR | HUMAN-IMMUNODEFICIENCY-VIRUS | CHRONIC VIRAL-INFECTION | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | EXPRESSION | T-CELLS | IL-10 | PROGRESSION | Lymphocytic choriomeningitis virus - immunology | Arenaviridae Infections - virology | Oligonucleotide Array Sequence Analysis | Dendritic Cells - immunology | Gene Expression Profiling | Interferon-gamma - metabolism | Interferon Type I - immunology | Receptor, Interferon alpha-beta - antagonists & inhibitors | CD4-Positive T-Lymphocytes - immunology | Antibodies - immunology | Interferon Type I - metabolism | Interleukin-10 - metabolism | Lymphocytic choriomeningitis virus - physiology | Receptor, Interferon alpha-beta - genetics | Arenaviridae Infections - immunology | Cytokines - immunology | Receptor, Interferon alpha-beta - metabolism | Cytokines - metabolism | Signal Transduction | Immune Tolerance | B7-H1 Antigen - metabolism | Animals | Virus Replication | Interferon-gamma - immunology | Interferon Type I - genetics | Mice | Signal transduction | Interferon | Viral infections | Immune system | Chronic illnesses | Human | HIV | Organs | Blocking | Hepatitis C virus
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 02/2002, Volume 195, Issue 4, pp. 517 - 528
Journal Article
Journal of Virology, ISSN 0022-538X, 08/2002, Volume 76, Issue 16, pp. 7949 - 7955
Journal Article