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1. Full Text Sustained cyclic AMP production by parathyroid hormone receptor endocytosis
by Ferrandon, Sébastien and Feinstein, Timothy N and Castro, Marian and Wang, Bin and Bouley, Richard and Potts, John T and Gardella, Thomas J and Vilardaga, Jean-Pierre
Nature chemical biology, ISSN 1552-4450, 2009, Volume 5, Issue 10, pp. 734 - 742
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Receptor, Parathyroid Hormone, Type 1 - physiology | Receptor, Parathyroid Hormone, Type 1 - agonists | Endocytosis - physiology | Protein Transport | Microscopy, Confocal | Animals | Cyclic AMP - biosynthesis | Parathyroid Hormone - metabolism | Bone Resorption - metabolism | Fluorescence Resonance Energy Transfer | Ligands | Protein Conformation | Signal Transduction - physiology | Cell Membrane - metabolism | Mice | Kinetics | Osteoblasts - metabolism | GTP-Binding Proteins - metabolism | Signal transduction | Biochemistry | Hormones | Cellular biology | Index Medicus
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2. Full Text Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation
by Gesty-Palmer, Diane and Chen, Minyong and Reiter, Eric and Ahn, Seungkirl and Nelson, Christopher D and Wang, Shuntai and Eckhardt, Allen E and Cowan, Conrad L and Spurney, Robert F and Luttrell, Louis M and Lefkowitz, Robert J
The Journal of biological chemistry, ISSN 0021-9258, 04/2006, Volume 281, Issue 16, pp. 10856 - 10864
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Arrestins - physiology | Maleimides - pharmacology | Immunoblotting | Arrestins - metabolism | MAP Kinase Signaling System | Isoquinolines - pharmacology | Transfection | Time Factors | Indoles - pharmacology | Culture Media, Serum-Free - pharmacology | Cyclic AMP - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | GTP-Binding Proteins - physiology | Signal Transduction | Cells, Cultured | DNA - metabolism | Sulfonamides - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | beta-Arrestin 2 | beta-Arrestin 1 | beta-Arrestins | Receptor, Parathyroid Hormone, Type 1 - genetics | Ligands | Mutation | DNA, Complementary - metabolism | GTP-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Index Medicus | Life Sciences | Biomolecules | Biochemistry, Molecular Biology
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3. Full Text Parathyroid hormone and parathyroid hormone-related peptide, and their receptors
by Gensure, Robert C and Gardella, Thomas J and Jüppner, Harald
Biochemical and biophysical research communications, ISSN 0006-291X, 2005, Volume 328, Issue 3, pp. 666 - 678
Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptors, Parathyroid Hormone - metabolism | Models, Chemical | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Receptors, Parathyroid Hormone - chemistry | Parathyroid Hormone-Related Protein - chemistry | Structure-Activity Relationship | Parathyroid Hormone-Related Protein - metabolism | Parathyroid Hormone - chemistry | Animals | Models, Biological | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Signal Transduction - physiology | Bone and Bones - embryology | Index Medicus
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4. Full Text Parathyroid hormone signaling through low-density lipoprotein-related protein 6
by Wan, Mei and Yang, Chaozhe and Li, Jun and Wu, Xiangwei and Yuan, Hongling and Ma, Hairong and He, Xi and Nie, Shuyi and Chang, Chenbei and Cao, Xu
Genes & development, ISSN 0890-9369, 11/2008, Volume 22, Issue 21, pp. 2968 - 2979
PTH signaling | β-catenin | Osteoblasts | PKA | LRP6 | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | LDL-Receptor Related Proteins - metabolism | Xenopus | Phosphorylation | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Embryo, Nonmammalian - metabolism | Male | Parathyroid Hormone - pharmacology | Wnt Proteins - metabolism | Repressor Proteins - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Parathyroid Hormone - physiology | Low Density Lipoprotein Receptor-Related Protein-6 | Mice, Inbred C57BL | Cells, Cultured | Rats | Receptors, LDL - metabolism | Xenopus Proteins | Rats, Sprague-Dawley | beta Catenin - metabolism | Animals | Axin Protein | Signal Transduction - physiology | Mice | Osteoblasts - metabolism | Osteogenesis | Proteolipids | Lipoproteins | Parathyroid hormone | Analysis | Genetic aspects | Chemical properties | Blood lipoproteins | Protein binding | Index Medicus | Research Paper | osteoblasts
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5. Full Text PTH receptor-1 signalling - Mechanistic insights and therapeutic prospects
by Cheloha, Ross W and Gellman, Samuel H and Vilardaga, Jean-Pierre and Gardella, Thomas J
Nature reviews. Endocrinology, ISSN 1759-5029, 12/2015, Volume 11, Issue 12, pp. 712 - 724
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Parathyroid Hormone - physiology | Signal Transduction - drug effects | Parathyroid Hormone - metabolism | Humans | Ligands | Osteoporosis - drug therapy | Osteoporosis - genetics | Receptor, Parathyroid Hormone, Type 1 - drug effects | Receptor, Parathyroid Hormone, Type 1 - physiology | Receptor, Parathyroid Hormone, Type 1 - deficiency | Medicine, Experimental | Hormone receptors | Medical research | Cellular signal transduction | Genetic aspects | Health aspects | Index Medicus
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6. Full Text Structure and dynamics of the active human parathyroid hormone receptor-1
by Zhao, Li-Hua and Ma, Shanshan and Sutkeviciute, Ieva and Shen, Dan-Dan and Zhou, X Edward and de Waal, Parker W and Li, Chen-Yao and Kang, Yanyong and Clark, Lisa J and Jean-Alphonse, Frederic G and White, Alex D and Yang, Dehua and Dai, Antao and Cai, Xiaoqing and Chen, Jian and Li, Cong and Jiang, Yi and Watanabe, Tomoyuki and Gardella, Thomas J and Melcher, Karsten and Wang, Ming-Wei and Vilardaga, Jean-Pierre and Xu, H Eric and Zhang, Yan
Science (American Association for the Advancement of Science), ISSN 0036-8075, 04/2019, Volume 364, Issue 6436, pp. 148 - 153
Cryoelectron Microscopy | Parathyroid Hormone - physiology | Receptor, Parathyroid Hormone, Type 1 - chemistry | Humans | Protein Binding | Protein Domains | Parathyroid Hormone - pharmacology | Receptor, Parathyroid Hormone, Type 1 - ultrastructure | Receptor, Parathyroid Hormone, Type 1 - agonists | Amino Acid Motifs | Parathyroid Hormone - chemistry | Protein research | Observations | Structure | Parathyroid hormone | Osteoporosis | G proteins | Peptides | Health aspects | Protein binding | Calcium | Human parathyroid hormone | Therapeutic applications | Unwinding | Homeostasis | Activation | Electron microscopy | Elections | Proteins | Receptors | Biomedical materials | Vitamin D | Microscopy | Hypoparathyroidism | Biocompatibility | Receptor mechanisms | Parathyroid | Calcium homeostasis | Index Medicus
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7. Full Text Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides
by Augen A. Pioszak and Naomi R. Parker and Thomas J. Gardella and H. Eric Xu and Argonne National Lab. (ANL), Argonne, IL (United States)
The Journal of biological chemistry, ISSN 0021-9258, 10/2009, Volume 284, Issue 41, pp. 28382 - 28391
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Peptides - genetics | Cercopithecus aethiops | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Recombinant Fusion Proteins - metabolism | Peptides - metabolism | Cyclic AMP - metabolism | Amino Acid Sequence | Peptides - chemistry | Parathyroid Hormone-Related Protein - genetics | Models, Molecular | Parathyroid Hormone-Related Protein - chemistry | Recombinant Fusion Proteins - chemistry | Parathyroid Hormone-Related Protein - metabolism | Animals | Protein Binding | Receptor, Parathyroid Hormone, Type 1 - genetics | Recombinant Fusion Proteins - genetics | Protein Conformation | Signal Transduction - physiology | COS Cells | Index Medicus | DESIGN | HOMEOSTASIS | PEPTIDES | MOLECULAR MODELS | RESOLUTION | CRYSTAL STRUCTURE | MATERIALS SCIENCE | CHAINS | PROTEINS | RESIDUES | FUNCTIONALS | HORMONES | Mechanisms of Signal Transduction
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8. Full Text Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm
by Vilardaga, Jean-Pierre and Vilardaga, Jean-Pierre and Romero, Guillermo and Romero, Guillermo and Friedman, Peter A and Friedman, Peter A and Gardella, Thomas J and Gardella, Thomas J
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 1/2011, Volume 68, Issue 1, pp. 1 - 13
Life Sciences | Biochemistry, general | G protein-coupled receptor | Signaling endosomes | Life Sciences, general | Parathyroid hormone | Internalization | Signaling selectivity | Cyclic AMP | G proteins | Biomedicine general | Cell Biology | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Protein Structure, Tertiary | Receptor, Parathyroid Hormone, Type 1 - chemistry | Receptor, Parathyroid Hormone, Type 1 - metabolism | Signal Transduction | Humans | Receptor, Parathyroid Hormone, Type 1 - physiology | Structure-Activity Relationship | Parathyroid Hormone-Related Protein - metabolism | Parathyroid Hormone - chemistry | Animals | Models, Biological | Parathyroid Hormone - metabolism | Cell Membrane - metabolism | Cyclic AMP - metabolism | GTP-Binding Proteins - metabolism | Peptides | Membrane proteins | Signal transduction | Hormones | Cellular biology | Molecular biology | Endocrinology | Index Medicus
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9. Full Text Na + /H + exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling
by Donowitz, Mark and Mahon, Matthew J and Yun, C. Chris and Segre, Gino V
Nature (London), ISSN 0028-0836, 06/2002, Volume 417, Issue 6891, pp. 858 - 861
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Signal transduction | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Humans | Sodium-Hydrogen Exchangers | Substrate Specificity | Type C Phospholipases - metabolism | Parathyroid Hormone - pharmacology | Virulence Factors, Bordetella - pharmacology | Phosphoproteins - metabolism | Kidney | Phosphoproteins - chemistry | Receptors, Parathyroid Hormone - genetics | Phospholipase C beta | Isoenzymes - metabolism | Inositol Phosphates - metabolism | Binding Sites | Cyclic AMP - metabolism | CHO Cells | Protein Structure, Tertiary | Cricetinae | Receptors, Parathyroid Hormone - metabolism | Isoenzymes - genetics | Gene Expression Regulation | Rats | Genes, Reporter - genetics | Phosphoproteins - genetics | Two-Hybrid System Techniques | Animals | Signal Transduction - drug effects | Protein Binding | Type C Phospholipases - genetics | Adenylate Cyclase Toxin | Proteins | Kidneys | Hormones | Cells | Index Medicus
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