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Nature (London), ISSN 1476-4687, 2016, Volume 531, Issue 7594, pp. 335 - 340
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 2014, Volume 39, Issue 7, pp. 1578 - 1593
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 4/2009, Volume 379, Issue 4, pp. 389 - 395
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 03/2010, Volume 35, Issue 4, pp. 855 - 869
...) muscarinic acetylcholine receptor (mAChR). This study characterized the molecular mode of action of this modulator in both recombinant and native systems... 
Schizophrenia | Drug discovery | Allosteric modulation | Functional selectivity | Multivariate Analysis | Cricetulus | Receptor, Muscarinic M4 - physiology | Acetylcholine - metabolism | Protein Transport - drug effects | Corpus Striatum - metabolism | Dose-Response Relationship, Drug | Allosteric Site - physiology | Nicotinic Acids - chemistry | Tritium - metabolism | Allosteric Regulation - physiology | Radioligand Assay - methods | Muscarinic Antagonists - pharmacokinetics | Phosphorylation - drug effects | Allosteric Regulation - drug effects | Cell Line | Cricetinae | Acetylcholine - pharmacology | Allosteric Site - drug effects | Models, Molecular | Rats | Thiophenes - pharmacology | Nicotinic Acids - pharmacology | Avoidance Learning - physiology | Mice, Knockout | Parasympatholytics - pharmacokinetics | Binding, Competitive - drug effects | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Antipsychotic Agents - chemistry | Signal Transduction - drug effects | Receptor, Muscarinic M4 - drug effects | Corpus Striatum - drug effects | Receptor, Muscarinic M4 - chemistry | Signal Transduction - physiology | Avoidance Learning - drug effects | Mice | N-Methylscopolamine - pharmacokinetics | Quinuclidinyl Benzilate - pharmacokinetics | Antipsychotic Agents - pharmacology | In Vitro Techniques | Receptor, Muscarinic M4 - deficiency | Thiophenes - chemistry | Tritium - pharmacokinetics | Receptor Pharmacology | drug discovery | molecular pharmacology | Development | GPCR | Acetylcholine | schizophrenia | Neuropharmacology | Original | functional selectivity | drug receptor interaction | allosteric modulation
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 2003, Volume 8, Issue 7, pp. 673 - 679
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2015, Volume 88, Issue 4, pp. 762 - 773
...—particularly in direct-pathway spiny projection neurons (dSPNs). Our studies show that in dSPNs, endogenous cholinergic signaling through M4 muscarinic receptors (M4Rs... 
RGS4 | NMDA RECEPTOR | PARKINSONISM | CHOLINERGIC INTERNEURONS | BASAL GANGLIA | MECHANISMS | MEDIUM SPINY NEURONS | BIDIRECTIONAL SYNAPTIC PLASTICITY | NEUROSCIENCES | DOPAMINERGIC CONTROL | MODULATION | Dyskinesia, Drug-Induced - etiology | Signal Transduction | Neurons | Allosteric Regulation | Neuronal Plasticity - drug effects | Mice, Transgenic | Levodopa - toxicity | Macaca mulatta | Receptor, Muscarinic M4 - metabolism | Long-Term Synaptic Depression - drug effects | Cerebral Cortex - metabolism | Glutamic Acid | Animals | Long-Term Potentiation - drug effects | Neostriatum - drug effects | Parkinsonian Disorders - drug therapy | RGS Proteins - metabolism | Neostriatum - metabolism | Dopamine Agents - toxicity | Mice | Dyskinesia, Drug-Induced - metabolism | Disease Models, Animal | Neurosciences | Animal behavior | Analysis | Resveratrol | Physiological aspects | Phenols | Models | G proteins | Dopa | Movement disorders | Medical colleges | Primates | Kidney diseases | Proteins | Studies | Hypotheses | Data analysis | Rodents | Behavior | Artificial chromosomes | Grants | Experiments | spiny projection neuron | Spike-timing-dependent plasticity | long-term depression | cholinergic interneuron | chemogenetics | depotentiation | positive allosteric modulator | long-term potentiation | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2010, Volume 29, Issue 12, pp. 2070 - 2081
Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the mammalian brain and are essential for neuronal functions... 
calcium | striatum | cAMP | cocaine | phosphorylation | Striatum | Phosphorylation | Cocaine | Calcium | NMDA RECEPTOR | RAT STRIATUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | PROJECTION NEURONS | SUBTYPE-SPECIFIC ANTIBODIES | CELL BIOLOGY | ACETYLCHOLINE-RECEPTORS | CALMODULIN-BINDING | D2 DOPAMINE | MODULATION
Journal Article
Journal Article