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1. Full Text PAR-1 contributes to the innate immune response during viral infection
by Antoniak, Silvio and Owens III, A. Phillip and Baunacke, Martin and Williams, Julie C and Lee, Rebecca D and Weithäuser, Alice and Sheridan, Patricia A and Malz, Ronny and Luyendyk, James P and Esserman, Denise A and Trejo, Jo Ann and Kirchhofer, Daniel and Blaxall, Burns C and Pawlinski, Rafal and Beck, Melinda A and Rauch, Ursula and Mackman, Nigel
The Journal of clinical investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1310 - 1322
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptor, PAR-1 - metabolism | Humans | Male | Troponin I - blood | STAT1 Transcription Factor - metabolism | Myocardium - metabolism | HEK293 Cells | Interferon-beta - genetics | Influenza A virus - immunology | Myocarditis - immunology | Influenza A virus - physiology | Orthomyxoviridae Infections - metabolism | Coxsackievirus Infections - metabolism | Liver - metabolism | Mice, Inbred C57BL | Enterovirus - physiology | Myocarditis - blood | Immunity, Innate | STAT1 Transcription Factor - genetics | Toll-Like Receptor 3 - metabolism | Receptor, PAR-1 - genetics | Mice, Knockout | Myocarditis - virology | Animals | Interferon-beta - metabolism | Thromboplastin - genetics | Enterovirus - immunology | Mice | HeLa Cells | Thrombin - metabolism | Thromboplastin - metabolism | Fibrin - metabolism | Chemokine CXCL10 - metabolism | Coxsackievirus Infections - immunology | Orthomyxoviridae Infections - immunology | Receptor, PAR-1 - physiology | Virus diseases | Cell receptors | Immune response | Physiological aspects | Development and progression | Genetic aspects | Research | Index Medicus | Abridged Index Medicus
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2. Full Text Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease
by Sparkenbaugh, Erica M and Chen, Chunsheng and Brzoska, Tomasz and Nguyen, Julia and Wang, Shaobin and Vercellotti, Gregory M and Key, Nigel S and Sundd, Prithu and Belcher, John D and Pawlinski, Rafal
Blood, ISSN 0006-4971, 05/2020, Volume 135, Issue 20, pp. 1783 - 1787
Life Sciences & Biomedicine | Hematology | Science & Technology | Anemia, Sickle Cell - pathology | Constriction, Pathologic - metabolism | Vascular Diseases - etiology | Receptor, PAR-1 - metabolism | Humans | Microvessels - metabolism | Microvessels - pathology | Male | Blood Coagulation Disorders - genetics | Female | Blood Coagulation Disorders - metabolism | Disease Models, Animal | Anemia, Sickle Cell - complications | Blood Coagulation Disorders - etiology | Constriction, Pathologic - genetics | Mice, Transgenic | Hemoglobin, Sickle - genetics | Receptor, PAR-1 - genetics | Animals | Blood Platelets - metabolism | Anemia, Sickle Cell - metabolism | Mice | Thrombin - metabolism | Vascular Diseases - metabolism | Anemia, Sickle Cell - genetics | Index Medicus | Abridged Index Medicus
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3. Full Text Colon cancer growth and dissemination relies upon thrombin, Stromal PAR-1, and fibrinogen
by Adams, Gregory N and Rosenfeldt, Leah and Frederick, Malinda and Miller, Whitney and Waltz, Dusty and Kombrinck, Keith and McElhinney, Kathryn E and Flick, Matthew J and Monia, Brett P and Revenko, Alexey S and Palumbo, Joseph S
Cancer research (Chicago, Ill.), ISSN 0008-5472, 10/2015, Volume 75, Issue 19, pp. 4235 - 4243
Life Sciences & Biomedicine | Oncology | Science & Technology | Adenocarcinoma - pathology | Prothrombin - analysis | Humans | Tumor Microenvironment | Male | Thrombin - physiology | Receptor, PAR-1 - deficiency | Colonic Neoplasms - metabolism | Adenocarcinoma - metabolism | HCT116 Cells - transplantation | Heterografts | Cell Division | Female | Neovascularization, Pathologic - physiopathology | Afibrinogenemia - genetics | Fibrinogen - physiology | Colonic Neoplasms - blood supply | Neoplasm Invasiveness | Thrombin - deficiency | Mice, Inbred C57BL | Stromal Cells - metabolism | Afibrinogenemia - complications | Melanoma, Experimental - pathology | Tumor Burden | Disease Progression | Adenocarcinoma - blood supply | Mice, Knockout | Animals | Mice, Nude | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice | Receptor, PAR-1 - physiology | Index Medicus
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4. Full Text PAR-1 and PAR-2 Expression Is Enhanced in Inflamed Odontoblast Cells
by Alvarez, M.M.P and Moura, G.E and Machado, M.F.M and Viana, G.M and de Souza Costa, C.A and Tjäderhane, L and Nader, H.B and Tersariol, I.L.S and Nascimento, F.D
Journal of dental research, ISSN 0022-0345, 12/2017, Volume 96, Issue 13, pp. 1518 - 1525
odontoblasts | proteolytic enzymes | proteinase-activated receptor (PAR) | matrix metalloproteinases | dentin-pulp complex | caries | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | Up-Regulation | Matrix Metalloproteinase 2 - metabolism | Receptor, PAR-1 - metabolism | Humans | Receptor, PAR-2 - metabolism | Odontoblasts - enzymology | Dental Pulp - cytology | Chromatography, High Pressure Liquid | RNA, Messenger - metabolism | Blotting, Western | Matrix Metalloproteinase 13 - metabolism | Microscopy, Confocal | Inflammation - metabolism | Matrix Metalloproteinase 9 - metabolism | Flow Cytometry | Adult | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Dentin | Flow cytometry | Peptides | Proteinase-activated receptor 1 | Confocal microscopy | Matrix metalloproteinase | Proteins | Par-2 protein | Odontoblasts | Bone marrow | Tumor necrosis factor-TNF | Metalloproteinase | Cytokines | Teeth | Tubules | Mass spectroscopy | Inflammation | Gene expression | High-performance liquid chromatography | Collagenase 3 | Gelatinase B | Polymerase chain reaction | Trypsin | Monoclonal antibodies | Protein expression | Ligands | Enzyme kinetics | Immunofluorescence | Dental pulp | Index Medicus | Dentistry
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5. Full Text Thrombin Upregulates PAI-1 and Mesothelial-Mesenchymal Transition Through PAR-1 and Contributes to Tuberculous Pleural Fibrosis
by Hsieh, Cheng-Ying and Sheu, Joen-Rong and Yang, Chih-Hao and Chen, Wei-Lin and Tsai, Jie-Heng and Chung, Chi-Li
International journal of molecular sciences, ISSN 1422-0067, 10/2019, Volume 20, Issue 20, p. 5076
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Follow-Up Studies | Receptor, PAR-1 - metabolism | Humans | Middle Aged | Mesoderm - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Exudates and Transudates - metabolism | Pleural Effusion - pathology | Young Adult | Plasminogen Activator Inhibitor 1 - metabolism | Aged, 80 and over | Adult | Female | Mycobacterium tuberculosis - metabolism | Tuberculosis - metabolism | Disease Models, Animal | Tuberculosis - pathology | Signal Transduction | Mice, Inbred C57BL | Pleural Effusion - metabolism | Animals | Fibrosis | Mesoderm - growth & development | Pleura - pathology | Aged | Mice | Thrombin - metabolism | Index Medicus | tuberculous pleural effusion | plasminogen activator inhibitor-1 | thrombin | residual pleura thickening | tuberculous pleural fibrosis | mesothelial–mesenchymal transition | pleural mesothelial cell | pleural fibrosis
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6. Full Text Thrombin Signaling Promotes Pancreatic Adenocarcinoma through PAR-1-Dependent Immune Evasion
by Yang, Yi and Stange, Amanda and Schweickert, Patrick G and Lanman, Nadia A and Paul, Erin N and Monia, Brett P and Revenko, Alexey S and Palumbo, Joseph S and Mullins, Eric S and Elzey, Bennett D and Janssen, Edith M and Konieczny, Stephen F and Flick, Matthew J
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2019, Volume 79, Issue 13, pp. 3417 - 3430
Life Sciences & Biomedicine | Oncology | Science & Technology | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Signal Transduction | Adenocarcinoma - immunology | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - metabolism | Mice, SCID | Carcinoma, Pancreatic Ductal - pathology | Tumor Microenvironment - immunology | Adenocarcinoma - metabolism | Animals | Pancreatic Neoplasms - immunology | Mice, Inbred NOD | Mice | Thrombin - metabolism | Thromboplastin - metabolism | Tumor Cells, Cultured | Carcinoma, Pancreatic Ductal - immunology | Immune Evasion - immunology | Receptor, PAR-1 - physiology | Index Medicus
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7. Full Text Inhibiting trophoblast PAR-1 overexpression suppresses sFlt-1-induced anti-angiogenesis and abnormal vascular remodeling: a possible therapeutic approach for preeclampsia
by Zhao, Yin and Zheng, YanFang and Liu, XiaoXia and Luo, QingQing and Wu, Di and Liu, XiaoPing and Zou, Li
Molecular human reproduction, ISSN 1360-9947, 03/2018, Volume 24, Issue 3, pp. 158 - 169
SFlt-1 | Angiogenesis | Trophoblast | PAR-1 | Preeclampsia | Life Sciences & Biomedicine | Developmental Biology | Obstetrics & Gynecology | Reproductive Biology | Science & Technology | Immunohistochemistry | Pre-Eclampsia - genetics | Cell Line | Enzyme-Linked Immunosorbent Assay | Receptor, PAR-1 - metabolism | Coculture Techniques | Rats | Male | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Blotting, Western | Receptor, PAR-1 - genetics | Placenta - metabolism | Pregnancy | Animals | Vascular Remodeling - genetics | Female | Vascular Remodeling - physiology | Pre-Eclampsia - metabolism | Vascular Endothelial Growth Factor Receptor-1 - genetics | Index Medicus
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8. Full Text PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease
by Ray, Tanusree and Pal, Amit
Apoptosis (London), ISSN 1360-8185, 05/2016, Volume 21, Issue 5, pp. 609 - 620
MAP kinase | PAR-1 | NFκB | HAP | Apoptosis | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Reactive Oxygen Species - metabolism | Signal Transduction | Receptor, PAR-1 - metabolism | Cells, Cultured | Metalloendopeptidases - metabolism | NF-kappa B - metabolism | Mammary Neoplasms, Experimental - metabolism | MAP Kinase Signaling System | Macrophages - metabolism | Animals | Mammary Glands, Animal - metabolism | Female | RAW 264.7 Cells | Mice | Mammary Neoplasms, Experimental - enzymology | Proteases | Analysis | Cancer cells | Lectins | Breast cancer | Cholera toxin | Index Medicus
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9. Full Text TGF‐β induced PAR‐1 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone
by Wang, Ting and Jiao, Jian and Zhang, Hao and Zhou, Wang and Li, Zhenxi and Han, Shuai and Wang, Jing and Yang, Xinghai and Huang, Quan and Wu, Zhipeng and Yan, Wangjun and Xiao, Jianru
International journal of cancer, ISSN 0020-7136, 10/2017, Volume 141, Issue 8, pp. 1630 - 1642
TGF‐β | giant cell tumor of bone | microvesicle | cell proliferation | angiogenesis | PAR‐1 | osteoclast differentiation | PAR-1 | TGF-β | Life Sciences & Biomedicine | Oncology | Science & Technology | Human Umbilical Vein Endothelial Cells | Up-Regulation | Humans | Middle Aged | Bone Neoplasms - pathology | Transforming Growth Factor beta - biosynthesis | Bone Neoplasms - metabolism | Gene Knockdown Techniques | Young Adult | Giant Cell Tumor of Bone - pathology | HEK293 Cells | Adult | Bone Neoplasms - genetics | Tumor Cells, Cultured | Cell Differentiation - physiology | Giant Cell Tumor of Bone - genetics | Osteoclasts - pathology | Chick Embryo | Osteoclasts - metabolism | Disease Progression | Receptor, PAR-1 - biosynthesis | Animals | Transforming Growth Factor beta - genetics | Giant Cell Tumor of Bone - metabolism | Transforming Growth Factor beta - metabolism | Index Medicus
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10. Full Text PAR-1 Phosphorylates Mind Bomb to Promote Vertebrate Neurogenesis
by Ossipova, Olga and Ezan, Jerome and Sokol, Sergei Y
Developmental cell, ISSN 1534-5807, 08/2009, Volume 17, Issue 2, pp. 222 - 233
CELLBIO | DEVBIO | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell differentiation, maturation, development, hematopoiesis | Protein Kinase C - genetics | Xenopus Proteins - genetics | Receptors, Notch - metabolism | Humans | Oligonucleotides, Antisense - metabolism | Vertebrates - embryology | Molecular Sequence Data | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Ubiquitination | Protein Kinase C - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Cell Line | Xenopus laevis - embryology | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Sequence Alignment | Animals | Oligonucleotides, Antisense - genetics | Neurogenesis - physiology | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Stem Cells - physiology | Xenopus Proteins - metabolism | Mice | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Neurons | Ligases | Index Medicus | Xenopus | PAR-1 | Mind bomb | Notch | neurogenesis | progenitor | aPKC
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