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1. Full Text Ankaferd hemostat (ABS) as a potential mucosal topical agent for the management of COVID-19 syndrome based on its PAR-1 inhibitory effect and oestrogen content
by Beyazit, Fatma and Beyazit, Yavuz and Tanoglu, Alpaslan and Haznedaroglu, Ibrahim C
Medical hypotheses, ISSN 0306-9877, 10/2020, Volume 143, pp. 110150 - 110150
COVID-19 | Oestrogen | SARS-CoV-2 | PAR-1 | Ankaferd hemostat | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Plant Extracts - chemistry | Age Distribution | Pandemics | Coronavirus Infections - drug therapy | Humans | Pneumonia, Viral - drug therapy | Endothelium, Vascular - drug effects | Stomatitis - drug therapy | Pneumonia, Viral - blood | Phytoestrogens - therapeutic use | Thrombophilia - etiology | Plant Extracts - administration & dosage | Coronavirus Infections - epidemiology | Pneumonia, Viral - epidemiology | Pneumonia, Viral - complications | Coronavirus Infections - blood | Anti-Inflammatory Agents - therapeutic use | Betacoronavirus | Coronavirus Infections - complications | Anti-Inflammatory Agents - administration & dosage | Phytoestrogens - administration & dosage | Phytotherapy | Estrogens - physiology | Cytokine Release Syndrome - physiopathology | Receptor, PAR-1 - antagonists & inhibitors | Drug Repositioning | Mucositis - drug therapy | Stomatitis - etiology | Estrogens - agonists | Cytokine Release Syndrome - etiology | Hemostatics - administration & dosage | Thrombophilia - blood | Mucositis - etiology | Hemostatics - therapeutic use | Administration, Topical | Plant Extracts - therapeutic use | Receptor, PAR-1 - physiology | Fibrin | Estrogen | Fibrinogen | Inflammation | Hormones | Health aspects | Endothelium | Index Medicus
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2. Full Text House Dust Mite Allergens Induce Proinflammatory Cytokines from Respiratory Epithelial Cells: The Cysteine Protease Allergen, Der p 1, Activates Protease-Activated Receptor (PAR)-2 and Inactivates PAR-1
by Asokananthan, Nithiananthan and Graham, Peter T and Stewart, David J and Bakker, Anthony J and Eidne, Karin A and Thompson, Philip J and Stewart, Geoffrey A
The Journal of immunology (1950), ISSN 0022-1767, 10/2002, Volume 169, Issue 8, pp. 4572 - 4578
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-6 - antagonists & inhibitors | Receptors, Thrombin - biosynthesis | Dermatophagoides pteronyssinus - immunology | Calcium - metabolism | Humans | DNA, Complementary - genetics | Molecular Sequence Data | HeLa Cells - metabolism | Antigens, Dermatophagoides - pharmacology | Receptors, Thrombin - antagonists & inhibitors | Receptor, PAR-1 | Arthropod Proteins | Cysteine Endopeptidases - metabolism | Receptor, PAR-2 | Receptors, Thrombin - agonists | Transfection | Respiratory Mucosa - immunology | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Amino Acid Sequence | Respiratory Mucosa - cytology | Tumor Cells, Cultured - immunology | Peptides - physiology | Bacterial Proteins - genetics | Respiratory Mucosa - enzymology | Tumor Cells, Cultured - metabolism | Interleukin-8 - antagonists & inhibitors | Animals | Receptors, Thrombin - genetics | Receptors, Thrombin - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Allergens - pharmacology | Respiratory Mucosa - metabolism | Peptides - agonists | Luminescent Proteins - metabolism | Index Medicus | Abridged Index Medicus
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3. Full Text High-resolution crystal structure of human protease-activated receptor 1
by Zhang, Cheng and Srinivasan, Yoga and Arlow, Daniel H and Fung, Juan Jose and Palmer, Daniel and Zheng, Yaowu and Green, Hillary F and Pandey, Anjali and Dror, Ron O and Shaw, David E and Weis, William I and Coughlin, Shaun R and Kobilka, Brian K
Nature (London), ISSN 0028-0836, 12/2012, Volume 492, Issue 7429, pp. 387 - 392
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Structure in molecular biology | Cell receptors | Miscellaneous | Analytical, structural and metabolic biochemistry | Molecular biophysics | Biological and medical sciences | Molecular and cellular biology | Cell structures and functions | Crystalline structure | Receptor, PAR-1 - chemistry | Receptors, Thrombin | Receptor, PAR-1 - antagonists & inhibitors | Pyridines - chemistry | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-1 - agonists | Crystallization | Models, Molecular | Crystallography, X-Ray | Receptors, G-Protein-Coupled - classification | Lactones - pharmacology | Molecular Dynamics Simulation | Amino Acid Motifs | Hydrolysis | Ligands | Protein Conformation | Myocardial Infarction - prevention & control | Pyridines - pharmacology | Enzyme Activation - genetics | Binding Sites | Receptors, G-Protein-Coupled - chemistry | Lactones - chemistry | Animal experimentation | Cell interaction | Usage | Proteases | Crystals | Physiological aspects | Research | Structure | Proteins | Amino acids | Heart attacks | Peptides | Methods | Index Medicus
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4. Full Text PAR-1 contributes to the innate immune response during viral infection
by Antoniak, Silvio and Owens III, A. Phillip and Baunacke, Martin and Williams, Julie C and Lee, Rebecca D and Weithäuser, Alice and Sheridan, Patricia A and Malz, Ronny and Luyendyk, James P and Esserman, Denise A and Trejo, Jo Ann and Kirchhofer, Daniel and Blaxall, Burns C and Pawlinski, Rafal and Beck, Melinda A and Rauch, Ursula and Mackman, Nigel
The Journal of clinical investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1310 - 1322
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptor, PAR-1 - metabolism | Humans | Male | Troponin I - blood | STAT1 Transcription Factor - metabolism | Myocardium - metabolism | HEK293 Cells | Interferon-beta - genetics | Influenza A virus - immunology | Myocarditis - immunology | Influenza A virus - physiology | Orthomyxoviridae Infections - metabolism | Coxsackievirus Infections - metabolism | Liver - metabolism | Mice, Inbred C57BL | Enterovirus - physiology | Myocarditis - blood | Immunity, Innate | STAT1 Transcription Factor - genetics | Toll-Like Receptor 3 - metabolism | Receptor, PAR-1 - genetics | Mice, Knockout | Myocarditis - virology | Animals | Interferon-beta - metabolism | Thromboplastin - genetics | Enterovirus - immunology | Mice | HeLa Cells | Thrombin - metabolism | Thromboplastin - metabolism | Fibrin - metabolism | Chemokine CXCL10 - metabolism | Coxsackievirus Infections - immunology | Orthomyxoviridae Infections - immunology | Receptor, PAR-1 - physiology | Virus diseases | Cell receptors | Immune response | Physiological aspects | Development and progression | Genetic aspects | Research | Index Medicus | Abridged Index Medicus
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5. Full Text HIV‐1 Tat promotes astrocytic release of CCL2 through MMP/PAR‐1 signaling
by Bozzelli, P. Lorenzo and Yin, Tao and Avdoshina, Valeria and Mocchetti, Italo and Conant, Katherine E and Maguire‐Zeiss, Kathleen A
Glia, ISSN 0894-1491, 09/2019, Volume 67, Issue 9, pp. 1719 - 1729
CCL2 | matrix metalloproteinase | HIV | protease activated receptor 1 | Tat | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | HIV-1 | Signal Transduction | Humans | Mice, Inbred C57BL | Middle Aged | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Cerebral Cortex - virology | Male | Cerebral Cortex - metabolism | Mice, Knockout | Animals | Adult | Female | Chemokine CCL2 - metabolism | Matrix Metalloproteinases - metabolism | Astrocytes - virology | Protein-Serine-Threonine Kinases - metabolism | Astrocytes - metabolism | tat Gene Products, Human Immunodeficiency Virus - metabolism | Highly active antiretroviral therapy | HIV (Viruses) | Proteases | Analysis | Brain | Matrix metalloproteinases | Astrocytes | Pathogenesis | Central nervous system | Cognitive ability | Tissue analysis | Cognition | Pharmacology | Inflammation | Matrix metalloproteinase | Proteins | Signaling | Tat protein | Neurotoxicity | Monocytes | Antiretroviral agents | Correlation analysis | Human immunodeficiency virus--HIV | Agonists | Monocyte chemoattractant protein 1 | Immune system | Index Medicus
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6. Full Text Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
by Mosnier, Laurent O and Sinha, Ranjeet K and Burnier, Laurent and Bouwens, Eveline A and Griffin, John H
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 26, pp. 5237 - 5246
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Receptor, PAR-1 - chemistry | Catalytic Domain | Receptor, PAR-1 - antagonists & inhibitors | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-1 - agonists | Cells, Cultured | Capillary Permeability - drug effects | Models, Molecular | Endothelium, Vascular - drug effects | Protein C - pharmacology | Arginine - chemistry | Drug Agonism | Proteolysis - drug effects | Pyrroles - pharmacology | Animals | Endothelium, Vascular - metabolism | Models, Biological | HEK293 Cells | Mice | Protein C - metabolism | Quinazolines - pharmacology | Index Medicus | Abridged Index Medicus | Thrombosis and Hemostasis
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7. Full Text The role of protease-activated receptors PAR-1 and PAR-2 in the repair of 16HBE 14o epithelial cell monolayers in vitro
by Ewen, D and Clarke, S.L and Smith, J.R and Berger, C and Salmon, G and Trevethick, M and Shute, J.K
Clinical and experimental allergy, ISSN 0954-7894, 03/2010, Volume 40, Issue 3, pp. 435 - 449
elastase | protease-activated receptor | factor Xa | fibrin | bronchial epithelium | coagulation | protease‐activated receptor | Fibrin | Factor Xa | Bronchial epithelium | Elastase | Protease-activated receptor | Coagulation | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Biological and medical sciences | Leukocyte Elastase - metabolism | Dinoprostone - pharmacology | Epithelial Cells - metabolism | Leukocyte Elastase - pharmacology | Receptor, PAR-1 - antagonists & inhibitors | Receptor, PAR-1 - metabolism | Epithelial Cells - drug effects | Humans | Receptor, PAR-1 - agonists | Receptor, PAR-2 - metabolism | Cells, Cultured | Factor Xa - metabolism | Indomethacin - pharmacology | Antibodies - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Factor Xa - pharmacology | Receptor, PAR-2 - agonists | Cell Membrane - metabolism | Epithelial Cells - cytology | Oligopeptides - pharmacology | Index Medicus
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8. Full Text Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand
by Jong-Sup Bae and Alireza R. Rezaie
Thrombosis and haemostasis, ISSN 0340-6245, 07/2008, Volume 100, Issue 1, pp. 101 - 109
Signaling | EPCR | thrombin | PAR-1 | inflammation | aPC | Endothelium and Vascular Development | Thrombin | Inflammation | APC | Tumor Necrosis Factor-alpha - metabolism | Endothelial Protein C Receptor | Capillary Permeability | Membrane Microdomains - metabolism | Receptor, PAR-1 - metabolism | Humans | Monocytes - metabolism | beta-Cyclodextrins - pharmacology | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Inflammation - metabolism | Pulmonary Artery - metabolism | RNA Interference | Receptors, Lysosphingolipid - metabolism | Cytoprotection | Cholesterol - deficiency | Endothelial Cells - metabolism | Receptor, PAR-1 - agonists | Cells, Cultured | Receptors, Cell Surface - metabolism | Pulmonary Artery - drug effects | Cell Adhesion | Receptor, PAR-1 - genetics | Peptides - pharmacology | Caveolin 1 - metabolism | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Receptors, Thrombin - metabolism | Ligands | Mutation | Protein C - metabolism | Thrombin - metabolism | Endothelial Cells - pathology | Protein C - genetics | Pulmonary Artery - pathology | Apoptosis | Endothelial Cells - drug effects | RNA, Small Interfering - metabolism | Index Medicus
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