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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 06/2012, Volume 26, Issue 11, pp. 1247 - 1262
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2002, Volume 347, Issue 7, pp. 481 - 487
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2007, Volume 282, Issue 35, pp. 25604 - 25612
The protein kinase mammalian target of rapamycin ( mTOR) plays an important role in the coordinate regulation of cellular responses to nutritional and growth... 
MAMMALIAN TARGET | RAPAMYCIN | BINDING PARTNER | TUBEROUS SCLEROSIS COMPLEX | PHOSPHORYLATION | TOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEINS | C-MYC | P70 S6 KINASE | MTOR | Protein Kinases - metabolism | Sequence Deletion | Phosphorylation | Protein Kinases - genetics | Ribosomal Protein S6 Kinases - metabolism | Colorectal Neoplasms - genetics | Humans | Multiprotein Complexes - genetics | Receptor, Platelet-Derived Growth Factor beta - genetics | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Cell Transformation, Neoplastic - genetics | Regulatory-Associated Protein of mTOR | Proto-Oncogene Proteins c-akt - metabolism | Colorectal Neoplasms - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Insulin - pharmacology | Gene Silencing | Gene Expression Regulation - physiology | Transcription Factors - genetics | Cell Transformation, Neoplastic - metabolism | Hypoglycemic Agents - pharmacology | Gene Expression Regulation - drug effects | Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Breast Neoplasms - genetics | Carrier Proteins - metabolism | Proteins - metabolism | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Epidermal Growth Factor - pharmacology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Ribosomal Protein S6 Kinases - genetics | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2012, Volume 18, Issue 11, pp. 1699 - 1704
Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma found in children and young adults. ALCLs frequently carry a chromosomal... 
MEDICINE, RESEARCH & EXPERIMENTAL | FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | NEUROBLASTOMA | LARGE-CELL LYMPHOMA | CELL BIOLOGY | LUNG-CANCER | INHIBITION | GENE | HODGKIN LYMPHOMA | C-JUN | ACTIVATING MUTATIONS | Piperazines - administration & dosage | Translocation, Genetic | Protein-Tyrosine Kinases - metabolism | Transcription Factor AP-1 - genetics | Humans | Molecular Targeted Therapy | Receptor, Platelet-Derived Growth Factor beta - genetics | Transcription Factor AP-1 - metabolism | Stem Cell Transplantation | Protein-Tyrosine Kinases - genetics | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Receptor, Platelet-Derived Growth Factor alpha - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Oncogene Protein p65(gag-jun) - genetics | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Lymphoma, Large-Cell, Anaplastic - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Pyrimidines - administration & dosage | Mice, Transgenic | Nuclear Proteins - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Imatinib Mesylate | Remission Induction | Animals | Receptor Protein-Tyrosine Kinases - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Lymphoma, Large-Cell, Anaplastic - drug therapy | Cell Line, Tumor | Lymphoma, Large-Cell, Anaplastic - pathology | Mice | Benzamides | Neoplasm Staging | Oncogene Protein p65(gag-jun) - metabolism | Receptors | Blood platelets | Physiological aspects | Genetic aspects | Non-Hodgkin's lymphomas | Research | Drug therapy | Protein kinases | Therapy | Lymphomas | Cells | Cancer | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2014, Volume 289, Issue 28, pp. 19747 - 19757
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 2014, Volume 307, Issue 3, pp. L231 - L239
Animal studies have shown that platelet-derived growth factor (PDGF) signaling is required for normal alveolarization. Changes in PDGF receptor (PDGFR)... 
PDGFR-β | Lung development | Prematurity | Hyperoxia | PDGFR-α | PDGFR-beta | CELLS | PHYSIOLOGY | prematurity | hyperoxia | PDGFR-alpha | ALPHA | MYOFIBROBLASTIC DIFFERENTIATION | CHRONIC LUNG-DISEASE | LAVAGE | RESPIRATORY SYSTEM | PDGF | TRANSFORMING GROWTH-FACTOR-BETA-1 | INFANTS | ALVEOLAR MACROPHAGES | lung development | MOUSE LUNG | Gene Expression - genetics | Humans | Bronchopulmonary Dysplasia - pathology | Male | Receptor, Platelet-Derived Growth Factor beta - genetics | Platelet-Derived Growth Factor - genetics | Bronchopulmonary Dysplasia - genetics | Infant, Premature - metabolism | Hyperoxia - metabolism | Pulmonary Alveoli - metabolism | Female | Lung - metabolism | Bronchopulmonary Dysplasia - etiology | Infant, Newborn | Receptor, Platelet-Derived Growth Factor beta - metabolism | Animals, Newborn | Lung - pathology | Pulmonary Alveoli - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Mesenchymal Stromal Cells - metabolism | Signal Transduction - genetics | Gestational Age | Hyperoxia - pathology | Platelet-Derived Growth Factor - metabolism | Animals | Hyperoxia - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Mice | Mesenchymal Stromal Cells - pathology | Physiological aspects | Bronchopulmonary dysplasia | Platelet-derived growth factor | Babies | Lungs | Ribonucleic acid--RNA | Gene expression | Rodents | Cells | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2012, Volume 22, Issue 2, pp. 153 - 166
Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic leukemia (B-ALL) with alteration of , a gene expression profile... 
GROWTH-FACTOR RECEPTOR | BCR-JAK2 FUSION GENE | ONCOLOGY | NUCLEAR-PORE | MYELOPROLIFERATIVE NEOPLASMS | ACUTE MYELOID-LEUKEMIA | OF-FUNCTION MUTATIONS | FLT3 MUTATIONS | CHILDHOOD | B-PROGENITOR | CHRONIC MYELOMONOCYTIC LEUKEMIA | CELL BIOLOGY | Recurrence | Humans | Molecular Sequence Data | RNA, Messenger - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Protein-Tyrosine Kinases - genetics | DNA Mutational Analysis | Base Sequence | Trans-Activators - genetics | Phosphorylation - drug effects | Philadelphia Chromosome | Receptors, Cytokine - genetics | Genetic Predisposition to Disease | RNA, Messenger - genetics | Risk Factors | Gene Expression Regulation, Leukemic - drug effects | Signal Transduction - genetics | Enzyme Activation - drug effects | Mutation - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Signal Transduction - drug effects | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology | Mice | Protein Kinase Inhibitors - pharmacology | Gene Rearrangement - genetics | Sequence Deletion - genetics | Tyrosine | Platelet-derived growth factor | Cytokines | Genes | Oncology, Experimental | Genomes | Research | Gene expression | Population genetics | Hunger | Medical genetics | Genetic research | Nucleotide sequencing | Acute lymphocytic leukemia | Cancer | DNA sequencing | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e92925 - e92925
Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is the 12th leading cause of death in the United States, and it... 
RAT HEPATIC LIPOCYTES | HEPATOCELLULAR-CARCINOMA | SMOOTH-MUSCLE ACTIN | MULTIDISCIPLINARY SCIENCES | PDGFR-ALPHA | IN-VIVO | CARBON-TETRACHLORIDE | EXPRESSION | PULMONARY-FIBROSIS | TRANSGENIC MICE | BETA | Liver - pathology | Humans | Gene Expression Regulation, Neoplastic | Hepatic Stellate Cells - metabolism | Male | RNA, Messenger - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Liver - drug effects | Carcinoma, Hepatocellular - genetics | Liver Cirrhosis - metabolism | Chemical and Drug Induced Liver Injury - pathology | Liver Cirrhosis - genetics | Cell Line | Liver Cirrhosis - drug therapy | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Liver Neoplasms - genetics | Liver - metabolism | RNA, Messenger - genetics | Gene Dosage | Chemical and Drug Induced Liver Injury - genetics | Animals | Chemical and Drug Induced Liver Injury - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Alleles | Liver Cirrhosis - pathology | Mice | Fluorescence | Liver cancer | Platelet-derived growth factor | Health aspects | Liver cirrhosis | Fibrosis | Liver | Carbon tetrachloride | Smooth muscle | Activation | Adipocytes | Kinases | Risk factors | Signal transduction | Cell growth | Rodents | Surgery | Growth factors | Stellate cells | Liver diseases | Health risks | Pathology | Cirrhosis | Signaling | Injury prevention | Pulmonary fibrosis | Hepatocytes | Collagen | Green fluorescent protein | Laboratory animals | Cancer | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2013, Volume 33, Issue 10, pp. 2355 - 2365
OBJECTIVE—Myocardin, a potent transcriptional coactivator of serum response factor, is involved in vascular development and promotes a contractile smooth... 
microRNAs | myocardin | carotid arteries | muscle, smooth | signal transduction | MUSCLE-CELL DIFFERENTIATION | STEM-CELLS | PHENOTYPIC MODULATION | ATHEROSCLEROSIS | ANGIOPLASTY | MESSENGER-RNA | muscle | IN-VIVO | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | smooth | Carotid Stenosis - prevention & control | Cell Proliferation | Apolipoproteins E - deficiency | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | Myocytes, Smooth Muscle - pathology | Male | MicroRNAs - metabolism | Receptor, Platelet-Derived Growth Factor beta - genetics | Carotid Stenosis - metabolism | Neointima | Transfection | Time Factors | Carotid Stenosis - genetics | Nuclear Proteins - deficiency | Trans-Activators - genetics | Carotid Artery Injuries - genetics | 3' Untranslated Regions | Nuclear Proteins - genetics | Myocytes, Smooth Muscle - metabolism | Carotid Artery Injuries - metabolism | Carotid Artery Injuries - pathology | Disease Models, Animal | Receptor, Platelet-Derived Growth Factor beta - metabolism | Signal Transduction | Carotid Artery, Common - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Rats | Nuclear Proteins - metabolism | Carotid Stenosis - pathology | Mice, Knockout | Carotid Artery Injuries - prevention & control | Muscle, Smooth, Vascular - injuries | Muscle, Smooth, Vascular - pathology | Animals | Trans-Activators - deficiency | Apolipoproteins E - genetics | Carotid Artery, Common - pathology | Trans-Activators - metabolism | Mice | Cell Movement | Index Medicus
Journal Article