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Nature, ISSN 0028-0836, 07/2010, Volume 466, Issue 7302, pp. 133 - 137
The question of whether tumorigenic cancer stem cells exist in human melanomas has arisen in the last few years(1). Here we show that in melanomas, tumour stem... 
PROGENITORS | PROSPECTIVE IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | CANCER STEM-CELLS | Bone and Bones - pathology | Neoplasm Transplantation | Neoplastic Stem Cells - cytology | Humans | Nerve Tissue Proteins - deficiency | Neural Crest - pathology | Receptors, Nerve Growth Factor - metabolism | Neoplasm Proteins - metabolism | DNA-Binding Proteins - deficiency | Neural Crest - metabolism | Neoplasm Metastasis | Lung Neoplasms - secondary | Neoplastic Stem Cells - metabolism | Antigens, Neoplasm - metabolism | Neoplastic Stem Cells - pathology | Skin Transplantation | Antigens, Neoplasm - analysis | Skin - pathology | Melanoma - metabolism | Melanoma-Specific Antigens | Neural Crest - cytology | Melanoma - pathology | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Neoplastic Stem Cells - transplantation | Receptors, Nerve Growth Factor - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Bone Transplantation | Neoplasm Proteins - analysis | Transplantation, Heterologous - pathology | Mice | Receptors, Nerve Growth Factor - deficiency | Care and treatment | Melanoma | Stem cells | Physiological aspects | Development and progression | Nerve growth factor | Genetic aspects | Growth factor receptors | Research | Risk factors | Transplants & implants | Skin & tissue grafts | Cancer | Tumors | Human | Enrichment | Antigens | Tumours | Bones | Transplantation
Journal Article
Neuron, ISSN 0896-6273, 2010, Volume 65, Issue 5, pp. 597 - 611
To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic mice in which microRNA... 
DEVBIO | MOLNEURO | TRANSCRIPTION FACTORS | NERVOUS-SYSTEM | GLIAL PROGENITOR-CELL | PROTEIN | CYCLE EXIT | NEURONS | GROWTH-FACTOR | IDENTIFICATION | MICRORNA EXPRESSION | LINEAGE | NEUROSCIENCES | Central Nervous System - metabolism | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | S100 Proteins - genetics | Oligodendroglia - drug effects | Basic Helix-Loop-Helix Transcription Factors - metabolism | Animals, Newborn | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | S100 Calcium Binding Protein beta Subunit | Oligonucleotide Array Sequence Analysis - methods | Rats | Mice, Transgenic | Oligodendrocyte Transcription Factor 2 | Myelin Proteins - genetics | Rats, Sprague-Dawley | Nerve Growth Factors - genetics | Mice | MicroRNAs - genetics | Myelin Proteins - metabolism | SOXD Transcription Factors - genetics | Optic Nerve - metabolism | Age Factors | SOXD Transcription Factors - metabolism | Gene Expression Regulation, Developmental - genetics | Sciatic Nerve - growth & development | Myelin Sheath - metabolism | Central Nervous System - growth & development | DNA-Binding Proteins - metabolism | Sciatic Nerve - metabolism | Oligodendroglia - physiology | Transfection | DEAD-box RNA Helicases - metabolism | Cell Differentiation - physiology | Optic Nerve - growth & development | Brain - cytology | 2',3'-Cyclic-Nucleotide Phosphodiesterases - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Profiling - methods | Transcription Factors - genetics | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | DEAD-box RNA Helicases - genetics | Animals | Cell Differentiation - drug effects | Receptor, Platelet-Derived Growth Factor alpha - genetics | Stem Cells - drug effects | Stem Cells - physiology | Proteins | Genotype & phenotype | Gene expression | Experiments | Rodents | Cell cycle
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2015, Volume 23, Issue 3, pp. 423 - 433
Journal Article
Neuron, ISSN 0896-6273, 02/2012, Volume 73, Issue 4, pp. 729 - 742
Following damage to peripheral nerves, a remarkable process of clearance and regeneration takes place. Axons downstream of the injury degenerate, while the... 
SCIATIC-NERVE | DEMYELINATION | MYELINATION | HUMAN CONNEXIN32 | MOUSE MODEL | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INJURY | ENSHEATHMENT | NEUREGULIN-1 | NEUROSCIENCES | NF1 LOSS | Cyclin D1 - metabolism | Leukocytes - pathology | MAP Kinase Signaling System - physiology | Diphenylamine - pharmacology | Receptor, Nerve Growth Factor - genetics | Recovery of Function - drug effects | Motor Activity - drug effects | Estrogen Antagonists - pharmacology | Male | Microscopy, Immunoelectron | Myelin Sheath - metabolism | Diphenylamine - analogs & derivatives | MAP Kinase Signaling System - genetics | Peripheral Nerve Injuries - physiopathology | T-Lymphocytes - metabolism | Time Factors | Reaction Time - drug effects | Schwann Cells - physiology | Benzamides - pharmacology | T-Lymphocytes - pathology | Neutrophils - metabolism | Receptor, Nerve Growth Factor - metabolism | Neutrophils - pathology | Animals, Newborn | Nerve Regeneration - genetics | Microscopy, Electron, Transmission | Recovery of Function - genetics | Receptors, Estrogen - genetics | Cytokines - metabolism | Proto-Oncogene Proteins c-raf - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Peripheral Nerve Injuries - pathology | Mice, Transgenic | Reaction Time - genetics | Proto-Oncogene Proteins c-raf - metabolism | Gene Expression Regulation - drug effects | Cell Movement - drug effects | Microscopy, Confocal | Motor Activity - genetics | Animals | MAP Kinase Signaling System - drug effects | Schwann Cells - ultrastructure | Mast Cells - pathology | Myelin Sheath - genetics | Nerve Regeneration - drug effects | Tamoxifen - pharmacology | Mice | Research | Analysis | Oncology, Experimental | Cells | Cancer | Proteins | Dehydrogenases | Rodents | Nervous system | Ligands | Kinases | Phosphatase | Vascular endothelial growth factor | Chemokines | Cell adhesion & migration | Tumors | Ataxia
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e92596
Background: Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure... 
CANCER-CELLS | METASTATIC MELANOMA | FACTOR-BETA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | EPIGENETIC REGULATION | NEURAL CREST | SOX10 | PROMOTES | TUMOR MICROENVIRONMENT | CD133 | Meta-Analysis as Topic | Antigens, CD - biosynthesis | Humans | Peptides - genetics | Male | Antigens, CD - genetics | Gene Knockdown Techniques | Neoplastic Stem Cells - metabolism | Melanoma - genetics | Nerve Tissue Proteins - biosynthesis | Neoplastic Stem Cells - pathology | Female | Neoplasm Proteins - genetics | SOXE Transcription Factors - biosynthesis | Glycoproteins - genetics | Melanoma - metabolism | Receptors, Nerve Growth Factor - biosynthesis | Neoplasm Proteins - biosynthesis | Melanoma - pathology | AC133 Antigen | Nerve Tissue Proteins - genetics | Receptors, Nerve Growth Factor - genetics | Glycoproteins - biosynthesis | Animals | Cell Line, Tumor | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Biomarkers, Tumor - biosynthesis | SOXE Transcription Factors - genetics | Nerve growth factor | Drug resistance | Analysis | Genomics | Stem cells | Transcription factors | Laboratories | Genes | Genomes | Metastasis | Cell surface | Metastases | Genotype & phenotype | Heterogeneity | Rodents | Fibroblasts | Growth factors | Antigens | Colonies | Markers | Melanoma | Cell division | Tumorigenicity | Gene expression | Neural crest | Sox10 protein | Pathology | Properties (attributes) | Cell lines | Epigenetics | Neural stem cells | Surface markers | Cancer | Tumors
Journal Article
Nature Communications, ISSN 2041-1723, 09/2013, Volume 4, Issue 1, pp. 2490 - 2490
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2014, Volume 23, Issue 3, pp. 478 - 486
Journal Article
Circulation Research, ISSN 0009-7330, 04/2010, Volume 106, Issue 7, pp. 1275 - 1284
RATIONALE:Nerve growth factor (NGF) promotes angiogenesis and cardiomyocyte survival, which are both desirable for postinfarction myocardial healing.... 
Myocardial infarction | Angiogenesis | Gene therapy |