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Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1310 - 1322
Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In... 
TOLL-LIKE RECEPTOR-3 | MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER-CELLS | ISCHEMIA/REPERFUSION INJURY | PROTEASE-ACTIVATED RECEPTORS | VIRUS-INFECTION | IN-VIVO | ENDOTHELIAL-CELLS | FACTOR MESSENGER-RNA | INTERFERON-BETA | TISSUE FACTOR EXPRESSION | Receptor, PAR-1 - metabolism | Humans | Male | Troponin I - blood | STAT1 Transcription Factor - metabolism | Myocardium - metabolism | HEK293 Cells | Interferon-beta - genetics | Influenza A virus - immunology | Myocarditis - immunology | Influenza A virus - physiology | Orthomyxoviridae Infections - metabolism | Coxsackievirus Infections - metabolism | Liver - metabolism | Mice, Inbred C57BL | Enterovirus - physiology | Myocarditis - blood | Immunity, Innate | STAT1 Transcription Factor - genetics | Toll-Like Receptor 3 - metabolism | Receptor, PAR-1 - genetics | Mice, Knockout | Myocarditis - virology | Animals | Interferon-beta - metabolism | Thromboplastin - genetics | Enterovirus - immunology | Mice | HeLa Cells | Thrombin - metabolism | Thromboplastin - metabolism | Fibrin - metabolism | Chemokine CXCL10 - metabolism | Coxsackievirus Infections - immunology | Orthomyxoviridae Infections - immunology | Receptor, PAR-1 - physiology | Virus diseases | Cell receptors | Immune response | Physiological aspects | Development and progression | Genetic aspects | Research | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, pp. e25103 - e25103
Galectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3... 
Immunohistochemistry | Stomach Neoplasms - genetics | Immunoprecipitation | Oligonucleotide Array Sequence Analysis | Receptor, PAR-1 - metabolism | Humans | Galectin 3 - metabolism | Stomach Neoplasms - metabolism | Zebrafish | Galectin 3 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cell Movement - genetics | Cell Movement - physiology | Genetic Vectors - genetics | Receptor, PAR-1 - genetics | Animals | Chromatin Immunoprecipitation | Cell Line, Tumor | Lentivirus - genetics | In Vitro Techniques | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 1 - genetics | Proteins | DNA microarrays | Proteases | Analysis | Metastasis | Stomach cancer | Cancer | Transcription factors | Motility | Matrix metalloproteinases | Leukocyte migration | Laboratories | Proteinase-activated receptor 1 | Galectin-3 | Matrix metalloproteinase | Tissues | Cell surface | Metastases | Cell adhesion & migration | Angiogenesis | Epidermal growth factor | Protease | Metalloproteinase | Gastric cancer | Interstitial collagenase | Deoxyribonucleic acid--DNA | Enzymes | Activator protein 1 | Pharmacology | Gene expression | Bladder cancer | Overexpression | Lymphocytes B | Medical prognosis | In vivo methods and tests | Paxillin | Cell migration | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e63607 - e63607
The incidence of carcinoma increases greatly with aging, but the cellular and molecular mechanisms underlying this correlation are only partly known. It is... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | ACTIVATED RECEPTOR-1 | MATRIX METALLOPROTEINASES | TUMOR PROGRESSION | THROMBIN RECEPTOR PAR-1 | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE GROWTH-FACTOR | MET TYROSINE KINASE | KERATINOCYTE MIGRATION | MELANOMA METASTASIS | Gene Expression | Matrix Metalloproteinases - genetics | Paracrine Communication | Receptor, PAR-1 - metabolism | Skin - metabolism | Humans | Cells, Cultured | Matrix Metalloproteinase 1 - biosynthesis | Epithelial-Mesenchymal Transition - genetics | Hepatocyte Growth Factor - pharmacology | Cell Transformation, Neoplastic - metabolism | Receptor, PAR-1 - genetics | Young Adult | Cell Movement - drug effects | Cell Transformation, Neoplastic - genetics | Cellular Senescence | Keratinocytes - metabolism | Adult | Female | Matrix Metalloproteinases - metabolism | Matrix Metalloproteinase 2 - biosynthesis | Skin - pathology | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Analysis | Skin | Transformation | Senescence | Matrix metalloproteinases | Mesenchyme | Proteinase-activated receptor 1 | Blocking antibodies | Antibodies | Paracrine signalling | Metastasis | Matrix metalloproteinase | Carcinogenesis | Metastases | Carcinogens | Compartments | Transformed cells | Fibroblasts | Aging | Conditioning | Age | Interstitial collagenase | Secretion | Melanoma | Keratinocytes | Pharmacology | Breast cancer | Secretome | Inflammation | Gelatinase A | Molecular modelling | Skin carcinoma | Cell migration | Cancer | Tumors | Index Medicus
Journal Article
Molecular Immunology, ISSN 0161-5890, 05/2019, Volume 109, pp. 1 - 11
Protease activity of allergens has been suggested to be involved in the pathogenesis of allergic diseases. The major allergen Der f 3 from harbors serine... 
Airway epithelial cell | House dust mite (HDM) | Inflammation | Protease-activated receptor (PAR) | Protease | Der f 3 | IL-8 EXPRESSION | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CA2+ CHANNELS | DER-P-1 | KAPPA-B | IMMUNOLOGY | MAJOR ALLERGEN | TIGHT JUNCTIONS | PROTEOLYTIC ACTIVITY | CYTOKINE PRODUCTION | SERINE-PROTEASE | Inflammation - chemically induced | Inflammation - pathology | Humans | NF-kappa B - immunology | Serine Endopeptidases - pharmacology | Th2 Cells - immunology | Extracellular Signal-Regulated MAP Kinases - genetics | MAP Kinase Signaling System - immunology | Extracellular Signal-Regulated MAP Kinases - immunology | Gene Knockdown Techniques | Receptor, PAR-2 - immunology | MAP Kinase Signaling System - genetics | Allergens - immunology | Respiratory Mucosa - immunology | Serine Endopeptidases - immunology | Calcium Signaling - immunology | Cytokines - genetics | Th2 Cells - pathology | Cytokines - immunology | Receptor, PAR-2 - genetics | Th17 Cells - pathology | Inflammation Mediators - immunology | A549 Cells | Gene Expression Regulation - immunology | Epithelial Cells - pathology | Inflammation - immunology | Arthropod Proteins - immunology | Receptor, PAR-1 - genetics | Receptor, PAR-1 - immunology | Gene Expression Regulation - drug effects | Arthropod Proteins - pharmacology | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | Calcium Signaling - drug effects | Epithelial Cells - immunology | Inflammation - genetics | Th17 Cells - immunology | Allergens - pharmacology | Calcium Signaling - genetics | Pyroglyphidae - immunology | Allergens | Allergy | Medical colleges | RNA | Biological control | Thrombin | Respiratory tract diseases | Genetic engineering | Pests | B cells | Allergic reaction | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2008, Volume 452, Issue 7187, pp. 654 - 658
Journal Article