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1. Full Text High-resolution crystal structure of human protease-activated receptor 1
by Zhang, Cheng and Srinivasan, Yoga and Arlow, Daniel H and Fung, Juan Jose and Palmer, Daniel and Zheng, Yaowu and Green, Hillary F and Pandey, Anjali and Dror, Ron O and Shaw, David E and Weis, William I and Coughlin, Shaun R and Kobilka, Brian K
Nature, ISSN 0028-0836, 12/2012, Volume 492, Issue 7429, pp. 387 - 392
Protease-activated receptor 1 (PAR1) is the prototypical member of a family of G-protein-coupled receptors that mediate cellular responses to thrombin and... 
LIPIDIC MESOPHASES | OPIOID RECEPTOR | MULTIDISCIPLINARY SCIENCES | COUPLED RECEPTOR | THROMBIN-RECEPTOR | AGONIST RECOGNITION | FORCE-FIELD | SODIUM-IONS | MOLECULAR-DYNAMICS SIMULATIONS | MEMBRANE-PROTEINS | BETA-ADRENERGIC RECEPTOR | Receptor, PAR-1 - chemistry | Receptors, Thrombin | Receptor, PAR-1 - antagonists & inhibitors | Pyridines - chemistry | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-1 - agonists | Crystallization | Models, Molecular | Crystallography, X-Ray | Receptors, G-Protein-Coupled - classification | Lactones - pharmacology | Molecular Dynamics Simulation | Amino Acid Motifs | Hydrolysis | Ligands | Protein Conformation | Myocardial Infarction - prevention & control | Pyridines - pharmacology | Enzyme Activation - genetics | Binding Sites | Receptors, G-Protein-Coupled - chemistry | Lactones - chemistry | Animal experimentation | Cell interaction | Usage | Proteases | Crystals | Physiological aspects | Research | Structure | Proteins | Amino acids | Heart attacks | Peptides | Methods | Index Medicus
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2. Full Text Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
by Mosnier, Laurent O and Sinha, Ranjeet K and Burnier, Laurent and Bouwens, Eveline A and Griffin, John H
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 26, pp. 5237 - 5246
Activated protein C (APC) exerts endothelial cytoprotective actions that require protease-activated receptor 1 (PAR1), whereas thrombin acting via PAR1 causes... 
PATHWAYS | MECHANISM | LIGANDS | PAR1 | ENHANCEMENT | THROMBIN-RECEPTOR | ANTICOAGULANT | VORAPAXAR | HEMATOLOGY | OCCUPANCY | SIGNALING SPECIFICITY | Receptor, PAR-1 - chemistry | Catalytic Domain | Receptor, PAR-1 - antagonists & inhibitors | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-1 - agonists | Cells, Cultured | Capillary Permeability - drug effects | Models, Molecular | Endothelium, Vascular - drug effects | Protein C - pharmacology | Arginine - chemistry | Drug Agonism | Proteolysis - drug effects | Pyrroles - pharmacology | Animals | Endothelium, Vascular - metabolism | Models, Biological | HEK293 Cells | Mice | Protein C - metabolism | Quinazolines - pharmacology | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
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3. Full Text Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand
by Jong-Sup Bae and Alireza R. Rezaie
Thrombosis and Haemostasis, ISSN 0340-6245, 07/2008, Volume 100, Issue 1, pp. 101 - 109
Summary We recently demonstrated that the occupancy of endothelial protein C receptor (EPCR) by its natural ligand activated protein C (APC)/protein C switches... 
Signaling | EPCR | thrombin | PAR-1 | inflammation | aPC | Endothelium and Vascular Development | Thrombin | Inflammation | APC | Tumor Necrosis Factor-alpha - metabolism | Endothelial Protein C Receptor | Capillary Permeability | Membrane Microdomains - metabolism | Receptor, PAR-1 - metabolism | Humans | Monocytes - metabolism | beta-Cyclodextrins - pharmacology | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Inflammation - metabolism | Pulmonary Artery - metabolism | RNA Interference | Receptors, Lysosphingolipid - metabolism | Cytoprotection | Cholesterol - deficiency | Endothelial Cells - metabolism | Receptor, PAR-1 - agonists | Cells, Cultured | Receptors, Cell Surface - metabolism | Pulmonary Artery - drug effects | Cell Adhesion | Receptor, PAR-1 - genetics | Peptides - pharmacology | Caveolin 1 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Receptors, Thrombin - metabolism | Ligands | Mutation | Protein C - metabolism | Thrombin - metabolism | Endothelial Cells - pathology | Protein C - genetics | Pulmonary Artery - pathology | Apoptosis | Endothelial Cells - drug effects | RNA, Small Interfering - metabolism | Index Medicus
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4. Full Text Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response
by Battinelli, Elisabeth M and Markens, Beth A and Kulenthirarajan, Rajesh A and Machlus, Kellie R and Flaumenhaft, Robert and Italiano Jr, Joseph E
Blood, ISSN 0006-4971, 01/2014, Volume 123, Issue 1, pp. 101 - 112
Platelets are a reservoir for angiogenic proteins that are secreted in a differentially regulated process. Because of the propensity for clotting, patients... 
SURVIVAL | ACTIVATION | PROGNOSTIC-FACTOR | METASTASIS | ALPHA-GRANULES | MOLECULAR-WEIGHT HEPARIN | THROMBOCYTOSIS | SECRETION | HEMATOLOGY | CANCER | ENDOSTATIN | Human Umbilical Vein Endothelial Cells | Receptor, PAR-1 - antagonists & inhibitors | Anticoagulants - metabolism | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-1 - agonists | Anticoagulants - therapeutic use | Vascular Endothelial Growth Factor A - metabolism | Polysaccharides - pharmacology | Blood Coagulation - drug effects | MCF-7 Cells | Blood Platelets - cytology | Blood Platelets - metabolism | Neovascularization, Pathologic - metabolism | Platelet Aggregation Inhibitors - metabolism | Angiogenic Proteins - metabolism | Microscopy, Fluorescence | Index Medicus | Abridged Index Medicus | 37 | 35 | Platelets and Thrombopoiesis
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5. Full Text α-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1
by Lee, Eun-Jung and Woo, Moon-Sook and Moon, Pyong-Gon and Baek, Moon-Chang and Choi, In-Young and Kim, Won-Ki and Junn, Eunsung and Kim, Hee-Sun
Journal of Immunology, ISSN 0022-1767, 07/2010, Volume 185, Issue 1, pp. 615 - 623
The mutation or overexpression of alpha-synuclein protein plays a pivotal role in the pathogenesis of Parkinson's disease. In our preliminary experiments, we... 
CELLS | DOPAMINERGIC NEURODEGENERATION | KINASE | CNS | MODEL | IMMUNOLOGY | NF-KAPPA-B | ASTROCYTES | MMP-9 | PARKINSONS-DISEASE | Microglia - metabolism | Receptor, PAR-1 - metabolism | Humans | alpha-Synuclein - physiology | Molecular Sequence Data | Paracrine Communication - immunology | Autocrine Communication - immunology | Inflammation Mediators - metabolism | Matrix Metalloproteinases - secretion | Microglia - pathology | Protein Processing, Post-Translational - immunology | Inflammation Mediators - physiology | Lipopolysaccharides - physiology | Matrix Metalloproteinases - biosynthesis | Amino Acid Sequence | Gene Expression Regulation - immunology | Receptor, PAR-1 - agonists | Cells, Cultured | Microglia - enzymology | Rats | Rats, Sprague-Dawley | Animals | Cell Line, Tumor | Matrix Metalloproteinase Inhibitors | Receptor, PAR-1 - physiology | Index Medicus | Abridged Index Medicus
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6. Full Text Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of beta-arrestin
by Smith, TH and Li, JG and Dores, MR and Trejo, J
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2017, Volume 292, Issue 33, pp. 13867 - 13878
Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs).... 
P2Y RECEPTORS | THROMBIN | CLONING | KINETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAFFICKING | HETERODIMER | PLATELET ACTIVATION | CLEAVAGE | MOTIF | ADP RECEPTOR | Immunoprecipitation | Receptor, PAR-1 - metabolism | Humans | Protein Multimerization | Cercopithecus aethiops | beta-Arrestin 2 - metabolism | Receptors, Thrombin - chemistry | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Endocytosis | Receptors, Thrombin - agonists | Proto-Oncogene Proteins c-akt - metabolism | Receptors, Purinergic P2Y12 - metabolism | Receptors, Purinergic P2Y12 - genetics | Receptor, PAR-1 - chemistry | Signal Transduction | Receptor, PAR-1 - agonists | Recombinant Fusion Proteins - chemistry | Bioluminescence Resonance Energy Transfer Techniques | Receptor, PAR-1 - genetics | Protein Transport | Receptors, Purinergic P2Y12 - chemistry | beta-Arrestin 2 - chemistry | Animals | Receptors, Thrombin - genetics | Proto-Oncogene Proteins c-akt - agonists | Cell Line, Tumor | Receptors, Thrombin - metabolism | COS Cells | Microscopy, Fluorescence | Amino Acid Substitution | Index Medicus | endosome | thrombin | dimerization | G protein-coupled receptor (GPCR) | Akt PKB | arrestin | ADP
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7. Full Text PAR1 contributes to influenza A virus pathogenicity in mice
by Khoufache, Khaled and Berri, Fatma and Nacken, Wolfgang and Vogel, Annette B and Delenne, Marie and Camerer, Eric and Coughlin, Shaun R and Carmeliet, Peter and Lina, Bruno and Rimmelzwaan, Guus F and Planz, Oliver and Ludwig, Stephan and Riteau, Béatrice
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 206 - 214
Influenza causes substantial morbidity and mortality, and highly pathogenic and drug-resistant strains are likely to emerge in the future. Protease-activated... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEASE-ACTIVATED RECEPTORS | THROMBIN | PANDEMIC INFLUENZA | INFLAMMATION | IN-VIVO | ANTAGONIST VORAPAXAR | LUNG INJURY | INFECTION | DEPENDENT PATHWAY | PLASMINOGEN | NIH 3T3 Cells | Receptor, PAR-1 - antagonists & inhibitors | Humans | Orthomyxoviridae Infections - pathology | Receptor, PAR-1 - agonists | Plasminogen - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Receptor, PAR-1 - genetics | Mice, Knockout | Orthomyxoviridae Infections - genetics | Receptor, PAR-1 - immunology | Animals | Influenza, Human - genetics | Dogs | Influenza A Virus, H5N1 Subtype - pathogenicity | Mice | Influenza, Human - drug therapy | Plasminogen - immunology | Oligopeptides - pharmacology | Orthomyxoviridae Infections - drug therapy | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Complications and side effects | Care and treatment | Influenza | Patient outcomes | Causes of | Thrombin | Inflammation | Research | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
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8. Full Text Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 kinase
by Bae, Jong-Sup and Kim, Yong-Ung and Park, Moon-Ki and Rezaie, Alireza R
Journal of Cellular Physiology, ISSN 0021-9541, 06/2009, Volume 219, Issue 3, pp. 744 - 751
Disruption of endothelial barrier is a critical pathophysiological factor in inflammation. Thrombin exerts a variety of cellular effects including inflammation... 
KAPPA-B ACTIVATION | IN-VITRO | PHYSIOLOGY | PROTEASE-ACTIVATED RECEPTORS | INTERCELLULAR-ADHESION MOLECULE-1 | MESSENGER-RNA | INFLAMMATION | GROWTH-FACTOR | VASCULAR-PERMEABILITY | EXPRESSION | PROSTAGLANDIN E-2 | CELL BIOLOGY | Thrombin - administration & dosage | Endothelial Cells - metabolism | Receptor, PAR-1 - metabolism | Humans | Neutrophils - drug effects | Receptor, PAR-1 - agonists | Cells, Cultured | Phosphatidylinositol 3-Kinases - metabolism | Cell Adhesion - drug effects | Cell Adhesion Molecules - metabolism | Dose-Response Relationship, Drug | Tumor Necrosis Factor-alpha - pharmacology | Cell Membrane Permeability - drug effects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Oligopeptides - administration & dosage | In Vitro Techniques | Endothelial Cells - physiology | Endothelial Cells - drug effects | Index Medicus | Thrombin | PAR-1 | inflammation | PI3 kinase | Endothelium
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9. Full Text Specific activation, signalling and secretion profiles of human platelets following PAR-1 and PAR-4 stimulation
by Nguyen, Kim Anh and Hamzeh-Cognasse, Hind and Laradi, Sandrine and Pozzetto, Bruno and Garraud, Olivier and Cognasse, Fabrice
Platelets, ISSN 0953-7104, 11/2015, Volume 26, Issue 8, pp. 795 - 798
Blood platelets play a central haemostatic function; however, they also play a role in inflammation and are capable of secreting various cytokines, chemokines... 
protease-activated receptors | platelet | inflammation | signal transduction | Immunologic factors | ALPHA-GRANULES | THROMBIN | RELEASE | LPS | CELL BIOLOGY | platelet protease-activated receptors | RECEPTORS | PROTEINS | HEMATOLOGY | REVEALS | Receptors, Thrombin - agonists | Signal Transduction - drug effects | Blood Platelets - metabolism | Receptor, PAR-1 - metabolism | Cytoplasmic Granules - metabolism | Humans | Receptor, PAR-1 - agonists | Biomarkers | Receptors, Thrombin - metabolism | Platelet Activation - drug effects | Blood Platelets - drug effects | Index Medicus
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10. Full Text Stimulation of PAR-1 or PAR-4 promotes similar pattern of VEGF and endostatin release and pro-angiogenic responses mediated by human platelets
by Etulain, J and Mena, H. A and Negrotto, S and Schattner, M
Platelets, ISSN 0953-7104, 11/2015, Volume 26, Issue 8, pp. 799 - 804
Background: Platelets mediate angiogenesis through the secretion of several factors, including the pro-angiogenic vascular endothelial growth factor (VEGF) and... 
protease-activated receptors | Angiogenesis | platelet alpha-granules | endostatin | VEGF | THROMBIN RECEPTORS | ACTIVATION | MECHANISMS | CELL BIOLOGY | SECRETION | PROTEINS | HEMATOLOGY | REVEALS | Receptors, Thrombin - agonists | Blood Platelets - metabolism | Endothelial Cells - metabolism | Humans | Receptor, PAR-1 - agonists | Endostatins - secretion | Platelet Activation - drug effects | Vascular Endothelial Growth Factor A - metabolism | Blood Platelets - drug effects | Oligopeptides - pharmacology | Neovascularization, Physiologic | Index Medicus
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11. Full Text Platelet secretion is kinetically heterogeneous in an agonist-responsive manner
by Jonnalagadda, Deepa and Izu, Leighton T and Whiteheart, Sidney W
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 26, pp. 5209 - 5216
Platelets release numerous bioactive molecules stored in their granules enabling them to exert a wide range of effects on the vascular microenvironment. Are... 
RELEASE REACTION | HUMAN MEGAKARYOCYTES | DENSE GRANULES | EXOCYTOSIS | ALPHA-GRANULES | SYNTAXIN 2 | PROTEINS | SNAP-23 | HEMATOLOGY | FIBRINOGEN | MOLECULAR-MECHANISMS | Enzyme-Linked Immunosorbent Assay - methods | Crotalid Venoms - pharmacology | beta-N-Acetylhexosaminidases - metabolism | Humans | Lectins, C-Type | Receptor, PAR-1 - agonists | Secretory Vesicles - metabolism | Male | Blood Platelets - secretion | Protein Array Analysis - methods | beta-N-Acetylhexosaminidases - secretion | Secretory Pathway - drug effects | Receptors, Thrombin - agonists | Thrombin - pharmacology | Blood Platelets - metabolism | Platelet Factor 4 - secretion | Secretory Vesicles - drug effects | Serotonin - metabolism | Serotonin - secretion | Platelet Factor 4 - metabolism | Kinetics | Blood Platelets - drug effects | Index Medicus | Abridged Index Medicus | Platelets and Thrombopoiesis
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12. Full Text Two Forms of Astrocyte Calcium Excitability Have Distinct Effects on NMDA Receptor-Mediated Slow Inward Currents in Pyramidal Neurons
by Shigetomi, Eiji and Bowser, David N and Sofroniew, Michael V and Khakh, Baljit S
Journal of Neuroscience, ISSN 0270-6474, 06/2008, Volume 28, Issue 26, pp. 6659 - 6663
Astrocytes display excitability in the form of intracellular calcium concentration ([Ca2+](i)) increases, but the signaling impact of these for neurons remains... 
Gliotransmitter | Astrocytic glutamate release | Astrocyte | Calcium | Glia | SIC | astrocytic glutamate release | LOCALIZATION | calcium | GLUTAMATE RELEASE | EXOCYTOSIS | gliotransmitter | glia | NEUROSCIENCES | INHIBITION | CULTURED ASTROCYTES | astrocyte | ATP | IN-SITU | CA2+ OSCILLATIONS | BRAIN | INTERNEURONS | Pyramidal Cells - metabolism | Synaptic Transmission - physiology | Calcium - metabolism | Receptor, PAR-1 - metabolism | Calcium Signaling - physiology | Receptors, N-Methyl-D-Aspartate - metabolism | Cell Communication - physiology | Receptors, Purinergic P2Y1 | Time Factors | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Organ Culture Techniques | Astrocytes - cytology | Membrane Potentials - drug effects | Pyramidal Cells - cytology | Astrocytes - drug effects | Receptors, N-Methyl-D-Aspartate - drug effects | Mice, Inbred C57BL | Receptor, PAR-1 - agonists | Mice, Transgenic | Purinergic P2 Receptor Agonists | Hippocampus - cytology | Membrane Potentials - physiology | Hippocampus - metabolism | Animals | Receptors, Purinergic P2 - metabolism | Cell Communication - drug effects | Glutamic Acid - metabolism | Mice | Astrocytes - metabolism | Index Medicus
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13. Full Text Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis
by Shi, Xiaoli and Gangadharan, Beena and Brass, Lawrence F and Ruf, Wolfram and Mueller, Barbara M
Molecular Cancer Research, ISSN 1541-7786, 07/2004, Volume 2, Issue 7, pp. 395 - 402
The effects of the pleiotropic serine protease thrombin on tumor cells are commonly thought to be mediated by the thrombin receptor protease-activated receptor... 
CANCER CELLS | ONCOLOGY | TRANSACTIVATION | ENDOTHELIAL-CELLS | COUPLED RECEPTORS | PROLIFERATION | MELANOMA-CELLS | GROWTH-FACTOR | THROMBIN RECEPTOR | EXPRESSION | TISSUE FACTOR | CELL BIOLOGY | Melanoma - metabolism | Cell Movement - drug effects | Neoplasm Metastasis | Thrombin - pharmacology | Receptor, PAR-1 - antagonists & inhibitors | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-1 - agonists | Receptor, PAR-2 - metabolism | Receptor, PAR-2 - agonists | Cell Line, Tumor | Melanoma - pathology | Index Medicus
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14. Full Text The role of protease-activated receptors PAR-1 and PAR-2 in the repair of 16HBE 14o epithelial cell monolayers in vitro
by Ewen, D and Clarke, S.L and Smith, J.R and Berger, C and Salmon, G and Trevethick, M and Shute, J.K
Clinical & Experimental Allergy, ISSN 0954-7894, 03/2010, Volume 40, Issue 3, pp. 435 - 449
Summary Background We recently reported that repair following mechanical wounding of epithelial cell layers in vitro is dependent on fibrin formation and the... 
elastase | protease-activated receptor | factor Xa | fibrin | bronchial epithelium | coagulation | Fibrin | Factor Xa | Bronchial epithelium | Elastase | Protease-activated receptor | Coagulation | BLOOD-COAGULATION | NEUTROPHIL ELASTASE | IMMUNOLOGY | ALLERGY | LUNG EPITHELIAL-CELLS | INFLAMMATION | AIRWAY EPITHELIUM | CROSS-REACTIVITY | FACTOR-XIII | ASTHMA | CATHEPSIN-G | EXPRESSION | Leukocyte Elastase - metabolism | Dinoprostone - pharmacology | Epithelial Cells - metabolism | Leukocyte Elastase - pharmacology | Receptor, PAR-1 - antagonists & inhibitors | Receptor, PAR-1 - metabolism | Epithelial Cells - drug effects | Humans | Receptor, PAR-1 - agonists | Receptor, PAR-2 - metabolism | Cells, Cultured | Factor Xa - metabolism | Indomethacin - pharmacology | Antibodies - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Factor Xa - pharmacology | Receptor, PAR-2 - agonists | Cell Membrane - metabolism | Epithelial Cells - cytology | Oligopeptides - pharmacology | Rodents | Index Medicus
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15. Full Text Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells
by Tripathi, Trivendra and Abdi, Mahshid and Alizadeh, Hassan
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 05/2014, Volume 55, Issue 6, pp. 3912 - 3921
PURPOSE. Acanthamoeba plasminogen activator (aPA) is a serine protease elaborated by Acanthamoeba trophozoites that facilitates the invasion of trophozoites to... 
Corneal epithelial cells | Plasminogen activator | PAR2 | IL-8 | PAR1 | Acanthamoeba | TISSUE | plasminogen activator | KERATITIS | CASTELLANII | INTERLEUKIN-8 | PATHOGENESIS | corneal epithelial cells | PATHOGENICITY | INFLAMMATION | MANNOSE | OPHTHALMOLOGY | LENS | PROTEINASE | Immunohistochemistry | Interleukin-8 - genetics | Up-Regulation | Enzyme-Linked Immunosorbent Assay | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-1 - agonists | Receptor, PAR-2 - metabolism | Cells, Cultured | Gene Expression Regulation - physiology | RNA, Messenger - metabolism | Receptor, PAR-1 - genetics | Animals | Flow Cytometry | Receptor, PAR-2 - agonists | Epithelium, Corneal - drug effects | Epithelium, Corneal - metabolism | Acanthamoeba castellanii - enzymology | Plasminogen Activators - pharmacology | Real-Time Polymerase Chain Reaction | Receptor, PAR-2 - genetics | Index Medicus
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16. Full Text Protease-activated receptor 1 and 2 contribute to angiotensin II-induced activation of adventitial fibroblasts from rat aorta
by He, Rui-Qing and Tang, Xiao-Feng and Zhang, Bao-Li and Li, Xiao-Dong and Hong, Mo-Na and Chen, Qi-Zhi and Han, Wei-Qing and Gao, Ping-Jin
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2016, Volume 473, Issue 2, pp. 517 - 523
Adventitial fibroblasts (AFs) can be activated by angiotensin II (Ang II) and exert pro-fibrotic and pro-inflammatory effects in vascular remodeling.... 
Adventitial fibroblast | Adventitial remodeling | Protease-activated receptor | Angiotensin II | Angiotensin II - metabolism | Receptor, PAR-1 - antagonists & inhibitors | Receptor, PAR-1 - metabolism | Aorta - drug effects | Receptor, PAR-1 - agonists | Receptor, PAR-2 - metabolism | Cells, Cultured | Rats | Male | Aorta - metabolism | Rats, Sprague-Dawley | Cell Movement - drug effects | Receptor, PAR-2 - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Fibroblasts - drug effects | Receptor, PAR-2 - agonists | Cell Proliferation - drug effects | Fibroblasts - cytology | Aorta - cytology | Fibroblasts - metabolism | Hypertension | Medical colleges | Proteases | Angiotensin | Medical genetics | Physiological aspects | Transforming growth factors | Index Medicus | LYMPHOKINES | BIOSYNTHESIS | INFLAMMATION | AORTA | RATS | CELL PROLIFERATION | RECEPTORS | 60 APPLIED LIFE SCIENCES | ANGIOTENSIN | FIBROBLASTS
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