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Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2014, Volume 394, Issue 1-2, pp. 99 - 104
Cushing’s disease, a hypercortisolemic state induced by an ACTH overexpressing pituitary adenoma, causes increased morbidity and mortality. Selective... 
Antagonist | Adrenocorticotropic hormone (ACTH) | Melanocortin 2 receptor (MC2R) | Cushing’s disease | ACTIVATION | ANALOGS | MEDICAL-TREATMENT | PEPTIDE | CELL BIOLOGY | CUSHINGS-SYNDROME | Cushing's disease | ADRENOCORTICOTROPIN RECEPTOR | DISEASE | ENDOCRINOLOGY & METABOLISM | CONSENSUS STATEMENT | BINDING | RESIDUES | Receptor, Melanocortin, Type 3 - genetics | Humans | Adrenocorticotropic Hormone - pharmacology | Molecular Sequence Data | Receptor, Melanocortin, Type 3 - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Structure-Activity Relationship | Receptor, Melanocortin, Type 1 - metabolism | Adrenocorticotropic Hormone - genetics | Pituitary ACTH Hypersecretion - drug therapy | Receptor, Melanocortin, Type 2 - metabolism | Dose-Response Relationship, Drug | Receptor, Melanocortin, Type 2 - genetics | Peptides - chemical synthesis | Transfection | Receptor, Melanocortin, Type 1 - chemistry | Receptors, Melanocortin - metabolism | Drug Design | HEK293 Cells | Receptor, Melanocortin, Type 2 - chemistry | Receptor, Melanocortin, Type 2 - antagonists & inhibitors | Receptor, Melanocortin, Type 3 - chemistry | Adrenocorticotropic Hormone - metabolism | Amino Acid Sequence | Gene Expression | Receptor, Melanocortin, Type 4 - chemistry | Receptor, Melanocortin, Type 1 - genetics | Receptor, Melanocortin, Type 4 - genetics | Receptors, Melanocortin - genetics | Peptides - pharmacology | Receptors, Melanocortin - chemistry | Protein Binding | Peptides
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 4/2017, Volume 74, Issue 7, pp. 1335 - 1345
The efficiency of drug research and development has paradoxically declined over the last decades despite major scientific and technological advances, promoting... 
Life Sciences | Biomedicine, general | Biochemistry, general | Life Sciences, general | Resolution of inflammation | Drug repositioning | GPCR | Inflammation | Arthritis | Cell Biology | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | APOPTOTIC RESPONSES | INFLAMMATORY ARTHRITIS | DISCOVERY | CELL BIOLOGY | PRORESOLVING PROPERTIES | PEPTIDES | MELANOCYTE-STIMULATING HORMONE | GOUTY-ARTHRITIS | TYPE-3 RECEPTOR | ADRENOCORTICOTROPIC HORMONE | Cricetulus | Receptor, Melanocortin, Type 3 - genetics | Receptor, Melanocortin, Type 3 - deficiency | Receptor, Melanocortin, Type 3 - metabolism | Male | Fenoprofen - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Fenoprofen - therapeutic use | Peritonitis - pathology | Prostaglandin-Endoperoxide Synthases - chemistry | Arthritis - etiology | Joints - metabolism | Macrophages - immunology | Receptor, Melanocortin, Type 3 - chemistry | CHO Cells | Disease Models, Animal | Allosteric Regulation - drug effects | Cricetinae | Phagocytosis - drug effects | Mice, Inbred C57BL | Melanocortins - analysis | Joints - pathology | Peritonitis - chemically induced | Drug Repositioning | Macrophages - cytology | Mice, Knockout | Macrophages - metabolism | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Prostaglandin-Endoperoxide Synthases - metabolism | Arthritis - drug therapy | Mice | Peritonitis - drug therapy | Drugs | Career development | Medical colleges | Anti-inflammatory drugs | Analysis | Therapeutics | Research institutes | Macrophages | Homeopathy | Materia medica and therapeutics | Pharmacology | Nonsteroidal anti-inflammatory drugs | Cellular biology | Original
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2005, Volume 326, Issue 2, pp. 349 - 354
Journal Article
Biochemistry, ISSN 0006-2960, 10/2009, Volume 48, Issue 41, pp. 9775 - 9784
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 01/2005, Volume 67, Issue 1, pp. 50 - 59
Journal Article
Regulatory Peptides, ISSN 0167-0115, 2007, Volume 142, Issue 3, pp. 111 - 122
Journal Article
Journal Article
Obesity Facts, ISSN 1662-4025, 04/2009, Volume 2, Issue 2, pp. 80 - 86
Background: Melanocortin 3 and 4 receptors (MC3R and MC4R) are known to play an essential role in hypothalamic weight regulation. In addition to these two... 
Original Article | GPCR | Weight regulation | Hypothalamus | Paraventricular nucleus | Dimerization | Arcuate nucleus | GABA(B) RECEPTORS | ONSET OBESITY | CROSS-TALK | MC4R | TARGETED DISRUPTION | NUTRITION & DIETETICS | ENDOCRINOLOGY & METABOLISM | NEURONS | FRAMESHIFT MUTATION | OLIGOMERIZATION | MELANOCORTIN-4 RECEPTOR | Receptors, G-Protein-Coupled - metabolism | Receptor, Melanocortin, Type 3 - genetics | Humans | Cercopithecus aethiops | Receptor, Melanocortin, Type 3 - metabolism | Receptors, Neuropeptide Y - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Receptors, Neuropeptide - metabolism | Receptors, Peptide - chemistry | Obesity - genetics | Receptors, Peptide - genetics | Transfection | Gene Expression - physiology | Receptor, Serotonin, 5-HT1B - genetics | Fluorescence Resonance Energy Transfer | Receptor, Cannabinoid, CB1 - chemistry | Receptor, Serotonin, 5-HT1B - metabolism | Receptors, Cell Surface - chemistry | Receptor, Melanocortin, Type 3 - chemistry | Receptors, Opioid, mu - chemistry | Enzyme-Linked Immunosorbent Assay | Receptor, Melanocortin, Type 4 - chemistry | Receptors, Opioid, mu - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Receptors, Cell Surface - metabolism | Receptors, Neuropeptide - genetics | Obesity - physiopathology | Kidney - cytology | Receptor, Melanocortin, Type 4 - genetics | Obesity - metabolism | Receptors, Neuropeptide Y - chemistry | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Receptors, Neuropeptide Y - genetics | Paraventricular Hypothalamic Nucleus - metabolism | Receptor, Serotonin, 5-HT1B - chemistry | Receptors, G-Protein-Coupled - genetics | Receptors, Opioid, mu - genetics | Body Weight - physiology | COS Cells | Receptors, G-Protein-Coupled - chemistry | Receptors, Neuropeptide - chemistry | Receptors, Cell Surface - genetics | Receptors, Peptide - metabolism | Original
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 9, pp. 2492 - 2498
Journal Article