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PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, pp. e0172000 - e0172000
Obesity is often associated with dyslipidemia and hepatosteatosis. A number of animal models of non-alcoholic fatty liver disease (NAFLD) are established but... 
PATHOGENESIS | NAFLD | DIET | FATTY LIVER-DISEASE | MULTIDISCIPLINARY SCIENCES | RATS | HUMAN OBESITY | NONALCOHOLIC STEATOHEPATITIS | DEFICIENT MICE | MUTATIONS | MOUSE MODELS | Receptor, Melanocortin, Type 4 - deficiency | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Diet, High-Fat - adverse effects | Non-alcoholic Fatty Liver Disease - etiology | Male | Gene Expression Profiling | Hypercholesterolemia - pathology | Lipogenesis - genetics | Receptors, LDL - deficiency | Female | Disease Models, Animal | Receptors, LDL - genetics | Obesity - complications | Liver - metabolism | Mice, Inbred C57BL | Lipid Metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Receptor, Melanocortin, Type 4 - genetics | Mutation - genetics | Mice, Knockout | Animals | Hypercholesterolemia - etiology | High-Throughput Nucleotide Sequencing | Mice | Hypercholesterolemia - metabolism | Obesity | Low density lipoproteins | Physiological aspects | Genetic aspects | Lipid metabolism | Research | Risk factors | Pediatrics | Pathogenesis | Liver | Dyslipidemia | Childrens health | Biochemistry | Health physics | Arachidonic acid | Gene sequencing | Magnetic resonance spectroscopy | Teenagers | Genetic modification | Liver diseases | Mass spectroscopy | Gene expression | Metabolism | Fatty acids | Children & youth | Nutrition research | Hospitals | Diet | Receptor density | Mutation | NMR spectroscopy | Mass spectrometry | Endocrinology | Animal models | Lipid composition | Nuclear magnetic resonance--NMR | Lipids | Biosynthesis | Metabolic syndrome | Fatty liver | Pathways | Rodents | Atherosclerosis | Lipoprotein (low density) receptors | Hyperphagia | Genotypes | Melanocortin | Data processing | Biophysics | Ribonucleic acid--RNA | Physics | Signaling | Womens health | Index Medicus | RNA | Nuclear magnetic resonance | Ribonucleic acid | NMR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 9, pp. 4471 - 4476
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0167888 - e0167888
Dysfunction of the melanocortin system can result in severe obesity accompanied with dyslipidemia and symptoms of the metabolic syndrome but the effect on... 
BRACHIOCEPHALIC ARTERY | LEPTIN | AORTIC ROOT | MULTIDISCIPLINARY SCIENCES | LIVER | HUMAN OBESITY | NONALCOHOLIC STEATOHEPATITIS | FRAMESHIFT MUTATION | KNOCKOUT MICE | E-DEFICIENT MICE | MOUSE MODELS | Receptor, Melanocortin, Type 4 - deficiency | Receptors, LDL - genetics | Bile Acids and Salts - biosynthesis | Body Size - drug effects | Atherosclerosis - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Body Weight - drug effects | Atherosclerosis - complications | Receptor, Melanocortin, Type 4 - genetics | RNA, Messenger - metabolism | Atherosclerosis - metabolism | Non-alcoholic Fatty Liver Disease - complications | Animals | Diet | Receptors, LDL - deficiency | Cholesterol - pharmacology | Hypercholesterolemia - complications | Mice | Hypercholesterolemia - genetics | Mutation | Cholesterol - biosynthesis | Hypercholesterolemia - metabolism | RNA sequencing | Genetically modified mice | Complications and side effects | Obesity | Atherosclerosis | Metabolic diseases | Research | Risk factors | Lipoproteins (low density) | Atherogenesis | Liver | Body weight | Dyslipidemia | Biosynthesis | Gene sequencing | Fatty liver | Rodents | Aorta | Lipoprotein (low density) receptors | Hyperphagia | Cardiovascular system | Melanocortin | Ribonucleic acid--RNA | Cholesterol | Lipoproteins (very low density) | Steatosis | Hypercholesterolemia | Food intake | Arteriosclerosis | Insulin resistance | Receptor density | Metabolic disorders | Bile | Index Medicus | RNA | Ribonucleic acid
Journal Article
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2014, Volume 394, Issue 1-2, pp. 99 - 104
Cushing’s disease, a hypercortisolemic state induced by an ACTH overexpressing pituitary adenoma, causes increased morbidity and mortality. Selective... 
Antagonist | Adrenocorticotropic hormone (ACTH) | Melanocortin 2 receptor (MC2R) | Cushing’s disease | ACTIVATION | ANALOGS | MEDICAL-TREATMENT | PEPTIDE | CELL BIOLOGY | CUSHINGS-SYNDROME | Cushing's disease | ADRENOCORTICOTROPIN RECEPTOR | DISEASE | ENDOCRINOLOGY & METABOLISM | CONSENSUS STATEMENT | BINDING | RESIDUES | Receptor, Melanocortin, Type 3 - genetics | Humans | Adrenocorticotropic Hormone - pharmacology | Molecular Sequence Data | Receptor, Melanocortin, Type 3 - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Structure-Activity Relationship | Receptor, Melanocortin, Type 1 - metabolism | Adrenocorticotropic Hormone - genetics | Pituitary ACTH Hypersecretion - drug therapy | Receptor, Melanocortin, Type 2 - metabolism | Dose-Response Relationship, Drug | Receptor, Melanocortin, Type 2 - genetics | Peptides - chemical synthesis | Transfection | Receptor, Melanocortin, Type 1 - chemistry | Receptors, Melanocortin - metabolism | Drug Design | HEK293 Cells | Receptor, Melanocortin, Type 2 - chemistry | Receptor, Melanocortin, Type 2 - antagonists & inhibitors | Receptor, Melanocortin, Type 3 - chemistry | Adrenocorticotropic Hormone - metabolism | Amino Acid Sequence | Gene Expression | Receptor, Melanocortin, Type 4 - chemistry | Receptor, Melanocortin, Type 1 - genetics | Receptor, Melanocortin, Type 4 - genetics | Receptors, Melanocortin - genetics | Peptides - pharmacology | Receptors, Melanocortin - chemistry | Protein Binding | Peptides | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 2014, Volume 17, Issue 7, pp. 911 - 913
Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy... 
RESPONSES | GLUCOSE-HOMEOSTASIS | OBESITY | ACTIVATION | CIRCUITRY | ADAPTIVE THERMOGENESIS | HUMANS | MICE | BROWN ADIPOSE-TISSUE | NEUROSCIENCES | Adipose tissues | Physiological aspects | Glucose metabolism | Research | Neurons | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 08/2014, Volume 20, Issue 2, pp. 333 - 345
The melanocortin system regulates metabolic homeostasis and inflammation. Melanocortin agonists have contradictorily been reported to both increase and... 
ALPHA-MSH | NERVOUS-SYSTEM | INDUCED HYPOTHERMIA | MELANOCYTE-STIMULATING HORMONE | ENERGY HOMEOSTASIS | FOOD-INTAKE | CARDIOVASCULAR FUNCTION | ENDOCRINOLOGY & METABOLISM |