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Cell death and differentiation, ISSN 1476-5403, 06/2014, Volume 21, Issue 10, pp. 1511 - 1521
Necroptosis is a form of programmed cell death that depends on the activation of receptor interacting protein kinase-1 (RIPK1... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Protein Structure, Tertiary | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Cell Line | Phosphorylation | Protein Kinases - genetics | Cell Survival | Humans | Protein Multimerization | Receptors, Tumor Necrosis Factor, Type I | Caspase 8 - metabolism | Imidazoles - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Necrosis - physiopathology | RNA Interference | Indoles - pharmacology | RNA, Small Interfering | Apoptosis - physiology | Enzyme Activation | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | Receptor-Interacting Protein Serine-Threonine Kinases/genetics | Protein Kinases/genetics | Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors | Caspase 8/metabolism | Receptor-Interacting Protein Serine-Threonine Kinases/metabolism | Tumor Necrosis Factor-alpha/antagonists & inhibitors | Indoles/pharmacology | Life Sciences | Tumor Necrosis Factor-alpha/metabolism | Imidazoles/pharmacology | Immunology | Apoptosis/physiology | Protein Kinases/metabolism | Necrosis/physiopathology | Original Paper
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 10/2013, Volume 288, Issue 43, pp. 31268 - 31279
Journal Article
Journal of pharmacy and pharmacology, ISSN 0022-3573, 04/2013, Volume 65, Issue 4, pp. 465 - 473
.... More recently it has been discovered that GPCRs can also transactivate protein serine/threonine kinase receptors such as that for transforming growth factor (TGF)‐β... 
GPCR | protein serine/threonine kinases | protein tyrosine kinases | transactivation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Receptors, Endothelin - agonists | Cardiovascular Diseases - drug therapy | Humans | Thrombin - antagonists & inhibitors | Receptor-Interacting Protein Serine-Threonine Kinases - chemistry | Endothelins - metabolism | Molecular Targeted Therapy | Receptors, Cell Surface - antagonists & inhibitors | Receptors, Thrombin - antagonists & inhibitors | Receptors, Thrombin - agonists | Drug Design | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - agonists | Endothelin Receptor Antagonists | Endothelins - antagonists & inhibitors | Cardiovascular Diseases - metabolism | Receptors, Cell Surface - agonists | Receptors, Endothelin - metabolism | Receptors, Cell Surface - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Cardiovascular Agents - pharmacology | Cardiovascular Agents - therapeutic use | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Receptors, Thrombin - metabolism | Protein Kinase Inhibitors - pharmacology | Thrombin - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Tyrosine | Medical colleges | Glycosaminoglycans | Drugstores | Thrombin | Transforming growth factors | Analysis | Atherosclerosis | Physiological aspects | Phenols | G proteins | Health aspects | Phosphotransferases | Proteins | Kinases | Muscular system | Index Medicus
Journal Article
Journal Article
Cell death & disease, ISSN 2041-4889, 02/2014, Volume 5, Issue 2, pp. e1084 - e1084
...) is a downstream effector of Akt that controls protein synthesis. We previously reported that dual inhibition of Akt and mTOR reduced acute cell death and improved long term cognitive deficits after controlled-cortical impact in mice... 
mTOR | neuron | RIPK1 | Akt | RIPK3 | necroptosis | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus | Original
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 09/2018, Volume 22, Issue 9, pp. 4183 - 4196
... such as the NO cascade, the reperfusion injury salvage kinase (RISK) pathway and the survival activating factor enhancement (SAFE) have been suggested to underlie the phenotypes... 
RIP1 inhibition | ischaemia‐reperfusion injury | heart | necroptosis | ischaemia-reperfusion injury | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Protein Kinases - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Protein Kinases - genetics | Oxidative Stress | Rats, Wistar | Apoptosis - drug effects | Anti-Arrhythmia Agents - pharmacology | Male | Protein Transport - drug effects | Necrosis - pathology | Myocardial Reperfusion Injury - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Cell Membrane - metabolism | Phosphorylation - drug effects | Myocardial Reperfusion Injury - genetics | Cell Membrane - drug effects | Organ Culture Techniques | Protein-Serine-Threonine Kinases - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Calcium-Binding Proteins - metabolism | Heart - physiopathology | Signal Transduction | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Rats | Necrosis - metabolism | Imidazoles - pharmacology | Necrosis - prevention & control | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Myocardial Reperfusion Injury - metabolism | Myocytes, Cardiac - pathology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Myocytes, Cardiac - drug effects | Myocardial Reperfusion Injury - therapy | Ischemic Preconditioning, Myocardial | Heart - drug effects | Myocytes, Cardiac - metabolism | Necrosis - genetics | Calcium-Binding Proteins - genetics | Anti-arrhythmia drugs | Heart | Translocation | Oxidative stress | Phosphorylation | Damage assessment | Oligomerization | Pharmacology | Heart function | Muscle contraction | Mitigation | Signaling | Reperfusion | Ischemia | Inhibition | Preconditioning | Peroxidation | Ca2+/calmodulin-dependent protein kinase II | Apoptosis | Index Medicus | Original
Journal Article
EMBO molecular medicine, ISSN 1757-4684, 11/2012, Volume 5, Issue 1, pp. 105 - 121
Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression via the I2PP2A/SET oncoprotein are unknown... 
sphingosine kinase 2 | ceramide | sphingolipids | sphingosine | FTY720 | Ceramide | Sphingolipids | Sphingosine kinase 2 | Sphingosine | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Lung Neoplasms - drug therapy | Phosphorylation | Transcription Factors - chemistry | Histone Chaperones - genetics | Humans | Lung Neoplasms - metabolism | Histone Chaperones - metabolism | Lung Neoplasms - pathology | Histone Chaperones - chemistry | Gene Knockdown Techniques | Necrosis | Antineoplastic Agents - pharmacology | Sphingosine - metabolism | Propylene Glycols - pharmacology | Propylene Glycols - metabolism | Fingolimod Hydrochloride | Models, Molecular | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Mice, SCID | Histone Chaperones - antagonists & inhibitors | Sphingosine - pharmacology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Sphingosine - analogs & derivatives | Animals | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Medical colleges | Phosphatases | Cell death | Lung cancer | Oncology, Experimental | Medical genetics | Research | Plant lipids | Cancer | Tumors | Enzymes | Statistical analysis | Phosphoprotein phosphatase | Phosphatase | Kinases | Experiments | Proteins | Molecular modelling | Simulation | Mutagenesis | Protein phosphatase | Mutation | Localization | Apoptosis | Index Medicus
Journal Article
Nature chemical biology, ISSN 1552-4469, 06/2015, Volume 11, Issue 8, pp. 611 - 617
Journal Article