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1. Full Text Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling
by Hattersley, Gary and Dean, Thomas and Corbin, Braden A and Bahar, Hila and Gardella, Thomas J
Endocrinology (Philadelphia), ISSN 0013-7227, 01/2016, Volume 157, Issue 1, pp. 141 - 149
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Peptide Fragments - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - chemistry | HEK293 Cells | Cell Membrane - metabolism | Bone Density Conservation Agents - metabolism | Cyclic AMP - metabolism | Binding Sites - drug effects | Cell Membrane - drug effects | Bone Density Conservation Agents - chemistry | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Second Messenger Systems - drug effects | Models, Molecular | Recombinant Proteins - chemistry | Parathyroid Hormone-Related Protein - chemistry | Parathyroid Hormone-Related Protein - metabolism | Bone Density Conservation Agents - pharmacology | Parathyroid Hormone-Related Protein - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Peptide Fragments - chemistry | MAP Kinase Signaling System - drug effects | Receptor, Parathyroid Hormone, Type 1 - genetics | Genes, Reporter - drug effects | Ligands | Protein Conformation | Kinetics | GTP-Binding Proteins - metabolism | Index Medicus | Abridged Index Medicus | Original Research
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2. Full Text Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate
by Fan, Yi and Hanai, Jun-ichi and Le, Phuong T and Bi, Ruiye and Maridas, David and DeMambro, Victoria and Figueroa, Carolina A and Kir, Serkan and Zhou, Xuedong and Mannstadt, Michael and Baron, Roland and Bronson, Roderick T and Horowitz, Mark C and Wu, Joy Y and Bilezikian, John P and Dempster, David W and Rosen, Clifford J and Lanske, Beate
Cell metabolism, ISSN 1550-4131, 03/2017, Volume 25, Issue 3, pp. 661 - 672
lineage | RANKL | receptor | PTH | bone resorption | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Bone and Bones | RANK Ligand - metabolism | Receptor, Parathyroid Hormone, Type 1 - metabolism | Cell Count | Humans | Male | Parathyroid Hormone - pharmacology | Cell Lineage - drug effects | Adipose Tissue - metabolism | Mesenchymal Stromal Cells - cytology | Bone Marrow Cells - drug effects | Integrases - metabolism | Adipogenesis | Biomarkers - metabolism | Mesenchymal Stromal Cells - drug effects | Signal Transduction | Bone Marrow Cells - cytology | Mesenchymal Stromal Cells - metabolism | Phenotype | Animals | Osteoporosis - pathology | Adipocytes - metabolism | Skull - cytology | Mice | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Osteoporosis | Medical colleges | Bones | Parathyroid hormone | Density | Stem cells | Index Medicus | Bone resorption | Lineage | Receptor
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3. Full Text Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling
by Yu, Bing and Zhao, Xiaoli and Yang, Chaozhe and Crane, Janet and Xian, Lingling and Lu, William and Wan, Mei and Cao, Xu
Journal of bone and mineral research, ISSN 0884-0431, 09/2012, Volume 27, Issue 9, pp. 2001 - 2014
BONE MORPHOGENETIC PROTEINS | LOW‐DENSITY LIPOPROTEIN RECEPTOR‐RELATED PROTEIN 6 | DIFFERENTIATION | PARATHYROID HORMONE | MESENCHYMAL STEM CELLS | LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vertebrates: osteoarticular system, musculoskeletal system | Skeleton and joints | Leukocyte Common Antigens - metabolism | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Parathyroid Hormone - pharmacology | Bone Morphogenetic Proteins - metabolism | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | HEK293 Cells | Osteoblasts - cytology | Phosphorylation - drug effects | Mesenchymal Stem Cells - metabolism | Green Fluorescent Proteins - metabolism | Endocytosis - drug effects | Mice, Inbred C57BL | Osteoblasts - drug effects | Bone Morphogenetic Protein Receptors, Type II - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Models, Biological | Smad1 Protein - metabolism | Mice | CD11b Antigen - metabolism | Osteoblasts - metabolism | Stem cell research | Medical colleges | Security software | Orthopedic surgery | Parathyroid hormone | Low density lipoproteins | Stem cells | Fluorescence | Bone morphogenetic proteins | Index Medicus
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4. Full Text Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival
by Maycas, Marta and Ardura, Juan A and de Castro, Luis F and Bravo, Beatriz and Gortázar, Arancha R and Esbrit, Pedro
Journal of bone and mineral research, ISSN 0884-0431, 07/2015, Volume 30, Issue 7, pp. 1231 - 1244
PTH TYPE 1 RECEPTOR | MLO‐Y4 CELLS | MECHANICAL STIMULUS | OSTEOCYTE SURVIVAL | PTHRP | MLO-Y4 CELLS | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Osteocytes - drug effects | Cell Line | Cell Survival - drug effects | Mechanotransduction, Cellular - drug effects | Osteocytes - metabolism | Receptor, Parathyroid Hormone, Type 1 - metabolism | Calcium - metabolism | Hypotonic Solutions - pharmacology | Osteocytes - cytology | Extracellular Signal-Regulated MAP Kinases - metabolism | beta Catenin - metabolism | Parathyroid Hormone-Related Protein - pharmacology | Animals | Models, Biological | Mice | Cyclic AMP - metabolism | Cellular signal transduction | Hormones | Index Medicus
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5. Full Text Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration
by Rodríguez-Ortiz, Maria E and Canalejo, Antonio and Herencia, Carmen and Martínez-Moreno, Julio M and Peralta-Ramírez, Alan and Perez-Martinez, Pablo and Navarro-González, Juan F and Rodríguez, Mariano and Peter, Mirjam and Gundlach, Kristina and Steppan, Sonja and Passlick-Deetjen, Jutta and Muñoz-Castañeda, Juan R and Almaden, Yolanda
Nephrology, dialysis, transplantation, ISSN 0931-0509, 02/2014, Volume 29, Issue 2, pp. 282 - 289
calcium-sensing receptor | magnesium | vitamin D receptor | PTH | parathyroid glands | Transplantation | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Immunohistochemistry | Up-Regulation | Rats, Wistar | Receptor, Parathyroid Hormone, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptors, Calcium-Sensing - metabolism | Receptors, Calcitriol - genetics | Calcium - blood | Phosphates - pharmacology | Real-Time Polymerase Chain Reaction | Magnesium Compounds - pharmacology | Disease Models, Animal | Gene Expression | Parathyroid Hormone - secretion | Calcium - pharmacology | Parathyroid Glands - drug effects | RNA, Messenger - genetics | Cells, Cultured | Rats | Receptors, Calcitriol - metabolism | Animals | Receptor, Parathyroid Hormone, Type 1 - genetics | Receptors, Calcium-Sensing - genetics | Parathyroid Glands - metabolism | Index Medicus | Original
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6. Full Text PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer
by Kir, Serkan and Komaba, Hirotaka and Garcia, Ana P and Economopoulos, Konstantinos P and Liu, Wei and Lanske, Beate and Hodin, Richard A and Spiegelman, Bruce M
Cell metabolism, ISSN 1550-4131, 02/2016, Volume 23, Issue 2, pp. 315 - 323
chronic kidney disease | skeletal muscle atrophy | cachexia | adipose tissue browning | parathyroid hormone (PTH) | cancer | PTHrP | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cachexia - complications | Thermogenesis - genetics | Receptor, Parathyroid Hormone, Type 1 - metabolism | Ion Channels - genetics | Hyperparathyroidism - complications | Male | Parathyroid Hormone - pharmacology | Mitochondrial Proteins - genetics | Atrophy | Adipose Tissue - metabolism | Carcinoma, Lewis Lung - complications | Hyperparathyroidism - genetics | Nephrectomy | Mitochondrial Proteins - metabolism | Parathyroid Hormone - metabolism | Renal Insufficiency - complications | Disease Models, Animal | Mice, Inbred C57BL | Rats | Mice, Knockout | Parathyroid Hormone-Related Protein - pharmacology | Gene Expression Regulation - drug effects | Animals | Ion Channels - metabolism | Signal Transduction - drug effects | Renal Insufficiency - pathology | Cachexia - pathology | Carcinoma, Lewis Lung - pathology | Muscle, Skeletal - pathology | Thermogenesis - drug effects | Uncoupling Protein 1 | Adipose Tissue - drug effects | Kidney failure | Parathyroid hormone | Mortality | Chronic diseases | Muscles | Models | Cachexia | Health aspects | Cancer | Index Medicus | Parathyroid hormone (PTH)
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7. Full Text Current perspectives on parathyroid hormone (PTH) and PTH-related protein (PTHrP) as bone anabolic therapies
by Esbrit, Pedro and Alcaraz, María José
Biochemical pharmacology, ISSN 0006-2952, 05/2013, Volume 85, Issue 10, pp. 1417 - 1423
Bone repair | Bone formation | PTHrP | PTH | Bone anabolic therapy | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Protein Structure, Tertiary | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Osteoblasts - drug effects | Osteogenesis - drug effects | Osteoporosis - drug therapy | Parathyroid Hormone - pharmacology | Parathyroid Hormone-Related Protein - metabolism | Bone Density Conservation Agents - pharmacology | Parathyroid Hormone-Related Protein - pharmacology | Gene Expression Regulation - drug effects | Animals | Osteoporosis - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Parathyroid Hormone - metabolism | Receptor, Parathyroid Hormone, Type 1 - genetics | Female | Osteoporosis - genetics | Cell Proliferation - drug effects | Osteoblasts - cytology | Bone Density Conservation Agents - metabolism | Index Medicus
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8. Full Text Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase
by Larsson, Sara and Jones, Helena A and Göransson, Olga and Degerman, Eva and Holm, Cecilia
Cellular signalling, ISSN 0898-6568, 03/2016, Volume 28, Issue 3, pp. 204 - 213
PDE | Adipocyte | cAMP | PTH | Lipolysis | PKA | CAMP | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lipolysis - drug effects | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Sterol Esterase - metabolism | Adipocytes - cytology | Male | Parathyroid Hormone - pharmacology | Phosphoproteins - metabolism | Receptor, Parathyroid Hormone, Type 2 - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Cyclic AMP-Dependent Protein Kinases - metabolism | Adenylyl Cyclase Inhibitors - pharmacology | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Cells, Cultured | Receptor, Parathyroid Hormone, Type 2 - genetics | Imines - pharmacology | Phosphodiesterase 4 Inhibitors - pharmacology | Animals | Carrier Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Adipocytes - metabolism | Receptor, Parathyroid Hormone, Type 1 - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Perilipin-1 | Vitamin D | Parathyroid hormone | Insulin resistance | Development and progression | Calcifediol | Alfacalcidol | Calcium-binding proteins | Lipase | Type 2 diabetes | Protein kinases | Index Medicus | Proteins | Phosphorylation | Inhibitors | Pathways | Hormones | Kinases | Vitamins | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
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