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Journal of Molecular Neuroscience, ISSN 0895-8696, 2003, Volume 20, Issue 3, pp. 349 - 356
Journal Article
Journal of Bionanoscience, ISSN 1557-7910, 02/2018, Volume 12, Issue 1, pp. 119 - 126
In the present study, Quantitative structure-activity relationship (QSAR) study have been performed on twenty molecules of 1,2,5-thiadiazole derivatives. The... 
1,2,5-Thiadiazole Derivatives | Muscarinic Agonists | MLR | QSAR | Thiadiazoles | Mathematical models | Derivatives | Acetylcholine receptors (muscarinic) | Structure-activity relationships | Biological activity
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2019, Volume 843, pp. 104 - 112
Muscarinic receptor stimulation induces depolarizing inward currents and catecholamine secretion in adrenal medullary (AM) cells from various mammals. In... 
Nonselective cation channels | TASK1 channel | Muscarinic M1 receptor | Knockout | Adrenal medullary cells | Muscarinic M | receptor
Journal Article
Neuroscience, ISSN 0306-4522, 08/2019, Volume 414, pp. 60 - 76
Activation of the M muscarinic acetylcholine receptor (M R) may be an effective therapeutic approach for Alzheimer's disease (AD), dementia with Lewy bodies,... 
donepezil | c-Fos | M1 muscarinic acetylcholine receptor | xanomeline | TAK-071
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 02/2009, Volume 75, Issue 2, pp. 331 - 341
Journal Article
International Journal of Neuropsychopharmacology, ISSN 1461-1457, 05/2013, Volume 16, Issue 4, pp. 717 - 720
  Muscarinic receptors as drug targets Due to their potential roles in the pathophysiologies of a number of central nervous system disorders such as depression... 
Receptor, Muscarinic M1 - agonists | Humans | Memory, Episodic | Male | Behavior, Addictive - psychology | Smoking Cessation - psychology | Benzimidazoles - therapeutic use | Cognition Disorders - psychology | Cognition & reasoning | Rodents | Schizophrenia | Ligands | Alzheimers disease | Drug dosages | Nicotine
Journal Article
Journal of Molecular Neuroscience, ISSN 0895-8696, 08/2002, Volume 19, Issue 1-2, pp. 145 - 153
The M-1 muscarinic agonists AF102B (Cevimeline, EVOXACTM: prescribed in USA and Japan for Sjogren's Syndrome), AF150(S) and AF267B-1) are neurotrophic and... 
Agonist | Memory | AF102B | AF150(S) | AF267B | Amyloid precursor protein | muscarinic | Tau protein | Cell death | Aged microcebes | Neurotrophic | β-amyloid | Alzheimer's | Apoptosis | ACTIVATION | memory | RECEPTOR AGONISTS | apoptosis | MICROCEBUS-MURINUS | CEREBROSPINAL-FLUID | TAU-PHOSPHORYLATION | beta-amyloid | amyloid precursor protein | BETA-PROTEIN | neurotrophic | CELLS | cell death | BIOCHEMISTRY & MOLECULAR BIOLOGY | agonist | aged microcebes | NEUROSCIENCES | CEREBRAL-CORTEX | M-1 muscarinic | SECRETION | tau protein | Water | Spinal Cord - drug effects | Spinal Cord - metabolism | Apoptosis - drug effects | Muscarinic Agonists - pharmacology | Muscarinic Agonists - therapeutic use | Amyloid beta-Peptides - drug effects | tau Proteins - metabolism | Receptors, Muscarinic - metabolism | Spiro Compounds - therapeutic use | Hippocampus - drug effects | Thiazoles - therapeutic use | PC12 Cells | Cerebral Cortex - metabolism | Receptors, Muscarinic - drug effects | Piperidines - pharmacology | Amyloid beta-Peptides - metabolism | Models, Animal | Cell Death - drug effects | Cerebral Cortex - drug effects | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Nerve Growth Factor - metabolism | Alzheimer Disease - drug therapy | Rats | Epidermal Growth Factor - metabolism | Cognition - drug effects | Maze Learning - drug effects | Receptor, Muscarinic M1 | Hippocampus - metabolism | Animals | Piperidines - therapeutic use | Alzheimer Disease - metabolism | Mice | Thiazoles - pharmacology | Oxidative Stress - drug effects | Spiro Compounds - pharmacology | Drug therapy | Alzheimer's disease | Amyloid beta-protein | Care and treatment | Research | Health aspects | Agonists (Biochemistry) | Alzheimers disease | Rodents
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 2, pp. 560 - 576
Aiming to design partial agonists for a G-protein-coupled receptor based on dynamic ligand binding, we synthesized three different series of bipharmacophoric... 
Receptor, Muscarinic M1 - agonists | Animals | Cricetulus | Muscarinic Agonists - pharmacology | Drug Design | Structure-Activity Relationship | CHO Cells | Muscarinic Agonists - chemical synthesis
Journal Article
Journal Article