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1. Full Text PAR-1 contributes to the innate immune response during viral infection
by Antoniak, Silvio and Owens III, A. Phillip and Baunacke, Martin and Williams, Julie C and Lee, Rebecca D and Weithäuser, Alice and Sheridan, Patricia A and Malz, Ronny and Luyendyk, James P and Esserman, Denise A and Trejo, Jo Ann and Kirchhofer, Daniel and Blaxall, Burns C and Pawlinski, Rafal and Beck, Melinda A and Rauch, Ursula and Mackman, Nigel
The Journal of clinical investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1310 - 1322
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptor, PAR-1 - metabolism | Humans | Male | Troponin I - blood | STAT1 Transcription Factor - metabolism | Myocardium - metabolism | HEK293 Cells | Interferon-beta - genetics | Influenza A virus - immunology | Myocarditis - immunology | Influenza A virus - physiology | Orthomyxoviridae Infections - metabolism | Coxsackievirus Infections - metabolism | Liver - metabolism | Mice, Inbred C57BL | Enterovirus - physiology | Myocarditis - blood | Immunity, Innate | STAT1 Transcription Factor - genetics | Toll-Like Receptor 3 - metabolism | Receptor, PAR-1 - genetics | Mice, Knockout | Myocarditis - virology | Animals | Interferon-beta - metabolism | Thromboplastin - genetics | Enterovirus - immunology | Mice | HeLa Cells | Thrombin - metabolism | Thromboplastin - metabolism | Fibrin - metabolism | Chemokine CXCL10 - metabolism | Coxsackievirus Infections - immunology | Orthomyxoviridae Infections - immunology | Receptor, PAR-1 - physiology | Virus diseases | Cell receptors | Immune response | Physiological aspects | Development and progression | Genetic aspects | Research | Index Medicus | Abridged Index Medicus
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2. Full Text Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease
by Sparkenbaugh, Erica M and Chen, Chunsheng and Brzoska, Tomasz and Nguyen, Julia and Wang, Shaobin and Vercellotti, Gregory M and Key, Nigel S and Sundd, Prithu and Belcher, John D and Pawlinski, Rafal
Blood, ISSN 0006-4971, 05/2020, Volume 135, Issue 20, pp. 1783 - 1787
Life Sciences & Biomedicine | Hematology | Science & Technology | Anemia, Sickle Cell - pathology | Constriction, Pathologic - metabolism | Vascular Diseases - etiology | Receptor, PAR-1 - metabolism | Humans | Microvessels - metabolism | Microvessels - pathology | Male | Blood Coagulation Disorders - genetics | Female | Blood Coagulation Disorders - metabolism | Disease Models, Animal | Anemia, Sickle Cell - complications | Blood Coagulation Disorders - etiology | Constriction, Pathologic - genetics | Mice, Transgenic | Hemoglobin, Sickle - genetics | Receptor, PAR-1 - genetics | Animals | Blood Platelets - metabolism | Anemia, Sickle Cell - metabolism | Mice | Thrombin - metabolism | Vascular Diseases - metabolism | Anemia, Sickle Cell - genetics | Index Medicus | Abridged Index Medicus
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3. Full Text Colon cancer growth and dissemination relies upon thrombin, Stromal PAR-1, and fibrinogen
by Adams, Gregory N and Rosenfeldt, Leah and Frederick, Malinda and Miller, Whitney and Waltz, Dusty and Kombrinck, Keith and McElhinney, Kathryn E and Flick, Matthew J and Monia, Brett P and Revenko, Alexey S and Palumbo, Joseph S
Cancer research (Chicago, Ill.), ISSN 0008-5472, 10/2015, Volume 75, Issue 19, pp. 4235 - 4243
Life Sciences & Biomedicine | Oncology | Science & Technology | Adenocarcinoma - pathology | Prothrombin - analysis | Humans | Tumor Microenvironment | Male | Thrombin - physiology | Receptor, PAR-1 - deficiency | Colonic Neoplasms - metabolism | Adenocarcinoma - metabolism | HCT116 Cells - transplantation | Heterografts | Cell Division | Female | Neovascularization, Pathologic - physiopathology | Afibrinogenemia - genetics | Fibrinogen - physiology | Colonic Neoplasms - blood supply | Neoplasm Invasiveness | Thrombin - deficiency | Mice, Inbred C57BL | Stromal Cells - metabolism | Afibrinogenemia - complications | Melanoma, Experimental - pathology | Tumor Burden | Disease Progression | Adenocarcinoma - blood supply | Mice, Knockout | Animals | Mice, Nude | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice | Receptor, PAR-1 - physiology | Index Medicus
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4. Full Text Inhibiting trophoblast PAR-1 overexpression suppresses sFlt-1-induced anti-angiogenesis and abnormal vascular remodeling: a possible therapeutic approach for preeclampsia
by Zhao, Yin and Zheng, YanFang and Liu, XiaoXia and Luo, QingQing and Wu, Di and Liu, XiaoPing and Zou, Li
Molecular human reproduction, ISSN 1360-9947, 03/2018, Volume 24, Issue 3, pp. 158 - 169
SFlt-1 | Angiogenesis | Trophoblast | PAR-1 | Preeclampsia | Life Sciences & Biomedicine | Developmental Biology | Obstetrics & Gynecology | Reproductive Biology | Science & Technology | Immunohistochemistry | Pre-Eclampsia - genetics | Cell Line | Enzyme-Linked Immunosorbent Assay | Receptor, PAR-1 - metabolism | Coculture Techniques | Rats | Male | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Blotting, Western | Receptor, PAR-1 - genetics | Placenta - metabolism | Pregnancy | Animals | Vascular Remodeling - genetics | Female | Vascular Remodeling - physiology | Pre-Eclampsia - metabolism | Vascular Endothelial Growth Factor Receptor-1 - genetics | Index Medicus
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5. Full Text PAR-1 Phosphorylates Mind Bomb to Promote Vertebrate Neurogenesis
by Ossipova, Olga and Ezan, Jerome and Sokol, Sergei Y
Developmental cell, ISSN 1534-5807, 08/2009, Volume 17, Issue 2, pp. 222 - 233
CELLBIO | DEVBIO | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell differentiation, maturation, development, hematopoiesis | Protein Kinase C - genetics | Xenopus Proteins - genetics | Receptors, Notch - metabolism | Humans | Oligonucleotides, Antisense - metabolism | Vertebrates - embryology | Molecular Sequence Data | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Ubiquitination | Protein Kinase C - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Cell Line | Xenopus laevis - embryology | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Sequence Alignment | Animals | Oligonucleotides, Antisense - genetics | Neurogenesis - physiology | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Stem Cells - physiology | Xenopus Proteins - metabolism | Mice | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Neurons | Ligases | Index Medicus | Xenopus | PAR-1 | Mind bomb | Notch | neurogenesis | progenitor | aPKC
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6. Full Text TGF‐β induced PAR‐1 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone
by Wang, Ting and Jiao, Jian and Zhang, Hao and Zhou, Wang and Li, Zhenxi and Han, Shuai and Wang, Jing and Yang, Xinghai and Huang, Quan and Wu, Zhipeng and Yan, Wangjun and Xiao, Jianru
International journal of cancer, ISSN 0020-7136, 10/2017, Volume 141, Issue 8, pp. 1630 - 1642
TGF‐β | giant cell tumor of bone | microvesicle | cell proliferation | angiogenesis | PAR‐1 | osteoclast differentiation | PAR-1 | TGF-β | Life Sciences & Biomedicine | Oncology | Science & Technology | Human Umbilical Vein Endothelial Cells | Up-Regulation | Humans | Middle Aged | Bone Neoplasms - pathology | Transforming Growth Factor beta - biosynthesis | Bone Neoplasms - metabolism | Gene Knockdown Techniques | Young Adult | Giant Cell Tumor of Bone - pathology | HEK293 Cells | Adult | Bone Neoplasms - genetics | Tumor Cells, Cultured | Cell Differentiation - physiology | Giant Cell Tumor of Bone - genetics | Osteoclasts - pathology | Chick Embryo | Osteoclasts - metabolism | Disease Progression | Receptor, PAR-1 - biosynthesis | Animals | Transforming Growth Factor beta - genetics | Giant Cell Tumor of Bone - metabolism | Transforming Growth Factor beta - metabolism | Index Medicus
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7. Full Text Dust mite-derived Der f 3 activates a pro-inflammatory program in airway epithelial cells via PAR-1 and PAR-2
by Li, Bizhou and Zou, Zehong and Meng, Fanmei and Raz, Eyal and Huang, Yuye and Tao, Ailin and Ai, Yuncan
Molecular immunology, ISSN 0161-5890, 05/2019, Volume 109, pp. 1 - 11
Airway epithelial cell | House dust mite (HDM) | Inflammation | Protease-activated receptor (PAR) | Protease | Der f 3 | Biochemistry & Molecular Biology | Immunology | Life Sciences & Biomedicine | Science & Technology | Inflammation - chemically induced | Inflammation - pathology | Humans | NF-kappa B - immunology | Serine Endopeptidases - pharmacology | Th2 Cells - immunology | Extracellular Signal-Regulated MAP Kinases - genetics | MAP Kinase Signaling System - immunology | Extracellular Signal-Regulated MAP Kinases - immunology | Gene Knockdown Techniques | Receptor, PAR-2 - immunology | MAP Kinase Signaling System - genetics | Allergens - immunology | Respiratory Mucosa - immunology | Serine Endopeptidases - immunology | Calcium Signaling - immunology | Cytokines - genetics | Th2 Cells - pathology | Cytokines - immunology | Receptor, PAR-2 - genetics | Th17 Cells - pathology | Inflammation Mediators - immunology | A549 Cells | Gene Expression Regulation - immunology | Epithelial Cells - pathology | Inflammation - immunology | Arthropod Proteins - immunology | Receptor, PAR-1 - genetics | Receptor, PAR-1 - immunology | Gene Expression Regulation - drug effects | Arthropod Proteins - pharmacology | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | Calcium Signaling - drug effects | Epithelial Cells - immunology | Inflammation - genetics | Th17 Cells - immunology | Allergens - pharmacology | Calcium Signaling - genetics | Pyroglyphidae - immunology | Allergens | Allergy | Medical colleges | RNA | Biological control | Thrombin | Respiratory tract diseases | Genetic engineering | Pests | B cells | Allergic reaction | Index Medicus
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8. Full Text PAR-1 and thrombin: The ties that bind the microenvironment to melanoma metastasis
by Zigler, Maya and Kamiya, Takafumi and Brantley, Emily C and Villares, Gabriel J and Bar-Eli, Menashe
Cancer research (Chicago, Ill.), ISSN 0008-5472, 11/2011, Volume 71, Issue 21, pp. 6561 - 6566
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | Dermatology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Melanoma - blood | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Thrombin - physiology | Antineoplastic Agents - therapeutic use | Tumor Microenvironment - physiology | Molecular Targeted Therapy | Lung Neoplasms - secondary | Melanoma, Experimental - secondary | Blood Coagulation | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Neoplasm Proteins - biosynthesis | Melanoma, Experimental - therapy | Lung Neoplasms - therapy | Melanoma - pathology | Cell Adhesion | Disease Progression | Melanoma - secondary | Receptor, PAR-1 - genetics | Xenograft Model Antitumor Assays | Phenotype | Receptor, PAR-1 - biosynthesis | Animals | RNA, Small Interfering - therapeutic use | Neoplastic Cells, Circulating | Signal Transduction - physiology | Mice | Endothelial Cells - pathology | Stromal Cells - physiology | Cell Movement | Receptor, PAR-1 - physiology | Index Medicus | Thrombin | PAR-1 | Microenvironment | Melanoma metastasis
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9. Full Text Overexpression of protease‐activated receptors‐1,‐2, and‐4 (PAR‐1, ‐2, and ‐4) in prostate cancer
by Black, Peter C and Mize, Gregory J and Karlin, Peter and Greenberg, Daniel L and Hawley, Sarah J and True, Lawrence D and Vessella, Robert L and Takayama, Thomas K
The Prostate, ISSN 0270-4137, 05/2007, Volume 67, Issue 7, pp. 743 - 756
prostate cancer | PAR‐2 | LNCaP | PAR‐1 | PAR‐4 | PAR-2 | PAR-1 | Prostate cancer | PAR-4 | Endocrinology & Metabolism | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Male genital diseases | Tumors | Multivariate Analysis | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Receptor, PAR-1 - metabolism | Humans | Middle Aged | RNA, Messenger - genetics | Receptor, PAR-2 - metabolism | Gene Expression Regulation, Neoplastic | Neoplasm Recurrence, Local | Male | cdc42 GTP-Binding Protein - physiology | RNA, Messenger - metabolism | Cell Movement - physiology | Receptor, PAR-1 - genetics | Disease-Free Survival | Prostatic Neoplasms - genetics | Receptors, Thrombin - genetics | rac1 GTP-Binding Protein - physiology | Receptors, Thrombin - metabolism | Signal Transduction - physiology | Aged | Tumor Cells, Cultured | Receptor, PAR-2 - genetics | Index Medicus
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