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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2008, Volume 327, Issue 3, pp. 941 - 953
Previous clinical and animal studies suggest that selective activators of M(1) and/or M(4) muscarinic acetylcholine receptors (mAChRs) have potential as novel... 
Animals | Dopamine | Mesencephalon | Acetylcholine - pharmacology | Allosteric Regulation | Motor Activity - drug effects | Rats | Thiophenes - pharmacology | Pyridines - pharmacology | Receptor, Muscarinic M4 - agonists
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 2014, Volume 39, Issue 7, pp. 1578 - 1593
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2019, Volume 10, Issue 6, pp. 941 - 948
It has been hypothesized that selective muscarinic acetylcholine receptor (mAChR) M4 subtype activation could provide therapeutic benefits to a number of... 
carbamate isosteres | M4 mAChR | selective mAChR agonist | ensemble docking | electrostatic potential isosurface | Muscarinic acetylcholine receptor | CHEMISTRY, MEDICINAL | XANOMELINE | ALLOSTERIC MODULATION | MODEL | M-1 | POTENT | DERIVATIVES
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2015, Volume 25, Issue 22, pp. 5357 - 5361
We designed and synthesized a series of dihydroquinazolinone derivatives as selective M and M muscarinic acetylcholine receptors agonists. Introduction of the... 
Dihydroquinazolinone derivatives | M1 muscarinic acetylcholine receptor | M4 muscarinic acetylcholine receptor | Partial agonist | Antipsychotic agent | Muscarinic acetylcholine receptors | muscarinic acetylcholine receptor
Journal Article
Neuroscience, ISSN 0306-4522, 08/2019, Volume 414, pp. 60 - 76
Activation of the M muscarinic acetylcholine receptor (M R) may be an effective therapeutic approach for Alzheimer's disease (AD), dementia with Lewy bodies,... 
donepezil | c-Fos | M1 muscarinic acetylcholine receptor | xanomeline | TAK-071
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3029 - 3033
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2014, Volume 24, Issue 13, pp. 2909 - 2912
We designed and synthesized novel -sulfonyl-7-azaindoline derivatives as selective M muscarinic acetylcholine receptor agonists. Modification of the... 
Subtype-selective agonist | Schizophrenia | N-Sulfonyl-7-azaindoline | M4 muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor agonist
Journal Article