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1. Full Text MiR-18a-5p inhibits endothelial–mesenchymal transition and cardiac fibrosis through the Notch2 pathway
by Geng, Huazhi and Guan, Jun
Biochemical and biophysical research communications, ISSN 0006-291X, 09/2017, Volume 491, Issue 2, pp. 329 - 336
MicroRNA | EndMT | Notch2 | Fibrosis | High glucose | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Dependovirus - genetics | Cadherins - metabolism | Genetic Vectors - administration & dosage | Humans | Aortic Valve - drug effects | Diabetes Mellitus, Experimental - genetics | Male | MicroRNAs - metabolism | Diabetes Mellitus, Experimental - chemically induced | Cadherins - genetics | Endomyocardial Fibrosis - prevention & control | Dependovirus - metabolism | Genetic Vectors - chemistry | Signal Transduction | Endothelial Cells - metabolism | Genetic Vectors - metabolism | Glucose - pharmacology | Heart Ventricles - metabolism | MicroRNAs - genetics | Calcium-Binding Proteins - genetics | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Streptozocin | Vimentin - metabolism | Actins - metabolism | Receptor, Notch2 - genetics | Actins - genetics | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Vimentin - genetics | Epithelial-Mesenchymal Transition | Diabetic Cardiomyopathies - prevention & control | Endomyocardial Fibrosis - genetics | Endomyocardial Fibrosis - chemically induced | Endomyocardial Fibrosis - pathology | Diabetes Mellitus, Experimental - metabolism | Heart Ventricles - pathology | Calcium-Binding Proteins - metabolism | Cell Line | Mice, Inbred C57BL | Gene Expression Regulation | Receptor, Notch2 - metabolism | Aortic Valve - cytology | Aortic Valve - metabolism | Fibronectins - metabolism | Diabetic Cardiomyopathies - genetics | Animals | Endothelial Cells - cytology | Diabetes Mellitus, Experimental - pathology | Diabetic Cardiomyopathies - pathology | Fibronectins - genetics | Diabetic Cardiomyopathies - chemically induced | Endothelial Cells - drug effects | Fibronectins | Hyperglycemia | Stem cells | Glucose | Muscle proteins | Dextrose | Endothelium | Index Medicus
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2. Full Text NOTCH2 mutations in Alagille syndrome
by Kamath, Binita Maya and Bauer, Robert C and Loomes, Kathleen M and Chao, Grace and Gerfen, Jennifer and Hutchinson, Anne and Hardikar, Winita and Hirschfield, Gideon and Jara, Paloma and Krantz, Ian D and Lapunzina, Pablo and Leonard, Laura and Ling, Simon and Ng, Vicky Lee and Hoang, Phuc Le and Piccoli, David A and Spinner, Nancy Bettina
Journal of medical genetics, ISSN 0022-2593, 02/2012, Volume 49, Issue 2, pp. 138 - 144
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Gastroenterology. Liver. Pancreas. Abdomen | General aspects. Genetic counseling | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Medical genetics | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Other diseases. Semiology | Cell Line | Gene Expression | Genetic Association Studies | Signal Transduction | Humans | Receptor, Notch2 - metabolism | Receptor, Notch2 - genetics | Alagille Syndrome - genetics | Phenotype | Animals | DNA Mutational Analysis | Facies | HEK293 Cells | Mice | Mutation | Index Medicus
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3. Full Text Notch2 activation ameliorates nephrosis
by Tanaka, Eriko and Asanuma, Katsuhiko and Kim, Eunhee and Sasaki, Yu and Trejo, Juan Alejandro Oliva and Seki, Takuto and Nonaka, Kanae and Asao, Rin and Nagai-Hosoe, Yoshiko and Akiba-Takagi, Miyuki and Hidaka, Teruo and Takagi, Masatoshi and Koyanagi, Akemi and Mizutani, Shuki and Yagita, Hideo and Tomino, Yasuhiko
Nature communications, ISSN 2041-1723, 02/2014, Volume 5, Issue 1, pp. 3296 - 3296
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cricetinae | Podocytes - metabolism | Cricetulus | Apoptosis - drug effects | Antibodies, Monoclonal - pharmacology | Humans | Kidney Diseases - drug therapy | Antibodies, Monoclonal - therapeutic use | Receptor, Notch2 - agonists | Doxorubicin | Mice, Inbred ICR | Animals | Podocytes - drug effects | Mice, Nude | Kidney Diseases - chemically induced | Female | Mice, Inbred BALB C | Drug Evaluation, Preclinical | Proto-Oncogene Proteins c-akt - metabolism | CHO Cells | Kidney Diseases - metabolism | Index Medicus
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4. Full Text Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine
by Lewis, Kanako L and Caton, Michele L and Bogunovic, Milena and Greter, Melanie and Grajkowska, Lucja T and Ng, Dennis and Klinakis, Apostolos and Charo, Israel F and Jung, Steffen and Gommerman, Jennifer L and Ivanov, Ivaylo I and Liu, Kang and Merad, Miriam and Reizis, Boris
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2011, Volume 35, Issue 5, pp. 780 - 791
Life Sciences & Biomedicine | Immunology | Science & Technology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Spleen - immunology | Signal Transduction | Dendritic Cells - immunology | Mice, Inbred C57BL | Cells, Cultured | Receptor, Notch2 - metabolism | Male | Mice, Transgenic | Gene Expression Profiling | Intestines - metabolism | Intestines - immunology | fms-Like Tyrosine Kinase 3 - genetics | Cell Differentiation - immunology | Phenotype | Animals | Spleen - metabolism | Gene Expression Regulation, Developmental | Female | Dendritic Cells - cytology | Mice | Dendritic Cells - metabolism | Dendritic cells | T cells | Genes | Spleen | Ligands | Software | Gene expression | Rodents | Index Medicus
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5. Full Text Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice
by Wang, Jingxiao and Dong, Mingjie and Xu, Zhong and Song, Xinhua and Zhang, Shanshan and Qiao, Yu and Che, Li and Gordan, John and Hu, Kaiwen and Liu, Yan and Calvisi, Diego F and Chen, Xin
Oncogene, ISSN 0950-9232, 06/2018, Volume 37, Issue 24, pp. 3229 - 3242
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Hepatocytes - pathology | Male | Receptor, Notch2 - genetics | Cholangiocarcinoma - metabolism | Hepatocytes - metabolism | Phosphoproteins - metabolism | Female | Liver Neoplasms - pathology | Proto-Oncogene Proteins c-akt - metabolism | Bile Ducts, Intrahepatic - pathology | Bile Duct Neoplasms - metabolism | Receptor, Notch2 - metabolism | Mice, Transgenic | Phosphoproteins - genetics | Receptor, Notch1 - metabolism | Cholangiocarcinoma - pathology | Animals | Adaptor Proteins, Signal Transducing - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Signal Transduction - physiology | Bile Duct Neoplasms - pathology | Adaptor Proteins, Signal Transducing - metabolism | Receptor, Notch1 - genetics | Cell Cycle Proteins | Carcinoma, Hepatocellular - metabolism | Liver cancer | Genetic aspects | Rats as laboratory animals | Research | Phenotypes | Tumor cells | Sox9 protein | Hepatocellular carcinoma | AKT protein | siRNA | Adenoma | Yes-associated protein | Signal transduction | Clonal deletion | Hepatocytes | Rodents | Notch protein | Cholangiocarcinoma | Tumors | Proto-oncogenes | Index Medicus
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6. Full Text Constitutive Notch2 signaling induces hepatic tumors in mice
by Dill, Michael T and Tornillo, Luigi and Fritzius, Thorsten and Terracciano, Luigi and Semela, David and Bettler, Bernhard and Heim, Markus H and Tchorz, Jan S
Hepatology (Baltimore, Md.), ISSN 0270-9139, 04/2013, Volume 57, Issue 4, pp. 1607 - 1619
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Hepatocyte Nuclear Factor 4 - metabolism | Carcinoma, Hepatocellular - chemically induced | Carcinoma, Hepatocellular - physiopathology | Cell Proliferation | Cholangiocarcinoma - physiopathology | Humans | Liver Neoplasms - chemically induced | Male | Mice, Transgenic | Receptor, Notch2 - genetics | Bile Duct Neoplasms - physiopathology | Receptor, Notch2 - physiology | Animals | Diethylnitrosamine - adverse effects | Liver Neoplasms - metabolism | Liver Neoplasms - physiopathology | Bile Ducts, Intrahepatic | Female | Signal Transduction - physiology | Cell Differentiation | Mice | Carcinoma, Hepatocellular - metabolism | Disease Models, Animal | Liver cancer | Rodents | Hepatology | Tumors | Index Medicus
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7. Full Text Mutations in NOTCH2 in patients with Hajdu–Cheney syndrome
by Zhao, W and Petit, E and Gafni, R I and Collins, M T and Robey, P G and Seton, M and Miller, K K and Mannstadt, M
Osteoporosis international, ISSN 0937-941X, 8/2013, Volume 24, Issue 8, pp. 2275 - 2281
NOTCH2 | Osteoporosis | Medicine & Public Health | Orthopedics | Rheumatology | Exome sequencing | Acroosteolysis | Hajdu–Cheney syndrome | Endocrinology | Hajdu-Cheney syndrome | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Humans | Middle Aged | Finger Phalanges - diagnostic imaging | Male | Receptor, Notch2 - genetics | Radiography | Young Adult | Finger Phalanges - pathology | Hajdu-Cheney Syndrome - genetics | Exome - genetics | Hajdu-Cheney Syndrome - pathology | Pedigree | Adolescent | Hajdu-Cheney Syndrome - diagnostic imaging | Adult | Female | Heterozygote | Osteoporosis - genetics | Mutation | Sequence Analysis, DNA - methods | Finger Phalanges - abnormalities | Complications and side effects | Genetic disorders | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Risk factors | Patients | Index Medicus
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8. Full Text The coding genome of splenic marginal zone lymphoma: Activation of NOTCH2 and other pathways regulating marginal zone development
by Rossi, Davide and Trifonov, Vladimir and Fangazio, Marco and Bruscaggin, Alessio and Rasi, Silvia and Spina, Valeria and Monti, Sara and Vaisitti, Tiziana and Arruga, Francesca and Famà, Rosella and Ciardullo, Carmela and Greco, Mariangela and Cresta, Stefania and Piranda, Daniela and Holmes, Antony and Fabbri, Giulia and Messina, Monica and Rinaldi, Andrea and Wang, Jiguang and Agostinelli, Claudio and Piccaluga, Pier Paolo and Lucioni, Marco and Tabbò, Fabrizio and Serra, Roberto and Franceschetti, Silvia and Deambrogi, Clara and Daniele, Giulia and Gattei, Valter and Marasca, Roberto and Facchetti, Fabio and Arcaini, Luca and Inghirami, Giorgio and Bertoni, Francesco and Pileri, Stefano A and Deaglio, Silvia and Foà, Robin and Dalla-Favera, Riccardo and Pasqualucci, Laura and Rabadan, Raul and Gaidano, Gianluca
The Journal of experimental medicine, ISSN 0022-1007, 08/2012, Volume 209, Issue 9, pp. 1537 - 1551
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Lymphoma, B-Cell - metabolism | Signal Transduction | Humans | Splenic Neoplasms - genetics | Gene Expression Regulation, Neoplastic | Receptor, Notch2 - metabolism | Chromatin Assembly and Disassembly | Receptor, Notch2 - genetics | Lymphoma, B-Cell - genetics | Homeodomain Proteins - genetics | Exome | Splenic Neoplasms - pathology | NF-kappa B - genetics | Lymphoma, B-Cell - pathology | Splenic Neoplasms - metabolism | Polymorphism, Single Nucleotide | B-Lymphocytes - pathology | Mutation | Nuclear Proteins - genetics | Receptor, Notch1 - genetics | B-Lymphocytes - metabolism | Index Medicus | 304
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9. Full Text Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart
by Yang, Jiwen and Bücker, Sandra and Jungblut, Benno and Böttger, Thomas and Cinnamon, Yuval and Tchorz, Jan and Müller, Matthias and Bettler, Bernhard and Harvey, Richard and Sun, Qing-Yuan and Schneider, Andre and Braun, Thomas
Cardiovascular research, ISSN 0008-6363, 11/2012, Volume 96, Issue 2, pp. 276 - 285
Numb/Numblike | Cardiac development | Compaction | Trabeculation | Notch2 | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Up-Regulation | Membrane Proteins - genetics | Heart - embryology | Homeodomain Proteins - metabolism | Embryo, Nonmammalian - metabolism | Receptor, Notch2 - metabolism | Zebrafish | Nerve Tissue Proteins - genetics | Embryo, Mammalian - metabolism | Gene Knockdown Techniques | Nerve Tissue Proteins - metabolism | Pregnancy | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | Bone Morphogenetic Proteins - metabolism | Animals | Myocardium - metabolism | Female | Membrane Proteins - metabolism | Mice | Genes, Reporter | Index Medicus
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