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1. Full Text Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor
by Harrison, Hannah and Farnie, Gillian and Howell, Sacha J and Rock, Rebecca E and Stylianou, Spyros and Brennan, Keith R and Bundred, Nigel J and Clarke, Robert B
Cancer Research, ISSN 0008-5472, 01/2010, Volume 70, Issue 2, pp. 709 - 718
Notch receptor signaling pathways play an important role not only in normal breast development but also in breast cancer development and progression. We... 
INITIATING CELLS | GAMMA-SECRETASE INHIBITOR | ACTIVATION | JAG1 | COMMITMENT | ONCOLOGY | PROSPECTIVE IDENTIFICATION | MOUSE | POOR | CHEMOTHERAPY | IN-VITRO PROPAGATION | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Receptors, Notch - metabolism | Humans | Hyaluronan Receptors - biosynthesis | Receptor, Notch1 - metabolism | Breast Neoplasms - metabolism | Mice, Knockout | Membrane Proteins - biosynthesis | Receptors, Notch - antagonists & inhibitors | Animals | Neoplastic Stem Cells - metabolism | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Mice | CD24 Antigen - biosynthesis | Receptor, Notch4 | stem cells | gamma secretase inhibitors | Breast cancer | CD44 | Notch receptors
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2. Full Text Notch4+ cancer stem‐like cells promote the metastatic and invasive ability of melanoma
by Lin, Xian and Sun, Baocun and Zhu, Dongwang and Zhao, Xiulan and Sun, Ran and Zhang, Yanhui and Zhang, Danfang and Dong, Xueyi and Gu, Qiang and Li, Yanlei and Liu, Fang
Cancer Science, ISSN 1347-9032, 08/2016, Volume 107, Issue 8, pp. 1079 - 1091
Sphere formation in conditioned serum‐free culture medium supplemented with epidermal growth factor and basic fibroblast growth factor (tumorospheres) is... 
Cancer stem cell | epithelial–mesenchymal transition | melanoma | Notch4 protein | Twist1 | Epithelial-mesenchymal transition | Melanoma | VASCULOGENIC MIMICRY | DRUG-RESISTANCE | TUMOR-INITIATING CELLS | BREAST-CANCER | IN-VITRO | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | PLACENTAL GROWTH-FACTOR | LUNG ADENOCARCINOMA | epithelial-mesenchymal transition | FUNCTIONAL-SIGNIFICANCE | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Cadherins - metabolism | Receptors, Notch - metabolism | Humans | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Receptors, Notch - genetics | Melanoma - pathology | Proto-Oncogene Proteins - deficiency | Epithelial-Mesenchymal Transition - genetics | Neoplasm Metastasis - genetics | Neoplastic Stem Cells - metabolism | Melanoma - genetics | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Neoplasm Invasiveness - genetics | Receptors, Notch - deficiency | Twist-Related Protein 1 - metabolism | Receptor, Notch4 | Epidermal growth factor | Analysis | Genes | Stem cells | Fibroblast growth factors | B cells | Metastasis | Gene expression | Cancer | Vimentin | Cell culture | Flow cytometry | Fibroblast growth factor | Mesenchyme | Western blotting | NOTCH4 protein | Metastases | Proteins | Angiogenesis | Signal transduction | Transfection | Vascular endothelial growth factor | Fibroblast growth factor 2 | Medical research | Immunoglobulins | Invasiveness | DNA microarrays | Protein expression | Immunofluorescence | Secretase | Tumors | Original
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3. Full Text Essential role of Notch4/STAT3 signaling in epithelial-mesenchymal transition of tamoxifen-resistant human breast cancer
by Bui, Quyen Thu and Im, Ji Hye and Jeong, Sung Baek and Kim, Young-Mi and Lim, Sung Chul and Kim, Bumseok and Kang, Keon Wook
Cancer Letters, ISSN 0304-3835, 2017, Volume 390, pp. 115 - 125
Abstract We previously demonstrated that tamoxifen (TAM)-resistant human breast cancer (TAMR-MCF-7) cells showed increased expression of mesenchymal marker... 
Hematology, Oncology and Palliative Medicine | Notch4 | Breast cancer | Metastasis | Tamoxifen resistance | STAT3 | STEM-CELLS | ACTIVATION | TRANSCRIPTION | NOTCH | MEDIATE | SERINE PHOSPHORYLATION | CROSS-TALK | GROWTH-FACTOR RECEPTOR | ONCOLOGY | EXPRESSION | Cell Proliferation | Receptors, Notch - metabolism | Epithelial-Mesenchymal Transition - physiology | Humans | Epithelial-Mesenchymal Transition - drug effects | Immunoblotting | Breast Neoplasms - physiopathology | Receptors, Notch - antagonists & inhibitors | Antineoplastic Agents, Hormonal - therapeutic use | Polymerase Chain Reaction | Female | STAT3 Transcription Factor - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Antineoplastic Agents, Hormonal - pharmacology | Breast Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Mice, Nude | Tamoxifen - therapeutic use | Tamoxifen - pharmacology | Cell Line, Tumor | Protein Binding | Signal Transduction - physiology | Receptor, Notch4 | Proteins | Tyrosine | Medical colleges | Analysis | Pharmacy | Liver | Stem cells | Drugstores | Development and progression | Tamoxifen | Polyols | Genotype & phenotype | Phosphorylation | Immunoglobulins | Genes | Conflicts of interest | Ligands | Fluorides | Kinases | Cell adhesion & migration
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4. Full Text Notch4 signaling induces a mesenchymal- Epithelial-like transition in melanoma cells to suppress malignant behaviors
by Rad, Ehsan Bonyadi and Hammerlindl, Heinz and Wels, Christian and Popper, Ulrich and Menon, Dinoop Ravindran and Breiteneder, Heimo and Kitzwoegerer, Melitta and Hafner, Christine and Herlyn, Meenhard and Bergler, Helmut and Schaider, Helmut
Cancer Research, ISSN 0008-5472, 04/2016, Volume 76, Issue 7, pp. 1690 - 1697
The effects of Notch signaling are context-dependent and both oncogenic and tumor-suppressive functions have been described. Notch signaling in melanoma is... 
ACTIVATION | REPRESSION | ONCOLOGY | GROWTH | HES | TWIST1 | E-CADHERIN | RECEPTORS | EXPRESSION | PROGRESSION | Signal Transduction | Melanoma - genetics | Epithelial-Mesenchymal Transition - physiology | Humans | Skin Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Receptors, Notch - genetics | Receptor, Notch4
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5. Full Text AKT and 14-3-3 regulate notch4 nuclear localization
by Ramakrishnan, Gopalakrishnan and Davaakhuu, Gantulga and Chung, Wen Cheng and Zhu, He and Rana, Ajay and Filipovic, Aleksandra and Green, Andrew R and Atfi, Azeddine and Pannuti, Antonio and Miele, Lucio and Tzivion, Guri
Scientific Reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 8782
Members of the Notch family of transmembrane receptors, Notch1-4 in mammals, are involved in the regulation of cell fate decisions and cell proliferation in... 
ACTIVATION | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENE FAMILY | CASCADE | DIFFERENTIATION | PROTEINS | PROTOONCOGENE | EXPRESSION | MAMMARY | Proto-Oncogene Proteins - metabolism | Cell Line | Phosphorylation | Receptors, Notch - metabolism | Humans | Proto-Oncogene Proteins - chemistry | 14-3-3 Proteins - metabolism | Animals | Receptors, Notch - chemistry | Protein Binding | Protein Interaction Domains and Motifs | Active Transport, Cell Nucleus | Proto-Oncogene Proteins c-akt - metabolism | Binding Sites | Cytoplasm | Receptor, Notch4 | Cell proliferation | Inositol | Transcription | Stem cell transplantation | AKT protein | Breast cancer | Kinases | Nuclei | 1-Phosphatidylinositol 3-kinase | 14-3-3 protein | Cell fate | Stem cells | Regulation | Notch protein | Localization | Growth factors | Regulatory proteins | Tumors
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6. Full Text Impaired Notch4 Activity Elicits Endothelial Cell Activation and Apoptosis: Implication for Transplant Arteriosclerosis
by Quillard, T and Coupel, S and Coulon, F and Fitau, J and Chatelais, M and Cuturi, M C and Chiffoleau, E and Charreau, B
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2008, Volume 28, Issue 12, pp. 2258 - 2265
OBJECTIVE—Notch signaling pathway controls key functions in vascular and endothelial cells (EC). However, little is known about the role of Notch in... 
Transplant arteriosclerosis | Activation | Endothelial cells | Notch | Apoptosis | transplant arteriosclerosis | endothelial cells | ANGIOGENESIS | apoptosis | MECHANISMS | INDUCTION | ARTERIAL-DISEASE | TUMOR-NECROSIS-FACTOR | INHIBITION | PERIPHERAL VASCULAR DISEASE | notch | DIFFERENTIATION | activation | HEMATOLOGY | EXPRESSION | VASCULOPATHY | SMOOTH-MUSCLE CELLS | RNA, Small Interfering - genetics | Transcription Factor HES-1 | Humans | Rats, Inbred Lew | Heart Transplantation - pathology | Receptors, Notch - genetics | RNA, Messenger - metabolism | Transplantation, Homologous | Receptors, Notch - antagonists & inhibitors | Coronary Artery Disease - physiopathology | Inflammation Mediators - pharmacology | Coronary Artery Disease - pathology | Heart Transplantation - physiology | Inflammation Mediators - metabolism | Endothelial Cells - physiology | Proto-Oncogene Proteins - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Coronary Artery Disease - etiology | Cytokines - metabolism | Signal Transduction | Down-Regulation | RNA, Messenger - genetics | Cells, Cultured | Gene Silencing | Heart Transplantation - adverse effects | Rats | Receptors, Notch - physiology | Proto-Oncogene Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Homeodomain Proteins - genetics | Animals | Homeodomain Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Apoptosis - physiology | Endothelial Cells - pathology | Homeodomain Proteins - physiology | Cytokines - pharmacology | Receptor, Notch4
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7. Full Text Notch4 promotes gastric cancer growth through activation of Wnt1/β-catenin signaling
by Qian, Cuijuan and Liu, Fuqiang and Ye, Bei and Zhang, Xin and Liang, Yong and Yao, Jun
Molecular and Cellular Biochemistry, ISSN 0300-8177, 3/2015, Volume 401, Issue 1, pp. 165 - 174
Gastric cancer (GC) is one of the most common cancers and lethal malignancies in the world. Discovering novel biomarkers that correlate with GC may provide... 
Life Sciences | Biochemistry, general | β-catenin | Growth | Notch | Medical Biochemistry | Oncology | Cardiology | Wnt1 | Gastric cancer | beta-catenin | PATHOGENESIS | TARGET | CELLS | ROLES | WNT/BETA-CATENIN PATHWAY | STEM | CELL BIOLOGY | Proto-Oncogene Proteins - metabolism | Neoplasm Transplantation | Up-Regulation | Adenocarcinoma - pathology | Cell Proliferation | Receptors, Notch - metabolism | Tissue Array Analysis | Humans | Gene Expression Regulation, Neoplastic | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | beta Catenin - metabolism | Adenocarcinoma - metabolism | Cell Line, Tumor | Female | Receptor, Notch4 | Wnt Signaling Pathway | Index Medicus
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8. Full Text Notch4 normalization reduces blood vessel size in arteriovenous malformations
by Murphy, Patrick A and Kim, Tyson N and Lu, Gloria and Bollen, Andrew W and Schaffer, Chris B and Wang, Rong A
Science Translational Medicine, ISSN 1946-6234, 01/2012, Volume 4, Issue 117, pp. 117ra8 - 117ra8
Abnormally enlarged blood vessels underlie many life-threatening disorders including arteriovenous (AV) malformations (AVMs). The core defect in AVMs is... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CAPILLARIES | DIFFERENCE | COUP-TFII | ANGIOGENESIS | VASCULATURE | MOUSE | MICE | EXPRESSION | BRAIN | CELL BIOLOGY | Signal Transduction | Models, Cardiovascular | Blood Vessels - pathology | Gene Expression Regulation | Receptors, Notch - physiology | Mice, Transgenic | Photons | Proto-Oncogene Proteins - biosynthesis | Receptor, EphB4 - metabolism | Brain - metabolism | Animals | Receptors, Notch - biosynthesis | Endothelial Cells - cytology | Proto-Oncogene Proteins - physiology | Arteriovenous Malformations - metabolism | Brain - pathology | Hypoxia | Mice | Capillaries | Receptor, Notch4
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9. Full Text Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3
by Cipriani, Valentina and Leung, Hin-Tak and Plagnol, Vincent and Bunce, Catey and Khan, Jane C and Shahid, Humma and Moore, Anthony T and Harding, Simon P and Bishop, Paul N and Hayward, Caroline and Campbell, Susan and Armbrecht, Ana Maria and Dhillon, Baljean and Deary, Ian J and Campbell, Harry and Dunlop, Malcolm and Dominiczak, Anna F and Mann, Samantha S and Jenkins, Sharon A and Webster, Andrew R and Bird, Alan C and Lathrop, Mark and Zelenika, Diana and Souied, Eric H and Sahel, José-Alain and Léveillard, Thierry and Cree, Angela J and Gibson, Jane and Ennis, Sarah and Lotery, Andrew J and Wright, Alan F and Clayton, David G and Yates, John R.W and French AMD Investigators
Human Molecular Genetics, ISSN 0964-6906, 09/2012, Volume 21, Issue 18, pp. 4138 - 4150
Age-related macular degeneration (AMD) is a leading cause of visual loss in Western populations. Susceptibility is influenced by age, environmental and genetic... 
Haplotypes | Genetic Predisposition to Disease | Genome-Wide Association Study | Tenascin - genetics | Humans | Linear Models | Logistic Models | Male | Proto-Oncogene Proteins - genetics | Receptors, Notch - genetics | Genetic Loci | Chromosomes, Human, Pair 6 | Sequence Analysis, DNA | Case-Control Studies | Immunophilins - genetics | Macular Degeneration - genetics | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Odds Ratio | Principal Component Analysis | Receptor, Notch4 | Association Studies
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10. Full Text Notch4 Inhibits Endothelial Apoptosis via RBP-Jκ-dependent and -independent Pathways
by MacKenzie, Farrell and Duriez, Patrick and Wong, Fred and Noseda, Michela and Karsan, Aly
Journal of Biological Chemistry, ISSN 0021-9258, 03/2004, Volume 279, Issue 12, pp. 11657 - 11663
Notch4, a member of the Notch family of transmembrane receptors, is expressed primarily on endothelial cells. Activation of Notch in various cell systems has... 
CELLS | TUMOR-NECROSIS-FACTOR | ANGIOGENESIS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | JUN NH2-TERMINAL KINASE | EXPRESSION | ACTIVATED NOTCH4 | FAMILY
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11. Full Text Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta; signaling
by Sun, Youping and Lowther, William and Kato, Katsuaki and Bianco, Caterina and Kenney, Nicholas and Strizzi, Luigi and Raafat, Dina and Hirota, Morihisa and Khan, Nadia I and Bargo, Sharon and Jones, Brenda and Salomon, David and Callahan, Robert
Oncogene, ISSN 0950-9232, 08/2005, Volume 24, Issue 34, pp. 5365 - 5374
We present evidence that Notch4ICD attenuates TGF-beta signaling. Cells expressing the activated form of the Notch4 receptor (ICD4) were resistant to the... 
TGF-β | Smad3 | Notch4ICD | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRANCHING MORPHOGENESIS | MAMMALIAN NOTCH | NEOPLASTIC TRANSFORMATION | CELL BIOLOGY | CROSS-TALK | TGF-beta | GROWTH-FACTOR-BETA | TRUNCATED INT3 GENE | ONCOLOGY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | RECEPTORS | EXPRESSION | MAMMARY EPITHELIAL-CELLS | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Humans | Receptors, Cell Surface - metabolism | Blotting, Western | Amino Acid Motifs | DNA-Binding Proteins - metabolism | Receptors, Notch | Smad3 Protein | Animals | Breast Neoplasms - pathology | Polymerase Chain Reaction | Proto-Oncogene Proteins - physiology | Transforming Growth Factor beta - antagonists & inhibitors | Female | Signal Transduction - physiology | Trans-Activators - metabolism | Mice | Receptors, Cell Surface - physiology | Tumor Cells, Cultured | Transforming Growth Factor beta - metabolism | Receptor, Notch4
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12. Full Text Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder
by Dieset, Ingrid and Djurovic, Srdjan and Tesli, Martin and Hope, Sigrun and Mattingsdal, Morten and Michelsen, Annika and Joa, Inge and Larsen, Tor Ketil and Agartz, Ingrid and Melle, Ingrid and Røssberg, Jan Ivar and Aukrust, Pål and Andreassen, Ole A and Ueland, Thor
American Journal of Psychiatry, ISSN 0002-953X, 12/2012, Volume 169, Issue 12, pp. 1292 - 1300
ObjectiveImmunopathogenic mechanisms have been implicated in schizophrenia and bipolar disorder, and genome-wide association studies (GWAS) point to the major... 
C-REACTIVE PROTEIN | CELLS | IMMUNE-SYSTEM | SIGNALING PATHWAY GENES | VARIANTS | PSYCHIATRY | INFLAMMATION | MENTAL-DISORDERS | SCHIZOPHRENIA | ASSOCIATION | GENOME | Up-Regulation | Oligonucleotide Array Sequence Analysis | Gene Expression Regulation - genetics | Humans | RNA, Messenger - genetics | Bipolar Disorder - physiopathology | Gene Expression Regulation - physiology | Receptors, Notch - physiology | Genotype | Male | Proto-Oncogene Proteins - genetics | Receptors, Notch - genetics | Bipolar Disorder - genetics | Case-Control Studies | Schizophrenia - genetics | Schizophrenia - physiopathology | Proto-Oncogene Proteins - physiology | Polymorphism, Single Nucleotide - genetics | Adult | Female | Receptor, Notch4 | Quantitative Trait Loci - genetics | Quantitative trait loci | Bipolar disorder | Genetic aspects | Gene expression | Observations
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