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Nature Chemical Biology, ISSN 1552-4450, 08/2015, Volume 11, Issue 8, pp. 611 - 617
The current predominant therapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally... 
CHIMERIC MOLECULES | CHEMICAL PROTEOMICS | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESTROGEN-RECEPTOR-ALPHA | KINASE INHIBITORS | CARD15 MUTATIONS | BLAU-SYNDROME | ABSOLUTE QUANTIFICATION | LIGASE COMPLEX | CELL-DEATH | Neoplasm Transplantation | Small Molecule Libraries - pharmacology | Receptors, Estrogen - metabolism | Humans | Ubiquitin - metabolism | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Ubiquitination | MCF-7 Cells | Proteolysis | Female | Antineoplastic Agents - pharmacology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Binding Sites | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Biocatalysis | Receptors, Estrogen - genetics | Models, Molecular | Receptors, Estrogen - antagonists & inhibitors | Ubiquitin - genetics | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Protein Binding | Mice | Proteasome Endopeptidase Complex - metabolism | Proteins | Molecular biology | Biocatalysts | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, pp. 6442 - 6442
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 01/2015, Volume 48, Issue 1, pp. 76 - 85
We report on the functional characterization of RIP2 of the goldfish. Quantitative expression analysis of goldfish RIP2 revealed the greatest mRNA levels in... 
Fish | Macrophages | Gene expression | NLR | Mycobacteria | RIP2 | ANTIMICROBIAL RESPONSES | KAPPA-B ACTIVATION | SIGNALING PATHWAYS | VIRUS-INFECTION | PROTEIN | NOD2 | IMMUNOLOGY | IDENTIFICATION | MYCOBACTERIUM-MARINUM | CELL-DEATH | ZOOLOGY | IMMUNE-RESPONSES | Monocytes - metabolism | NF-kappa B - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - immunology | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Antibodies - immunology | Interleukin-1beta - biosynthesis | Macrophages - immunology | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Poly I-C - pharmacology | Neutrophils - immunology | Imidazoles - pharmacology | Inflammation - immunology | Recombinant Proteins - genetics | Spleen - cytology | Goldfish - immunology | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Aeromonas salmonicida - immunology | Animals | Mycobacterium marinum - immunology | Nod2 Signaling Adaptor Protein - metabolism | Recombinant Proteins - immunology | Spleen - metabolism | Inflammasomes - immunology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Pyridines - pharmacology | Peptidoglycan - pharmacology | Tumor Necrosis Factor-alpha - biosynthesis | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1060 - 1073
ObjectivePatients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with... 
IBD-GENETICS | IBD CLINICAL | IMMUNODEFICIENCY | IBD BASIC RESEARCH | Crohn'S DISEASE | MIGLUSTAT THERAPY | PATHOGENESIS | APOPTOSIS | DENDRITIC CELLS | MACROPHAGES | SUSCEPTIBILITY | ILEAL MUCOSA | PHAGOSOME PROTEOME | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | INNATE IMMUNITY | Tumor Necrosis Factor-alpha - metabolism | Crohn Disease - genetics | X-Linked Inhibitor of Apoptosis Protein - deficiency | Humans | Child, Preschool | Lysosomes | Male | Nod2 Signaling Adaptor Protein - genetics | Leukocytes, Mononuclear | Pyridazines - pharmacology | Niemann-Pick Disease, Type C - physiopathology | Autophagy - drug effects | Crohn Disease - complications | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Young Adult | Gentamicins - pharmacology | Adult | Bacteria | Female | Genetic Diseases, X-Linked - genetics | Autophagy - genetics | Child | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Macrophages - physiology | Granuloma - genetics | Cells, Cultured | Chlorpromazine - pharmacology | Imidazoles - pharmacology | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Granuloma - pathology | Nod2 Signaling Adaptor Protein - metabolism | Crohn Disease - pathology | Dopamine Antagonists - pharmacology | Adolescent | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Anti-Bacterial Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Niemann-Pick Disease, Type C - complications | Niemann-Pick Disease, Type C - genetics | Autophagy (Cytology) | Inflammatory bowel diseases | Gastrointestinal diseases | Causes of | Colorectal diseases | Crohn's disease | Research | Niemann-Pick disease | Salmonella | Granuloma | Muramyl dipeptide | Liver | XIAP protein | Kinases | Macrophages | Autophagy | Defects | Genotype & phenotype | Cell activation | Intestine | Neurodegeneration | Npc1 protein | Age | NOD2 protein | Oligomerization | Dendritic cells | Cytokines | Blood & organ donations | Inflammation | Patients | Crohns disease | Studies | Inflammatory bowel disease | Monocytes | Proteomics | Colitis | Adapter proteins | Phagocytosis | Apoptosis | Index Medicus | Abridged Index Medicus | IBD - GENETICS | CROHN'S DISEASE | Inflammatory Bowel Disease | 1506
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4867 - 4880
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 43, pp. 29651 - 29664
Journal Article
Journal of Molecular Modeling, ISSN 1610-2940, 9/2018, Volume 24, Issue 9, pp. 1 - 16
Receptor-interacting protein kinase 2 (RIPK2) plays an essential role in autoimmune response and is suggested as a target for inflammatory diseases. A... 
Theoretical and Computational Chemistry | Chemistry | Anti-inflammatory drugs | RIPK2 | Molecular dynamics | Toxicological | Characterization and Evaluation of Materials | Molecular Medicine | Pharmacokinetic | Computer Applications in Chemistry | Computer Appl. in Life Sciences | RHEUMATOID-ARTHRITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | BIOPHYSICS | CONTINUUM SOLVENT | QUALITY-OF-LIFE | ARTEMISININ | DERIVATIVES | PROGRAM | Cell Line | Drug Evaluation, Preclinical - methods | Inflammation - pathology | Humans | Molecular Dynamics Simulation | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Protein Kinase Inhibitors - chemistry | Inflammation - drug therapy | Receptor-Interacting Protein Serine-Threonine Kinase 2 - chemistry | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Inflammation - enzymology | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Autoimmunity | Hydrogen | Protein kinases | Analysis | Binding | Statistical analysis | Molecular structure | Computer simulation | Correlation coefficients | Standard error | Pharmacology | Kinases | Hydrogen bonding | Variance | Inflammatory diseases | Data bases | Free energy | Biological activity | Proteins | Zinc compounds | Screening | Toxicology | Databases | Inhibitors | Docking | Index Medicus
Journal Article
Chemistry & Biology, ISSN 1074-5521, 09/2015, Volume 22, Issue 9, pp. 1174 - 1184
RIPK2 mediates pro-inflammatory signaling from the bacterial sensors NOD1 and NOD2, and is an emerging therapeutic target in autoimmune and inflammatory... 
BINDING MODE | CROHNS-DISEASE | SOLID TUMORS | HOST RECOGNITION | IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-KAPPA-B | NOD2 | BACTERIAL PEPTIDOGLYCAN | PHASE-I | BOWEL-DISEASE | Ubiquitin | Structure | Drug approval | Crystals | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2008, Volume 283, Issue 18, pp. 11964 - 11971
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 14, pp. 10553 - 10562
Journal Article