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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2007, Volume 282, Issue 35, pp. 25604 - 25612
The protein kinase mammalian target of rapamycin ( mTOR) plays an important role in the coordinate regulation of cellular responses to nutritional and growth... 
MAMMALIAN TARGET | RAPAMYCIN | BINDING PARTNER | TUBEROUS SCLEROSIS COMPLEX | PHOSPHORYLATION | TOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEINS | C-MYC | P70 S6 KINASE | MTOR | Protein Kinases - metabolism | Sequence Deletion | Phosphorylation | Protein Kinases - genetics | Ribosomal Protein S6 Kinases - metabolism | Colorectal Neoplasms - genetics | Humans | Multiprotein Complexes - genetics | Receptor, Platelet-Derived Growth Factor beta - genetics | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Cell Transformation, Neoplastic - genetics | Regulatory-Associated Protein of mTOR | Proto-Oncogene Proteins c-akt - metabolism | Colorectal Neoplasms - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Insulin - pharmacology | Gene Silencing | Gene Expression Regulation - physiology | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Hypoglycemic Agents - pharmacology | Gene Expression Regulation - drug effects | Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Breast Neoplasms - genetics | Carrier Proteins - metabolism | Proteins - metabolism | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Epidermal Growth Factor - pharmacology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Ribosomal Protein S6 Kinases - genetics | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 973 - 977
Journal Article
Cancer Research, ISSN 0008-5472, 07/2005, Volume 65, Issue 13, pp. 5711 - 5719
Journal Article
Cancer Research, ISSN 0008-5472, 04/2004, Volume 64, Issue 8, pp. 2725 - 2733
Journal Article
Arthritis Research & Therapy, ISSN 1478-6354, 2011, Volume 13, Issue 2, pp. R61 - R61
Journal Article
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2004, Volume 94, Issue 8, pp. 1050 - 1058
ABSTRACT—Sphingosine 1-phosphate (S1P) is a bioactive lipid generated during vascular injury that regulates cell growth, differentiation, survival, and... 
Signal transduction | Epidermal growth factor | Sphingosine 1-phosphate | SIGNALING PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | signal transduction | PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 3-KINASE | TYROSINE KINASE | PROTEIN-COUPLED RECEPTORS | ANGIOTENSIN-II | MAMMALIAN-CELLS | FOCAL ADHESIONS | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | epidermal growth factor | sphingosine 1-phosphate | HEMATOLOGY | C-SRC | Receptor, Epidermal Growth Factor - genetics | Cricetulus | Muscle, Smooth, Vascular - metabolism | Transcriptional Activation - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - physiology | Quinazolines | Receptor, Platelet-Derived Growth Factor beta - genetics | Protein Processing, Post-Translational - drug effects | Lysophospholipids - pharmacology | Superoxides - metabolism | Aorta | Phosphorylation - drug effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | CHO Cells | Cricetinae | Receptor, Epidermal Growth Factor - biosynthesis | Protein-Serine-Threonine Kinases - physiology | Enzyme Inhibitors - pharmacology | Rats | Membrane Lipids - physiology | Tyrphostins - pharmacology | Enzyme Activation - drug effects | Muscle, Smooth, Vascular - cytology | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-akt | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins - physiology | Phosphatidylinositol 3-Kinases - physiology | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Index Medicus
Journal Article